Mutagenetix > Incidental Mutation

Incidental Mutation 'R9468:Kmt2b'

715275

Institutional Source

Beutler Lab

Gene Symbol

Kmt2b

Ensembl Gene

ENSMUSG00000006307

Gene Name

lysine (K)-specific methyltransferase 2B

Synonyms

2610014H22Rik, Mll2, Wbp7

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9468 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

30268283-30288151 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 30284513 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 793 (V793A)

Ref Sequence

ENSEMBL: ENSMUSP00000103789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006470] [ENSMUST00000108150] [ENSMUST00000108151] [ENSMUST00000108154]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000006470
AA Change: V793A

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000006470
Gene: ENSMUSG00000006307
AA Change: V793A

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	7.2e-15	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1881	1899	N/A	INTRINSIC
low complexity region	1912	1942	N/A	INTRINSIC
low complexity region	1961	1978	N/A	INTRINSIC
low complexity region	1991	2003	N/A	INTRINSIC
low complexity region	2013	2026	N/A	INTRINSIC
low complexity region	2048	2061	N/A	INTRINSIC
low complexity region	2087	2105	N/A	INTRINSIC
low complexity region	2127	2138	N/A	INTRINSIC
low complexity region	2215	2235	N/A	INTRINSIC
low complexity region	2239	2270	N/A	INTRINSIC
low complexity region	2396	2406	N/A	INTRINSIC
FYRC	2419	2504	4.83e-36	SMART
SET	2581	2703	1.67e-42	SMART
PostSET	2705	2721	4.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108150

SMART Domains

Protein: ENSMUSP00000103785
Gene: ENSMUSG00000006310

Domain	Start	End	E-Value	Type
ZnF_C2H2	14	36	1.67e-2	SMART
ZnF_C2H2	41	63	2.4e-3	SMART
low complexity region	81	101	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108151

SMART Domains

Protein: ENSMUSP00000103786
Gene: ENSMUSG00000006310

Domain	Start	End	E-Value	Type
BTB	29	117	1.67e-8	SMART
low complexity region	207	222	N/A	INTRINSIC
ZnF_C2H2	350	372	1.28e-3	SMART
ZnF_C2H2	378	400	1.67e-2	SMART
ZnF_C2H2	405	427	2.4e-3	SMART
low complexity region	445	465	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108154
AA Change: V793A

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000103789
Gene: ENSMUSG00000006307
AA Change: V793A

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	1e-14	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1872	1890	N/A	INTRINSIC
low complexity region	1903	1933	N/A	INTRINSIC
low complexity region	1952	1969	N/A	INTRINSIC
low complexity region	1982	1994	N/A	INTRINSIC
low complexity region	2004	2017	N/A	INTRINSIC
low complexity region	2039	2052	N/A	INTRINSIC
low complexity region	2078	2096	N/A	INTRINSIC
low complexity region	2118	2129	N/A	INTRINSIC
low complexity region	2206	2226	N/A	INTRINSIC
low complexity region	2230	2261	N/A	INTRINSIC
low complexity region	2383	2398	N/A	INTRINSIC
FYRC	2411	2496	4.83e-36	SMART
SET	2573	2695	1.67e-42	SMART
PostSET	2697	2713	4.65e-4	SMART

Predicted Effect

SMART Domains

Protein: ENSMUSP00000118486
Gene: ENSMUSG00000006307
AA Change: V84A

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
low complexity region	30	69	N/A	INTRINSIC
low complexity region	202	214	N/A	INTRINSIC
Pfam:zf-CXXC	255	302	5.2e-15	PFAM
low complexity region	331	353	N/A	INTRINSIC
low complexity region	395	407	N/A	INTRINSIC
PHD	501	548	1.25e-5	SMART
PHD	549	599	5.4e-10	SMART
PHD	635	692	1.27e-6	SMART
low complexity region	707	719	N/A	INTRINSIC
PHD	938	984	3.82e-1	SMART
FYRN	1037	1080	3.25e-19	SMART
low complexity region	1173	1191	N/A	INTRINSIC
low complexity region	1204	1234	N/A	INTRINSIC
low complexity region	1253	1270	N/A	INTRINSIC
low complexity region	1283	1295	N/A	INTRINSIC
low complexity region	1305	1318	N/A	INTRINSIC
low complexity region	1340	1353	N/A	INTRINSIC
low complexity region	1379	1397	N/A	INTRINSIC
low complexity region	1419	1430	N/A	INTRINSIC
low complexity region	1507	1527	N/A	INTRINSIC
low complexity region	1531	1562	N/A	INTRINSIC
low complexity region	1684	1699	N/A	INTRINSIC
FYRC	1712	1797	4.83e-36	SMART
SET	1874	1996	1.67e-42	SMART
PostSET	1998	2014	4.65e-4	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to embryonic growth retardation, abnormal somite development, neural tube defects, increased apoptosis, and complete embryonic lethality. Homozygotes for a hypomorphic allele show embryonic growth arrest, altered DNA methylation, and reduced female fertility. [provided by MGI curators]

