Incidental Mutation 'R9468:Tmem156'
ID 715264
Institutional Source Beutler Lab
Gene Symbol Tmem156
Ensembl Gene ENSMUSG00000037913
Gene Name transmembrane protein 156
Synonyms LOC243025
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R9468 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 65215558-65249524 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 65237531 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 43 (R43K)
Ref Sequence ENSEMBL: ENSMUSP00000148480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043352] [ENSMUST00000212080] [ENSMUST00000212194] [ENSMUST00000212640]
AlphaFold A0A1D5RLR8
Predicted Effect possibly damaging
Transcript: ENSMUST00000043352
AA Change: R31K

PolyPhen 2 Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044102
Gene: ENSMUSG00000037913
AA Change: R31K

DomainStartEndE-ValueType
transmembrane domain 5 22 N/A INTRINSIC
Pfam:TMEM156 39 264 1.2e-111 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212080
AA Change: R43K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000212194
Predicted Effect probably benign
Transcript: ENSMUST00000212640
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik T A 1: 161,784,736 (GRCm39) N68Y probably damaging Het
Acsf3 A T 8: 123,539,769 (GRCm39) I466F probably damaging Het
Akr1b7 T C 6: 34,392,316 (GRCm39) I43T probably benign Het
Alyref T A 11: 120,486,790 (GRCm39) D157V probably damaging Het
Anapc2 T C 2: 25,163,132 (GRCm39) L123P possibly damaging Het
Catsperg2 A T 7: 29,409,432 (GRCm39) probably null Het
Ccz1 G T 5: 143,929,438 (GRCm39) T330K probably benign Het
Chordc1 T A 9: 18,213,425 (GRCm39) F92Y probably benign Het
Cyp2c29 A T 19: 39,296,166 (GRCm39) D199V probably benign Het
Cyp2c70 A G 19: 40,168,889 (GRCm39) S133P probably damaging Het
Dync1li2 G A 8: 105,147,258 (GRCm39) P479S probably benign Het
Fcmr G T 1: 130,801,951 (GRCm39) K68N possibly damaging Het
Frmpd2 T A 14: 33,266,432 (GRCm39) D949E possibly damaging Het
Fscn2 A G 11: 120,253,283 (GRCm39) E250G probably damaging Het
Grk2 A T 19: 4,344,952 (GRCm39) I39N probably damaging Het
Hmmr T A 11: 40,614,314 (GRCm39) R125* probably null Het
Jarid2 T A 13: 45,073,306 (GRCm39) C1195S probably damaging Het
Kcnq4 A T 4: 120,568,494 (GRCm39) D407E probably benign Het
Kif24 A T 4: 41,404,794 (GRCm39) I402N probably damaging Het
Kmt2b A G 7: 30,284,513 (GRCm39) V793A probably damaging Het
Kntc1 T C 5: 123,954,776 (GRCm39) Y2065H probably damaging Het
Krt5 C A 15: 101,615,980 (GRCm39) S545I unknown Het
Larp1b A T 3: 40,930,990 (GRCm39) I290L probably benign Het
Lnx2 C T 5: 146,979,289 (GRCm39) probably benign Het
Lonrf2 A G 1: 38,839,839 (GRCm39) S419P probably damaging Het
Lrrc19 A T 4: 94,526,521 (GRCm39) D345E probably benign Het
Micu3 T A 8: 40,807,422 (GRCm39) L251* probably null Het
Mucl1 G T 15: 103,784,035 (GRCm39) T57N possibly damaging Het
Myh8 C T 11: 67,197,730 (GRCm39) R1866W probably damaging Het
Ndc80 G A 17: 71,806,306 (GRCm39) Q583* probably null Het
Nrap G A 19: 56,330,632 (GRCm39) T1143I possibly damaging Het
Nrde2 A G 12: 100,106,268 (GRCm39) V523A probably benign Het
Or12e9 T A 2: 87,202,116 (GRCm39) V80E probably damaging Het
Or2at4 A T 7: 99,385,180 (GRCm39) I277F possibly damaging Het
Or4c11 C T 2: 88,695,795 (GRCm39) P282L possibly damaging Het
Or5p70 C T 7: 107,994,849 (GRCm39) P174L possibly damaging Het
Pcdhb16 T A 18: 37,611,482 (GRCm39) S147R probably damaging Het
Phf21b T C 15: 84,689,299 (GRCm39) T76A probably damaging Het
Pknox2 A G 9: 36,822,495 (GRCm39) V218A probably benign Het
Plekhg3 C T 12: 76,607,009 (GRCm39) T23I probably damaging Het
Ptprb A G 10: 116,113,274 (GRCm39) T85A probably benign Het
Ptprc A G 1: 138,044,754 (GRCm39) L36P probably benign Het
Rasgrf1 A G 9: 89,880,756 (GRCm39) Q834R probably benign Het
