Incidental Mutation 'R9467:Fmo4'
ID 715186
Institutional Source Beutler Lab
Gene Symbol Fmo4
Ensembl Gene ENSMUSG00000026692
Gene Name flavin containing monooxygenase 4
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R9467 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 162620757-162641541 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 162631238 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 243 (V243A)
Ref Sequence ENSEMBL: ENSMUSP00000028014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028014] [ENSMUST00000111525] [ENSMUST00000140274] [ENSMUST00000144916]
AlphaFold Q8VHG0
Predicted Effect probably benign
Transcript: ENSMUST00000028014
AA Change: V243A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000028014
Gene: ENSMUSG00000026692
AA Change: V243A

DomainStartEndE-ValueType
Pfam:FMO-like 2 531 9.4e-272 PFAM
Pfam:Pyr_redox_2 4 430 1e-8 PFAM
Pfam:Pyr_redox_3 6 220 5.1e-16 PFAM
Pfam:K_oxygenase 68 227 1.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111525
AA Change: V243A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107150
Gene: ENSMUSG00000026692
AA Change: V243A

DomainStartEndE-ValueType
Pfam:FMO-like 2 531 9.4e-272 PFAM
Pfam:Pyr_redox_2 3 225 1.7e-11 PFAM
Pfam:Pyr_redox_3 6 220 2.5e-9 PFAM
Pfam:K_oxygenase 67 227 6e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140274
SMART Domains Protein: ENSMUSP00000118476
Gene: ENSMUSG00000026692

DomainStartEndE-ValueType
Pfam:FMO-like 2 99 1.5e-57 PFAM
Pfam:NAD_binding_8 7 94 1.6e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144916
SMART Domains Protein: ENSMUSP00000119389
Gene: ENSMUSG00000026692

