Incidental Mutation 'R9462:Myt1'
| ID |
714909 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myt1
|
| Ensembl Gene |
ENSMUSG00000010505 |
| Gene Name |
myelin transcription factor 1 |
| Synonyms |
NZF-2b, NZF-2a, Nztf2, Nzf2 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9462 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
181405125-181469590 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 181467729 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 1134
(Y1134*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079900
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081125]
[ENSMUST00000108756]
[ENSMUST00000108757]
|
| AlphaFold |
Q8CFC2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000081125
AA Change: Y1134*
|
| SMART Domains |
Protein: ENSMUSP00000079900
Gene: ENSMUSG00000010505
AA Change: Y1134*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
71 |
99 |
8.7e-16 |
PFAM |
|
low complexity region
|
155 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
201 |
N/A |
INTRINSIC |
|
coiled coil region
|
300 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
405 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
485 |
512 |
2.9e-14 |
PFAM |
|
Pfam:zf-C2HC
|
529 |
557 |
4.3e-16 |
PFAM |
|
Pfam:MYT1
|
604 |
660 |
2e-28 |
PFAM |
|
Pfam:MYT1
|
659 |
835 |
2.3e-56 |
PFAM |
|
Pfam:zf-C2HC
|
843 |
871 |
2e-18 |
PFAM |
|
Pfam:zf-C2HC
|
887 |
915 |
1.9e-18 |
PFAM |
|
Pfam:zf-C2HC
|
936 |
964 |
2.1e-16 |
PFAM |
|
Pfam:zf-C2HC
|
989 |
1017 |
8.4e-16 |
PFAM |
|
coiled coil region
|
1037 |
1109 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108756
AA Change: Y1092*
|
| SMART Domains |
Protein: ENSMUSP00000104387
Gene: ENSMUSG00000010505
AA Change: Y1092*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
27 |
57 |
5.1e-18 |
PFAM |
|
low complexity region
|
113 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
143 |
159 |
N/A |
INTRINSIC |
|
coiled coil region
|
258 |
312 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
363 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
441 |
471 |
5e-17 |
PFAM |
|
Pfam:zf-C2HC
|
485 |
515 |
3.1e-18 |
PFAM |
|
Pfam:MYT1
|
562 |
618 |
2.4e-32 |
PFAM |
|
Pfam:MYT1
|
617 |
794 |
2e-74 |
PFAM |
|
Pfam:zf-C2HC
|
799 |
829 |
1.9e-19 |
PFAM |
|
Pfam:zf-C2HC
|
843 |
873 |
9.7e-20 |
PFAM |
|
Pfam:zf-C2HC
|
892 |
922 |
2.2e-18 |
PFAM |
|
Pfam:zf-C2HC
|
945 |
975 |
1.7e-16 |
PFAM |
|
coiled coil region
|
995 |
1067 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108757
AA Change: Y1054*
|
| SMART Domains |
Protein: ENSMUSP00000104388
Gene: ENSMUSG00000010505
AA Change: Y1054*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-C2HC
|
27 |
57 |
1e-17 |
PFAM |
|
low complexity region
|
113 |
118 |
N/A |
INTRINSIC |
|
low complexity region
|
143 |
159 |
N/A |
INTRINSIC |
|
coiled coil region
|
258 |
312 |
N/A |
INTRINSIC |
|
low complexity region
|
346 |
363 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
441 |
471 |
1e-16 |
PFAM |
|
Pfam:zf-C2HC
|
485 |
510 |
6.2e-12 |
PFAM |
|
Pfam:MYT1
|
524 |
580 |
2.7e-32 |
PFAM |
|
Pfam:MYT1
|
579 |
756 |
2.3e-74 |
PFAM |
|
Pfam:zf-C2HC
|
761 |
791 |
3.8e-19 |
PFAM |
|
Pfam:zf-C2HC
