Mutagenetix > Incidental Mutation

Incidental Mutation 'R9459:Vmn1r1'

714737

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r1

Ensembl Gene

ENSMUSG00000091013

Gene Name

vomeronasal 1 receptor 1

Synonyms

Gm6628

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R9459 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

182154704-182164486 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 182157938 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 54 (V54A)

Ref Sequence

ENSEMBL: ENSMUSP00000133035 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169123] [ENSMUST00000227586] [ENSMUST00000227629]

AlphaFold

E9PVR6

Predicted Effect

probably benign
Transcript: ENSMUST00000169123
AA Change: V54A

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000133035
Gene: ENSMUSG00000091013
AA Change: V54A

Domain	Start	End	E-Value	Type
Pfam:V1R	38	301	8e-79	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227586
AA Change: V54A

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)

Predicted Effect

probably benign
Transcript: ENSMUST00000227629
AA Change: V54A

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700020D05Rik	T	A	19: 5,503,729	H8L	probably benign	Het
Abcb1a	T	A	5: 8,685,414		probably null	Het
Alms1	T	A	6: 85,627,964	C2199S	probably damaging	Het
Aox3	A	G	1: 58,150,309	I390V	probably benign	Het
Ap3b2	T	C	7: 81,473,903	N400S	probably benign	Het
Baalc	A	T	15: 38,934,024	N70I	probably benign	Het
Brca2	T	A	5: 150,540,629	V1286D	probably damaging	Het
Ccdc30	T	C	4: 119,377,273	R81G	possibly damaging	Het
Cd209g	T	C	8: 4,135,610	S15P	probably benign	Het
Chrnb3	G	A	8: 27,393,856	W207*	probably null	Het
Cmpk2	C	T	12: 26,478,023	T413M	probably damaging	Het
Coq4	T	A	2: 29,788,550	Y63N	probably damaging	Het
Depdc5	T	A	5: 32,990,773	S1478T	probably damaging	Het
Etf1	A	G	18: 34,906,081	F378L	probably benign	Het
Exoc6	T	C	19: 37,585,893	V324A	probably benign	Het
Frem2	A	G	3: 53,653,486	L1200P	probably benign	Het
Gadl1	T	C	9: 115,965,611	W285R	probably damaging	Het
Gbp3	A	G	3: 142,564,946		probably null	Het
Gm14295	C	T	2: 176,807,372	T5I	possibly damaging	Het
Hps4	T	C	5: 112,375,009	S578P	probably benign	Het
Kctd13	T	A	7: 126,945,082	D317E	probably damaging	Het
Kdm4b	T	A	17: 56,399,509	D881E	probably benign	Het
Klf10	G	A	15: 38,295,927	P473L	probably damaging	Het
Lrch3	A	T	16: 32,979,405	D371V	probably damaging	Het
Msh2	T	C	17: 87,678,330	S112P	possibly damaging	Het
Msh3	A	G	13: 92,215,539	V1036A	possibly damaging	Het
Mybl1	A	G	1: 9,676,259	V392A	possibly damaging	Het
Myo7a	T	C	7: 98,073,173	I1182V	possibly damaging	Het
Nectin1	A	C	9: 43,803,793	E442A	probably benign	Het
Obsl1	G	T	1: 75,498,240	H839N	probably benign	Het
Olfr1202	T	C	2: 88,817,623	F151L	probably benign	Het
Olfr1505	T	C	19: 13,919,310	C97R	possibly damaging	Het
Pacs1	C	T	19: 5,145,070		probably null	Het
Pcdh17	G	T	14: 84,448,623	E843D	probably benign	Het
Pcnt	A	G	10: 76,392,738	L1531P	probably damaging	Het
Pdgfra	A	G	5: 75,192,468	D973G	probably damaging	Het
Pkd2	A	G	5: 104,466,934	Y214C	probably damaging	Het
Plcb1	T	C	2: 135,322,638	Y427H	probably benign	Het
Ppm1h	A	G	10: 122,907,577	N402S	possibly damaging	Het
Rassf4	T	A	6: 116,641,788		probably null	Het
Ryr1	G	A	7: 29,068,643	T2856I	probably damaging	Het
Serpinb8	A	T	1: 107,605,790	K192*	probably null	Het
Slfn14	T	G	11: 83,279,372	Q482P	possibly damaging	Het
Spata2	A	G	2: 167,485,285	V64A	probably benign	Het
Tax1bp1	T	G	6: 52,729,329	V105G	probably damaging	Het
Tbc1d22a	T	G	15: 86,235,820	S142A	possibly damaging	Het
Tdrd9	T	C	12: 112,025,573	F594S	probably damaging	Het
Uba3	T	C	6: 97,189,598	I281V	probably benign	Het
Uggt2	T	C	14: 119,049,183	E723G	probably benign	Het
Usp20	C	T	2: 31,011,012	S391F	probably damaging	Het
Usp24	T	A	4: 106,342,358	D166E	probably damaging	Het
Zfp442	T	A	2: 150,408,748	E411D	unknown	Het
Zfp804a	T	C	2: 82,259,409	I1194T	probably damaging	Het

Other mutations in Vmn1r1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0535:Vmn1r1	UTSW	1	182157951	missense	probably benign	0.00
R1330:Vmn1r1	UTSW	1	182158007	missense	probably damaging	1.00
R1696:Vmn1r1	UTSW	1	182158059	missense	probably benign	0.26
R1809:Vmn1r1	UTSW	1	182157806	missense	possibly damaging	0.82
R4661:Vmn1r1	UTSW	1	182157224	missense	possibly damaging	0.90
R4717:Vmn1r1	UTSW	1	182157209	missense	possibly damaging	0.66
R4765:Vmn1r1	UTSW	1	182157906	missense	probably benign	0.00
R4772:Vmn1r1	UTSW	1	182157546	missense	probably benign	0.41
R4864:Vmn1r1	UTSW	1	182157767	missense	probably benign
R5369:Vmn1r1	UTSW	1	182157776	missense	possibly damaging	0.87
R5594:Vmn1r1	UTSW	1	182157407	missense	probably damaging	1.00
R6240:Vmn1r1	UTSW	1	182157621	missense	probably damaging	1.00
R6667:Vmn1r1	UTSW	1	182157777	missense	probably benign	0.22
R7075:Vmn1r1	UTSW	1	182158032	missense	probably benign	0.00
R7686:Vmn1r1	UTSW	1	182158025	missense	probably damaging	1.00
R7908:Vmn1r1	UTSW	1	182157350	missense	probably benign	0.45
R8514:Vmn1r1	UTSW	1	182157573	missense	probably benign	0.04
R8951:Vmn1r1	UTSW	1	182157744	missense	probably damaging	1.00
R9332:Vmn1r1	UTSW	1	182157437	missense	probably damaging	1.00
R9450:Vmn1r1	UTSW	1	182157205	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AAACAGGAACTTCTGGGGCTG -3'
(R):5'- GCATTGCTTTCAGATGTGTCC -3'

Sequencing Primer
(F):5'- AACTTCTGGGGCTGAGGAG -3'
(R):5'- GTGTGTTCCTTTCCCCCATAAGATG -3'

Posted On

2022-06-15