Mutagenetix > Incidental Mutation

Incidental Mutation 'R9454:Syne2'

714489

Institutional Source

Beutler Lab

Gene Symbol

Syne2

Ensembl Gene

ENSMUSG00000063450

Gene Name

spectrin repeat containing, nuclear envelope 2

Synonyms

syne-2, D12Ertd777e, nesprin-2, 6820443O06Rik, Nesp2g

MMRRC Submission

Accession Numbers

Genbank: NM_001005510

Essential gene?

Possibly non essential (E-score: 0.305) question?

Stock #

R9454 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

75818134-76110926 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 76095070 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 1388 (K1388*)

Ref Sequence

ENSEMBL: ENSMUSP00000082383 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044217] [ENSMUST00000085280] [ENSMUST00000126903] [ENSMUST00000131480] [ENSMUST00000143031] [ENSMUST00000154509]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000044217
AA Change: K6127*

SMART Domains

Protein: ENSMUSP00000047697
Gene: ENSMUSG00000063450
AA Change: K6127*

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
coiled coil region	844	869	N/A	INTRINSIC
coiled coil region	936	969	N/A	INTRINSIC
coiled coil region	1006	1032	N/A	INTRINSIC
SPEC	1427	1525	4.96e0	SMART
SPEC	1528	1632	2.48e-1	SMART
coiled coil region	1660	1699	N/A	INTRINSIC
SPEC	2034	2131	1.83e0	SMART
coiled coil region	2173	2194	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
coiled coil region	2316	2348	N/A	INTRINSIC
SPEC	2720	2820	1.44e-5	SMART
coiled coil region	2905	2934	N/A	INTRINSIC
coiled coil region	2962	2989	N/A	INTRINSIC
coiled coil region	3108	3136	N/A	INTRINSIC
low complexity region	3333	3350	N/A	INTRINSIC
low complexity region	3514	3523	N/A	INTRINSIC
low complexity region	3666	3676	N/A	INTRINSIC
coiled coil region	3678	3708	N/A	INTRINSIC
coiled coil region	3761	3788	N/A	INTRINSIC
coiled coil region	3846	3903	N/A	INTRINSIC
coiled coil region	4015	4067	N/A	INTRINSIC
low complexity region	4102	4115	N/A	INTRINSIC
coiled coil region	4483	4511	N/A	INTRINSIC
low complexity region	4557	4569	N/A	INTRINSIC
coiled coil region	4655	4688	N/A	INTRINSIC
low complexity region	4749	4763	N/A	INTRINSIC
SPEC	4827	4926	5.25e-1	SMART
SPEC	4933	5038	2.64e-4	SMART
SPEC	5048	5152	1.47e-2	SMART
SPEC	5159	5259	4.29e0	SMART
SPEC	5263	5371	4.47e0	SMART
low complexity region	5373	5393	N/A	INTRINSIC
SPEC	5583	5681	5.7e-1	SMART
Blast:SPEC	5690	5793	2e-53	BLAST
SPEC	5800	5900	2.11e0	SMART
SPEC	5907	6005	6.91e-8	SMART
SPEC	6012	6119	4.45e-11	SMART
SPEC	6126	6228	6.39e-12	SMART
SPEC	6235	6335	7.75e-11	SMART
SPEC	6539	6642	5.53e-7	SMART
SPEC	6649	6753	5.12e-2	SMART
KASH	6817	6874	8.17e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000085280
AA Change: K1388*

SMART Domains

Protein: ENSMUSP00000082383
Gene: ENSMUSG00000063450
AA Change: K1388*

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
SPEC	88	187	5.25e-1	SMART
SPEC	194	299	2.64e-4	SMART
SPEC	309	413	1.47e-2	SMART
SPEC	420	520	4.29e0	SMART
SPEC	524	632	4.47e0	SMART
low complexity region	634	654	N/A	INTRINSIC
SPEC	844	942	5.7e-1	SMART
Blast:SPEC	951	1054	2e-53	BLAST
SPEC	1061	1161	2.11e0	SMART
SPEC	1168	1266	6.91e-8	SMART
SPEC	1273	1380	4.45e-11	SMART
SPEC	1387	1489	6.39e-12	SMART
SPEC	1496	1596	7.75e-11	SMART
SPEC	1823	1926	5.53e-7	SMART
SPEC	1933	2037	5.12e-2	SMART
KASH	2095	2152	8.17e-34	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000126903
AA Change: E71V

SMART Domains

Protein: ENSMUSP00000115053
Gene: ENSMUSG00000063450
AA Change: E71V

Domain	Start	End	E-Value	Type
Blast:SPEC	19	62	5e-24	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000131480

SMART Domains

Protein: ENSMUSP00000114364
Gene: ENSMUSG00000063450

Domain	Start	End	E-Value	Type
Blast:SPEC	1	63	3e-33	BLAST
SPEC	70	168	6.91e-8	SMART
SPEC	175	269	3.46e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000132161
AA Change: K124*

SMART Domains

Protein: ENSMUSP00000122781
Gene: ENSMUSG00000063450
AA Change: K124*

Domain	Start	End	E-Value	Type
SPEC	10	117	4.45e-11	SMART
SPEC	124	226	6.39e-12	SMART
SPEC	233	333	7.75e-11	SMART
SPEC	560	663	5.53e-7	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000139204
AA Change: K902*

SMART Domains

Protein: ENSMUSP00000118921
Gene: ENSMUSG00000063450
AA Change: K902*

Domain	Start	End	E-Value	Type
SPEC	39	147	4.47e0	SMART
low complexity region	149	169	N/A	INTRINSIC
SPEC	359	457	5.7e-1	SMART
Blast:SPEC	466	569	3e-53	BLAST
SPEC	576	676	2.11e0	SMART
SPEC	683	781	6.91e-8	SMART
SPEC	788	895	4.45e-11	SMART
SPEC	902	1004	6.39e-12	SMART
SPEC	1011	1111	7.75e-11	SMART
SPEC	1315	1418	5.53e-7	SMART
SPEC	1425	1529	5.12e-2	SMART
KASH	1587	1644	8.17e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000143031
AA Change: K6128*