Rnft1 G A 11: 86,381,242 (GRCm39) V211I probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,127 (GRCm39) probably benign Het
Ryr1 G A 7: 28,772,510 (GRCm39) L2468F probably damaging Het
Scaf4 C T 16: 90,026,287 (GRCm39) A1177T unknown Het
Sec14l3 A G 11: 4,025,200 (GRCm39) Y270C probably damaging Het
Serpind1 A T 16: 17,154,179 (GRCm39) K2I possibly damaging Het
Slc6a20b A G 9: 123,439,416 (GRCm39) S138P probably damaging Het
Son T A 16: 91,454,439 (GRCm39) M1062K possibly damaging Het
Sorl1 T C 9: 42,035,384 (GRCm39) E9G probably benign Het
Spmip9 T C 6: 70,890,627 (GRCm39) Q55R probably benign Het
Stx16 T C 2: 173,933,327 (GRCm39) L102P probably damaging Het
Syt12 A T 19: 4,497,744 (GRCm39) S413T probably damaging Het
Tie1 A G 4: 118,333,376 (GRCm39) L830P probably damaging Het
Tnfrsf19 A G 14: 61,261,623 (GRCm39) S59P possibly damaging Het
Tpk1 T C 6: 43,536,901 (GRCm39) D54G probably benign Het
Trim39 G T 17: 36,571,492 (GRCm39) T422K probably benign Het
Ttn T G 2: 76,536,112 (GRCm39) E35082A Het
Vac14 T A 8: 111,397,738 (GRCm39) D484E probably benign Het
Vmn1r158 G T 7: 22,489,888 (GRCm39) T107N probably damaging Het
Vmn1r51 T A 6: 90,106,930 (GRCm39) I282N probably damaging Het
Vps26a A T 10: 62,300,516 (GRCm39) Y217N probably damaging Het
Zfp942 G A 17: 22,148,422 (GRCm39) T69I probably benign Het
Zmym4 A G 4: 126,800,993 (GRCm39) S536P probably benign Het
Znrf3 A G 11: 5,288,696 (GRCm39) V24A probably damaging Het
Zranb3 A G 1: 127,891,496 (GRCm39) probably null Het
Zzef1 T C 11: 72,814,009 (GRCm39) probably null Het
Other mutations in Tmem156
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Tmem156 APN 5 65,231,183 (GRCm39) missense probably damaging 1.00
IGL01064:Tmem156 APN 5 65,237,327 (GRCm39) missense probably damaging 0.99
IGL01330:Tmem156 APN 5 65,237,525 (GRCm39) missense probably benign 0.17
IGL03336:Tmem156 APN 5 65,233,107 (GRCm39) missense probably benign 0.01
IGL03383:Tmem156 APN 5 65,233,040 (GRCm39) missense probably damaging 0.98
R0526:Tmem156 UTSW 5 65,233,161 (GRCm39) missense probably benign 0.02
R2006:Tmem156 UTSW 5 65,237,294 (GRCm39) missense probably damaging 1.00
R4721:Tmem156 UTSW 5 65,248,870 (GRCm39) missense probably benign 0.10
R4773:Tmem156 UTSW 5 65,237,502 (GRCm39) missense probably damaging 1.00
R4810:Tmem156 UTSW 5 65,248,790 (GRCm39) intron probably benign
R4910:Tmem156 UTSW 5 65,248,805 (GRCm39) intron probably benign
R5148:Tmem156 UTSW 5 65,231,111 (GRCm39) missense probably benign 0.00
R5510:Tmem156 UTSW 5 65,232,917 (GRCm39) missense probably benign 0.02
R5809:Tmem156 UTSW 5 65,232,950 (GRCm39) missense possibly damaging 0.55
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R7731:Tmem156 UTSW 5 65,232,905 (GRCm39) critical splice donor site probably null
R7772:Tmem156 UTSW 5 65,237,517 (GRCm39) missense probably damaging 1.00
R7788:Tmem156 UTSW 5 65,232,912 (GRCm39) missense possibly damaging 0.47
R7979:Tmem156 UTSW 5 65,237,352 (GRCm39) missense possibly damaging 0.47
R8017:Tmem156 UTSW 5 65,231,204 (GRCm39) missense probably damaging 1.00
R8132:Tmem156 UTSW 5 65,233,098 (GRCm39) missense probably benign 0.00
R8249:Tmem156 UTSW 5 65,232,969 (GRCm39) nonsense probably null
R8492:Tmem156 UTSW 5 65,222,438 (GRCm39) missense possibly damaging 0.87
R9209:Tmem156 UTSW 5 65,231,127 (GRCm39) missense probably damaging 1.00
R9287:Tmem156 UTSW 5 65,231,148 (GRCm39) missense probably damaging 1.00
R9470:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9471:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9696:Tmem156 UTSW 5 65,231,147 (GRCm39) missense possibly damaging 0.83
RF020:Tmem156 UTSW 5 65,248,890 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TCGGCAATCTACTTGTGATGC -3'
(R):5'- GTTCTCTGAAAACTAACACGGAATG -3'

Sequencing Primer
(F):5'- GCAATCTACTTGTGATGCCTCGG -3'
(R):5'- CTTGTCAAGGACTAGCCA -3'
Posted On 2022-06-15