Incidental Mutation 'R9461:H1f7'
ID 714889
Institutional Source Beutler Lab
Gene Symbol H1f7
Ensembl Gene ENSMUSG00000048077
Gene Name H1.7 linker histone
Synonyms H1T2, 1700026P10Rik, H1-7, H1fnt
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.224) question?
Stock # R9461 (G1)
Quality Score 211.009
Status Not validated
Chromosome 15
Chromosomal Location 98153867-98155174 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 98155138 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 4 (A4T)
Ref Sequence ENSEMBL: ENSMUSP00000127616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060855]
AlphaFold Q8CJI4
Predicted Effect probably damaging
Transcript: ENSMUST00000060855
AA Change: A4T

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000127616
Gene: ENSMUSG00000048077
AA Change: A4T

DomainStartEndE-ValueType
low complexity region 134 245 N/A INTRINSIC
low complexity region 253 276 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. This gene encodes a testis specific protein that is required for spermatogenesis and male fertility. [provided by RefSeq, Oct 2015]
PHENOTYPE: Homozygous null male mice display reduced fertility with asthenozoospermia, oligozoospermia, and teratozoospermia. [provided by MGI curators]
Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb9 T C 5: 124,228,176 (GRCm39) T22A possibly damaging Het
Abhd18 A T 3: 40,859,319 (GRCm39) probably null Het
Aox1 G A 1: 58,116,736 (GRCm39) probably null Het
Arpp21 C A 9: 111,965,704 (GRCm39) R422L probably damaging Het
Ccdc190 G A 1: 169,761,489 (GRCm39) G197D probably benign Het
Cdc42bpa G T 1: 179,969,861 (GRCm39) L1243F probably damaging Het
Ces2b T A 8: 105,564,011 (GRCm39) F462I probably benign Het
Cfap45 A G 1: 172,362,894 (GRCm39) E295G possibly damaging Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Col24a1 G T 3: 145,186,879 (GRCm39) E1227* probably null Het
Col5a1 A T 2: 27,922,616 (GRCm39) D1717V unknown Het
Dab2 T C 15: 6,460,435 (GRCm39) S448P possibly damaging Het
Dnajb1 T C 8: 84,335,173 (GRCm39) probably null Het
Dock9 C T 14: 121,842,601 (GRCm39) G1223D probably benign Het
Elp2 A G 18: 24,765,869 (GRCm39) R670G probably damaging Het
Eppk1 T C 15: 75,994,668 (GRCm39) I738V probably benign Het
Gas2l2 T A 11: 83,313,031 (GRCm39) R760S probably damaging Het
Kif17 G A 4: 138,005,253 (GRCm39) V273I probably damaging Het
Klhdc4 T C 8: 122,526,224 (GRCm39) D336G probably damaging Het
Lmod2 A G 6: 24,603,568 (GRCm39) N181S probably benign Het
Lrp8 G A 4: 107,700,515 (GRCm39) G151D possibly damaging Het
Mb21d2 C T 16: 28,647,261 (GRCm39) V238M probably damaging Het
Mfsd4b3-ps T G 10: 39,823,247 (GRCm39) I338L probably benign Het
Nkain2 C T 10: 32,766,125 (GRCm39) A112T unknown Het
Or14c41 T A 7: 86,235,247 (GRCm39) Y255N possibly damaging Het
Or52n2b T A 7: 104,565,583 (GRCm39) I307F probably benign Het
Or5b12b T A 19: 12,861,875 (GRCm39) V210E possibly damaging Het
Or5i1 A G 2: 87,612,883 (GRCm39) I2V probably benign Het
Pacs2 A G 12: 113,010,727 (GRCm39) I126V probably benign Het
