Incidental Mutation 'R9464:Zgrf1'
ID 715047
Institutional Source Beutler Lab
Gene Symbol Zgrf1
Ensembl Gene ENSMUSG00000051278
Gene Name zinc finger, GRF-type containing 1
Synonyms 4930422G04Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R9464 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 127347138-127411672 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 127377741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 995 (N995K)
Ref Sequence ENSEMBL: ENSMUSP00000044432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043108] [ENSMUST00000196141] [ENSMUST00000196341] [ENSMUST00000199888] [ENSMUST00000200490]
AlphaFold Q0VGT4
Predicted Effect probably benign
Transcript: ENSMUST00000043108
AA Change: N995K

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000044432
Gene: ENSMUSG00000051278
AA Change: N995K

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.7e-23 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
low complexity region 896 906 N/A INTRINSIC
Pfam:zf-GRF 1109 1153 1.5e-17 PFAM
low complexity region 1316 1328 N/A INTRINSIC
Pfam:AAA_11 1501 1608 1.6e-21 PFAM
Pfam:AAA_12 1616 1802 1.3e-51 PFAM
coiled coil region 1833 1861 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196141
AA Change: N995K

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000143761
Gene: ENSMUSG00000051278
AA Change: N995K

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.7e-23 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
low complexity region 896 906 N/A INTRINSIC
Pfam:zf-GRF 1109 1153 1.5e-17 PFAM
low complexity region 1316 1328 N/A INTRINSIC
Pfam:AAA_11 1501 1608 1.6e-21 PFAM
Pfam:AAA_12 1616 1802 1.3e-51 PFAM
coiled coil region 1833 1861 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196341
AA Change: N111K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000143570
Gene: ENSMUSG00000051278
AA Change: N111K

DomainStartEndE-ValueType
low complexity region 12 22 N/A INTRINSIC
Pfam:zf-GRF 225 269 6.7e-15 PFAM
low complexity region 432 444 N/A INTRINSIC
Pfam:AAA_11 491 659 7.1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000199888
SMART Domains Protein: ENSMUSP00000142693
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 82 3.5e-22 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000200490
SMART Domains Protein: ENSMUSP00000143585
Gene: ENSMUSG00000051278

