Incidental Mutation 'R9466:Vmn1r68'
ID 715160
Institutional Source Beutler Lab
Gene Symbol Vmn1r68
Ensembl Gene ENSMUSG00000047031
Gene Name vomeronasal 1 receptor 68
Synonyms Gm6898
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R9466 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 10261137-10262096 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 10261417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 227 (V227A)
Ref Sequence ENSEMBL: ENSMUSP00000050927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058362]
AlphaFold E9Q0V3
Predicted Effect probably damaging
Transcript: ENSMUST00000058362
AA Change: V227A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000050927
Gene: ENSMUSG00000047031
AA Change: V227A

DomainStartEndE-ValueType
Pfam:V1R 49 306 2e-33 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox2 A G 14: 8,248,092 (GRCm38) S397P probably benign Het
Arhgef28 T A 13: 98,124,825 (GRCm39) S486C Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Atp8b2 A T 3: 89,851,484 (GRCm39) Y928N probably benign Het
Brip1 T C 11: 86,048,584 (GRCm39) T253A possibly damaging Het
Brsk2 A T 7: 141,536,800 (GRCm39) Y91F probably benign Het
C7 C T 15: 5,044,884 (GRCm39) V385I probably benign Het
Cdk5rap1 C A 2: 154,192,756 (GRCm39) V414F possibly damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Cyp2d26 A T 15: 82,674,424 (GRCm39) M486K probably benign Het
Dchs2 G T 3: 83,176,564 (GRCm39) A841S probably damaging Het
Dnajb1 T G 8: 84,337,384 (GRCm39) V320G probably damaging Het
Dusp10 T C 1: 183,769,234 (GRCm39) S67P probably damaging Het
Epha8 T C 4: 136,662,414 (GRCm39) T548A probably benign Het
Grhl3 A T 4: 135,283,412 (GRCm39) S276T probably benign Het
Hspd1 A T 1: 55,119,483 (GRCm39) N331K probably benign Het
Ikbke T A 1: 131,193,445 (GRCm39) Q519L probably damaging Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Kdm4b A C 17: 56,696,548 (GRCm39) E421D probably benign Het
Krt6b A T 15: 101,586,027 (GRCm39) Y349N probably damaging Het
Larp1 T C 11: 57,943,461 (GRCm39) S845P possibly damaging Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nup98 G A 7: 101,818,611 (GRCm39) S473L probably benign Het
Or10w1 T A 19: 13,631,796 (GRCm39) M1K probably null Het
Or14c45 C G 7: 86,176,080 (GRCm39) F38L probably benign Het
Or8g28 T A 9: 39,169,491 (GRCm39) H159L possibly damaging Het
Ovgp1 G A 3: 105,887,484 (GRCm39) R265H Het
Pgap3 C T 11: 98,289,796 (GRCm39) R65Q probably benign Het
Pip5k1c C A 10: 81,152,710 (GRCm39) probably benign Het
Plcg1 C A 2: 160,596,520 (GRCm39) H680N probably benign Het
Pnliprp1 A T 19: 58,723,081 (GRCm39) D194V probably damaging Het
Pramel1 A G 4: 143,123,799 (GRCm39) D158G probably benign Het
Prkd2 A T 7: 16,589,696 (GRCm39) H466L probably damaging Het
Prkd3 T C 17: 79,264,049 (GRCm39) I683V probably damaging Het
Prrc2c A T 1: 162,503,258 (GRCm39) H2734Q possibly damaging Het
Scnn1b A T 7: 121,502,013 (GRCm39) I224F probably damaging Het
Sis A T 3: 72,872,910 (GRCm39) probably null Het
Syt15 C T 14: 33,942,991 (GRCm39) L17F probably damaging Het
Tenm4 T C 7: 96,199,252 (GRCm39) F15S possibly damaging Het
Thsd7b A G 1: 130,122,866 (GRCm39) K1495R probably benign Het
Ttc28 T C 5: 111,330,895 (GRCm39) S372P probably damaging Het
Other mutations in Vmn1r68
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01892:Vmn1r68 APN 7 10,261,334 (GRCm39) missense possibly damaging 0.76
IGL02051:Vmn1r68 APN 7 10,261,948 (GRCm39) missense probably benign 0.00
IGL02112:Vmn1r68 APN 7 10,261,787 (GRCm39) missense probably damaging 0.96
IGL02619:Vmn1r68 APN 7 10,261,603 (GRCm39) missense probably benign 0.14
IGL03033:Vmn1r68 APN 7 10,262,074 (GRCm39) missense probably damaging 0.99
IGL03184:Vmn1r68 APN 7 10,261,799 (GRCm39) missense probably benign 0.16
PIT4354001:Vmn1r68 UTSW 7 10,261,958 (GRCm39) missense probably benign
R0141:Vmn1r68 UTSW 7 10,261,252 (GRCm39) missense possibly damaging 0.69
R0359:Vmn1r68 UTSW 7 10,261,201 (GRCm39) missense probably damaging 1.00
R0634:Vmn1r68 UTSW 7 10,261,162 (GRCm39) missense probably benign 0.00
R1731:Vmn1r68 UTSW 7 10,261,802 (GRCm39) missense probably damaging 1.00
R2021:Vmn1r68 UTSW 7 10,261,918 (GRCm39) missense probably damaging 1.00
R2022:Vmn1r68 UTSW 7 10,261,918 (GRCm39) missense probably damaging 1.00
R2243:Vmn1r68 UTSW 7 10,262,089 (GRCm39) missense probably damaging 0.98
R2262:Vmn1r68 UTSW 7 10,261,372 (GRCm39) missense probably damaging 1.00
R3877:Vmn1r68 UTSW 7 10,261,408 (GRCm39) missense probably damaging 1.00
R4470:Vmn1r68 UTSW 7 10,261,275 (GRCm39) missense probably benign 0.23
R4843:Vmn1r68 UTSW 7 10,261,904 (GRCm39) missense probably benign 0.00
R5198:Vmn1r68 UTSW 7 10,261,723 (GRCm39) missense probably benign 0.00
R5835:Vmn1r68 UTSW 7 10,261,747 (GRCm39) missense possibly damaging 0.68
R5906:Vmn1r68 UTSW 7 10,261,550 (GRCm39) missense probably benign 0.02
R6015:Vmn1r68 UTSW 7 10,261,616 (GRCm39) missense probably benign 0.31
R7073:Vmn1r68 UTSW 7 10,261,778 (GRCm39) missense probably benign 0.00
R7614:Vmn1r68 UTSW 7 10,261,553 (GRCm39) missense probably benign 0.05
R7699:Vmn1r68 UTSW 7 10,261,559 (GRCm39) missense probably benign 0.15
R7700:Vmn1r68 UTSW 7 10,261,559 (GRCm39) missense probably benign 0.15
R7912:Vmn1r68 UTSW 7 10,261,237 (GRCm39) missense probably benign 0.01
R8166:Vmn1r68 UTSW 7 10,261,888 (GRCm39) missense probably benign 0.10
R8426:Vmn1r68 UTSW 7 10,261,382 (GRCm39) missense probably benign 0.02
R9466:Vmn1r68 UTSW 7 10,261,317 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTTCACGAGCCACCAATTG -3'
(R):5'- TTCTCTGGGTCTTGCACATG -3'

Sequencing Primer
(F):5'- CCACCAATTGGGATTATTCAGAAGAG -3'
(R):5'- GGGTCTTGCACATGTTTTTAAATTTC -3'
Posted On 2022-06-15