Incidental Mutation 'R9467:Nicn1'
ID 715218
Institutional Source Beutler Lab
Gene Symbol Nicn1
Ensembl Gene ENSMUSG00000032606
Gene Name nicolin 1
Synonyms 1500032A17Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R9467 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 108167642-108173697 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 108171708 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 163 (R163C)
Ref Sequence ENSEMBL: ENSMUSP00000035227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035227] [ENSMUST00000035230]
AlphaFold Q9CQM0
Predicted Effect possibly damaging
Transcript: ENSMUST00000035227
AA Change: R163C

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000035230
SMART Domains Protein: ENSMUSP00000035230
Gene: ENSMUSG00000032607

DomainStartEndE-ValueType
Pfam:GCV_T 38 291 7.8e-86 PFAM
Pfam:GCV_T_C 300 392 1.6e-23 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A C 2: 68,423,934 (GRCm39) M46L Het
Aars2 A G 17: 45,827,410 (GRCm39) E484G probably benign Het
Abcd2 C T 15: 91,075,825 (GRCm39) probably benign Het
Acap2 A G 16: 30,929,901 (GRCm39) S361P possibly damaging Het
Arap2 T C 5: 62,887,900 (GRCm39) E482G probably benign Het
Axin2 G T 11: 108,833,782 (GRCm39) L576F possibly damaging Het
B4galt2 T A 4: 117,738,123 (GRCm39) Y161F probably damaging Het
Cdh3 A T 8: 107,266,425 (GRCm39) probably null Het
Cfap61 A T 2: 145,971,149 (GRCm39) I920F probably benign Het
Chaf1b T C 16: 93,681,394 (GRCm39) I4T probably benign Het
Clptm1 T C 7: 19,371,449 (GRCm39) N328S probably benign Het
Cthrc1 A G 15: 38,947,689 (GRCm39) N136S probably benign Het
Dlec1 G T 9: 118,971,652 (GRCm39) R1279L probably damaging Het
Dnah5 A T 15: 28,366,293 (GRCm39) T2669S possibly damaging Het
Efcab14 C A 4: 115,610,208 (GRCm39) L190I probably damaging Het
Eml6 A T 11: 29,769,076 (GRCm39) C690S probably damaging Het
Fignl1 T C 11: 11,751,483 (GRCm39) E524G probably damaging Het
Fmo4 A G 1: 162,631,238 (GRCm39) V243A probably benign Het
Ghr A G 15: 3,357,506 (GRCm39) V254A probably benign Het
Igkv8-28 A G 6: 70,120,691 (GRCm39) V84A probably damaging Het
Itgb7 T C 15: 102,131,989 (GRCm39) D198G probably damaging Het
Klra2 A G 6: 131,197,070 (GRCm39) probably null Het
Klrc2 A T 6: 129,633,363 (GRCm39) Y230N probably damaging Het
Lacc1 A G 14: 77,267,024 (GRCm39) V413A probably damaging Het
Muc16 T C 9: 18,508,331 (GRCm39) N6355S probably benign Het
Ncor1 AGCTGCTGCTGCTGCTGCTGCTGCTG AGCTGCTGCTGCTGCTGCTGCTGCTGCTG 11: 62,324,437 (GRCm39) probably benign Het
Ncor1 CTG CTGGTG 11: 62,324,448 (GRCm39) probably benign Het
Ndn A G 7: 61,998,903 (GRCm39) K250E possibly damaging Het
Nt5e A G 9: 88,249,416 (GRCm39) E450G probably benign Het
Or4d6 A T 19: 12,086,313 (GRCm39) M199K possibly damaging Het
Or5p75-ps1 T A 7: 108,107,790 (GRCm39) *176K probably null Het
Or8k16 G T 2: 85,520,626 (GRCm39) M284I Het
Palld A G 8: 61,968,264 (GRCm39) S1343P unknown Het
Pcdha8 T A 18: 37,126,843 (GRCm39) S442T possibly damaging Het
Pole2 T C 12: 69,255,719 (GRCm39) I349V probably benign Het
Ptprb C T 10: 116,158,390 (GRCm39) T487M probably benign Het
Ptprc C T 1: 137,993,960 (GRCm39) D1020N probably damaging Het
Relch C T 1: 105,669,039 (GRCm39) T1023I probably damaging Het
Rnf26rt C T 6: 76,473,615 (GRCm39) E334K probably benign Het
Rsf1 GCGGCGGCG GCGGCGGCGACGGCGGCG 7: 97,229,120 (GRCm39) probably benign Het
Ryr2 T C 13: 11,571,490 (GRCm39) N4916S possibly damaging Het
Selp C T 1: 163,957,674 (GRCm39) P268S probably damaging Het
Sema7a T A 9: 57,864,608 (GRCm39) C333S probably damaging Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sh2b1 CAGCCACGGGGACCAGCT CAGCCACGGGGACCAGCTAAGCCACGGGGACCAGCT 7: 126,066,754 (GRCm39) probably null Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Shisa5 G A 9: 108,867,712 (GRCm39) probably benign Het