DomainStartEndE-ValueType
Pfam:DUF2439 3 81 3.4e-20 PFAM
low complexity region 92 105 N/A INTRINSIC
low complexity region 628 639 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik T C 1: 159,902,865 (GRCm39) F45S possibly damaging Het
Abca4 A G 3: 121,913,714 (GRCm39) T897A probably benign Het
Abhd5 A T 9: 122,208,029 (GRCm39) T308S probably benign Het
Abi2 G A 1: 60,478,100 (GRCm39) probably null Het
Abi3bp C A 16: 56,409,046 (GRCm39) T283N possibly damaging Het
Adcy2 A C 13: 68,882,776 (GRCm39) N320K probably damaging Het
Adcy3 T A 12: 4,256,939 (GRCm39) M819K probably benign Het
Anapc5 A G 5: 122,940,209 (GRCm39) V354A probably benign Het
Card14 A G 11: 119,208,031 (GRCm39) I34V probably benign Het
Ccdc153 A T 9: 44,157,011 (GRCm39) T118S possibly damaging Het
Champ1 G A 8: 13,929,114 (GRCm39) G424D probably damaging Het
Crybg3 A T 16: 59,376,120 (GRCm39) probably benign Het
Ctsr T A 13: 61,307,295 (GRCm39) I334F possibly damaging Het
Dlgap1 A T 17: 70,823,964 (GRCm39) Q316H probably benign Het
Dnajc18 A C 18: 35,830,166 (GRCm39) C80G probably damaging Het
Dthd1 G A 5: 63,039,626 (GRCm39) R676H probably benign Het
Fam186b G A 15: 99,177,616 (GRCm39) A570V probably damaging Het
Fancc T C 13: 63,550,769 (GRCm39) K18E possibly damaging Het
Fbxo46 G C 7: 18,870,791 (GRCm39) R470P probably damaging Het
Fbxw20 A C 9: 109,050,399 (GRCm39) W409G probably damaging Het
Gcnt4 C T 13: 97,083,493 (GRCm39) T263M probably benign Het
Gfy T C 7: 44,827,251 (GRCm39) T282A probably benign Het
Glb1l3 A G 9: 26,761,351 (GRCm39) M227T probably damaging Het
Gm8267 T C 14: 44,960,346 (GRCm39) E133G probably damaging Het
Hmcn1 A C 1: 150,599,248 (GRCm39) I1556R possibly damaging Het
Ifnl3 T C 7: 28,223,287 (GRCm39) V102A probably damaging Het
Kifc3 C T 8: 95,830,622 (GRCm39) R548Q possibly damaging Het
Lonrf1 T A 8: 36,690,024 (GRCm39) Q678L probably benign Het
Map2 A G 1: 66,454,497 (GRCm39) E1129G probably damaging Het
Mug2 C A 6: 122,028,690 (GRCm39) D561E probably benign Het
Myo3a G T 2: 22,232,383 (GRCm39) probably benign Het
N4bp1 A G 8: 87,587,165 (GRCm39) V591A probably damaging Het
Nckap5 C T 1: 125,952,494 (GRCm39) G1353R probably benign Het
Nek10 T A 14: 14,937,766 (GRCm38) H828Q probably benign Het
Or52n3 T A 7: 104,530,050 (GRCm39) C45* probably null Het
Or5k1b G T 16: 58,581,202 (GRCm39) C112* probably null Het
Pclo T C 5: 14,816,830 (GRCm39) S1297P Het
Pkhd1l1 T C 15: 44,343,009 (GRCm39) I162T probably damaging Het
Plaat5 A G 19: 7,591,923 (GRCm39) E113G probably damaging Het
Plekhg2 T C 7: 28,062,297 (GRCm39) E541G probably damaging Het
Ppp1r15a T C 7: 45,174,149 (GRCm39) N220D possibly damaging Het
Prss3l A G 6: 41,420,486 (GRCm39) V80A probably benign Het
Psmd4 A G 3: 94,940,735 (GRCm39) S343P probably benign Het
Rnf213 A T 11: 119,354,406 (GRCm39) H4063L Het
Rnf40 T C 7: 127,190,954 (GRCm39) V313A probably benign Het
Ryr2 T A 13: 11,752,680 (GRCm39) E1880D probably benign Het
Slc30a4 A T 2: 122,527,200 (GRCm39) L398I probably damaging Het
Sp100 A T 1: 85,624,751 (GRCm39) N380I probably damaging Het
Speer4d T G 5: 15,828,393 (GRCm39) L175W probably damaging Het
Srcap T A 7: 127,137,273 (GRCm39) I985K possibly damaging Het
Tesk2 T C 4: 116,658,443 (GRCm39) probably null Het
Tgfbrap1 A G 1: 43,114,608 (GRCm39) V164A probably damaging Het
Tlk1 T C 2: 70,544,341 (GRCm39) T765A probably benign Het
Tmem207 A T 16: 26,345,413 (GRCm39) C18S Het