SMART Domains

Protein: ENSMUSP00000119120
Gene: ENSMUSG00000063450
AA Change: K6128*

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
coiled coil region	845	870	N/A	INTRINSIC
coiled coil region	937	970	N/A	INTRINSIC
coiled coil region	1007	1033	N/A	INTRINSIC
SPEC	1428	1526	4.96e0	SMART
SPEC	1529	1633	2.48e-1	SMART
coiled coil region	1661	1700	N/A	INTRINSIC
SPEC	2035	2132	1.83e0	SMART
coiled coil region	2174	2195	N/A	INTRINSIC
low complexity region	2296	2308	N/A	INTRINSIC
coiled coil region	2317	2349	N/A	INTRINSIC
SPEC	2721	2821	1.44e-5	SMART
coiled coil region	2906	2935	N/A	INTRINSIC
coiled coil region	2963	2990	N/A	INTRINSIC
coiled coil region	3109	3137	N/A	INTRINSIC
low complexity region	3334	3351	N/A	INTRINSIC
low complexity region	3515	3524	N/A	INTRINSIC
low complexity region	3667	3677	N/A	INTRINSIC
coiled coil region	3679	3709	N/A	INTRINSIC
coiled coil region	3762	3789	N/A	INTRINSIC
coiled coil region	3847	3904	N/A	INTRINSIC
coiled coil region	4016	4068	N/A	INTRINSIC
low complexity region	4103	4116	N/A	INTRINSIC
coiled coil region	4484	4512	N/A	INTRINSIC
low complexity region	4558	4570	N/A	INTRINSIC
coiled coil region	4656	4689	N/A	INTRINSIC
low complexity region	4750	4764	N/A	INTRINSIC
SPEC	4828	4927	5.25e-1	SMART
SPEC	4934	5039	2.64e-4	SMART
SPEC	5049	5153	1.47e-2	SMART
SPEC	5160	5260	4.29e0	SMART
SPEC	5264	5372	4.47e0	SMART
low complexity region	5374	5394	N/A	INTRINSIC
SPEC	5584	5682	5.7e-1	SMART
Blast:SPEC	5691	5794	2e-53	BLAST
SPEC	5801	5901	2.11e0	SMART
SPEC	5908	6006	6.91e-8	SMART
SPEC	6013	6120	4.45e-11	SMART
SPEC	6127	6229	6.39e-12	SMART
SPEC	6236	6336	7.75e-11	SMART
SPEC	6540	6643	5.53e-7	SMART
SPEC	6650	6754	5.12e-2	SMART
KASH	6813	6870	8.17e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000154509

SMART Domains

Protein: ENSMUSP00000116718
Gene: ENSMUSG00000063450

Domain	Start	End	E-Value	Type
SPEC	19	125	3.13e-6	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture inprimary dermal fibroblasts and keratinocytes. Mice homozygous for a spontaneous mutation exhibit early retinal defects in photoreceptors, secondary Neurons, and muller glia. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted, knock-out(2) Gene trapped(3)

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim3	G	T	18: 61,818,996 (GRCm38)	H431Q	possibly damaging	Het
Adam25	A	T	8: 40,754,449 (GRCm38)	I251F	probably damaging	Het
Ankrd31	A	T	13: 96,780,334 (GRCm38)	T119S	probably damaging	Het
Ankrd31	T	C	13: 96,780,338 (GRCm38)	V120A	possibly damaging	Het
Anks6	T	C	4: 47,016,789 (GRCm38)	E809G	possibly damaging	Het
Arhgap21	A	T	2: 20,865,342 (GRCm38)	S928T	probably damaging	Het
Arhgef10l	G	T	4: 140,580,925 (GRCm38)	S39*	probably null	Het
Aspm	G	A	1: 139,480,994 (GRCm38)	E2540K	probably benign	Het
Atp10a	T	C	7: 58,658,591 (GRCm38)	I46T	probably benign	Het
Atp13a5	C	A	16: 29,314,520 (GRCm38)	V483L	possibly damaging	Het
BC028528	T	C	3: 95,889,770 (GRCm38)	D29G	possibly damaging	Het
Ccdc187	T	A	2: 26,276,102 (GRCm38)	T772S	possibly damaging	Het
Ccnh	G	A	13: 85,202,402 (GRCm38)	A199T	probably benign	Het
Cfap65	A	T	1: 74,905,051 (GRCm38)	Y1504N	probably damaging	Het
Ckap2	C	A	8: 22,175,883 (GRCm38)	E383*	probably null	Het
Clec4n	T	C	6: 123,235,573 (GRCm38)	V116A	possibly damaging	Het
Cmc2	G	T	8: 116,889,811 (GRCm38)	D58E	unknown	Het
Cntn6	A	G	6: 104,804,347 (GRCm38)	K465E	possibly damaging	Het
Col6a6	G	A	9: 105,783,860 (GRCm38)	A350V	probably damaging	Het
Cps1	A	G	1: 67,180,152 (GRCm38)	I884V	probably damaging	Het
E2f7	C	T	10: 110,784,681 (GRCm38)	A853V	probably benign	Het
E330034G19Rik	A	T	14: 24,296,792 (GRCm38)	Q114L	unknown	Het
Egfr	G	T	11: 16,887,155 (GRCm38)	G632V	probably damaging	Het
Fam98b	T	C	2: 117,249,769 (GRCm38)	M1T	probably null	Het
Fcgr2b	T	A	1: 170,961,088 (GRCm38)	I317F	probably damaging	Het
Galntl6	T	C	8: 57,958,401 (GRCm38)	D265G	probably damaging	Het
Gm35911	C	T	5: 99,923,093 (GRCm38)	P76S	probably damaging	Het
Gm4922	A	G	10: 18,784,581 (GRCm38)	L131P	probably damaging	Het
H1fnt	T	C	15: 98,256,942 (GRCm38)	I109V	probably benign	Het
H2-Q1	A	T	17: 35,321,373 (GRCm38)	I145F	probably damaging	Het
Heatr5a	AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA	AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA	12: 51,887,919 (GRCm38)		probably benign	Het
Ica1	A	T	6: 8,667,288 (GRCm38)	S293T	probably benign	Het
Klra5	C	A	6: 129,906,723 (GRCm38)	W147L	possibly damaging	Het
Magi2	G	T	5: 20,466,178 (GRCm38)	V507F	probably damaging	Het
Malrd1	T	C	2: 15,752,849 (GRCm38)	I978T	unknown	Het
Malrd1	G	A	2: 15,797,726 (GRCm38)	W1083*	probably null	Het
Mgarp	T	C	3: 51,396,481 (GRCm38)	T10A	probably damaging	Het
Mtnr1a	A	G	8: 45,085,575 (GRCm38)	I17V		Het
Muc5ac	C	T	7: 141,808,694 (GRCm38)	T1914I	unknown	Het
Naf1	GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC	GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC	8: 66,860,548 (GRCm38)		probably benign	Het
Nav3	T	C	10: 110,000,003 (GRCm38)	T73A	probably benign	Het
Olfr1053	A	T	2: 86,314,834 (GRCm38)	Y151N	probably damaging	Het
Olfr1270	A	C	2: 90,149,476 (GRCm38)	C177G	probably damaging	Het
Pclo	T	A	5: 14,712,438 (GRCm38)	S357T	probably benign	Het
Pkdrej	T	A	15: 85,818,219 (GRCm38)	N1172I	probably benign	Het
Psmb9	G	A	17: 34,183,104 (GRCm38)	R173C	probably benign	Het
Ralgapb	T	A	2: 158,473,152 (GRCm38)	H1146Q	probably benign	Het
Raph1	T	A	1: 60,489,594 (GRCm38)	Q836L	unknown	Het
Rcc1	A	G	4: 132,334,763 (GRCm38)	S280P	probably damaging	Het
Recql	T	C	6: 142,374,891 (GRCm38)	M144V	possibly damaging	Het
Rela	T	C	19: 5,645,340 (GRCm38)	I298T	probably damaging	Het
Rfc1	T	A	5: 65,274,431 (GRCm38)	I792F		Het
Rnf31	A	G	14: 55,596,152 (GRCm38)	E539G		Het
Rrp9	T	C	9: 106,483,641 (GRCm38)	S274P	possibly damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,579,923 (GRCm38)		probably benign	Het
Scmh1	A	G	4: 120,515,079 (GRCm38)	I360V	probably benign	Het
Sh3yl1	T	C	12: 30,940,421 (GRCm38)		probably null	Het
Shisa9	T	C	16: 11,984,659 (GRCm38)	S27P	probably benign	Het
Slc17a4	A	G	13: 23,901,927 (GRCm38)	V359A	probably benign	Het
Slfn5	C	A	11: 82,960,059 (GRCm38)	A394E	probably benign	Het
Sun3	A	G	11: 9,038,281 (GRCm38)	F14L	probably benign	Het
Surf1	A	T	2: 26,914,796 (GRCm38)	D148E	possibly damaging	Het
Tacr1	A	G	6: 82,554,872 (GRCm38)	M250V	probably damaging	Het
Tenm2	T	C	11: 36,221,459 (GRCm38)	T420A	probably benign	Het
Tm7sf3	C	A	6: 146,618,543 (GRCm38)	A282S	probably benign	Het
Tmf1	T	C	6: 97,178,905 (GRCm38)	E40G	probably benign	Het
Tnfrsf12a	A	G	17: 23,676,517 (GRCm38)		probably null	Het
Ttc30a2	T	A	2: 75,976,468 (GRCm38)	I567F	probably benign	Het
Unc80	C	A	1: 66,695,590 (GRCm38)	H3325Q	possibly damaging	Het
Zfp142	A	G	1: 74,569,857 (GRCm38)	L1593S	probably damaging	Het
Zfp869	T	A	8: 69,706,591 (GRCm38)	Y444F	probably benign	Het
Zscan10	G	A	17: 23,607,645 (GRCm38)		probably null	Het