Snx27 A G 3: 94,489,723 (GRCm39) V45A possibly damaging Het
Srcap T C 7: 127,139,531 (GRCm39) V1284A probably damaging Het
Ssrp1 A G 2: 84,872,610 (GRCm39) D416G probably damaging Het
Tcstv1b C T 13: 120,634,061 (GRCm39) probably benign Het
Tectb A G 19: 55,181,093 (GRCm39) Y144C Het
Thap12 G T 7: 98,359,348 (GRCm39) V76F probably damaging Het
Ticam2 G C 18: 46,693,748 (GRCm39) P113R probably damaging Het
Tsg101 A G 7: 46,558,772 (GRCm39) Y80H probably benign Het
Unc5cl T A 17: 48,770,656 (GRCm39) M368K probably damaging Het
Utp20 G T 10: 88,640,390 (GRCm39) Q717K possibly damaging Het
Vmn1r159 T A 7: 22,542,141 (GRCm39) D297V possibly damaging Het
Vmn2r98 G T 17: 19,287,517 (GRCm39) S450I probably benign Het
Zbtb8b T C 4: 129,326,319 (GRCm39) E282G probably benign Het
Zfp831 T C 2: 174,486,789 (GRCm39) V488A probably benign Het
Zng1 T A 19: 24,930,684 (GRCm39) M122L possibly damaging Het
Zzef1 G A 11: 72,807,251 (GRCm39) V2710I probably damaging Het
Other mutations in Nicn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02935:Nicn1 APN 9 108,167,845 (GRCm39) missense probably benign
R7148:Nicn1 UTSW 9 108,172,306 (GRCm39) makesense probably null
R8121:Nicn1 UTSW 9 108,172,304 (GRCm39) missense probably damaging 1.00
R8353:Nicn1 UTSW 9 108,170,572 (GRCm39) missense probably damaging 1.00
R8453:Nicn1 UTSW 9 108,170,572 (GRCm39) missense probably damaging 1.00
R8925:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8927:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8937:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8951:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8962:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8965:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8967:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8987:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R8988:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9079:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9145:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9148:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9245:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9246:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9248:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9249:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9253:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9254:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9255:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9272:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9273:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9274:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9282:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9320:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9321:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9326:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9379:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9380:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9507:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9508:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9581:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9582:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9624:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9625:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9628:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
R9629:Nicn1 UTSW 9 108,171,708 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- TATGGTTCTGAACATGGATTTCCC -3'
(R):5'- ACCAGGGATGACTCAAAGCC -3'

Sequencing Primer
(F):5'- TCCCAGTGTCTTAGGCTCAAGG -3'
(R):5'- TTGAACCATAGGCCCTAGGTC -3'
Posted On 2022-06-15