|
805 |
835 |
1.9e-19 |
PFAM |
|
Pfam:zf-C2HC
|
854 |
884 |
4.3e-18 |
PFAM |
|
Pfam:zf-C2HC
|
907 |
937 |
3.3e-16 |
PFAM |
|
coiled coil region
|
957 |
1029 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000129843
AA Change: Y751*
|
| SMART Domains |
Protein: ENSMUSP00000115697
Gene: ENSMUSG00000010505
AA Change: Y751*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
50 |
67 |
N/A |
INTRINSIC |
|
Pfam:zf-C2HC
|
147 |
174 |
6.2e-15 |
PFAM |
|
Pfam:zf-C2HC
|
191 |
219 |
9.2e-17 |
PFAM |
|
Pfam:MYT1
|
266 |
322 |
7.3e-29 |
PFAM |
|
Pfam:MYT1
|
321 |
497 |
7.2e-57 |
PFAM |
|
Pfam:zf-C2HC
|
505 |
533 |
9.6e-19 |
PFAM |
|
Pfam:zf-C2HC
|
554 |
582 |
4.4e-17 |
PFAM |
|
Pfam:zf-C2HC
|
607 |
635 |
1.8e-16 |
PFAM |
|
coiled coil region
|
654 |
726 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth displaying improper diaphragm innervation and a failture to initiate breathing; mutant embryonic pancreata contain abnormal islet cells that express multiple hormones. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921539E11Rik |
G |
A |
4: 103,092,964 (GRCm39) |
T220I |
probably benign |
Het |
| Abca8b |
T |
A |
11: 109,844,433 (GRCm39) |
H928L |
|
Het |
| Ahnak |
A |
T |
19: 8,981,299 (GRCm39) |
D861V |
probably damaging |
Het |
| Ahnak2 |
C |
A |
12: 112,750,655 (GRCm39) |
R89L |
|
Het |
| Aipl1 |
C |
T |
11: 71,928,253 (GRCm39) |
G11D |
probably damaging |
Het |
| Anks6 |
A |
G |
4: 47,033,142 (GRCm39) |
L573P |
unknown |
Het |
| Ano5 |
T |
C |
7: 51,235,200 (GRCm39) |
V711A |
probably benign |
Het |
| Arl2bp |
C |
A |
8: 95,398,755 (GRCm39) |
A120D |
probably damaging |
Het |
| Asap1 |
A |
G |
15: 64,038,328 (GRCm39) |
Y223H |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,160 (GRCm39) |
M1151K |
probably damaging |
Het |
| B4galnt3 |
A |
T |
6: 120,271,438 (GRCm39) |
L28Q |
probably null |
Het |
| Ccdc39 |
T |
C |
3: 33,868,519 (GRCm39) |
K856E |
probably benign |
Het |
| Ccr9 |
A |
G |
9: 123,608,600 (GRCm39) |
D94G |
probably damaging |
Het |
| Cdan1 |
A |
G |
2: 120,560,060 (GRCm39) |
I368T |
possibly damaging |
Het |
| Cdhr17 |
G |
T |
5: 17,027,213 (GRCm39) |
A379S |
|
Het |
| Cfap54 |
T |
C |
10: 92,737,920 (GRCm39) |
Q2326R |
unknown |
Het |
| Chrm3 |
T |
C |
13: 9,927,437 (GRCm39) |
Y533C |
|
Het |
| Ckap4 |
C |
T |
10: 84,363,924 (GRCm39) |
E380K |
possibly damaging |
Het |
| Cntnap2 |
T |
C |
6: 46,211,217 (GRCm39) |
F544L |
probably damaging |
Het |
| Cwh43 |
A |
G |
5: 73,591,695 (GRCm39) |
K596R |
probably benign |
Het |
| Cyp26c1 |
A |
G |
19: 37,681,634 (GRCm39) |
E479G |
probably damaging |
Het |
| Deup1 |
A |
G |
9: 15,493,882 (GRCm39) |
V420A |
probably benign |
Het |
| Dnah3 |
A |
G |
7: 119,551,523 (GRCm39) |
V2932A |
probably benign |
Het |
| Dthd1 |
G |
A |
5: 63,039,626 (GRCm39) |
R676H |
probably benign |
Het |
| Eef1e1 |
A |
G |
13: 38,838,997 (GRCm39) |
L120P |
probably damaging |
Het |
| Elane |
T |
C |
10: 79,723,883 (GRCm39) |
S244P |
probably benign |
Het |
| Esp6 |
A |
G |
17: 40,876,315 (GRCm39) |
E121G |
probably benign |
Het |
| Eya1 |
T |
C |
1: 14,299,775 (GRCm39) |
E326G |
probably damaging |
Het |
| Fut2 |
G |
T |
7: 45,300,492 (GRCm39) |
N93K |
probably damaging |