Other mutations in Syne2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00329:Syne2	APN	12	76,031,700 (GRCm38)	unclassified	probably benign
IGL00595:Syne2	APN	12	75,925,646 (GRCm38)	missense	possibly damaging	0.76
IGL00672:Syne2	APN	12	76,064,184 (GRCm38)	missense	probably damaging	1.00
IGL00781:Syne2	APN	12	76,024,062 (GRCm38)	missense	probably benign	0.00
IGL00823:Syne2	APN	12	75,989,242 (GRCm38)	missense	probably damaging	0.98
IGL01014:Syne2	APN	12	75,905,277 (GRCm38)	missense	probably damaging	0.99
IGL01074:Syne2	APN	12	76,031,587 (GRCm38)	nonsense	probably null
IGL01074:Syne2	APN	12	75,987,011 (GRCm38)	missense	probably benign	0.00
IGL01324:Syne2	APN	12	76,043,752 (GRCm38)	missense	probably damaging	1.00
IGL01325:Syne2	APN	12	75,926,514 (GRCm38)	missense	probably benign	0.01
IGL01331:Syne2	APN	12	75,929,253 (GRCm38)	splice site	probably benign
IGL01338:Syne2	APN	12	76,060,226 (GRCm38)	missense	possibly damaging	0.55
IGL01373:Syne2	APN	12	75,987,107 (GRCm38)	missense	probably damaging	1.00
IGL01446:Syne2	APN	12	76,041,375 (GRCm38)	missense	probably damaging	1.00
IGL01556:Syne2	APN	12	76,087,815 (GRCm38)	missense	probably damaging	1.00
IGL01585:Syne2	APN	12	75,949,060 (GRCm38)	critical splice acceptor site	probably null
IGL01629:Syne2	APN	12	76,004,603 (GRCm38)	missense	possibly damaging	0.49
IGL01686:Syne2	APN	12	75,909,336 (GRCm38)	missense	probably benign
IGL01935:Syne2	APN	12	75,925,313 (GRCm38)	missense	probably damaging	1.00
IGL01941:Syne2	APN	12	75,967,220 (GRCm38)	missense	probably benign	0.01
IGL01956:Syne2	APN	12	76,097,974 (GRCm38)	missense	probably damaging	1.00
IGL01967:Syne2	APN	12	75,941,303 (GRCm38)	missense	probably damaging	1.00
IGL01990:Syne2	APN	12	76,054,933 (GRCm38)	missense	probably damaging	1.00
IGL02000:Syne2	APN	12	76,015,645 (GRCm38)	missense	probably damaging	0.99
IGL02063:Syne2	APN	12	76,052,100 (GRCm38)	missense	probably damaging	0.96
IGL02069:Syne2	APN	12	75,927,412 (GRCm38)	missense	probably benign	0.13
IGL02120:Syne2	APN	12	75,946,706 (GRCm38)	missense	probably damaging	1.00
IGL02222:Syne2	APN	12	75,952,843 (GRCm38)	missense	probably damaging	0.96
IGL02223:Syne2	APN	12	76,108,305 (GRCm38)	missense	probably benign	0.00
IGL02321:Syne2	APN	12	75,918,999 (GRCm38)	missense	possibly damaging	0.58
IGL02488:Syne2	APN	12	75,965,738 (GRCm38)	missense	probably benign	0.24
IGL02491:Syne2	APN	12	76,072,179 (GRCm38)	missense	probably benign	0.10
IGL02525:Syne2	APN	12	76,101,003 (GRCm38)	missense	probably damaging	0.99
IGL02578:Syne2	APN	12	76,022,279 (GRCm38)	missense	possibly damaging	0.76
IGL02615:Syne2	APN	12	76,096,994 (GRCm38)	missense	probably damaging	1.00
IGL02702:Syne2	APN	12	76,097,924 (GRCm38)	missense	probably damaging	1.00
IGL02726:Syne2	APN	12	76,015,582 (GRCm38)	missense	probably damaging	0.99
IGL02795:Syne2	APN	12	75,966,549 (GRCm38)	missense	probably damaging	0.99
IGL02803:Syne2	APN	12	76,031,546 (GRCm38)	missense	probably damaging	1.00
IGL02814:Syne2	APN	12	75,945,376 (GRCm38)	missense	possibly damaging	0.64
IGL03013:Syne2	APN	12	75,929,337 (GRCm38)	missense	probably benign	0.00
IGL03131:Syne2	APN	12	76,057,490 (GRCm38)	missense	probably damaging	1.00
IGL03152:Syne2	APN	12	75,965,712 (GRCm38)	missense	probably benign	0.12
IGL03216:Syne2	APN	12	75,942,961 (GRCm38)	splice site	probably benign
IGL03228:Syne2	APN	12	75,979,912 (GRCm38)	missense	probably benign	0.01
IGL03259:Syne2	APN	12	75,989,079 (GRCm38)	missense	probably benign	0.05
IGL03374:Syne2	APN	12	76,074,586 (GRCm38)	missense	possibly damaging	0.66
IGL03375:Syne2	APN	12	75,925,435 (GRCm38)	missense	possibly damaging	0.57
3-1:Syne2	UTSW	12	75,930,632 (GRCm38)	missense	probably benign	0.02
B5639:Syne2	UTSW	12	75,929,790 (GRCm38)	missense	probably benign
K3955:Syne2	UTSW	12	75,930,665 (GRCm38)	missense	probably damaging	1.00
P0026:Syne2	UTSW	12	75,880,220 (GRCm38)	splice site	probably benign
PIT4514001:Syne2	UTSW	12	76,105,015 (GRCm38)	missense	probably damaging	0.99
R0089:Syne2	UTSW	12	75,963,876 (GRCm38)	missense	probably damaging	1.00
R0110:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0113:Syne2	UTSW	12	76,033,722 (GRCm38)	missense	probably damaging	1.00
R0113:Syne2	UTSW	12	75,930,578 (GRCm38)	missense	probably damaging	1.00
