Incidental Mutation 'R9456:Gm3336'
ID 714581
Institutional Source Beutler Lab
Gene Symbol Gm3336
Ensembl Gene ENSMUSG00000095026
Gene Name predicted gene 3336
Synonyms 2410018E23Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R9456 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 71171192-71175283 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) A to G at 71174740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Tryptophan at position 96 (*96W)
Ref Sequence ENSEMBL: ENSMUSP00000148772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034307] [ENSMUST00000110095] [ENSMUST00000123739] [ENSMUST00000179347] [ENSMUST00000212436] [ENSMUST00000213065]
AlphaFold J3QMQ6
Predicted Effect probably benign
Transcript: ENSMUST00000034307
SMART Domains Protein: ENSMUSP00000034307
Gene: ENSMUSG00000031842

DomainStartEndE-ValueType
low complexity region 40 56 N/A INTRINSIC
HDc 386 512 1.48e0 SMART
Pfam:PDEase_I 526 598 5.3e-21 PFAM
low complexity region 625 636 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110095
SMART Domains Protein: ENSMUSP00000105722
Gene: ENSMUSG00000031842

DomainStartEndE-ValueType
low complexity region 40 56 N/A INTRINSIC
HDc 386 561 5.11e-6 SMART
low complexity region 659 670 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123739
SMART Domains Protein: ENSMUSP00000119312
Gene: ENSMUSG00000031842

DomainStartEndE-ValueType
low complexity region 40 56 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000179347
AA Change: *199W
SMART Domains Protein: ENSMUSP00000136399
Gene: ENSMUSG00000095026
AA Change: *199W