Het |
| Garin5b |
A |
G |
7: 4,761,330 (GRCm39) |
S461P |
|
Het |
| Gm12695 |
A |
G |
4: 96,651,075 (GRCm39) |
V126A |
probably benign |
Het |
| Gucy2g |
A |
G |
19: 55,221,469 (GRCm39) |
|
probably null |
Het |
| Hbs1l |
T |
C |
10: 21,218,304 (GRCm39) |
V267A |
probably damaging |
Het |
| Hsd17b1 |
A |
T |
11: 100,969,806 (GRCm39) |
N106I |
possibly damaging |
Het |
| Ino80d |
G |
A |
1: 63,097,393 (GRCm39) |
L939F |
probably damaging |
Het |
| Lilra6 |
A |
G |
7: 3,914,994 (GRCm39) |
W505R |
probably damaging |
Het |
| Map3k14 |
T |
A |
11: 103,118,360 (GRCm39) |
K609* |
probably null |
Het |
| Mark1 |
T |
A |
1: 184,651,868 (GRCm39) |
K212N |
probably damaging |
Het |
| Muc5b |
T |
A |
7: 141,415,216 (GRCm39) |
C2721S |
|
Het |
| Myh4 |
A |
G |
11: 67,141,811 (GRCm39) |
D890G |
possibly damaging |
Het |
| Mylk2 |
T |
G |
2: 152,761,373 (GRCm39) |
L492R |
probably damaging |
Het |
| N4bp2 |
G |
A |
5: 65,947,898 (GRCm39) |
G176D |
probably benign |
Het |
| Ncstn |
A |
C |
1: 171,899,707 (GRCm39) |
M325R |
probably damaging |
Het |
| Ndor1 |
C |
T |
2: 25,144,875 (GRCm39) |
|
probably null |
Het |
| Notch4 |
G |
A |
17: 34,806,667 (GRCm39) |
R1868H |
probably benign |
Het |
| Ogfr |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG |
2: 180,236,850 (GRCm39) |
|
probably benign |
Het |
| Or2b2b |
A |
T |
13: 21,859,015 (GRCm39) |
V33E |
probably benign |
Het |
| Or8s16 |
T |
A |
15: 98,211,186 (GRCm39) |
N82Y |
possibly damaging |
Het |
| Oxct2a |
G |
T |
4: 123,216,441 (GRCm39) |
D313E |
probably damaging |
Het |
| Pcdha2 |
T |
A |
18: 37,073,546 (GRCm39) |
H392Q |
probably benign |
Het |
| Pcdhb20 |
T |
G |
18: 37,639,799 (GRCm39) |
L775R |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,840,408 (GRCm39) |
D1449G |
|
Het |
| Pcx |
A |
G |
19: 4,651,970 (GRCm39) |
T73A |
probably benign |
Het |
| Pou6f2 |
A |
G |
13: 18,314,189 (GRCm39) |
S395P |
probably benign |
Het |
| Prss35 |
C |
G |
9: 86,638,392 (GRCm39) |
I387M |
|
Het |
| Radil |
C |
A |
5: 142,471,220 (GRCm39) |
D1019Y |
probably damaging |
Het |
| Rnf40 |
G |
T |
7: 127,191,010 (GRCm39) |
|
probably null |
Het |
| Scarb1 |
A |
T |
5: 125,417,891 (GRCm39) |
L19Q |
probably damaging |
Het |
| Scn8a |
T |
A |
15: 100,930,159 (GRCm39) |
F1457I |
|
Het |
| Sdk2 |
C |
T |
11: 113,760,744 (GRCm39) |
V339I |
possibly damaging |
Het |
| Siglec1 |
A |
G |
2: 130,916,404 (GRCm39) |
L1182P |
probably damaging |
Het |
| Slc4a4 |
G |
A |
5: 89,194,131 (GRCm39) |
V204I |
probably damaging |
Het |
| Sp9 |
T |
C |
2: 73,104,243 (GRCm39) |
S266P |
probably benign |
Het |
| Spata21 |
A |
G |
4: 140,831,316 (GRCm39) |
E421G |
probably damaging |
Het |
| Sulf1 |
C |
T |
1: 12,929,459 (GRCm39) |
P242L |
probably damaging |
Het |
| Sval3 |
G |
A |
6: 41,945,105 (GRCm39) |
G11E |
possibly damaging |
Het |
| Tecta |
T |
A |
9: 42,248,576 (GRCm39) |
Y1942F |
probably damaging |
Het |
| Thbs2 |
C |
T |
17: 14,890,243 (GRCm39) |
G1121D |
probably damaging |
Het |
| Thrap3 |
G |
T |
4: 126,070,048 (GRCm39) |
S613* |
probably null |
Het |
| Ttc34 |
A |
C |
4: 154,942,539 (GRCm39) |
K59Q |
probably damaging |
Het |
| Tut7 |
A |
T |
13: 59,929,957 (GRCm39) |
L1428H |