DomainStartEndE-ValueType
Pfam:FMO-like 1 114 2.6e-63 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A C 2: 68,423,934 (GRCm39) M46L Het
Aars2 A G 17: 45,827,410 (GRCm39) E484G probably benign Het
Abcd2 C T 15: 91,075,825 (GRCm39) probably benign Het
Acap2 A G 16: 30,929,901 (GRCm39) S361P possibly damaging Het
Arap2 T C 5: 62,887,900 (GRCm39) E482G probably benign Het
Axin2 G T 11: 108,833,782 (GRCm39) L576F possibly damaging Het
B4galt2 T A 4: 117,738,123 (GRCm39) Y161F probably damaging Het
Cdh3 A T 8: 107,266,425 (GRCm39) probably null Het
Cfap61 A T 2: 145,971,149 (GRCm39) I920F probably benign Het
Chaf1b T C 16: 93,681,394 (GRCm39) I4T probably benign Het
Clptm1 T C 7: 19,371,449 (GRCm39) N328S probably benign Het
Cthrc1 A G 15: 38,947,689 (GRCm39) N136S probably benign Het
Dlec1 G T 9: 118,971,652 (GRCm39) R1279L probably damaging Het
Dnah5 A T 15: 28,366,293 (GRCm39) T2669S possibly damaging Het
Efcab14 C A 4: 115,610,208 (GRCm39) L190I probably damaging Het
Eml6 A T 11: 29,769,076 (GRCm39) C690S probably damaging Het
Fignl1 T C 11: 11,751,483 (GRCm39) E524G probably damaging Het
Ghr A G 15: 3,357,506 (GRCm39) V254A probably benign Het
Igkv8-28 A G 6: 70,120,691 (GRCm39) V84A probably damaging Het
Itgb7 T C 15: 102,131,989 (GRCm39) D198G probably damaging Het
Klra2 A G 6: 131,197,070 (GRCm39) probably null Het
Klrc2 A T 6: 129,633,363 (GRCm39) Y230N probably damaging Het
Lacc1 A G 14: 77,267,024 (GRCm39) V413A probably damaging Het
Muc16 T C 9: 18,508,331 (GRCm39) N6355S probably benign Het
Ncor1 AGCTGCTGCTGCTGCTGCTGCTGCTG AGCTGCTGCTGCTGCTGCTGCTGCTGCTG 11: 62,324,437 (GRCm39) probably benign Het
Ncor1 CTG CTGGTG 11: 62,324,448 (GRCm39) probably benign Het
Ndn A G 7: 61,998,903 (GRCm39) K250E possibly damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nt5e A G 9: 88,249,416 (GRCm39) E450G probably benign Het
Or4d6 A T 19: 12,086,313 (GRCm39) M199K possibly damaging Het
Or5p75-ps1 T A 7: 108,107,790 (GRCm39) *176K probably null Het
Or8k16 G T 2: 85,520,626 (GRCm39) M284I Het
Palld A G 8: 61,968,264 (GRCm39) S1343P unknown Het
Pcdha8 T A 18: 37,126,843 (GRCm39) S442T possibly damaging Het
Pole2 T C 12: 69,255,719 (GRCm39) I349V probably benign Het
Ptprb C T 10: 116,158,390 (GRCm39) T487M probably benign Het
Ptprc C T 1: 137,993,960 (GRCm39) D1020N probably damaging Het
Relch C T 1: 105,669,039 (GRCm39) T1023I probably damaging Het
Rnf26rt C T 6: 76,473,615 (GRCm39) E334K probably benign Het
Rsf1 GCGGCGGCG GCGGCGGCGACGGCGGCG 7: 97,229,120 (GRCm39) probably benign Het
Ryr2 T C 13: 11,571,490 (GRCm39) N4916S possibly damaging Het
Selp C T 1: 163,957,674 (GRCm39) P268S probably damaging Het
Sema7a T A 9: 57,864,608 (GRCm39) C333S probably damaging Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sh2b1 CAGCCACGGGGACCAGCT CAGCCACGGGGACCAGCTAAGCCACGGGGACCAGCT 7: 126,066,754 (GRCm39) probably null Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Shisa5 G A 9: 108,867,712 (GRCm39) probably benign Het
Snx27 A G 3: 94,489,723 (GRCm39) V45A possibly damaging Het
Srcap T C 7: 127,139,531 (GRCm39) V1284A probably damaging Het
Ssrp1 A G 2: 84,872,610 (GRCm39) D416G probably damaging Het
Tcstv1b C T 13: 120,634,061 (GRCm39) probably benign Het
Tectb A G 19: 55,181,093 (GRCm39) Y144C Het
Thap12 G T 7: 98,359,348 (GRCm39) V76F probably damaging Het
Ticam2 G C 18: 46,693,748 (GRCm39) P113R probably damaging Het
Tsg101 A G 7: 46,558,772 (GRCm39) Y80H probably benign Het
Unc5cl T A 17: 48,770,656 (GRCm39) M368K probably damaging Het
Utp20 G T 10: 88,640,390 (GRCm39) Q717K possibly damaging Het