R0141:Syne2	UTSW	12	75,941,298 (GRCm38)	missense	probably damaging	1.00
R0211:Syne2	UTSW	12	76,097,957 (GRCm38)	missense	probably damaging	1.00
R0219:Syne2	UTSW	12	76,042,004 (GRCm38)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,098,034 (GRCm38)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,098,034 (GRCm38)	missense	probably damaging	1.00
R0279:Syne2	UTSW	12	76,095,613 (GRCm38)	missense	probably damaging	1.00
R0319:Syne2	UTSW	12	76,064,162 (GRCm38)	missense	probably damaging	0.99
R0325:Syne2	UTSW	12	75,962,641 (GRCm38)	missense	probably benign	0.00
R0329:Syne2	UTSW	12	75,966,953 (GRCm38)	missense	probably benign
R0330:Syne2	UTSW	12	75,966,953 (GRCm38)	missense	probably benign
R0361:Syne2	UTSW	12	75,918,610 (GRCm38)	missense	probably benign	0.22
R0363:Syne2	UTSW	12	76,072,207 (GRCm38)	missense	probably damaging	0.98
R0367:Syne2	UTSW	12	75,880,177 (GRCm38)	missense	probably damaging	1.00
R0371:Syne2	UTSW	12	75,933,845 (GRCm38)	missense	probably damaging	1.00
R0374:Syne2	UTSW	12	75,921,226 (GRCm38)	nonsense	probably null
R0388:Syne2	UTSW	12	75,986,975 (GRCm38)	missense	probably benign	0.41
R0411:Syne2	UTSW	12	76,059,584 (GRCm38)	splice site	probably null
R0432:Syne2	UTSW	12	75,949,064 (GRCm38)	missense	probably damaging	0.99
R0469:Syne2	UTSW	12	75,854,149 (GRCm38)	critical splice donor site	probably null
R0492:Syne2	UTSW	12	75,982,063 (GRCm38)	critical splice donor site	probably null
R0496:Syne2	UTSW	12	76,038,940 (GRCm38)	missense	possibly damaging	0.80
R0504:Syne2	UTSW	12	76,033,591 (GRCm38)	splice site	probably benign
R0505:Syne2	UTSW	12	76,099,464 (GRCm38)	missense	probably damaging	1.00
R0510:Syne2	UTSW	12	75,854,149 (GRCm38)	critical splice donor site	probably null
R0518:Syne2	UTSW	12	76,108,862 (GRCm38)	critical splice acceptor site	probably null
R0539:Syne2	UTSW	12	76,024,121 (GRCm38)	missense	possibly damaging	0.69
R0552:Syne2	UTSW	12	75,931,004 (GRCm38)	missense	probably benign	0.00
R0557:Syne2	UTSW	12	75,929,301 (GRCm38)	missense	probably benign	0.04
R0567:Syne2	UTSW	12	75,890,230 (GRCm38)	missense	probably damaging	0.98
R0599:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0602:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0608:Syne2	UTSW	12	75,963,813 (GRCm38)	missense	probably damaging	1.00
R0614:Syne2	UTSW	12	75,912,353 (GRCm38)	splice site	probably null
R0636:Syne2	UTSW	12	75,930,983 (GRCm38)	missense	possibly damaging	0.75
R0647:Syne2	UTSW	12	75,888,203 (GRCm38)	missense	probably benign
R0654:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0658:Syne2	UTSW	12	76,094,336 (GRCm38)	missense	probably damaging	1.00
R0666:Syne2	UTSW	12	75,923,013 (GRCm38)	missense	probably damaging	0.99
R0707:Syne2	UTSW	12	75,982,063 (GRCm38)	critical splice donor site	probably null
R0714:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0841:Syne2	UTSW	12	76,074,435 (GRCm38)	splice site	probably benign
R0848:Syne2	UTSW	12	76,097,960 (GRCm38)	nonsense	probably null
R0848:Syne2	UTSW	12	76,097,959 (GRCm38)	frame shift	probably null
R1077:Syne2	UTSW	12	76,042,035 (GRCm38)	missense	possibly damaging	0.94
R1103:Syne2	UTSW	12	76,109,835 (GRCm38)	missense	probably benign	0.00
R1144:Syne2	UTSW	12	75,966,524 (GRCm38)	missense	probably benign	0.04
R1194:Syne2	UTSW	12	75,934,513 (GRCm38)	missense	probably damaging	1.00
R1247:Syne2	UTSW	12	75,967,490 (GRCm38)	missense	probably benign	0.39
R1276:Syne2	UTSW	12	75,941,189 (GRCm38)	critical splice acceptor site	probably null
R1343:Syne2	UTSW	12	76,033,643 (GRCm38)	missense	probably damaging	1.00
R1442:Syne2	UTSW	12	75,946,715 (GRCm38)	missense	probably damaging	1.00
R1448:Syne2	UTSW	12	76,052,178 (GRCm38)	missense	possibly damaging	0.56
R1448:Syne2	UTSW	12	76,020,325 (GRCm38)	splice site	probably null
R1522:Syne2	UTSW	12	76,103,783 (GRCm38)	missense	probably damaging	0.98
R1528:Syne2	UTSW	12	75,966,100 (GRCm38)	missense	probably benign	0.00
R1636:Syne2	UTSW	12	76,004,732 (GRCm38)	missense	probably benign	0.01
R1637:Syne2	UTSW	12	75,996,002 (GRCm38)	missense	probably damaging	1.00
R1650:Syne2	UTSW	12	75,904,259 (GRCm38)	nonsense	probably null
R1654:Syne2	UTSW	12	76,101,094 (GRCm38)	missense	possibly damaging	0.56
R1714:Syne2	UTSW	12	76,054,939 (GRCm38)	missense	probably benign	0.26
