Incidental Mutation 'R9468:Zmym4'
ID 715263
Institutional Source Beutler Lab
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Name zinc finger, MYM-type 4
Synonyms Zfp262, 6330503C17Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.586) question?
Stock # R9468 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 126755732-126861928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 126800993 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 536 (S536P)
Ref Sequence ENSEMBL: ENSMUSP00000101714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106108]
AlphaFold A2A791
Predicted Effect probably benign
Transcript: ENSMUST00000106108
AA Change: S536P

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: S536P

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135003
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik T A 1: 161,784,736 (GRCm39) N68Y probably damaging Het
Acsf3 A T 8: 123,539,769 (GRCm39) I466F probably damaging Het
Akr1b7 T C 6: 34,392,316 (GRCm39) I43T probably benign Het
Alyref T A 11: 120,486,790 (GRCm39) D157V probably damaging Het
Anapc2 T C 2: 25,163,132 (GRCm39) L123P possibly damaging Het
Catsperg2 A T 7: 29,409,432 (GRCm39) probably null Het
Ccz1 G T 5: 143,929,438 (GRCm39) T330K probably benign Het
Chordc1 T A 9: 18,213,425 (GRCm39) F92Y probably benign Het
Cyp2c29 A T 19: 39,296,166 (GRCm39) D199V probably benign Het
Cyp2c70 A G 19: 40,168,889 (GRCm39) S133P probably damaging Het
Dync1li2 G A 8: 105,147,258 (GRCm39) P479S probably benign Het
Fcmr G T 1: 130,801,951 (GRCm39) K68N possibly damaging Het
Frmpd2 T A 14: 33,266,432 (GRCm39) D949E possibly damaging Het
Fscn2 A G 11: 120,253,283 (GRCm39) E250G probably damaging Het
Grk2 A T 19: 4,344,952 (GRCm39) I39N probably damaging Het
Hmmr T A 11: 40,614,314 (GRCm39) R125* probably null Het
Jarid2 T A 13: 45,073,306 (GRCm39) C1195S probably damaging Het
Kcnq4 A T 4: 120,568,494 (GRCm39) D407E probably benign Het
Kif24 A T 4: 41,404,794 (GRCm39) I402N probably damaging Het
Kmt2b A G 7: 30,284,513 (GRCm39) V793A probably damaging Het
Kntc1 T C 5: 123,954,776 (GRCm39) Y2065H probably damaging Het
Krt5 C A 15: 101,615,980 (GRCm39) S545I unknown Het
Larp1b A T 3: 40,930,990 (GRCm39) I290L probably benign Het
Lnx2 C T 5: 146,979,289 (GRCm39) probably benign Het
Lonrf2 A G 1: 38,839,839 (GRCm39) S419P probably damaging Het
Lrrc19 A T 4: 94,526,521 (GRCm39) D345E probably benign Het
Micu3 T A 8: 40,807,422 (GRCm39) L251* probably null Het
Mucl1 G T 15: 103,784,035 (GRCm39) T57N possibly damaging Het
Myh8 C T 11: 67,197,730 (GRCm39) R1866W probably damaging Het
Ndc80 G A 17: 71,806,306 (GRCm39) Q583* probably null Het
Nrap G A 19: 56,330,632 (GRCm39) T1143I possibly damaging Het
Nrde2 A G 12: 100,106,268 (GRCm39) V523A probably benign Het
Or12e9 T A 2: 87,202,116 (GRCm39) V80E probably damaging Het
Or2at4 A T 7: 99,385,180 (GRCm39) I277F possibly damaging Het
Or4c11 C T 2: 88,695,795 (GRCm39) P282L possibly damaging Het
Or5p70 C T 7: 107,994,849 (GRCm39) P174L possibly damaging Het
Pcdhb16 T A 18: 37,611,482 (GRCm39) S147R probably damaging Het
Phf21b T C 15: 84,689,299 (GRCm39) T76A probably damaging Het
Pknox2 A G 9: 36,822,495 (GRCm39) V218A probably benign Het
Plekhg3 C T 12: 76,607,009 (GRCm39) T23I probably damaging Het
Ptprb A G 10: 116,113,274 (GRCm39) T85A probably benign Het
Ptprc A G 1: 138,044,754 (GRCm39) L36P probably benign Het
Rasgrf1 A G 9: 89,880,756 (GRCm39) Q834R probably benign Het
Rnft1 G A 11: 86,381,242 (GRCm39) V211I probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,127 (GRCm39) probably benign Het
Ryr1 G A 7: 28,772,510 (GRCm39) L2468F probably damaging Het
Scaf4 C T 16: 90,026,287 (GRCm39) A1177T unknown Het
Sec14l3 A G 11: 4,025,200 (GRCm39) Y270C probably damaging Het
Serpind1 A T 16: 17,154,179 (GRCm39) K2I possibly damaging Het
Slc6a20b A G 9: 123,439,416 (GRCm39) S138P probably damaging Het
Son T A 16: 91,454,439 (GRCm39) M1062K possibly damaging Het
Sorl1 T C 9: 42,035,384 (GRCm39) E9G probably benign Het
Spmip9 T C 6: 70,890,627 (GRCm39) Q55R probably benign Het
Stx16 T C 2: 173,933,327 (GRCm39) L102P probably damaging Het
Syt12 A T 19: 4,497,744 (GRCm39) S413T probably damaging Het
Tie1 A G 4: 118,333,376 (GRCm39) L830P probably damaging Het
Tmem156 C T 5: 65,237,531 (GRCm39) R43K probably damaging Het
Tnfrsf19 A G 14: 61,261,623 (GRCm39) S59P possibly damaging Het
Tpk1 T C 6: 43,536,901 (GRCm39) D54G probably benign Het
Trim39 G T 17: 36,571,492 (GRCm39) T422K probably benign Het
Ttn T G 2: 76,536,112 (GRCm39) E35082A Het
Vac14 T A 8: 111,397,738 (GRCm39) D484E probably benign Het
Vmn1r158 G T 7: 22,489,888 (GRCm39) T107N probably damaging Het
Vmn1r51 T A 6: 90,106,930 (GRCm39) I282N probably damaging Het
Vps26a A T 10: 62,300,516 (GRCm39) Y217N probably damaging Het
Zfp942 G A 17: 22,148,422 (GRCm39) T69I probably benign Het
Znrf3 A G 11: 5,288,696 (GRCm39) V24A probably damaging Het
