Incidental Mutation 'R9467:Zfp831'
| ID |
715192 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp831
|
| Ensembl Gene |
ENSMUSG00000050600 |
| Gene Name |
zinc finger protein 831 |
| Synonyms |
ENSMUSG00000050600, OTTMUSG00000017459 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9467 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
174485327-174552625 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 174486789 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 488
(V488A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000060255
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059452]
|
| AlphaFold |
A2ADM8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059452
AA Change: V488A
PolyPhen 2
Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: V488A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
120 |
135 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
143 |
165 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
171 |
195 |
7.78e-3 |
SMART |
|
low complexity region
|
201 |
216 |
N/A |
INTRINSIC |
|
low complexity region
|
237 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
345 |
371 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
392 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
717 |
736 |
N/A |
INTRINSIC |
|
low complexity region
|
856 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
1520 |
1529 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933409G03Rik |
A |
C |
2: 68,423,934 (GRCm39) |
M46L |
|
Het |
| Aars2 |
A |
G |
17: 45,827,410 (GRCm39) |
E484G |
probably benign |
Het |
| Abcd2 |
C |
T |
15: 91,075,825 (GRCm39) |
|
probably benign |
Het |
| Acap2 |
A |
G |
16: 30,929,901 (GRCm39) |
S361P |
possibly damaging |
Het |
| Arap2 |
T |
C |
5: 62,887,900 (GRCm39) |
E482G |
probably benign |
Het |
| Axin2 |
G |
T |
11: 108,833,782 (GRCm39) |
L576F |
possibly damaging |
Het |
| B4galt2 |
T |
A |
4: 117,738,123 (GRCm39) |
Y161F |
probably damaging |
Het |
| Cdh3 |
A |
T |
8: 107,266,425 (GRCm39) |
|
probably null |
Het |
| Cfap61 |
A |
T |
2: 145,971,149 (GRCm39) |
I920F |
probably benign |
Het |
| Chaf1b |
T |
C |
16: 93,681,394 (GRCm39) |
I4T |
probably benign |
Het |
| Clptm1 |
T |
C |
7: 19,371,449 (GRCm39) |
N328S |
probably benign |
Het |
| Cthrc1 |
A |
G |
15: 38,947,689 (GRCm39) |
N136S |
probably benign |
Het |
| Dlec1 |
G |
T |
9: 118,971,652 (GRCm39) |
R1279L |
probably damaging |
Het |
| Dnah5 |
A |
T |
15: 28,366,293 (GRCm39) |
T2669S |
possibly damaging |
Het |
| Efcab14 |
C |
A |
4: 115,610,208 (GRCm39) |
L190I |
probably damaging |
Het |
| Eml6 |
A |
T |
11: 29,769,076 (GRCm39) |
C690S |
probably damaging |
Het |
| Fignl1 |
T |
C |
11: 11,751,483 (GRCm39) |
E524G |
probably damaging |
Het |
| Fmo4 |
A |
G |
1: 162,631,238 (GRCm39) |
V243A |
probably benign |
Het |
| Ghr |
A |
G |
15: 3,357,506 (GRCm39) |
V254A |
probably benign |
Het |
| Igkv8-28 |
A |
G |
6: 70,120,691 (GRCm39) |
V84A |
probably damaging |
Het |
| Itgb7 |
T |
C |
15: 102,131,989 (GRCm39) |
D198G |
probably damaging |
Het |
| Klra2 |
A |
G |
6: 131,197,070 (GRCm39) |
|
probably null |
Het |
| Klrc2 |
A |
T |
6: 129,633,363 (GRCm39) |
Y230N |
probably damaging |
Het |
| Lacc1 |
A |
G |
14: 77,267,024 (GRCm39) |
V413A |
probably damaging |
Het |
| Muc16 |
T |
C |
9: 18,508,331 (GRCm39) |
N6355S |
probably benign |
Het |
| Ncor1 |
AGCTGCTGCTGCTGCTGCTGCTGCTG |
AGCTGCTGCTGCTGCTGCTGCTGCTGCTG |
11: 62,324,437 (GRCm39) |
|
probably benign |
Het |
| Ncor1 |
CTG |
CTGGTG |
11: 62,324,448 (GRCm39) |
|
probably benign |
Het |
| Ndn |
A |
G |
7: 61,998,903 (GRCm39) |
K250E |
possibly damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nt5e |
A |
G |
9: 88,249,416 (GRCm39) |
E450G |
probably benign |
Het |
| Or4d6 |
A |
T |
19: 12,086,313 (GRCm39) |
M199K |
possibly damaging |
Het |
| Or5p75-ps1 |
T |
A |
7: 108,107,790 (GRCm39) |
*176K |
probably null |
Het |
| Or8k16 |
G |
T |
2: 85,520,626 (GRCm39) |
M284I |
|
Het |
| Palld |
A |
G |
8: 61,968,264 (GRCm39) |
S1343P |
unknown |
Het |
| Pcdha8 |
T |
A |
18: 37,126,843 (GRCm39) |
S442T |
possibly damaging |
Het |
| Pole2 |
T |
C |
12: 69,255,719 (GRCm39) |
I349V |
probably benign |
Het |
| Ptprb |
C |
T |
10: 116,158,390 (GRCm39) |
T487M |
probably benign |
Het |
| Ptprc |
C |
T |
1: 137,993,960 (GRCm39) |
D1020N |
probably damaging |
Het |
| Relch |
C |
T |
1: 105,669,039 (GRCm39) |
T1023I |
probably damaging |
Het |
| Rnf26rt |
C |
T |
6: 76,473,615 (GRCm39) |