R1750:Syne2	UTSW	12	76,052,805 (GRCm38)	missense	probably damaging	1.00
R1772:Syne2	UTSW	12	75,938,729 (GRCm38)	missense	probably benign	0.19
R1797:Syne2	UTSW	12	75,963,783 (GRCm38)	missense	probably benign	0.00
R1830:Syne2	UTSW	12	76,109,862 (GRCm38)	missense	probably damaging	1.00
R1837:Syne2	UTSW	12	75,967,660 (GRCm38)	missense	probably damaging	0.99
R1908:Syne2	UTSW	12	76,094,279 (GRCm38)	critical splice acceptor site	probably null
R1913:Syne2	UTSW	12	75,899,246 (GRCm38)	missense	possibly damaging	0.60
R1944:Syne2	UTSW	12	76,074,544 (GRCm38)	missense	probably damaging	1.00
R1950:Syne2	UTSW	12	75,952,870 (GRCm38)	missense	probably benign
R1958:Syne2	UTSW	12	75,969,545 (GRCm38)	missense	probably benign	0.11
R2018:Syne2	UTSW	12	76,074,579 (GRCm38)	missense	probably damaging	1.00
R2037:Syne2	UTSW	12	76,025,569 (GRCm38)	missense	probably benign	0.04
R2067:Syne2	UTSW	12	75,888,342 (GRCm38)	critical splice donor site	probably null
R2073:Syne2	UTSW	12	76,015,579 (GRCm38)	missense	possibly damaging	0.54
R2099:Syne2	UTSW	12	75,979,973 (GRCm38)	missense	probably benign	0.06
R2102:Syne2	UTSW	12	76,028,079 (GRCm38)	missense	probably benign	0.01
R2134:Syne2	UTSW	12	75,952,786 (GRCm38)	missense	probably damaging	0.99
R2135:Syne2	UTSW	12	75,952,786 (GRCm38)	missense	probably damaging	0.99
R2157:Syne2	UTSW	12	76,094,456 (GRCm38)	missense	probably damaging	1.00
R2173:Syne2	UTSW	12	76,100,989 (GRCm38)	splice site	probably benign
R2248:Syne2	UTSW	12	76,096,904 (GRCm38)	missense	probably damaging	1.00
R2276:Syne2	UTSW	12	75,927,466 (GRCm38)	missense	possibly damaging	0.87
R2277:Syne2	UTSW	12	75,927,466 (GRCm38)	missense	possibly damaging	0.87
R2278:Syne2	UTSW	12	75,927,466 (GRCm38)	missense	possibly damaging	0.87
R2279:Syne2	UTSW	12	75,927,466 (GRCm38)	missense	possibly damaging	0.87
R2483:Syne2	UTSW	12	76,095,537 (GRCm38)	missense	probably damaging	1.00
R2877:Syne2	UTSW	12	76,000,831 (GRCm38)	missense	probably benign	0.00
R2884:Syne2	UTSW	12	75,963,759 (GRCm38)	missense	probably benign	0.00
R3119:Syne2	UTSW	12	75,909,284 (GRCm38)	missense	probably benign	0.01
R3499:Syne2	UTSW	12	76,054,978 (GRCm38)	splice site	probably null
R3827:Syne2	UTSW	12	75,987,031 (GRCm38)	missense	probably benign	0.02
R3847:Syne2	UTSW	12	76,048,622 (GRCm38)	missense	probably damaging	1.00
R3849:Syne2	UTSW	12	76,046,065 (GRCm38)	nonsense	probably null
R3850:Syne2	UTSW	12	76,048,622 (GRCm38)	missense	probably damaging	1.00
R3859:Syne2	UTSW	12	75,929,784 (GRCm38)	missense	possibly damaging	0.55
R3861:Syne2	UTSW	12	75,966,479 (GRCm38)	missense	probably damaging	0.98
R4078:Syne2	UTSW	12	76,035,624 (GRCm38)	missense	probably damaging	1.00
R4116:Syne2	UTSW	12	75,931,079 (GRCm38)	missense	probably damaging	1.00
R4326:Syne2	UTSW	12	75,952,742 (GRCm38)	missense	probably damaging	1.00
R4335:Syne2	UTSW	12	76,028,092 (GRCm38)	missense	probably damaging	1.00
R4410:Syne2	UTSW	12	76,094,393 (GRCm38)	missense	probably damaging	1.00
R4412:Syne2	UTSW	12	76,106,060 (GRCm38)	missense	probably benign	0.01
R4444:Syne2	UTSW	12	76,023,030 (GRCm38)	missense	probably damaging	1.00
R4595:Syne2	UTSW	12	75,967,071 (GRCm38)	missense	possibly damaging	0.88
R4604:Syne2	UTSW	12	75,967,710 (GRCm38)	missense	probably damaging	0.99
R4606:Syne2	UTSW	12	75,989,253 (GRCm38)	missense	probably damaging	1.00
R4651:Syne2	UTSW	12	75,989,239 (GRCm38)	missense	probably damaging	0.99
R4656:Syne2	UTSW	12	76,031,373 (GRCm38)	missense	probably damaging	1.00
R4675:Syne2	UTSW	12	75,949,301 (GRCm38)	missense	probably damaging	1.00
R4790:Syne2	UTSW	12	76,020,391 (GRCm38)	missense	probably benign	0.19
R4791:Syne2	UTSW	12	75,909,244 (GRCm38)	missense	possibly damaging	0.96
R4799:Syne2	UTSW	12	75,899,167 (GRCm38)	missense	probably benign	0.04
R4836:Syne2	UTSW	12	75,979,819 (GRCm38)	missense	probably damaging	1.00
R4880:Syne2	UTSW	12	75,979,819 (GRCm38)	missense	probably damaging	1.00
R4881:Syne2	UTSW	12	75,979,819 (GRCm38)	missense	probably damaging	1.00
R4899:Syne2	UTSW	12	75,854,101 (GRCm38)	missense	probably benign	0.03
R4934:Syne2	UTSW	12	75,899,272 (GRCm38)	missense	probably benign	0.14
R4981:Syne2	UTSW	12	75,941,219 (GRCm38)	missense	probably damaging	0.98
R4996:Syne2	UTSW	12	75,943,950 (GRCm38)	missense	possibly damaging	0.87
