Incidental Mutation 'R9468:Zmym4'
ID |
715263 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zmym4
|
Ensembl Gene |
ENSMUSG00000042446 |
Gene Name |
zinc finger, MYM-type 4 |
Synonyms |
Zfp262, 6330503C17Rik |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.586)
|
Stock # |
R9468 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 126800993 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 536
(S536P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
AlphaFold |
A2A791 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000106108
AA Change: S536P
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
SMART Domains |
Protein: ENSMUSP00000101714 Gene: ENSMUSG00000042446 AA Change: S536P
Domain | Start | End | E-Value | Type |
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
TRASH
|
441 |
479 |
1.77e0 |
SMART |
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
TRASH
|
579 |
615 |
2.82e1 |
SMART |
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000135003
|
SMART Domains |
Protein: ENSMUSP00000120813 Gene: ENSMUSG00000042446
Domain | Start | End | E-Value | Type |
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
TRASH
|
190 |
228 |
1.77e0 |
SMART |
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 69 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930558K02Rik |
T |
A |
1: 161,784,736 (GRCm39) |
N68Y |
probably damaging |
Het |
Acsf3 |
A |
T |
8: 123,539,769 (GRCm39) |
I466F |
probably damaging |
Het |
Akr1b7 |
T |
C |
6: 34,392,316 (GRCm39) |
I43T |
probably benign |
Het |
Alyref |
T |
A |
11: 120,486,790 (GRCm39) |
D157V |
probably damaging |
Het |
Anapc2 |
T |
C |
2: 25,163,132 (GRCm39) |
L123P |
possibly damaging |
Het |
Catsperg2 |
A |
T |
7: 29,409,432 (GRCm39) |
|
probably null |
Het |
Ccz1 |
G |
T |
5: 143,929,438 (GRCm39) |
T330K |
probably benign |
Het |
Chordc1 |
T |
A |
9: 18,213,425 (GRCm39) |
F92Y |
probably benign |
Het |
Cyp2c29 |
A |
T |
19: 39,296,166 (GRCm39) |
D199V |
probably benign |
Het |
Cyp2c70 |
A |
G |
19: 40,168,889 (GRCm39) |
S133P |
probably damaging |
Het |
Dync1li2 |
G |
A |
8: 105,147,258 (GRCm39) |
P479S |
probably benign |
Het |
Fcmr |
G |
T |
1: 130,801,951 (GRCm39) |
K68N |
possibly damaging |
Het |
Frmpd2 |
T |
A |
14: 33,266,432 (GRCm39) |
D949E |
possibly damaging |
Het |
Fscn2 |
A |
G |
11: 120,253,283 (GRCm39) |
E250G |
probably damaging |
Het |
Grk2 |
A |
T |
19: 4,344,952 (GRCm39) |
I39N |
probably damaging |
Het |
Hmmr |
T |
A |
11: 40,614,314 (GRCm39) |
R125* |
probably null |
Het |
Jarid2 |
T |
A |
13: 45,073,306 (GRCm39) |
C1195S |
probably damaging |
Het |
Kcnq4 |
A |
T |
4: 120,568,494 (GRCm39) |
D407E |
probably benign |
Het |
Kif24 |
A |
T |
4: 41,404,794 (GRCm39) |
I402N |
probably damaging |
Het |
Kmt2b |
A |
G |
7: 30,284,513 (GRCm39) |
V793A |
probably damaging |
Het |
Kntc1 |
T |
C |
5: 123,954,776 (GRCm39) |
Y2065H |
probably damaging |
Het |
Krt5 |
C |
A |
15: 101,615,980 (GRCm39) |
S545I |
unknown |
Het |
Larp1b |
A |
T |
3: 40,930,990 (GRCm39) |
I290L |
probably benign |
Het |
Lnx2 |
C |
T |
5: 146,979,289 (GRCm39) |
|
probably benign |
Het |
Lonrf2 |
A |
G |
1: 38,839,839 (GRCm39) |
S419P |
probably damaging |
Het |
Lrrc19 |
A |
T |
4: 94,526,521 (GRCm39) |
D345E |
probably benign |
Het |
Micu3 |
T |
A |
8: 40,807,422 (GRCm39) |
L251* |
probably null |
Het |
Mucl1 |
G |
T |
15: 103,784,035 (GRCm39) |
T57N |