Zranb3 A G 1: 127,891,496 (GRCm39) probably null Het
Zzef1 T C 11: 72,814,009 (GRCm39) probably null Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126,783,851 (GRCm39) missense probably benign
IGL00845:Zmym4 APN 4 126,794,406 (GRCm39) missense probably benign 0.28
IGL01122:Zmym4 APN 4 126,758,045 (GRCm39) missense probably damaging 1.00
IGL01374:Zmym4 APN 4 126,762,750 (GRCm39) missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126,805,073 (GRCm39) missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126,794,462 (GRCm39) missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126,764,066 (GRCm39) missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126,842,268 (GRCm39) missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126,808,881 (GRCm39) missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126,816,920 (GRCm39) missense probably benign 0.12
arriba UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
foreclosed UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
Foreshortened UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
levantese UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
terminated UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
BB004:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
BB014:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R0149:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0361:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0423:Zmym4 UTSW 4 126,776,112 (GRCm39) splice site probably benign
R0532:Zmym4 UTSW 4 126,792,194 (GRCm39) nonsense probably null
R0745:Zmym4 UTSW 4 126,796,496 (GRCm39) splice site probably benign
R1183:Zmym4 UTSW 4 126,819,632 (GRCm39) missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126,804,962 (GRCm39) missense probably benign 0.00
R1446:Zmym4 UTSW 4 126,776,275 (GRCm39) missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126,776,105 (GRCm39) critical splice acceptor site probably null
R1566:Zmym4 UTSW 4 126,804,940 (GRCm39) missense possibly damaging 0.94
R1962:Zmym4 UTSW 4 126,796,463 (GRCm39) missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126,816,929 (GRCm39) missense probably damaging 1.00
R2930:Zmym4 UTSW 4 126,819,316 (GRCm39) missense probably benign 0.00
R3891:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R3892:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R4659:Zmym4 UTSW 4 126,842,221 (GRCm39) splice site probably null
R4702:Zmym4 UTSW 4 126,816,958 (GRCm39) missense probably benign 0.01
R5160:Zmym4 UTSW 4 126,763,977 (GRCm39) missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126,799,163 (GRCm39) missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126,808,878 (GRCm39) missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126,762,593 (GRCm39) missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126,776,385 (GRCm39) missense probably benign 0.09
R7468:Zmym4 UTSW 4 126,776,029 (GRCm39) missense probably benign 0.40
R7546:Zmym4 UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
R7609:Zmym4 UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
R7764:Zmym4 UTSW 4 126,819,409 (GRCm39) missense probably benign 0.06
R7897:Zmym4 UTSW 4 126,783,332 (GRCm39) missense possibly damaging 0.76
R7918:Zmym4 UTSW 4 126,804,797 (GRCm39) critical splice acceptor site probably null
R7927:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R8129:Zmym4 UTSW 4 126,808,956 (GRCm39) missense possibly damaging 0.87
R8240:Zmym4 UTSW 4 126,798,188 (GRCm39) critical splice donor site probably null
R8248:Zmym4 UTSW 4 126,799,162 (GRCm39) missense possibly damaging 0.56
R8261:Zmym4 UTSW 4 126,798,360 (GRCm39) missense probably damaging 1.00
R8313:Zmym4 UTSW 4 126,804,762 (GRCm39) missense probably benign 0.19
R8353:Zmym4 UTSW 4 126,800,905 (GRCm39) missense possibly damaging 0.46
R8747:Zmym4 UTSW 4 126,787,198 (GRCm39) missense probably damaging 1.00
R8787:Zmym4 UTSW 4 126,816,953 (GRCm39) missense probably benign 0.41
R8795:Zmym4 UTSW 4 126,799,819 (GRCm39) missense probably benign 0.35
R8948:Zmym4 UTSW 4 126,758,060 (GRCm39) missense probably damaging 1.00
R9218:Zmym4 UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
R9233:Zmym4 UTSW 4 126,776,310 (GRCm39) missense probably damaging 0.99
R9286:Zmym4 UTSW 4 126,783,812 (GRCm39) missense probably damaging 1.00
R9542:Zmym4 UTSW 4 126,799,164 (GRCm39) missense probably benign 0.00
R9756:Zmym4 UTSW 4 126,771,502 (GRCm39) missense probably damaging 1.00
R9776:Zmym4 UTSW 4 126,804,942 (GRCm39) missense possibly damaging 0.51
U24488:Zmym4 UTSW 4 126,819,453 (GRCm39) missense possibly damaging 0.69
Z1177:Zmym4 UTSW 4 126,801,005 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATCCATTCAGTAAGGGGATGC -3'
(R):5'- AAATGTACCATGCAGGGCCC -3'

Sequencing Primer
(F):5'- ACGGTAACAGGTAATAGTTTACAAC -3'
(R):5'- CTGGGATTGACTCCTGCTAC -3'
Posted On 2022-06-15