Vmn1r159 T A 7: 22,542,141 (GRCm39) D297V possibly damaging Het
Vmn2r98 G T 17: 19,287,517 (GRCm39) S450I probably benign Het
Zbtb8b T C 4: 129,326,319 (GRCm39) E282G probably benign Het
Zfp831 T C 2: 174,486,789 (GRCm39) V488A probably benign Het
Zng1 T A 19: 24,930,684 (GRCm39) M122L possibly damaging Het
Zzef1 G A 11: 72,807,251 (GRCm39) V2710I probably damaging Het
Other mutations in Fmo4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Fmo4 APN 1 162,621,592 (GRCm39) missense probably benign 0.00
IGL01090:Fmo4 APN 1 162,637,354 (GRCm39) splice site probably null
IGL01295:Fmo4 APN 1 162,626,693 (GRCm39) missense probably damaging 1.00
IGL02089:Fmo4 APN 1 162,626,649 (GRCm39) missense probably benign 0.04
IGL02483:Fmo4 APN 1 162,635,990 (GRCm39) missense possibly damaging 0.60
R0608:Fmo4 UTSW 1 162,631,220 (GRCm39) missense possibly damaging 0.95
R0660:Fmo4 UTSW 1 162,637,417 (GRCm39) missense probably benign 0.05
R0737:Fmo4 UTSW 1 162,635,961 (GRCm39) nonsense probably null
R1117:Fmo4 UTSW 1 162,631,232 (GRCm39) missense probably benign 0.03
R1464:Fmo4 UTSW 1 162,621,924 (GRCm39) missense possibly damaging 0.54
R1464:Fmo4 UTSW 1 162,621,924 (GRCm39) missense possibly damaging 0.54
R1577:Fmo4 UTSW 1 162,631,269 (GRCm39) missense possibly damaging 0.50
R1792:Fmo4 UTSW 1 162,621,859 (GRCm39) missense probably benign
R1875:Fmo4 UTSW 1 162,631,187 (GRCm39) missense possibly damaging 0.95
R1929:Fmo4 UTSW 1 162,626,616 (GRCm39) missense possibly damaging 0.95
R1956:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R1957:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R1958:Fmo4 UTSW 1 162,631,259 (GRCm39) missense probably benign 0.01
R2011:Fmo4 UTSW 1 162,626,458 (GRCm39) missense probably damaging 1.00
R2030:Fmo4 UTSW 1 162,621,741 (GRCm39) missense probably damaging 1.00
R2072:Fmo4 UTSW 1 162,637,456 (GRCm39) missense probably benign 0.20
R2272:Fmo4 UTSW 1 162,626,616 (GRCm39) missense possibly damaging 0.95
R3890:Fmo4 UTSW 1 162,621,624 (GRCm39) missense probably benign 0.39
R4255:Fmo4 UTSW 1 162,621,895 (GRCm39) missense probably benign 0.00
R4273:Fmo4 UTSW 1 162,632,748 (GRCm39) missense probably damaging 0.97
R4760:Fmo4 UTSW 1 162,637,396 (GRCm39) missense probably damaging 1.00
R5445:Fmo4 UTSW 1 162,632,842 (GRCm39) missense probably benign 0.24
R5726:Fmo4 UTSW 1 162,635,828 (GRCm39) critical splice donor site probably null
R5786:Fmo4 UTSW 1 162,631,286 (GRCm39) missense probably benign 0.00
R6391:Fmo4 UTSW 1 162,621,538 (GRCm39) nonsense probably null
R6826:Fmo4 UTSW 1 162,631,338 (GRCm39) missense probably damaging 1.00
R7457:Fmo4 UTSW 1 162,621,672 (GRCm39) missense probably benign 0.00
R7913:Fmo4 UTSW 1 162,621,741 (GRCm39) missense possibly damaging 0.69
R8031:Fmo4 UTSW 1 162,626,421 (GRCm39) nonsense probably null
R8055:Fmo4 UTSW 1 162,636,015 (GRCm39) missense probably benign
R8234:Fmo4 UTSW 1 162,632,757 (GRCm39) missense probably damaging 1.00
R8346:Fmo4 UTSW 1 162,621,792 (GRCm39) missense probably benign 0.01
R8706:Fmo4 UTSW 1 162,621,592 (GRCm39) nonsense probably null
R9050:Fmo4 UTSW 1 162,635,099 (GRCm39) missense probably benign 0.15
R9488:Fmo4 UTSW 1 162,631,337 (GRCm39) missense probably damaging 1.00
R9633:Fmo4 UTSW 1 162,631,191 (GRCm39) missense probably benign 0.00
X0020:Fmo4 UTSW 1 162,621,947 (GRCm39) missense probably benign 0.02
Z1177:Fmo4 UTSW 1 162,631,289 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTACATGCACATATAGAACTCCACTG -3'
(R):5'- TGCCAGACCAACATATTATAGCTAC -3'

Sequencing Primer
(F):5'- CTCAAGTACCCTTTTGCAATG -3'
(R):5'- CATATGGTCACACACAAGTCTATG -3'
Posted On 2022-06-15