Allele List at MGI

All alleles(8) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930558K02Rik	T	A	1: 161,784,736 (GRCm39)	N68Y	probably damaging	Het
Acsf3	A	T	8: 123,539,769 (GRCm39)	I466F	probably damaging	Het
Akr1b7	T	C	6: 34,392,316 (GRCm39)	I43T	probably benign	Het
Alyref	T	A	11: 120,486,790 (GRCm39)	D157V	probably damaging	Het
Anapc2	T	C	2: 25,163,132 (GRCm39)	L123P	possibly damaging	Het
Catsperg2	A	T	7: 29,409,432 (GRCm39)		probably null	Het
Ccz1	G	T	5: 143,929,438 (GRCm39)	T330K	probably benign	Het
Chordc1	T	A	9: 18,213,425 (GRCm39)	F92Y	probably benign	Het
Cyp2c29	A	T	19: 39,296,166 (GRCm39)	D199V	probably benign	Het
Cyp2c70	A	G	19: 40,168,889 (GRCm39)	S133P	probably damaging	Het
Dync1li2	G	A	8: 105,147,258 (GRCm39)	P479S	probably benign	Het
Fcmr	G	T	1: 130,801,951 (GRCm39)	K68N	possibly damaging	Het
Frmpd2	T	A	14: 33,266,432 (GRCm39)	D949E	possibly damaging	Het
Fscn2	A	G	11: 120,253,283 (GRCm39)	E250G	probably damaging	Het
Grk2	A	T	19: 4,344,952 (GRCm39)	I39N	probably damaging	Het
Hmmr	T	A	11: 40,614,314 (GRCm39)	R125*	probably null	Het
Jarid2	T	A	13: 45,073,306 (GRCm39)	C1195S	probably damaging	Het
Kcnq4	A	T	4: 120,568,494 (GRCm39)	D407E	probably benign	Het
Kif24	A	T	4: 41,404,794 (GRCm39)	I402N	probably damaging	Het
Kntc1	T	C	5: 123,954,776 (GRCm39)	Y2065H	probably damaging	Het
Krt5	C	A	15: 101,615,980 (GRCm39)	S545I	unknown	Het
Larp1b	A	T	3: 40,930,990 (GRCm39)	I290L	probably benign	Het
Lnx2	C	T	5: 146,979,289 (GRCm39)		probably benign	Het
Lonrf2	A	G	1: 38,839,839 (GRCm39)	S419P	probably damaging	Het
Lrrc19	A	T	4: 94,526,521 (GRCm39)	D345E	probably benign	Het
Micu3	T	A	8: 40,807,422 (GRCm39)	L251*	probably null	Het
Mucl1	G	T	15: 103,784,035 (GRCm39)	T57N	possibly damaging	Het
Myh8	C	T	11: 67,197,730 (GRCm39)	R1866W	probably damaging	Het
Ndc80	G	A	17: 71,806,306 (GRCm39)	Q583*	probably null	Het
Nrap	G	A	19: 56,330,632 (GRCm39)	T1143I	possibly damaging	Het
Nrde2	A	G	12: 100,106,268 (GRCm39)	V523A	probably benign	Het
Or12e9	T	A	2: 87,202,116 (GRCm39)	V80E	probably damaging	Het
Or2at4	A	T	7: 99,385,180 (GRCm39)	I277F	possibly damaging	Het
Or4c11	C	T	2: 88,695,795 (GRCm39)	P282L	possibly damaging	Het