R5056:Syne2	UTSW	12	75,909,131 (GRCm38)	unclassified	probably benign
R5066:Syne2	UTSW	12	75,966,551 (GRCm38)	missense	probably benign	0.05
R5095:Syne2	UTSW	12	75,952,826 (GRCm38)	missense	probably damaging	0.99
R5151:Syne2	UTSW	12	76,043,710 (GRCm38)	missense	probably benign	0.06
R5193:Syne2	UTSW	12	76,094,420 (GRCm38)	missense	probably damaging	1.00
R5267:Syne2	UTSW	12	75,938,741 (GRCm38)	missense	possibly damaging	0.74
R5288:Syne2	UTSW	12	76,099,338 (GRCm38)	missense	possibly damaging	0.94
R5402:Syne2	UTSW	12	76,059,439 (GRCm38)	missense	probably damaging	0.98
R5434:Syne2	UTSW	12	75,971,875 (GRCm38)	missense	probably damaging	1.00
R5441:Syne2	UTSW	12	75,989,143 (GRCm38)	missense	possibly damaging	0.75
R5488:Syne2	UTSW	12	75,888,172 (GRCm38)	missense	probably benign	0.13
R5497:Syne2	UTSW	12	75,880,389 (GRCm38)	missense	probably benign	0.19
R5506:Syne2	UTSW	12	75,938,721 (GRCm38)	missense	probably benign	0.01
R5509:Syne2	UTSW	12	75,921,244 (GRCm38)	missense	probably damaging	1.00
R5518:Syne2	UTSW	12	75,945,170 (GRCm38)	missense	possibly damaging	0.88
R5561:Syne2	UTSW	12	76,094,458 (GRCm38)	nonsense	probably null
R5581:Syne2	UTSW	12	75,945,085 (GRCm38)	missense	probably benign	0.01
R5625:Syne2	UTSW	12	76,095,112 (GRCm38)	missense	probably benign	0.06
R5642:Syne2	UTSW	12	75,918,532 (GRCm38)	missense	probably damaging	1.00
R5665:Syne2	UTSW	12	76,108,217 (GRCm38)	critical splice donor site	probably null
R5666:Syne2	UTSW	12	75,950,959 (GRCm38)	missense	probably benign	0.16
R5670:Syne2	UTSW	12	75,950,959 (GRCm38)	missense	probably benign	0.16
R5691:Syne2	UTSW	12	76,027,856 (GRCm38)	frame shift	probably null
R5696:Syne2	UTSW	12	75,994,145 (GRCm38)	missense	probably benign	0.00
R5720:Syne2	UTSW	12	75,967,667 (GRCm38)	missense	probably benign	0.03
R5739:Syne2	UTSW	12	75,997,465 (GRCm38)	missense	possibly damaging	0.53
R5840:Syne2	UTSW	12	75,880,291 (GRCm38)	splice site	probably null
R5846:Syne2	UTSW	12	76,028,124 (GRCm38)	missense	probably benign	0.01
R5850:Syne2	UTSW	12	76,097,975 (GRCm38)	missense	probably damaging	1.00
R5889:Syne2	UTSW	12	76,072,252 (GRCm38)	nonsense	probably null
R5912:Syne2	UTSW	12	75,908,947 (GRCm38)	critical splice donor site	probably null
R5931:Syne2	UTSW	12	76,008,865 (GRCm38)	missense	probably benign	0.37
R5985:Syne2	UTSW	12	75,966,159 (GRCm38)	missense	probably damaging	0.96
R5988:Syne2	UTSW	12	75,929,417 (GRCm38)	critical splice donor site	probably null
R5990:Syne2	UTSW	12	76,024,144 (GRCm38)	missense	probably benign	0.10
R6038:Syne2	UTSW	12	75,878,384 (GRCm38)	nonsense	probably null
R6038:Syne2	UTSW	12	75,878,384 (GRCm38)	nonsense	probably null
R6132:Syne2	UTSW	12	75,945,147 (GRCm38)	missense	probably benign	0.14
R6136:Syne2	UTSW	12	75,905,325 (GRCm38)	missense	probably benign	0.24
R6229:Syne2	UTSW	12	75,921,220 (GRCm38)	missense	probably benign	0.00
R6252:Syne2	UTSW	12	75,969,436 (GRCm38)	missense	probably benign	0.39
R6271:Syne2	UTSW	12	75,890,381 (GRCm38)	missense	probably damaging	1.00
R6320:Syne2	UTSW	12	76,061,650 (GRCm38)	missense	probably damaging	0.96
R6339:Syne2	UTSW	12	75,989,153 (GRCm38)	missense	probably benign	0.34
R6380:Syne2	UTSW	12	76,104,980 (GRCm38)	missense	probably damaging	0.98
R6394:Syne2	UTSW	12	75,990,495 (GRCm38)	missense	probably benign	0.09
R6419:Syne2	UTSW	12	76,096,966 (GRCm38)	missense	probably damaging	1.00
R6426:Syne2	UTSW	12	75,923,083 (GRCm38)	missense	probably null	0.97
R6434:Syne2	UTSW	12	76,041,456 (GRCm38)	missense	probably damaging	0.99
R6437:Syne2	UTSW	12	75,990,414 (GRCm38)	missense	possibly damaging	0.87
R6466:Syne2	UTSW	12	75,943,901 (GRCm38)	missense	probably damaging	0.97
R6501:Syne2	UTSW	12	76,027,847 (GRCm38)	splice site	probably null
R6552:Syne2	UTSW	12	75,890,241 (GRCm38)	missense	possibly damaging	0.89
R6744:Syne2	UTSW	12	76,074,447 (GRCm38)	missense	probably damaging	1.00
R6810:Syne2	UTSW	12	75,942,885 (GRCm38)	missense	probably benign	0.00
R6831:Syne2	UTSW	12	75,966,794 (GRCm38)	missense	probably benign	0.39
R6861:Syne2	UTSW	12	75,909,266 (GRCm38)	missense	probably damaging	1.00
R6875:Syne2	UTSW	12	76,035,630 (GRCm38)	missense	probably damaging	0.99
R6892:Syne2	UTSW	12	75,962,528 (GRCm38)	missense	probably damaging	0.98
R6899:Syne2	UTSW	12	76,095,729 (GRCm38)	splice site	probably null