Tph2 A T 10: 114,915,992 (GRCm39) C394S probably benign Het
Trrap C A 5: 144,763,517 (GRCm39) H2470N probably damaging Het
Ttc21b T C 2: 66,053,866 (GRCm39) Y771C probably damaging Het
Uchl3 T C 14: 101,904,451 (GRCm39) F122L probably damaging Het
Vipr1 G A 9: 121,471,993 (GRCm39) probably null Het
Vmn2r117 G T 17: 23,696,578 (GRCm39) D276E probably benign Het
Vps13c T C 9: 67,858,674 (GRCm39) L2708P probably damaging Het
Vwa3a T A 7: 120,385,682 (GRCm39) S675T possibly damaging Het
Zfp473 A G 7: 44,383,766 (GRCm39) L189P probably benign Het
Zfp956 T A 6: 47,941,041 (GRCm39) C467S probably damaging Het
Other mutations in Zgrf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Zgrf1 APN 3 127,381,790 (GRCm39) splice site probably benign
IGL01153:Zgrf1 APN 3 127,396,055 (GRCm39) missense probably damaging 1.00
IGL01330:Zgrf1 APN 3 127,377,656 (GRCm39) missense probably damaging 1.00
IGL01501:Zgrf1 APN 3 127,396,211 (GRCm39) splice site probably null
IGL01827:Zgrf1 APN 3 127,409,930 (GRCm39) missense probably benign 0.06
IGL02600:Zgrf1 APN 3 127,394,623 (GRCm39) splice site probably benign
IGL03122:Zgrf1 APN 3 127,381,782 (GRCm39) missense possibly damaging 0.91
IGL03365:Zgrf1 APN 3 127,392,423 (GRCm39) missense possibly damaging 0.48
R0015_Zgrf1_014 UTSW 3 127,349,046 (GRCm39) splice site probably benign
R1298_Zgrf1_204 UTSW 3 127,377,538 (GRCm39) missense possibly damaging 0.95
R7175_zgrf1_533 UTSW 3 127,357,239 (GRCm39) missense probably damaging 1.00
R0015:Zgrf1 UTSW 3 127,349,046 (GRCm39) splice site probably benign
R0243:Zgrf1 UTSW 3 127,409,095 (GRCm39) missense probably damaging 0.99
R0468:Zgrf1 UTSW 3 127,355,690 (GRCm39) missense possibly damaging 0.72
R0497:Zgrf1 UTSW 3 127,378,299 (GRCm39) splice site probably benign
R0505:Zgrf1 UTSW 3 127,366,887 (GRCm39) missense probably benign 0.30
R0511:Zgrf1 UTSW 3 127,378,309 (GRCm39) missense possibly damaging 0.93
R0539:Zgrf1 UTSW 3 127,408,841 (GRCm39) missense probably damaging 1.00
R0617:Zgrf1 UTSW 3 127,381,687 (GRCm39) missense probably benign 0.39
R1298:Zgrf1 UTSW 3 127,377,538 (GRCm39) missense possibly damaging 0.95
R1353:Zgrf1 UTSW 3 127,405,452 (GRCm39) missense probably damaging 1.00
R1593:Zgrf1 UTSW 3 127,354,675 (GRCm39) missense possibly damaging 0.86
R1846:Zgrf1 UTSW 3 127,409,112 (GRCm39) missense probably damaging 1.00
R1912:Zgrf1 UTSW 3 127,356,786 (GRCm39) missense probably benign
R2062:Zgrf1 UTSW 3 127,406,999 (GRCm39) missense probably damaging 1.00
R2064:Zgrf1 UTSW 3 127,406,999 (GRCm39) missense probably damaging 1.00
R2065:Zgrf1 UTSW 3 127,406,999 (GRCm39) missense probably damaging 1.00
R2066:Zgrf1 UTSW 3 127,406,999 (GRCm39) missense probably damaging 1.00
R2067:Zgrf1 UTSW 3 127,406,999 (GRCm39) missense probably damaging 1.00
R2256:Zgrf1 UTSW 3 127,355,646 (GRCm39) missense probably benign 0.18
R2321:Zgrf1 UTSW 3 127,356,056 (GRCm39) nonsense probably null
R2381:Zgrf1 UTSW 3 127,349,863 (GRCm39) missense probably benign 0.02
R2913:Zgrf1 UTSW 3 127,392,356 (GRCm39) missense possibly damaging 0.65
R3147:Zgrf1 UTSW 3 127,377,797 (GRCm39) missense possibly damaging 0.84
R3236:Zgrf1 UTSW 3 127,407,024 (GRCm39) missense probably damaging 1.00
R3237:Zgrf1 UTSW 3 127,407,024 (GRCm39) missense probably damaging 1.00
R4433:Zgrf1 UTSW 3 127,355,727 (GRCm39) missense probably benign
R4441:Zgrf1 UTSW 3 127,379,786 (GRCm39) missense possibly damaging 0.45
R4457:Zgrf1 UTSW 3 127,389,578 (GRCm39) missense probably damaging 1.00