Or5p70	C	T	7: 107,994,849 (GRCm39)	P174L	possibly damaging	Het
Pcdhb16	T	A	18: 37,611,482 (GRCm39)	S147R	probably damaging	Het
Phf21b	T	C	15: 84,689,299 (GRCm39)	T76A	probably damaging	Het
Pknox2	A	G	9: 36,822,495 (GRCm39)	V218A	probably benign	Het
Plekhg3	C	T	12: 76,607,009 (GRCm39)	T23I	probably damaging	Het
Ptprb	A	G	10: 116,113,274 (GRCm39)	T85A	probably benign	Het
Ptprc	A	G	1: 138,044,754 (GRCm39)	L36P	probably benign	Het
Rasgrf1	A	G	9: 89,880,756 (GRCm39)	Q834R	probably benign	Het
Rnft1	G	A	11: 86,381,242 (GRCm39)	V211I	probably benign	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,229,127 (GRCm39)		probably benign	Het
Ryr1	G	A	7: 28,772,510 (GRCm39)	L2468F	probably damaging	Het
Scaf4	C	T	16: 90,026,287 (GRCm39)	A1177T	unknown	Het
Sec14l3	A	G	11: 4,025,200 (GRCm39)	Y270C	probably damaging	Het
Serpind1	A	T	16: 17,154,179 (GRCm39)	K2I	possibly damaging	Het
Slc6a20b	A	G	9: 123,439,416 (GRCm39)	S138P	probably damaging	Het
Son	T	A	16: 91,454,439 (GRCm39)	M1062K	possibly damaging	Het
Sorl1	T	C	9: 42,035,384 (GRCm39)	E9G	probably benign	Het
Spmip9	T	C	6: 70,890,627 (GRCm39)	Q55R	probably benign	Het
Stx16	T	C	2: 173,933,327 (GRCm39)	L102P	probably damaging	Het
Syt12	A	T	19: 4,497,744 (GRCm39)	S413T	probably damaging	Het
Tie1	A	G	4: 118,333,376 (GRCm39)	L830P	probably damaging	Het
Tmem156	C	T	5: 65,237,531 (GRCm39)	R43K	probably damaging	Het
Tnfrsf19	A	G	14: 61,261,623 (GRCm39)	S59P	possibly damaging	Het
Tpk1	T	C	6: 43,536,901 (GRCm39)	D54G	probably benign	Het
Trim39	G	T	17: 36,571,492 (GRCm39)	T422K	probably benign	Het
Ttn	T	G	2: 76,536,112 (GRCm39)	E35082A		Het
Vac14	T	A	8: 111,397,738 (GRCm39)	D484E	probably benign	Het
Vmn1r158	G	T	7: 22,489,888 (GRCm39)	T107N	probably damaging	Het
Vmn1r51	T	A	6: 90,106,930 (GRCm39)	I282N	probably damaging	Het
Vps26a	A	T	10: 62,300,516 (GRCm39)	Y217N	probably damaging	Het
Zfp942	G	A	17: 22,148,422 (GRCm39)	T69I	probably benign	Het
Zmym4	A	G	4: 126,800,993 (GRCm39)	S536P	probably benign	Het
Znrf3	A	G	11: 5,288,696 (GRCm39)	V24A	probably damaging	Het
Zranb3	A	G	1: 127,891,496 (GRCm39)		probably null	Het
Zzef1	T	C	11: 72,814,009 (GRCm39)		probably null	Het