R6906:Syne2	UTSW	12	75,995,986 (GRCm38)	missense	possibly damaging	0.93
R6909:Syne2	UTSW	12	76,064,195 (GRCm38)	missense	probably benign	0.04
R6925:Syne2	UTSW	12	75,854,132 (GRCm38)	missense	possibly damaging	0.58
R6949:Syne2	UTSW	12	75,965,997 (GRCm38)	missense	probably benign	0.00
R6952:Syne2	UTSW	12	75,927,431 (GRCm38)	missense	possibly damaging	0.76
R6996:Syne2	UTSW	12	76,028,012 (GRCm38)	missense	probably damaging	0.99
R7080:Syne2	UTSW	12	76,052,727 (GRCm38)	missense	probably benign	0.00
R7083:Syne2	UTSW	12	75,943,888 (GRCm38)	missense	probably damaging	1.00
R7090:Syne2	UTSW	12	75,942,351 (GRCm38)	missense	probably benign
R7144:Syne2	UTSW	12	76,005,378 (GRCm38)	missense	probably benign	0.03
R7154:Syne2	UTSW	12	76,059,457 (GRCm38)	missense	possibly damaging	0.63
R7177:Syne2	UTSW	12	75,971,880 (GRCm38)	nonsense	probably null
R7190:Syne2	UTSW	12	76,066,587 (GRCm38)	missense	probably benign	0.01
R7206:Syne2	UTSW	12	76,004,757 (GRCm38)	missense	probably benign	0.02
R7208:Syne2	UTSW	12	76,031,398 (GRCm38)	splice site	probably null
R7230:Syne2	UTSW	12	75,933,900 (GRCm38)	missense	probably benign	0.12
R7260:Syne2	UTSW	12	75,945,079 (GRCm38)	missense	probably damaging	1.00
R7272:Syne2	UTSW	12	76,048,643 (GRCm38)	missense	probably benign	0.00
R7296:Syne2	UTSW	12	76,103,036 (GRCm38)	missense	probably benign	0.00
R7322:Syne2	UTSW	12	75,984,024 (GRCm38)	missense	probably damaging	1.00
R7329:Syne2	UTSW	12	75,966,984 (GRCm38)	missense	probably benign	0.01
R7332:Syne2	UTSW	12	75,967,755 (GRCm38)	critical splice donor site	probably null
R7381:Syne2	UTSW	12	75,926,489 (GRCm38)	missense	probably benign	0.11
R7401:Syne2	UTSW	12	75,967,381 (GRCm38)	missense	probably damaging	0.98
R7403:Syne2	UTSW	12	75,915,246 (GRCm38)	missense	not run
R7429:Syne2	UTSW	12	76,040,410 (GRCm38)	nonsense	probably null
R7429:Syne2	UTSW	12	75,933,996 (GRCm38)	missense	probably damaging	1.00
R7430:Syne2	UTSW	12	76,040,410 (GRCm38)	nonsense	probably null
R7430:Syne2	UTSW	12	75,933,996 (GRCm38)	missense	probably damaging	1.00
R7438:Syne2	UTSW	12	76,015,563 (GRCm38)	missense	probably benign	0.04
R7447:Syne2	UTSW	12	76,028,079 (GRCm38)	missense	probably benign	0.01
R7466:Syne2	UTSW	12	76,046,186 (GRCm38)	missense	possibly damaging	0.92
R7493:Syne2	UTSW	12	75,965,880 (GRCm38)	missense	probably benign	0.00
R7502:Syne2	UTSW	12	76,094,326 (GRCm38)	missense	probably damaging	1.00
R7543:Syne2	UTSW	12	75,906,842 (GRCm38)	missense	possibly damaging	0.93
R7569:Syne2	UTSW	12	75,927,390 (GRCm38)	missense	probably benign	0.00
R7599:Syne2	UTSW	12	75,966,371 (GRCm38)	missense	probably benign	0.04
R7618:Syne2	UTSW	12	75,945,334 (GRCm38)	missense	probably benign	0.01
R7639:Syne2	UTSW	12	75,934,499 (GRCm38)	missense	probably damaging	1.00
R7698:Syne2	UTSW	12	75,949,064 (GRCm38)	missense	probably damaging	0.99
R7702:Syne2	UTSW	12	75,990,387 (GRCm38)	missense	probably benign	0.16
R7737:Syne2	UTSW	12	75,942,848 (GRCm38)	missense	probably damaging	1.00
R7742:Syne2	UTSW	12	76,059,435 (GRCm38)	missense	probably benign	0.02
R7753:Syne2	UTSW	12	76,038,923 (GRCm38)	missense	probably benign	0.43
R7755:Syne2	UTSW	12	75,997,407 (GRCm38)	missense	probably benign	0.19
R7757:Syne2	UTSW	12	76,061,779 (GRCm38)	missense	possibly damaging	0.87
R7790:Syne2	UTSW	12	75,929,103 (GRCm38)	splice site	probably null
R7808:Syne2	UTSW	12	75,983,727 (GRCm38)	splice site	probably null
R7809:Syne2	UTSW	12	75,967,456 (GRCm38)	missense	probably benign	0.00
R7811:Syne2	UTSW	12	75,983,727 (GRCm38)	splice site	probably null
R7834:Syne2	UTSW	12	75,967,247 (GRCm38)	missense	probably benign	0.00
R7853:Syne2	UTSW	12	76,031,504 (GRCm38)	missense	probably damaging	1.00
R7867:Syne2	UTSW	12	75,983,727 (GRCm38)	splice site	probably null
R7896:Syne2	UTSW	12	76,035,623 (GRCm38)	missense	probably damaging	0.99
R7903:Syne2	UTSW	12	76,064,184 (GRCm38)	missense	probably damaging	1.00
R7944:Syne2	UTSW	12	75,904,305 (GRCm38)	missense	probably damaging	0.98
R7945:Syne2	UTSW	12	75,904,305 (GRCm38)	missense	probably damaging	0.98
R7963:Syne2	UTSW	12	76,020,400 (GRCm38)	missense	probably benign	0.38
R7996:Syne2	UTSW	12	76,004,667 (GRCm38)	missense	probably damaging	1.00
R7998:Syne2	UTSW	12	76,087,858 (GRCm38)	missense	probably damaging	1.00
