Incidental Mutation 'R9463:Or8b46'
ID 715009
Institutional Source Beutler Lab
Gene Symbol Or8b46
Ensembl Gene ENSMUSG00000060114
Gene Name olfactory receptor family 8 subfamily B member 46
Synonyms GA_x6K02T2PVTD-32239063-32239995, Olfr910, MOR165-3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R9463 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38449178-38451125 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38450665 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 158 (I158T)
Ref Sequence ENSEMBL: ENSMUSP00000149263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000215122]
AlphaFold Q8VG76
Predicted Effect probably damaging
Transcript: ENSMUST00000215122
AA Change: I158T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox2 C T 14: 8,256,789 (GRCm38) E25K probably damaging Het
Acss2 A G 2: 155,392,032 (GRCm39) Y218C probably benign Het
Armc8 C T 9: 99,378,203 (GRCm39) probably null Het
Aspg G A 12: 112,089,824 (GRCm39) G454D probably damaging Het
Atp9b T C 18: 80,809,051 (GRCm39) T623A Het
Cacna1e A G 1: 154,357,411 (GRCm39) L655P probably damaging Het
Cant1 T A 11: 118,302,281 (GRCm39) N12I probably damaging Het
Cep63 T C 9: 102,475,382 (GRCm39) T445A probably benign Het
Clstn1 A T 4: 149,698,564 (GRCm39) D50V possibly damaging Het
Cnnm2 T A 19: 46,750,990 (GRCm39) I260N probably damaging Het
Col4a4 T C 1: 82,431,076 (GRCm39) M1609V unknown Het
Dand5 A T 8: 85,542,938 (GRCm39) C179* probably null Het
Dbndd1 A G 8: 124,233,547 (GRCm39) L153P probably damaging Het
Dnhd1 A G 7: 105,306,454 (GRCm39) I437V probably benign Het
Dnhd1 T A 7: 105,344,223 (GRCm39) S1856T probably benign Het
Dpp8 T A 9: 64,973,700 (GRCm39) Y641* probably null Het
Dthd1 G A 5: 63,039,626 (GRCm39) R676H probably benign Het
Efl1 C T 7: 82,426,733 (GRCm39) T1077M probably damaging Het
Eif3e G T 15: 43,138,709 (GRCm39) Q83K probably benign Het
Firrm A T 1: 163,795,907 (GRCm39) M428K probably benign Het
Gfm2 G A 13: 97,286,910 (GRCm39) A170T probably damaging Het
Gm14496 T A 2: 181,642,256 (GRCm39) H642Q probably benign Het
Gmip G A 8: 70,269,693 (GRCm39) R596Q possibly damaging Het
Hook1 A T 4: 95,910,510 (GRCm39) Q708L probably damaging Het
Krtap9-3 G A 11: 99,488,526 (GRCm39) R119C unknown Het
Lnpk A C 2: 74,381,403 (GRCm39) probably null Het
Lrp1 G T 10: 127,429,334 (GRCm39) Y484* probably null Het
Lrrc8e C T 8: 4,285,185 (GRCm39) P470L probably damaging Het
Mapre1 A G 2: 153,606,960 (GRCm39) N231D probably benign Het
Muc5b T A 7: 141,405,503 (GRCm39) N937K unknown Het
Ndufaf7 T C 17: 79,253,900 (GRCm39) probably null Het
Nlrp5 A T 7: 23,118,225 (GRCm39) I650F probably benign Het
Notch1 T C 2: 26,359,845 (GRCm39) D1290G probably benign Het
Or7g27 C T 9: 19,250,320 (GRCm39) A188V possibly damaging Het
Orc4 C T 2: 48,826,783 (GRCm39) probably null Het
Plekhm2 A G 4: 141,357,949 (GRCm39) V664A probably benign Het
Pom121l2 T G 13: 22,168,402 (GRCm39) I891S probably benign Het
Prkcsh T C 9: 21,923,982 (GRCm39) Y425H probably damaging Het
Prps1l1 A C 12: 35,035,559 (GRCm39) T225P probably damaging Het
Prr18 T G 17: 8,560,324 (GRCm39) V160G probably damaging Het
Psd2 T A 18: 36,143,798 (GRCm39) F701L probably damaging Het
Sclt1 T C 3: 41,601,931 (GRCm39) E593G probably damaging Het
Sdk1 T C 5: 141,948,548 (GRCm39) I631T probably benign Het
Sirt1 A T 10: 63,171,487 (GRCm39) D231E probably benign Het
Slc22a30 C T 19: 8,378,259 (GRCm39) C139Y probably damaging Het
Sntg1 T A 1: 8,624,974 (GRCm39) N274I probably damaging Het
Spocd1 A G 4: 129,847,398 (GRCm39) Q529R Het
Trarg1 T A 11: 76,571,098 (GRCm39) L38Q probably damaging Het
Trbv3 T A 6: 41,025,530 (GRCm39) L40H probably damaging Het
Trpm6 T C 19: 18,761,264 (GRCm39) probably null Het
Ttn A G 2: 76,578,519 (GRCm39) Y24125H probably damaging Het
Ush1g C A 11: 115,209,056 (GRCm39) L379F probably damaging Het
Vipr1 G A 9: 121,471,993 (GRCm39) probably null Het
Vmn2r73 A T 7: 85,506,795 (GRCm39) M839K Het
Wee1 T C 7: 109,721,917 (GRCm39) S121P probably damaging Het
Zfp608 T C 18: 55,030,274 (GRCm39) K1222R probably damaging Het
Other mutations in Or8b46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02740:Or8b46 APN 9 38,450,226 (GRCm39) missense probably damaging 1.00
R0096:Or8b46 UTSW 9 38,450,832 (GRCm39) missense probably damaging 0.96
R0550:Or8b46 UTSW 9 38,450,676 (GRCm39) missense probably damaging 0.97
R1375:Or8b46 UTSW 9 38,450,830 (GRCm39) missense possibly damaging 0.63
R1698:Or8b46 UTSW 9 38,450,552 (GRCm39) nonsense probably null
R2067:Or8b46 UTSW 9 38,450,576 (GRCm39) missense probably benign 0.09
R2111:Or8b46 UTSW 9 38,450,576 (GRCm39) missense probably benign 0.09
R2519:Or8b46 UTSW 9 38,450,281 (GRCm39) missense probably damaging 0.99
R4742:Or8b46 UTSW 9 38,450,952 (GRCm39) missense probably damaging 1.00
R4782:Or8b46 UTSW 9 38,450,371 (GRCm39) missense probably damaging 1.00
R6491:Or8b46 UTSW 9 38,558,751 (GRCm39) missense probably damaging 1.00
R7101:Or8b46 UTSW 9 38,450,966 (GRCm39) missense probably benign 0.02
R8108:Or8b46 UTSW 9 38,450,706 (GRCm39) missense probably damaging 0.97
R8270:Or8b46 UTSW 9 38,450,644 (GRCm39) missense noncoding transcript
R8426:Or8b46 UTSW 9 38,450,620 (GRCm39) missense probably damaging 0.98
R8446:Or8b46 UTSW 9 38,450,964 (GRCm39) missense probably benign 0.10
R9004:Or8b46 UTSW 9 38,450,530 (GRCm39) missense probably benign 0.29
Z1088:Or8b46 UTSW 9 38,450,445 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTACACCCAAATTGCTGATG -3'
(R):5'- TGATGATGACAATACTGGGCAC -3'

Sequencing Primer
(F):5'- GCGGGATGTATGACTCAACTCTAC -3'
(R):5'- GGGCACAGTGATATCTTTTCCC -3'
Posted On 2022-06-15