Phyhipl T C 10: 70,395,243 (GRCm39) Y321C possibly damaging Het
Ppm1k T C 6: 57,487,720 (GRCm39) S368G probably damaging Het
Ranbp6 T C 19: 29,787,163 (GRCm39) D1063G possibly damaging Het
Sars2 T C 7: 28,449,438 (GRCm39) M322T probably benign Het
Serbp1 G A 6: 67,244,313 (GRCm39) R78H probably benign Het
Sfxn2 T A 19: 46,574,192 (GRCm39) N127K probably damaging Het
Sgsm1 A T 5: 113,423,898 (GRCm39) probably null Het
Slc22a22 T C 15: 57,108,342 (GRCm39) Y491C probably damaging Het
Slc22a22 T A 15: 57,127,052 (GRCm39) I6F probably damaging Het
Smpd1 C T 7: 105,204,789 (GRCm39) L223F probably damaging Het
Spem1 T C 11: 69,711,741 (GRCm39) K308E probably benign Het
Spsb1 A T 4: 149,990,907 (GRCm39) C220* probably null Het
Syngap1 T A 17: 27,173,962 (GRCm39) S190R possibly damaging Het
Tars3 T C 7: 65,339,719 (GRCm39) S705P possibly damaging Het
Tbc1d16 G T 11: 119,044,781 (GRCm39) F553L probably damaging Het
Thbs2 A G 17: 14,910,435 (GRCm39) Y55H probably damaging Het
Tmem220 T C 11: 66,924,979 (GRCm39) I138T possibly damaging Het
Tut7 G A 13: 59,963,512 (GRCm39) T282I probably damaging Het
Txnl1 T C 18: 63,810,050 (GRCm39) N131S probably benign Het
Vat1 T C 11: 101,353,846 (GRCm39) T175A possibly damaging Het
Veph1 T A 3: 66,029,066 (GRCm39) D651V probably benign Het
Zfp281 T A 1: 136,554,500 (GRCm39) S493T probably benign Het
Zpld2 G A 4: 133,929,312 (GRCm39) P331L probably benign Het
Other mutations in H1f7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01693:H1f7 APN 15 98,154,262 (GRCm39) missense unknown
IGL02088:H1f7 APN 15 98,155,059 (GRCm39) missense probably damaging 0.98
IGL02322:H1f7 APN 15 98,154,757 (GRCm39) missense possibly damaging 0.94
IGL02697:H1f7 APN 15 98,155,050 (GRCm39) missense probably benign 0.02
F2404:H1f7 UTSW 15 98,155,090 (GRCm39) missense possibly damaging 0.95
R0584:H1f7 UTSW 15 98,154,958 (GRCm39) nonsense probably null
R1022:H1f7 UTSW 15 98,154,636 (GRCm39) missense unknown
R1024:H1f7 UTSW 15 98,154,636 (GRCm39) missense unknown
R1462:H1f7 UTSW 15 98,154,454 (GRCm39) missense unknown
R1462:H1f7 UTSW 15 98,154,454 (GRCm39) missense unknown
R1665:H1f7 UTSW 15 98,154,796 (GRCm39) missense probably benign 0.00
R1733:H1f7 UTSW 15 98,154,016 (GRCm39) missense unknown
R2213:H1f7 UTSW 15 98,154,219 (GRCm39) missense unknown
R4683:H1f7 UTSW 15 98,154,921 (GRCm39) missense probably damaging 0.99
R4969:H1f7 UTSW 15 98,154,216 (GRCm39) missense unknown
R6241:H1f7 UTSW 15 98,154,652 (GRCm39) missense unknown
R6489:H1f7 UTSW 15 98,154,888 (GRCm39) nonsense probably null
R6703:H1f7 UTSW 15 98,155,153 (GRCm39) start gained probably benign
R7131:H1f7 UTSW 15 98,154,250 (GRCm39) nonsense probably null
R7750:H1f7 UTSW 15 98,154,565 (GRCm39) missense unknown
R9454:H1f7 UTSW 15 98,154,823 (GRCm39) missense probably benign 0.01
Z1177:H1f7 UTSW 15 98,155,128 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGAGCGCATCCAGAGTCAG -3'
(R):5'- ATGGTTATGACGATTACACTGGC -3'

Sequencing Primer
(F):5'- ATCCAGAGTCAGGTGCTGG -3'
(R):5'- TTACATACTTGCAGGTGTGAAGAGC -3'
Posted On 2022-06-15