Other mutations in Kmt2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00580:Kmt2b	APN	7	30,285,938 (GRCm39)	unclassified	probably benign
IGL00821:Kmt2b	APN	7	30,270,038 (GRCm39)	missense	probably damaging	1.00
IGL00985:Kmt2b	APN	7	30,279,352 (GRCm39)	missense	probably damaging	1.00
IGL01092:Kmt2b	APN	7	30,279,932 (GRCm39)	missense	probably damaging	1.00
IGL01933:Kmt2b	APN	7	30,268,939 (GRCm39)	critical splice donor site	probably null
IGL01949:Kmt2b	APN	7	30,276,586 (GRCm39)	splice site	probably null
IGL02253:Kmt2b	APN	7	30,281,152 (GRCm39)	missense	probably damaging	1.00
IGL02455:Kmt2b	APN	7	30,278,303 (GRCm39)	critical splice donor site	probably null
IGL02493:Kmt2b	APN	7	30,268,936 (GRCm39)	unclassified	probably benign
IGL02504:Kmt2b	APN	7	30,285,968 (GRCm39)	unclassified	probably benign
IGL02532:Kmt2b	APN	7	30,286,314 (GRCm39)	unclassified	probably benign
IGL02698:Kmt2b	APN	7	30,278,118 (GRCm39)	splice site	probably benign
IGL02717:Kmt2b	APN	7	30,282,869 (GRCm39)	missense	probably damaging	1.00
IGL02826:Kmt2b	APN	7	30,276,569 (GRCm39)	missense	probably damaging	1.00
IGL02966:Kmt2b	APN	7	30,274,887 (GRCm39)	missense	probably benign	0.02
IGL03386:Kmt2b	APN	7	30,273,396 (GRCm39)	missense	possibly damaging	0.94
Dean	UTSW	7	30,268,835 (GRCm39)	missense	possibly damaging	0.83
provost	UTSW	7	30,281,633 (GRCm39)	missense	probably damaging	1.00
tenure	UTSW	7	30,268,600 (GRCm39)	missense	probably damaging	1.00
3-1:Kmt2b	UTSW	7	30,269,040 (GRCm39)	nonsense	probably null
FR4304:Kmt2b	UTSW	7	30,285,788 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,800 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,794 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,788 (GRCm39)	unclassified	probably benign
FR4342:Kmt2b	UTSW	7	30,285,800 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,794 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,786 (GRCm39)	unclassified	probably benign
FR4548:Kmt2b	UTSW	7	30,285,805 (GRCm39)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,285,806 (GRCm39)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,285,789 (GRCm39)	nonsense	probably null
FR4589:Kmt2b	UTSW	7	30,285,786 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,795 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,792 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,803 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,787 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,785 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,798 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,789 (GRCm39)	nonsense	probably null
PIT4403001:Kmt2b	UTSW	7	30,285,114 (GRCm39)	missense	probably damaging	1.00
PIT4802001:Kmt2b	UTSW	7	30,278,996 (GRCm39)	missense	probably damaging	0.99
R0057:Kmt2b	UTSW	7	30,276,217 (GRCm39)	splice site	probably benign
R0131:Kmt2b	UTSW	7	30,283,346 (GRCm39)	missense	probably damaging	0.99
R0241:Kmt2b	UTSW	7	30,276,494 (GRCm39)	missense	probably damaging	1.00
R0241:Kmt2b	UTSW	7	30,276,494 (GRCm39)	missense	probably damaging	1.00
R0377:Kmt2b	UTSW	7	30,273,618 (GRCm39)	missense	probably damaging	1.00
R0396:Kmt2b	UTSW	7	30,276,180 (GRCm39)	missense	probably damaging	1.00
R1241:Kmt2b	UTSW	7	30,274,365 (GRCm39)	missense	probably damaging	0.98
R1252:Kmt2b	UTSW	7	30,279,912 (GRCm39)	missense	probably damaging	0.99
R1418:Kmt2b	UTSW	7	30,276,385 (GRCm39)	splice site	probably benign
R1599:Kmt2b	UTSW	7	30,270,000 (GRCm39)	missense	probably damaging	1.00
R1632:Kmt2b	UTSW	7	30,283,387 (GRCm39)	missense	probably damaging	1.00
R1745:Kmt2b	UTSW	7	30,285,275 (GRCm39)	missense	possibly damaging	0.90
R1867:Kmt2b	UTSW	7	30,274,083 (GRCm39)	missense	possibly damaging	0.71
R1955:Kmt2b	UTSW	7	30,274,776 (GRCm39)	missense	possibly damaging	0.90
R2040:Kmt2b	UTSW	7	30,268,845 (GRCm39)	missense	probably damaging	1.00
R2113:Kmt2b	UTSW	7	30,282,812 (GRCm39)	missense	probably damaging	1.00
R2216:Kmt2b	UTSW	7	30,273,490 (GRCm39)	missense	probably benign	0.25