possibly damaging |
Het |
| Ube4b |
A |
T |
4: 149,444,748 (GRCm39) |
L504Q |
probably damaging |
Het |
| Uncx |
A |
T |
5: 139,529,771 (GRCm39) |
E8V |
probably damaging |
Het |
| Vmn1r79 |
A |
T |
7: 11,910,261 (GRCm39) |
I48F |
probably damaging |
Het |
| Vmn2r99 |
C |
A |
17: 19,598,388 (GRCm39) |
Y137* |
probably null |
Het |
| Zfp354b |
G |
A |
11: 50,814,523 (GRCm39) |
T134I |
probably benign |
Het |
| Zfp618 |
G |
A |
4: 63,051,510 (GRCm39) |
V764I |
possibly damaging |
Het |
| Zfp873 |
T |
G |
10: 81,897,131 (GRCm39) |
C621G |
probably benign |
Het |
|
| Other mutations in Myt1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00478:Myt1
|
APN |
2 |
181,442,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00816:Myt1
|
APN |
2 |
181,449,308 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Myt1
|
APN |
2 |
181,439,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01069:Myt1
|
APN |
2 |
181,467,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01292:Myt1
|
APN |
2 |
181,446,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Myt1
|
APN |
2 |
181,467,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01926:Myt1
|
APN |
2 |
181,463,790 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01976:Myt1
|
APN |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Myt1
|
APN |
2 |
181,438,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02109:Myt1
|
APN |
2 |
181,457,410 (GRCm39) |
splice site |
probably benign |
|
|
IGL02209:Myt1
|
APN |
2 |
181,439,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02499:Myt1
|
APN |
2 |
181,467,342 (GRCm39) |
splice site |
probably benign |
|
|
IGL03064:Myt1
|
APN |
2 |
181,439,594 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03394:Myt1
|
APN |
2 |
181,439,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Myt1
|
UTSW |
2 |
181,467,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Myt1
|
UTSW |
2 |
181,443,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Myt1
|
UTSW |
2 |
181,443,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0362:Myt1
|
UTSW |
2 |
181,405,186 (GRCm39) |
unclassified |
probably benign |
|
|
R0627:Myt1
|
UTSW |
2 |
181,437,482 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0650:Myt1
|
UTSW |
2 |
181,424,408 (GRCm39) |
nonsense |
probably null |
|
|
R0735:Myt1
|
UTSW |
2 |
181,449,180 (GRCm39) |
unclassified |
probably benign |
|
|
R0744:Myt1
|
UTSW |
2 |
181,439,298 (GRCm39) |
intron |
probably benign |
|
|
R1115:Myt1
|
UTSW |
2 |
181,453,024 (GRCm39) |
nonsense |
probably null |
|
|
R1460:Myt1
|
UTSW |
2 |
181,444,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Myt1
|
UTSW |
2 |
181,438,904 (GRCm39) |
missense |
probably benign |
|
|
R1836:Myt1
|
UTSW |
2 |
181,439,068 (GRCm39) |
missense |
probably benign |
|
|
R1905:Myt1
|
UTSW |
2 |
181,439,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Myt1
|
UTSW |
2 |
181,437,552 (GRCm39) |
missense |
probably benign |
|
|
R2040:Myt1
|
UTSW |
2 |
181,467,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Myt1
|
UTSW |
2 |
181,467,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2323:Myt1
|
UTSW |
2 |
181,448,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Myt1