R8010:Syne2	UTSW	12	75,930,738 (GRCm38)	missense	probably benign	0.39
R8016:Syne2	UTSW	12	75,942,907 (GRCm38)	missense	probably benign	0.19
R8140:Syne2	UTSW	12	75,912,353 (GRCm38)	missense	possibly damaging	0.63
R8141:Syne2	UTSW	12	76,061,668 (GRCm38)	missense	possibly damaging	0.66
R8206:Syne2	UTSW	12	76,015,591 (GRCm38)	missense	probably benign	0.03
R8258:Syne2	UTSW	12	75,949,369 (GRCm38)	missense	possibly damaging	0.95
R8259:Syne2	UTSW	12	75,949,369 (GRCm38)	missense	possibly damaging	0.95
R8320:Syne2	UTSW	12	76,103,830 (GRCm38)	missense	probably damaging	0.99
R8464:Syne2	UTSW	12	75,965,772 (GRCm38)	missense	probably benign	0.39
R8465:Syne2	UTSW	12	75,854,124 (GRCm38)	missense	possibly damaging	0.92
R8486:Syne2	UTSW	12	76,042,107 (GRCm38)	nonsense	probably null
R8488:Syne2	UTSW	12	75,965,772 (GRCm38)	missense	probably benign	0.39
R8511:Syne2	UTSW	12	76,008,873 (GRCm38)	missense	probably benign	0.03
R8540:Syne2	UTSW	12	76,094,374 (GRCm38)	missense	probably damaging	1.00
R8711:Syne2	UTSW	12	76,057,484 (GRCm38)	missense	probably damaging	1.00
R8722:Syne2	UTSW	12	75,925,321 (GRCm38)	missense	probably benign	0.04
R8827:Syne2	UTSW	12	76,048,583 (GRCm38)	missense	probably benign	0.00
R8867:Syne2	UTSW	12	75,942,846 (GRCm38)	missense	probably damaging	1.00
R8878:Syne2	UTSW	12	75,905,293 (GRCm38)	missense	probably benign
R8924:Syne2	UTSW	12	75,896,670 (GRCm38)	missense	probably damaging	0.97
R8966:Syne2	UTSW	12	76,099,423 (GRCm38)	missense	probably damaging	1.00
R9007:Syne2	UTSW	12	76,099,450 (GRCm38)	missense	possibly damaging	0.82
R9019:Syne2	UTSW	12	75,952,844 (GRCm38)	missense	possibly damaging	0.93
R9057:Syne2	UTSW	12	75,890,393 (GRCm38)	missense	probably damaging	1.00
R9067:Syne2	UTSW	12	75,904,220 (GRCm38)	missense	probably damaging	1.00
R9081:Syne2	UTSW	12	75,969,516 (GRCm38)	nonsense	probably null
R9091:Syne2	UTSW	12	75,931,060 (GRCm38)	missense	probably damaging	1.00
R9123:Syne2	UTSW	12	75,994,064 (GRCm38)	missense	probably damaging	1.00
R9147:Syne2	UTSW	12	75,890,384 (GRCm38)	missense	probably damaging	1.00
R9148:Syne2	UTSW	12	75,890,384 (GRCm38)	missense	probably damaging	1.00
R9163:Syne2	UTSW	12	75,962,575 (GRCm38)	missense	possibly damaging	0.88
R9192:Syne2	UTSW	12	76,109,929 (GRCm38)	missense	probably damaging	1.00
R9248:Syne2	UTSW	12	76,107,456 (GRCm38)	intron	probably benign
R9270:Syne2	UTSW	12	75,931,060 (GRCm38)	missense	probably damaging	1.00
R9292:Syne2	UTSW	12	75,951,049 (GRCm38)	missense	probably benign
R9397:Syne2	UTSW	12	75,994,075 (GRCm38)	missense	possibly damaging	0.59
R9454:Syne2	UTSW	12	76,020,501 (GRCm38)	missense	probably damaging	0.99
R9478:Syne2	UTSW	12	76,107,613 (GRCm38)	missense	probably damaging	0.96
R9492:Syne2	UTSW	12	75,949,065 (GRCm38)	missense	possibly damaging	0.77
R9573:Syne2	UTSW	12	75,880,360 (GRCm38)	missense	probably damaging	1.00
R9611:Syne2	UTSW	12	76,033,686 (GRCm38)	missense	probably benign	0.05
R9623:Syne2	UTSW	12	75,939,986 (GRCm38)	missense	probably benign	0.12
R9647:Syne2	UTSW	12	76,105,101 (GRCm38)	missense	possibly damaging	0.55
R9652:Syne2	UTSW	12	76,054,846 (GRCm38)	missense	probably benign	0.00
R9667:Syne2	UTSW	12	75,880,177 (GRCm38)	missense	probably damaging	1.00
R9701:Syne2	UTSW	12	75,990,423 (GRCm38)	missense	probably damaging	1.00
R9794:Syne2	UTSW	12	76,000,843 (GRCm38)	missense	probably benign	0.04
R9802:Syne2	UTSW	12	75,990,423 (GRCm38)	missense	probably damaging	1.00
X0019:Syne2	UTSW	12	75,973,287 (GRCm38)	missense	probably benign	0.41
X0026:Syne2	UTSW	12	76,101,016 (GRCm38)	missense	possibly damaging	0.78
X0061:Syne2	UTSW	12	75,927,511 (GRCm38)	critical splice donor site	probably null
X0066:Syne2	UTSW	12	76,096,927 (GRCm38)	missense	probably damaging	1.00
Z1176:Syne2	UTSW	12	76,040,383 (GRCm38)	missense	possibly damaging	0.48
Z1176:Syne2	UTSW	12	75,967,541 (GRCm38)	missense	probably benign	0.01
Z1177:Syne2	UTSW	12	75,973,423 (GRCm38)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,097,974 (GRCm38)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,064,138 (GRCm38)	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- AGCTATTTCCTGGGAAGGGATG -3'
(R):5'- GGAACATCTGGCCATGCAAAG -3'

Sequencing Primer
(F):5'- CCTGGGAAGGGATGACGGG -3'
(R):5'- TCTGGCCATGCAAAGTCACTTAG -3'

Posted On

2022-06-15