E334K |
probably benign |
Het |
| Rsf1 |
GCGGCGGCG |
GCGGCGGCGACGGCGGCG |
7: 97,229,120 (GRCm39) |
|
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,571,490 (GRCm39) |
N4916S |
possibly damaging |
Het |
| Selp |
C |
T |
1: 163,957,674 (GRCm39) |
P268S |
probably damaging |
Het |
| Sema7a |
T |
A |
9: 57,864,608 (GRCm39) |
C333S |
probably damaging |
Het |
| Sh2b1 |
TGGGGACCAGCTCAGCCACGGGGACCAGCTC |
TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC |
7: 126,066,742 (GRCm39) |
|
probably benign |
Het |
| Sh2b1 |
CAGCCACGGGGACCAGCT |
CAGCCACGGGGACCAGCTAAGCCACGGGGACCAGCT |
7: 126,066,754 (GRCm39) |
|
probably null |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Shisa5 |
G |
A |
9: 108,867,712 (GRCm39) |
|
probably benign |
Het |
| Snx27 |
A |
G |
3: 94,489,723 (GRCm39) |
V45A |
possibly damaging |
Het |
| Srcap |
T |
C |
7: 127,139,531 (GRCm39) |
V1284A |
probably damaging |
Het |
| Ssrp1 |
A |
G |
2: 84,872,610 (GRCm39) |
D416G |
probably damaging |
Het |
| Tcstv1b |
C |
T |
13: 120,634,061 (GRCm39) |
|
probably benign |
Het |
| Tectb |
A |
G |
19: 55,181,093 (GRCm39) |
Y144C |
|
Het |
| Thap12 |
G |
T |
7: 98,359,348 (GRCm39) |
V76F |
probably damaging |
Het |
| Ticam2 |
G |
C |
18: 46,693,748 (GRCm39) |
P113R |
probably damaging |
Het |
| Tsg101 |
A |
G |
7: 46,558,772 (GRCm39) |
Y80H |
probably benign |
Het |
| Unc5cl |
T |
A |
17: 48,770,656 (GRCm39) |
M368K |
probably damaging |
Het |
| Utp20 |
G |
T |
10: 88,640,390 (GRCm39) |
Q717K |
possibly damaging |
Het |
| Vmn1r159 |
T |
A |
7: 22,542,141 (GRCm39) |
D297V |
possibly damaging |
Het |
| Vmn2r98 |
G |
T |
17: 19,287,517 (GRCm39) |
S450I |
probably benign |
Het |
| Zbtb8b |
T |
C |
4: 129,326,319 (GRCm39) |
E282G |
probably benign |
Het |
| Zng1 |
T |
A |
19: 24,930,684 (GRCm39) |
M122L |
possibly damaging |
Het |
| Zzef1 |
G |
A |
11: 72,807,251 (GRCm39) |
V2710I |
probably damaging |
Het |
|
| Other mutations in Zfp831 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Zfp831
|
APN |
2 |
174,488,078 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00091:Zfp831
|
APN |
2 |
174,487,451 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL00764:Zfp831
|
APN |
2 |
174,487,701 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01538:Zfp831
|
APN |
2 |
174,486,399 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01700:Zfp831
|
APN |
2 |
174,486,711 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01718:Zfp831
|
APN |
2 |
174,485,631 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02221:Zfp831
|
APN |
2 |
174,485,519 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02250:Zfp831
|
APN |
2 |
174,489,994 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03209:Zfp831
|
APN |
2 |
174,487,059 (GRCm39) |
missense |
probably benign |
0.40 |
|
D4043:Zfp831
|
UTSW |
2 |
174,487,059 (GRCm39) |
missense |
probably benign |
0.40 |
|
FR4304:Zfp831
|
UTSW |
2 |
174,487,274 (GRCm39) |
small insertion |
probably benign |
|
|
FR4340:Zfp831
|
UTSW |
2 |
174,487,273 (GRCm39) |
small insertion |
probably benign |
|
|
FR4449:Zfp831
|
UTSW |
2 |
174,487,275 (GRCm39) |
small insertion |
probably benign |
|
|
FR4449:Zfp831
|
UTSW |
2 |
174,487,264 (GRCm39) |
small insertion |
probably benign |
|
|
FR4589:Zfp831
|
UTSW |
2 |
174,487,261 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,276 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,269 (GRCm39) |
small insertion |
probably benign |
|
|
FR4737:Zfp831
|
UTSW |
2 |
174,487,264 (GRCm39) |
small insertion |
probably benign |
|
|
IGL02802:Zfp831
|
UTSW |
2 |
174,486,945 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
P0028:Zfp831
|
UTSW |
2 |
174,487,139 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
PIT4531001:Zfp831
|
UTSW |
2 |
174,488,516 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0631:Zfp831
|
UTSW |
2 |
174,487,083 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0644:Zfp831
|
UTSW |
2 |
174,487,656 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0782:Zfp831
|
UTSW |
2 |
174,488,423 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1156:Zfp831
|
UTSW |
2 |
174,488,710 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1280:Zfp831
|
UTSW |
2 |
174,545,852 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Zfp831
|
UTSW |
2 |
174,487,683 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1883:Zfp831
|
UTSW |
2 |
174,545,870 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1884:Zfp831
