Incidental Mutation 'R9466:Or14c45'
ID 715162
Institutional Source Beutler Lab
Gene Symbol Or14c45
Ensembl Gene ENSMUSG00000057067
Gene Name olfactory receptor family 14 subfamily C member 45
Synonyms Olfr297, GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R9466 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 86175967-86176899 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 86176080 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 38 (F38L)
Ref Sequence ENSEMBL: ENSMUSP00000134371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071112] [ENSMUST00000172965]
AlphaFold Q7TS07
Predicted Effect probably benign
Transcript: ENSMUST00000071112
AA Change: F38L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132942
Gene: ENSMUSG00000057067
AA Change: F38L

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.9e-45 PFAM
Pfam:7tm_1 39 288 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172965
AA Change: F38L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: F38L

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox2 A G 14: 8,248,092 (GRCm38) S397P probably benign Het
Arhgef28 T A 13: 98,124,825 (GRCm39) S486C Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Atp8b2 A T 3: 89,851,484 (GRCm39) Y928N probably benign Het
Brip1 T C 11: 86,048,584 (GRCm39) T253A possibly damaging Het
Brsk2 A T 7: 141,536,800 (GRCm39) Y91F probably benign Het
C7 C T 15: 5,044,884 (GRCm39) V385I probably benign Het
Cdk5rap1 C A 2: 154,192,756 (GRCm39) V414F possibly damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Cyp2d26 A T 15: 82,674,424 (GRCm39) M486K probably benign Het
Dchs2 G T 3: 83,176,564 (GRCm39) A841S probably damaging Het
Dnajb1 T G 8: 84,337,384 (GRCm39) V320G probably damaging Het
Dusp10 T C 1: 183,769,234 (GRCm39) S67P probably damaging Het
Epha8 T C 4: 136,662,414 (GRCm39) T548A probably benign Het
Grhl3 A T 4: 135,283,412 (GRCm39) S276T probably benign Het
Hspd1 A T 1: 55,119,483 (GRCm39) N331K probably benign Het
Ikbke T A 1: 131,193,445 (GRCm39) Q519L probably damaging Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Kdm4b A C 17: 56,696,548 (GRCm39) E421D probably benign Het
Krt6b A T 15: 101,586,027 (GRCm39) Y349N probably damaging Het
Larp1 T C 11: 57,943,461 (GRCm39) S845P possibly damaging Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nup98 G A 7: 101,818,611 (GRCm39) S473L probably benign Het
Or10w1 T A 19: 13,631,796 (GRCm39) M1K probably null Het
Or8g28 T A 9: 39,169,491 (GRCm39) H159L possibly damaging Het
Ovgp1 G A 3: 105,887,484 (GRCm39) R265H Het
Pgap3 C T 11: 98,289,796 (GRCm39) R65Q probably benign Het
Pip5k1c C A 10: 81,152,710 (GRCm39) probably benign Het
Plcg1 C A 2: 160,596,520 (GRCm39) H680N probably benign Het
Pnliprp1 A T 19: 58,723,081 (GRCm39) D194V probably damaging Het
Pramel1 A G 4: 143,123,799 (GRCm39) D158G probably benign Het
Prkd2 A T 7: 16,589,696 (GRCm39) H466L probably damaging Het
Prkd3 T C 17: 79,264,049 (GRCm39) I683V probably damaging Het
Prrc2c A T 1: 162,503,258 (GRCm39) H2734Q possibly damaging Het
Scnn1b A T 7: 121,502,013 (GRCm39) I224F probably damaging Het
Sis A T 3: 72,872,910 (GRCm39) probably null Het
Syt15 C T 14: 33,942,991 (GRCm39) L17F probably damaging Het
Tenm4 T C 7: 96,199,252 (GRCm39) F15S possibly damaging Het
Thsd7b A G 1: 130,122,866 (GRCm39) K1495R probably benign Het
Ttc28 T C 5: 111,330,895 (GRCm39) S372P probably damaging Het
Vmn1r68 A T 7: 10,261,317 (GRCm39) Y260* probably null Het
Vmn1r68 A G 7: 10,261,417 (GRCm39) V227A probably damaging Het
Other mutations in Or14c45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Or14c45 APN 7 86,175,986 (GRCm39) missense probably benign 0.10
IGL01823:Or14c45 APN 7 86,176,249 (GRCm39) missense probably damaging 1.00
PIT4378001:Or14c45 UTSW 7 86,176,306 (GRCm39) missense possibly damaging 0.50
R0304:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R0737:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R2177:Or14c45 UTSW 7 86,176,870 (GRCm39) missense probably benign 0.01
R2436:Or14c45 UTSW 7 86,176,591 (GRCm39) missense probably damaging 0.99
R4289:Or14c45 UTSW 7 86,176,262 (GRCm39) missense probably damaging 1.00
R4639:Or14c45 UTSW 7 86,175,969 (GRCm39) start codon destroyed probably null 1.00
R5202:Or14c45 UTSW 7 86,176,324 (GRCm39) missense probably damaging 1.00
R5782:Or14c45 UTSW 7 86,176,421 (GRCm39) missense probably damaging 0.98
R6446:Or14c45 UTSW 7 86,176,310 (GRCm39) missense possibly damaging 0.90
R6615:Or14c45 UTSW 7 86,176,120 (GRCm39) missense probably benign 0.06
R6920:Or14c45 UTSW 7 86,176,522 (GRCm39) missense probably benign 0.00
R7150:Or14c45 UTSW 7 86,176,322 (GRCm39) missense probably damaging 1.00
R7309:Or14c45 UTSW 7 86,176,349 (GRCm39) missense probably damaging 1.00
R7621:Or14c45 UTSW 7 86,176,280 (GRCm39) missense probably benign 0.37
R8257:Or14c45 UTSW 7 86,176,678 (GRCm39) missense possibly damaging 0.95
R9349:Or14c45 UTSW 7 86,176,373 (GRCm39) missense probably benign 0.01
R9479:Or14c45 UTSW 7 86,176,285 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- AGACCATTTGACAGACAGCC -3'
(R):5'- CCCAGTCACAGAAATGTTCCTG -3'

Sequencing Primer
(F):5'- CATTTGACAGACAGCCACATATATG -3'
(R):5'- CAGTCACAGAAATGTTCCTGTGGTC -3'
Posted On 2022-06-15