possibly damaging |
Het |
Myh8 |
C |
T |
11: 67,197,730 (GRCm39) |
R1866W |
probably damaging |
Het |
Ndc80 |
G |
A |
17: 71,806,306 (GRCm39) |
Q583* |
probably null |
Het |
Nrap |
G |
A |
19: 56,330,632 (GRCm39) |
T1143I |
possibly damaging |
Het |
Nrde2 |
A |
G |
12: 100,106,268 (GRCm39) |
V523A |
probably benign |
Het |
Or12e9 |
T |
A |
2: 87,202,116 (GRCm39) |
V80E |
probably damaging |
Het |
Or2at4 |
A |
T |
7: 99,385,180 (GRCm39) |
I277F |
possibly damaging |
Het |
Or4c11 |
C |
T |
2: 88,695,795 (GRCm39) |
P282L |
possibly damaging |
Het |
Or5p70 |
C |
T |
7: 107,994,849 (GRCm39) |
P174L |
possibly damaging |
Het |
Pcdhb16 |
T |
A |
18: 37,611,482 (GRCm39) |
S147R |
probably damaging |
Het |
Phf21b |
T |
C |
15: 84,689,299 (GRCm39) |
T76A |
probably damaging |
Het |
Pknox2 |
A |
G |
9: 36,822,495 (GRCm39) |
V218A |
probably benign |
Het |
Plekhg3 |
C |
T |
12: 76,607,009 (GRCm39) |
T23I |
probably damaging |
Het |
Ptprb |
A |
G |
10: 116,113,274 (GRCm39) |
T85A |
probably benign |
Het |
Ptprc |
A |
G |
1: 138,044,754 (GRCm39) |
L36P |
probably benign |
Het |
Rasgrf1 |
A |
G |
9: 89,880,756 (GRCm39) |
Q834R |
probably benign |
Het |
Rnft1 |
G |
A |
11: 86,381,242 (GRCm39) |
V211I |
probably benign |
Het |
Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,127 (GRCm39) |
|
probably benign |
Het |
Ryr1 |
G |
A |
7: 28,772,510 (GRCm39) |
L2468F |
probably damaging |
Het |
Scaf4 |
C |
T |
16: 90,026,287 (GRCm39) |
A1177T |
unknown |
Het |
Sec14l3 |
A |
G |
11: 4,025,200 (GRCm39) |
Y270C |
probably damaging |
Het |
Serpind1 |
A |
T |
16: 17,154,179 (GRCm39) |
K2I |
possibly damaging |
Het |
Slc6a20b |
A |
G |
9: 123,439,416 (GRCm39) |
S138P |
probably damaging |
Het |
Son |
T |
A |
16: 91,454,439 (GRCm39) |
M1062K |
possibly damaging |
Het |
Sorl1 |
T |
C |
9: 42,035,384 (GRCm39) |
E9G |
probably benign |
Het |
Spmip9 |
T |
C |
6: 70,890,627 (GRCm39) |
Q55R |
probably benign |
Het |
Stx16 |
T |
C |
2: 173,933,327 (GRCm39) |
L102P |
probably damaging |
Het |
Syt12 |
A |
T |
19: 4,497,744 (GRCm39) |
S413T |
probably damaging |
Het |
Tie1 |
A |
G |
4: 118,333,376 (GRCm39) |
L830P |
probably damaging |
Het |
Tmem156 |
C |
T |
5: 65,237,531 (GRCm39) |
R43K |
probably damaging |
Het |
Tnfrsf19 |
A |
G |
14: 61,261,623 (GRCm39) |
S59P |
possibly damaging |
Het |
Tpk1 |
T |
C |
6: 43,536,901 (GRCm39) |
D54G |
probably benign |
Het |
Trim39 |
G |
T |
17: 36,571,492 (GRCm39) |
T422K |
probably benign |
Het |
Ttn |
T |
G |
2: 76,536,112 (GRCm39) |
E35082A |
|
Het |
Vac14 |
T |
A |
8: 111,397,738 (GRCm39) |
D484E |
probably benign |
Het |
Vmn1r158 |
G |
T |
7: 22,489,888 (GRCm39) |
T107N |
probably damaging |
Het |
Vmn1r51 |
T |
A |
6: 90,106,930 (GRCm39) |
I282N |
probably damaging |
Het |
Vps26a |
A |
T |
10: 62,300,516 (GRCm39) |
Y217N |
probably damaging |
Het |
Zfp942 |
G |
A |
17: 22,148,422 (GRCm39) |
T69I |
probably benign |
Het |
Znrf3 |
A |
G |
11: 5,288,696 (GRCm39) |
V24A |
probably damaging |
Het |
Zranb3 |
A |
G |
1: 127,891,496 (GRCm39) |
|
probably null |
Het |
Zzef1 |
T |
C |
11: 72,814,009 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Zmym4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ATCCATTCAGTAAGGGGATGC -3'
(R):5'- AAATGTACCATGCAGGGCCC -3'
Sequencing Primer
(F):5'- ACGGTAACAGGTAATAGTTTACAAC -3'
(R):5'- CTGGGATTGACTCCTGCTAC -3'
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Posted On |
2022-06-15 |