R4498:Zgrf1 UTSW 3 127,379,749 (GRCm39) nonsense probably null
R4598:Zgrf1 UTSW 3 127,394,679 (GRCm39) missense probably benign 0.14
R4701:Zgrf1 UTSW 3 127,392,353 (GRCm39) missense probably benign 0.03
R4898:Zgrf1 UTSW 3 127,396,085 (GRCm39) missense probably damaging 1.00
R4944:Zgrf1 UTSW 3 127,355,517 (GRCm39) nonsense probably null
R5256:Zgrf1 UTSW 3 127,396,094 (GRCm39) missense probably damaging 1.00
R5294:Zgrf1 UTSW 3 127,394,629 (GRCm39) missense probably benign 0.14
R5358:Zgrf1 UTSW 3 127,361,352 (GRCm39) critical splice donor site probably null
R5359:Zgrf1 UTSW 3 127,394,814 (GRCm39) missense possibly damaging 0.95
R5447:Zgrf1 UTSW 3 127,356,768 (GRCm39) missense possibly damaging 0.73
R5569:Zgrf1 UTSW 3 127,354,674 (GRCm39) missense probably benign 0.33
R5887:Zgrf1 UTSW 3 127,378,414 (GRCm39) missense probably damaging 1.00
R5914:Zgrf1 UTSW 3 127,354,672 (GRCm39) missense probably damaging 0.99
R5925:Zgrf1 UTSW 3 127,366,853 (GRCm39) missense possibly damaging 0.84
R5936:Zgrf1 UTSW 3 127,355,902 (GRCm39) missense possibly damaging 0.72
R6087:Zgrf1 UTSW 3 127,409,135 (GRCm39) missense probably damaging 1.00
R6089:Zgrf1 UTSW 3 127,389,642 (GRCm39) missense probably damaging 1.00
R6181:Zgrf1 UTSW 3 127,381,590 (GRCm39) missense probably damaging 1.00
R6277:Zgrf1 UTSW 3 127,392,461 (GRCm39) missense possibly damaging 0.81
R6441:Zgrf1 UTSW 3 127,381,683 (GRCm39) missense possibly damaging 0.93
R6659:Zgrf1 UTSW 3 127,410,155 (GRCm39) missense probably damaging 0.99
R6857:Zgrf1 UTSW 3 127,375,096 (GRCm39) missense probably damaging 0.99
R6932:Zgrf1 UTSW 3 127,353,281 (GRCm39) critical splice donor site probably null
R7008:Zgrf1 UTSW 3 127,355,421 (GRCm39) missense probably benign 0.18
R7175:Zgrf1 UTSW 3 127,357,239 (GRCm39) missense probably damaging 1.00
R7264:Zgrf1 UTSW 3 127,357,218 (GRCm39) missense probably benign 0.00
R7272:Zgrf1 UTSW 3 127,392,409 (GRCm39) missense probably damaging 0.99
R7298:Zgrf1 UTSW 3 127,377,299 (GRCm39) nonsense probably null
R7412:Zgrf1 UTSW 3 127,356,720 (GRCm39) missense probably benign 0.06
R7836:Zgrf1 UTSW 3 127,357,080 (GRCm39) missense probably damaging 0.96
R7945:Zgrf1 UTSW 3 127,356,409 (GRCm39) missense probably benign 0.37
R7996:Zgrf1 UTSW 3 127,389,573 (GRCm39) missense possibly damaging 0.94
R8165:Zgrf1 UTSW 3 127,357,032 (GRCm39) missense possibly damaging 0.76
R8198:Zgrf1 UTSW 3 127,389,673 (GRCm39) critical splice donor site probably null
R8296:Zgrf1 UTSW 3 127,377,644 (GRCm39) missense probably damaging 0.99
R8298:Zgrf1 UTSW 3 127,408,878 (GRCm39) missense probably damaging 1.00
R8341:Zgrf1 UTSW 3 127,354,564 (GRCm39) nonsense probably null
R8445:Zgrf1 UTSW 3 127,379,854 (GRCm39) critical splice donor site probably null
R9088:Zgrf1 UTSW 3 127,377,326 (GRCm39) missense probably benign 0.21
R9236:Zgrf1 UTSW 3 127,378,312 (GRCm39) missense probably benign 0.09
R9250:Zgrf1 UTSW 3 127,379,797 (GRCm39) missense probably damaging 1.00
R9253:Zgrf1 UTSW 3 127,392,428 (GRCm39) missense probably damaging 1.00
R9647:Zgrf1 UTSW 3 127,355,251 (GRCm39) missense probably benign 0.02
R9680:Zgrf1 UTSW 3 127,409,216 (GRCm39) missense probably benign 0.38
RF015:Zgrf1 UTSW 3 127,356,882 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAGTGCAACTCAACTGCTCC -3'
(R):5'- GGTGTACGAAACAACTATCTGATC -3'

Sequencing Primer
(F):5'- TGCTCCGAACAGACTTGC -3'
(R):5'- TCTGATCAAAAAGTAAACTGTCTCC -3'
Posted On 2022-06-15