Incidental Mutation 'R9459:Klf10'
ID 714776
Institutional Source Beutler Lab
Gene Symbol Klf10
Ensembl Gene ENSMUSG00000037465
Gene Name Kruppel-like factor 10
Synonyms Tieg1, mGIF, Egral, Gdnfif
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.671) question?
Stock # R9459 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 38291463-38300706 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38295927 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 473 (P473L)
Ref Sequence ENSEMBL: ENSMUSP00000073690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074043] [ENSMUST00000226363] [ENSMUST00000227920] [ENSMUST00000228416] [ENSMUST00000228732] [ENSMUST00000228772]
AlphaFold O89091
Predicted Effect probably damaging
Transcript: ENSMUST00000074043
AA Change: P473L

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000073690
Gene: ENSMUSG00000037465
AA Change: P473L

DomainStartEndE-ValueType
low complexity region 134 149 N/A INTRINSIC
low complexity region 285 298 N/A INTRINSIC
low complexity region 316 336 N/A INTRINSIC
ZnF_C2H2 368 392 1.56e-2 SMART
ZnF_C2H2 398 422 5.99e-4 SMART
ZnF_C2H2 428 450 3.63e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000226363
AA Change: P458L

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000227920
Predicted Effect probably benign
Transcript: ENSMUST00000228416
Predicted Effect probably benign
Transcript: ENSMUST00000228732
Predicted Effect probably benign
Transcript: ENSMUST00000228772
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous mutants display increased osteoblast formation and impaired osteoblast function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020D05Rik T A 19: 5,503,729 H8L probably benign Het
Abcb1a T A 5: 8,685,414 probably null Het
Alms1 T A 6: 85,627,964 C2199S probably damaging Het
Aox3 A G 1: 58,150,309 I390V probably benign Het
Ap3b2 T C 7: 81,473,903 N400S probably benign Het
Baalc A T 15: 38,934,024 N70I probably benign Het
Brca2 T A 5: 150,540,629 V1286D probably damaging Het
Ccdc30 T C 4: 119,377,273 R81G possibly damaging Het
Cd209g T C 8: 4,135,610 S15P probably benign Het
Chrnb3 G A 8: 27,393,856 W207* probably null Het
Cmpk2 C T 12: 26,478,023 T413M probably damaging Het
Coq4 T A 2: 29,788,550 Y63N probably damaging Het
Depdc5 T A 5: 32,990,773 S1478T probably damaging Het
Etf1 A G 18: 34,906,081 F378L probably benign Het
Exoc6 T C 19: 37,585,893 V324A probably benign Het
Frem2 A G 3: 53,653,486 L1200P probably benign Het
Gadl1 T C 9: 115,965,611 W285R probably damaging Het
Gbp3 A G 3: 142,564,946 probably null Het
Gm14295 C T 2: 176,807,372 T5I possibly damaging Het
Hps4 T C 5: 112,375,009 S578P probably benign Het
Kctd13 T A 7: 126,945,082 D317E probably damaging Het
Kdm4b T A 17: 56,399,509 D881E probably benign Het
Lrch3 A T 16: 32,979,405 D371V probably damaging Het
Msh2 T C 17: 87,678,330 S112P possibly damaging Het
Msh3 A G 13: 92,215,539 V1036A possibly damaging Het
Mybl1 A G 1: 9,676,259 V392A possibly damaging Het
Myo7a T C 7: 98,073,173 I1182V possibly damaging Het
Nectin1 A C 9: 43,803,793 E442A probably benign Het
Obsl1 G T 1: 75,498,240 H839N probably benign Het
Olfr1202 T C 2: 88,817,623 F151L probably benign Het
Olfr1505 T C 19: 13,919,310 C97R possibly damaging Het
Pacs1 C T 19: 5,145,070 probably null Het
Pcdh17 G T 14: 84,448,623 E843D probably benign Het
Pcnt A G 10: 76,392,738 L1531P probably damaging Het
Pdgfra A G 5: 75,192,468 D973G probably damaging Het
Pkd2 A G 5: 104,466,934 Y214C probably damaging Het
Plcb1 T C 2: 135,322,638 Y427H probably benign Het
Ppm1h A G 10: 122,907,577 N402S possibly damaging Het
Rassf4 T A 6: 116,641,788 probably null Het
Ryr1 G A 7: 29,068,643 T2856I probably damaging Het
Serpinb8 A T 1: 107,605,790 K192* probably null Het
Slfn14 T G 11: 83,279,372 Q482P possibly damaging Het
Spata2 A G 2: 167,485,285 V64A probably benign Het
Tax1bp1 T G 6: 52,729,329 V105G probably damaging Het
Tbc1d22a T G 15: 86,235,820 S142A possibly damaging Het
Tdrd9 T C 12: 112,025,573 F594S probably damaging Het
Uba3 T C 6: 97,189,598 I281V probably benign Het
Uggt2 T C 14: 119,049,183 E723G probably benign Het
Usp20 C T 2: 31,011,012 S391F probably damaging Het
Usp24 T A 4: 106,342,358 D166E probably damaging Het
Vmn1r1 A G 1: 182,157,938 V54A probably benign Het
Zfp442 T A 2: 150,408,748 E411D unknown Het
Zfp804a T C 2: 82,259,409 I1194T probably damaging Het
Other mutations in Klf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01934:Klf10 APN 15 38297284 missense probably benign 0.35
IGL02168:Klf10 APN 15 38296841 missense probably damaging 1.00
IGL02444:Klf10 APN 15 38297824 missense probably damaging 1.00
R0360:Klf10 UTSW 15 38296846 missense probably benign
R1544:Klf10 UTSW 15 38296786 missense probably damaging 1.00
R1961:Klf10 UTSW 15 38295996 missense probably damaging 0.99
R2301:Klf10 UTSW 15 38297082 missense possibly damaging 0.83
R2517:Klf10 UTSW 15 38297113 missense probably benign 0.26
R5217:Klf10 UTSW 15 38296087 missense probably damaging 1.00
R5498:Klf10 UTSW 15 38296039 missense probably damaging 1.00
R5994:Klf10 UTSW 15 38296041 missense probably damaging 0.99
R6086:Klf10 UTSW 15 38296937 missense probably benign 0.02
R7386:Klf10 UTSW 15 38296949 missense possibly damaging 0.68
R7474:Klf10 UTSW 15 38297202 missense probably benign 0.05
R7579:Klf10 UTSW 15 38297038 missense probably benign 0.02
R7617:Klf10 UTSW 15 38296836 missense probably damaging 0.97
R9269:Klf10 UTSW 15 38297758 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGAACTGAGCCCTGTCCTC -3'
(R):5'- CGATGAACTGTCCAGACACC -3'

Sequencing Primer
(F):5'- CCTGTGGCTGAAGCACTTC -3'
(R):5'- CAGACACCGGCGGACAC -3'
Posted On 2022-06-15