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
low complexity region 45 71 N/A INTRINSIC
low complexity region 103 114 N/A INTRINSIC
transmembrane domain 143 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000212436
Predicted Effect probably null
Transcript: ENSMUST00000213065
AA Change: *96W
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd3 T C 18: 10,645,121 (GRCm39) D391G probably benign Het
Arhgdia A C 11: 120,470,068 (GRCm39) W202G probably damaging Het
Atp2a3 A T 11: 72,871,131 (GRCm39) D575V probably benign Het
Cep350 C A 1: 155,744,457 (GRCm39) V2121L probably benign Het
Clcn2 CCCGCCGCCGCCGCCGC CCCGCCGCCGCCGC 16: 20,534,702 (GRCm39) probably benign Het
Cldn9 A T 17: 23,902,556 (GRCm39) V23E probably damaging Het
Cltc G A 11: 86,593,237 (GRCm39) S1542F probably benign Het
Cmbl A G 15: 31,589,948 (GRCm39) D226G probably damaging Het
Dennd4b C T 3: 90,178,515 (GRCm39) T537I probably damaging Het
Dnah7b C A 1: 46,165,953 (GRCm39) D539E possibly damaging Het
Fam219a T C 4: 41,521,871 (GRCm39) T70A probably damaging Het
Fat4 T A 3: 38,942,571 (GRCm39) V488E possibly damaging Het
Hectd1 A G 12: 51,832,584 (GRCm39) I930T probably benign Het
Hmcn1 A T 1: 150,506,053 (GRCm39) C3824* probably null Het
Ift140 T C 17: 25,254,758 (GRCm39) F413L probably benign Het
Itfg1 A G 8: 86,565,566 (GRCm39) V90A probably benign Het
Jph4 A T 14: 55,351,090 (GRCm39) W309R probably damaging Het
Kdm2a C T 19: 4,393,141 (GRCm39) D405N Het
Klhl5 T C 5: 65,305,939 (GRCm39) F302S probably damaging Het
Klk1b8 T C 7: 43,453,177 (GRCm39) M256T probably benign Het
Klre1 A T 6: 129,559,368 (GRCm39) R99S probably benign Het
Krt79 T C 15: 101,839,904 (GRCm39) T364A probably benign Het
Lin7a C T 10: 107,218,483 (GRCm39) P131L possibly damaging Het
Lrrc49 A G 9: 60,594,699 (GRCm39) Y9H probably benign Het
Lrrc8a T A 2: 30,145,663 (GRCm39) I159N probably damaging Het
Mdga2 T C 12: 66,615,532 (GRCm39) S692G probably benign Het
Myo15a G A 11: 60,392,668 (GRCm39) V1017M Het
Nol4 T C 18: 23,172,897 (GRCm39) D68G probably benign Het
Or4f53 T C 2: 111,088,348 (GRCm39) V296A probably benign Het
Or6c75 T C 10: 129,337,515 (GRCm39) V254A probably damaging Het
Pigw C A 11: 84,768,040 (GRCm39) A430S probably benign Het
Pla2g4c T C 7: 13,077,900 (GRCm39) L356P probably damaging Het
Prorp T C 12: 55,385,015 (GRCm39) V410A probably damaging Het
Prr5 A G 15: 84,585,682 (GRCm39) T226A probably benign Het
Pygo1 C T 9: 72,833,056 (GRCm39) probably benign Het
Rnf214 A G 9: 45,779,286 (GRCm39) I333T possibly damaging Het
Septin3 A G 15: 82,167,352 (GRCm39) I86V probably benign Het
Slc30a3 AGGGCTTACCTGAGCGG AGG 5: 31,246,889 (GRCm39) probably null Het
Socs5 C A 17: 87,442,266 (GRCm39) T402K probably damaging Het
Speer3 T A 5: 13,846,368 (GRCm39) N229K Het
Stk16 T C 1: 75,187,804 (GRCm39) probably benign Het
Taar7d T A 10: 23,903,287 (GRCm39) F56L probably benign Het
Tmprss2 C T 16: 97,392,669 (GRCm39) V93I probably benign Het
Tnpo2 G A 8: 85,774,015 (GRCm39) E350K probably benign Het
Tor1aip2 C T 1: 155,937,525 (GRCm39) P87S possibly damaging Het
Trgv7 A T 13: 19,362,385 (GRCm39) R25* probably null Het
Ush2a A G 1: 188,558,589 (GRCm39) E3606G probably benign Het
Zeb1 C T 18: 5,766,709 (GRCm39) Q407* probably null Het
Zfp609 A G 9: 65,611,125 (GRCm39) S613P Het
Zfp735 A G 11: 73,602,403 (GRCm39) N449S possibly damaging Het
Other mutations in Gm3336
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0375:Gm3336 UTSW 8 71,171,294 (GRCm39) splice site probably benign
R1824:Gm3336 UTSW 8 71,173,066 (GRCm39) splice site probably null
R2156:Gm3336 UTSW 8 71,174,509 (GRCm39) missense probably benign 0.01
R2901:Gm3336 UTSW 8 71,173,275 (GRCm39) missense possibly damaging 0.83
R4200:Gm3336 UTSW 8 71,173,261 (GRCm39) missense probably benign 0.24
R4328:Gm3336 UTSW 8 71,173,234 (GRCm39) missense probably benign 0.31
R5171:Gm3336 UTSW 8 71,174,524 (GRCm39) missense probably benign 0.01
R5180:Gm3336 UTSW 8 71,173,110 (GRCm39) intron probably benign
R7128:Gm3336 UTSW 8 71,171,203 (GRCm39) start codon destroyed probably null
R7985:Gm3336 UTSW 8 71,173,176 (GRCm39) missense unknown
R7996:Gm3336 UTSW 8 71,173,146 (GRCm39) missense unknown
R8955:Gm3336 UTSW 8 71,174,545 (GRCm39) nonsense probably null
R9036:Gm3336 UTSW 8 71,173,069 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ATCATACAGGAACCCCGGTG -3'
(R):5'- GTGTACTAGATCTGTGGGCC -3'

Sequencing Primer
(F):5'- CGTCGCTGTGAGACATTATAACCG -3'
(R):5'- CAAACTGGCCTTGAAATTCCTGGG -3'
Posted On 2022-06-15