|
UTSW |
2 |
174,545,870 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2127:Zfp831
|
UTSW |
2 |
174,489,917 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2137:Zfp831
|
UTSW |
2 |
174,547,539 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2268:Zfp831
|
UTSW |
2 |
174,486,034 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2330:Zfp831
|
UTSW |
2 |
174,489,882 (GRCm39) |
nonsense |
probably null |
|
|
R3547:Zfp831
|
UTSW |
2 |
174,499,476 (GRCm39) |
missense |
probably benign |
|
|
R3821:Zfp831
|
UTSW |
2 |
174,485,816 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4163:Zfp831
|
UTSW |
2 |
174,485,822 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4232:Zfp831
|
UTSW |
2 |
174,547,447 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4778:Zfp831
|
UTSW |
2 |
174,488,600 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4820:Zfp831
|
UTSW |
2 |
174,547,097 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4912:Zfp831
|
UTSW |
2 |
174,486,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5119:Zfp831
|
UTSW |
2 |
174,547,103 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5152:Zfp831
|
UTSW |
2 |
174,486,357 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5723:Zfp831
|
UTSW |
2 |
174,487,200 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5741:Zfp831
|
UTSW |
2 |
174,486,945 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5888:Zfp831
|
UTSW |
2 |
174,485,420 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5975:Zfp831
|
UTSW |
2 |
174,485,885 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6092:Zfp831
|
UTSW |
2 |
174,547,299 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6158:Zfp831
|
UTSW |
2 |
174,485,651 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6212:Zfp831
|
UTSW |
2 |
174,487,661 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6233:Zfp831
|
UTSW |
2 |
174,488,490 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6248:Zfp831
|
UTSW |
2 |
174,486,308 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6255:Zfp831
|
UTSW |
2 |
174,488,214 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6460:Zfp831
|
UTSW |
2 |
174,488,360 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6477:Zfp831
|
UTSW |
2 |
174,545,960 (GRCm39) |
missense |
probably benign |
|
|
R6864:Zfp831
|
UTSW |
2 |
174,488,533 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7396:Zfp831
|
UTSW |
2 |
174,487,002 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7447:Zfp831
|
UTSW |
2 |
174,487,896 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7499:Zfp831
|
UTSW |
2 |
174,485,816 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7662:Zfp831
|
UTSW |
2 |
174,487,934 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7857:Zfp831
|
UTSW |
2 |
174,547,035 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7889:Zfp831
|
UTSW |
2 |
174,487,097 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7896:Zfp831
|
UTSW |
2 |
174,488,921 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8074:Zfp831
|
UTSW |
2 |
174,486,528 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8089:Zfp831
|
UTSW |
2 |
174,486,717 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8438:Zfp831
|
UTSW |
2 |
174,486,796 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8716:Zfp831
|
UTSW |
2 |
174,547,049 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8757:Zfp831
|
UTSW |
2 |
174,487,874 (GRCm39) |
missense |
probably benign |
|
|
R8759:Zfp831
|
UTSW |
2 |
174,487,874 (GRCm39) |
missense |
probably benign |
|
|
R8899:Zfp831
|
UTSW |
2 |
174,485,978 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8976:Zfp831
|
UTSW |
2 |
174,487,079 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9146:Zfp831
|
UTSW |
2 |
174,487,461 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9257:Zfp831
|
UTSW |
2 |
174,488,156 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9324:Zfp831
|
UTSW |
2 |
174,547,113 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9729:Zfp831
|
UTSW |
2 |
174,487,938 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Zfp831
|
UTSW |
2 |
174,547,662 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1177:Zfp831
|
UTSW |
2 |
174,485,981 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCATATACCTACAAGGATTCC -3'
(R):5'- CATCTAGTTCCTCAGCAGCG -3'
Sequencing Primer
(F):5'- CTTCCACTTTGACATCCGGG -3'
(R):5'- CAGCAGCCTGTCTTACCAG -3'
|
| Posted On |
2022-06-15 |
Incidental Mutation