|
UTSW |
2 |
181,467,803 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3895:Myt1
|
UTSW |
2 |
181,461,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4093:Myt1
|
UTSW |
2 |
181,453,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Myt1
|
UTSW |
2 |
181,439,207 (GRCm39) |
missense |
probably benign |
|
|
R4693:Myt1
|
UTSW |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4775:Myt1
|
UTSW |
2 |
181,464,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4835:Myt1
|
UTSW |
2 |
181,439,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5111:Myt1
|
UTSW |
2 |
181,437,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5120:Myt1
|
UTSW |
2 |
181,439,413 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5622:Myt1
|
UTSW |
2 |
181,438,915 (GRCm39) |
missense |
probably benign |
|
|
R6457:Myt1
|
UTSW |
2 |
181,405,218 (GRCm39) |
splice site |
probably null |
|
|
R6704:Myt1
|
UTSW |
2 |
181,453,005 (GRCm39) |
start codon destroyed |
probably null |
|
|
R6752:Myt1
|
UTSW |
2 |
181,442,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Myt1
|
UTSW |
2 |
181,439,387 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7337:Myt1
|
UTSW |
2 |
181,444,756 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7362:Myt1
|
UTSW |
2 |
181,439,033 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7368:Myt1
|
UTSW |
2 |
181,424,384 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7385:Myt1
|
UTSW |
2 |
181,409,498 (GRCm39) |
splice site |
probably null |
|
|
R7411:Myt1
|
UTSW |
2 |
181,456,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7593:Myt1
|
UTSW |
2 |
181,439,532 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7790:Myt1
|
UTSW |
2 |
181,439,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8035:Myt1
|
UTSW |
2 |
181,437,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8156:Myt1
|
UTSW |
2 |
181,464,554 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8338:Myt1
|
UTSW |
2 |
181,443,655 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8419:Myt1
|
UTSW |
2 |
181,424,399 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Myt1
|
UTSW |
2 |
181,439,344 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9071:Myt1
|
UTSW |
2 |
181,448,420 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9144:Myt1
|
UTSW |
2 |
181,467,805 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9290:Myt1
|
UTSW |
2 |
181,437,667 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9502:Myt1
|
UTSW |
2 |
181,461,991 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9668:Myt1
|
UTSW |
2 |
181,452,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9700:Myt1
|
UTSW |
2 |
181,452,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF006:Myt1
|
UTSW |
2 |
181,439,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myt1
|
UTSW |
2 |
181,449,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myt1
|
UTSW |
2 |
181,438,955 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGAGTAGCTCATGAATTGTGG -3'
(R):5'- GCACCCAGGCTTCCAATTAG -3'
Sequencing Primer
(F):5'- AGCTCATGAATTGTGGCTAATAGG -3'
(R):5'- CCAGGCTTCCAATTAGAAGTAGCTAG -3'
|
| Posted On |
2022-06-15 |
Incidental Mutation