R2401:Kmt2b	UTSW	7	30,276,133 (GRCm39)	missense	probably damaging	1.00
R2518:Kmt2b	UTSW	7	30,275,493 (GRCm39)	missense	probably benign	0.10
R3436:Kmt2b	UTSW	7	30,276,117 (GRCm39)	missense	probably damaging	1.00
R4248:Kmt2b	UTSW	7	30,273,489 (GRCm39)	missense	probably benign	0.25
R4259:Kmt2b	UTSW	7	30,280,506 (GRCm39)	missense	probably damaging	0.99
R4290:Kmt2b	UTSW	7	30,281,261 (GRCm39)	critical splice donor site	probably null
R4388:Kmt2b	UTSW	7	30,288,015 (GRCm39)	unclassified	probably benign
R4542:Kmt2b	UTSW	7	30,279,684 (GRCm39)	missense	probably damaging	0.99
R4649:Kmt2b	UTSW	7	30,285,783 (GRCm39)	unclassified	probably benign
R4722:Kmt2b	UTSW	7	30,282,627 (GRCm39)	missense	probably damaging	1.00
R4891:Kmt2b	UTSW	7	30,276,186 (GRCm39)	nonsense	probably null
R4916:Kmt2b	UTSW	7	30,277,942 (GRCm39)	missense	probably damaging	0.99
R5104:Kmt2b	UTSW	7	30,269,265 (GRCm39)	missense	probably damaging	1.00
R5254:Kmt2b	UTSW	7	30,268,600 (GRCm39)	missense	probably damaging	1.00
R5262:Kmt2b	UTSW	7	30,269,219 (GRCm39)	missense	probably damaging	1.00
R5307:Kmt2b	UTSW	7	30,281,098 (GRCm39)	missense	possibly damaging	0.91
R5526:Kmt2b	UTSW	7	30,279,869 (GRCm39)	missense	probably damaging	1.00
R5609:Kmt2b	UTSW	7	30,276,570 (GRCm39)	missense	probably damaging	0.99
R6150:Kmt2b	UTSW	7	30,287,902 (GRCm39)	unclassified	probably benign
R6727:Kmt2b	UTSW	7	30,283,984 (GRCm39)	missense	probably damaging	0.98
R6824:Kmt2b	UTSW	7	30,285,701 (GRCm39)	unclassified	probably benign
R7048:Kmt2b	UTSW	7	30,268,731 (GRCm39)	missense	probably damaging	0.99
R7155:Kmt2b	UTSW	7	30,279,388 (GRCm39)	missense	probably damaging	0.99
R7307:Kmt2b	UTSW	7	30,279,896 (GRCm39)	missense	probably damaging	0.99
R7388:Kmt2b	UTSW	7	30,281,385 (GRCm39)	missense	probably damaging	1.00
R7555:Kmt2b	UTSW	7	30,268,835 (GRCm39)	missense	possibly damaging	0.83
R7569:Kmt2b	UTSW	7	30,268,978 (GRCm39)	missense	possibly damaging	0.54
R7616:Kmt2b	UTSW	7	30,281,633 (GRCm39)	missense	probably damaging	1.00
R7669:Kmt2b	UTSW	7	30,282,656 (GRCm39)	missense	possibly damaging	0.84
R7881:Kmt2b	UTSW	7	30,279,208 (GRCm39)	missense	probably damaging	1.00
R7999:Kmt2b	UTSW	7	30,276,199 (GRCm39)	missense	probably damaging	1.00
R8003:Kmt2b	UTSW	7	30,268,802 (GRCm39)	missense	probably damaging	0.98
R8189:Kmt2b	UTSW	7	30,268,756 (GRCm39)	missense	probably damaging	0.98
R8291:Kmt2b	UTSW	7	30,284,894 (GRCm39)	missense	probably damaging	1.00
R8314:Kmt2b	UTSW	7	30,278,347 (GRCm39)	missense	probably damaging	0.99
R8802:Kmt2b	UTSW	7	30,283,496 (GRCm39)	missense	probably damaging	1.00
R8954:Kmt2b	UTSW	7	30,273,640 (GRCm39)	missense	probably damaging	1.00
R9046:Kmt2b	UTSW	7	30,285,479 (GRCm39)	missense	probably benign	0.00
R9225:Kmt2b	UTSW	7	30,286,172 (GRCm39)	missense	unknown
R9258:Kmt2b	UTSW	7	30,281,893 (GRCm39)	missense	probably null	0.99
R9414:Kmt2b	UTSW	7	30,282,307 (GRCm39)	missense	probably damaging	0.99
R9508:Kmt2b	UTSW	7	30,269,259 (GRCm39)	missense	probably damaging	0.99
R9642:Kmt2b	UTSW	7	30,283,340 (GRCm39)	critical splice donor site	probably null
R9667:Kmt2b	UTSW	7	30,287,784 (GRCm39)	missense	unknown
R9709:Kmt2b	UTSW	7	30,279,228 (GRCm39)	missense	probably damaging	0.98
RF001:Kmt2b	UTSW	7	30,285,807 (GRCm39)	unclassified	probably benign
RF006:Kmt2b	UTSW	7	30,285,802 (GRCm39)	unclassified	probably benign
RF020:Kmt2b	UTSW	7	30,285,807 (GRCm39)	unclassified	probably benign
RF021:Kmt2b	UTSW	7	30,285,782 (GRCm39)	unclassified	probably benign
RF030:Kmt2b	UTSW	7	30,285,802 (GRCm39)	unclassified	probably benign
RF035:Kmt2b	UTSW	7	30,285,782 (GRCm39)	unclassified	probably benign
X0067:Kmt2b	UTSW	7	30,278,998 (GRCm39)	missense	probably damaging	0.99
Z1088:Kmt2b	UTSW	7	30,284,676 (GRCm39)	missense	probably benign	0.28
Z1176:Kmt2b	UTSW	7	30,276,795 (GRCm39)	missense	probably damaging	1.00
Z1177:Kmt2b	UTSW	7	30,285,841 (GRCm39)	missense	unknown
Z1177:Kmt2b	UTSW	7	30,283,588 (GRCm39)	missense	probably damaging	0.98
Z1177:Kmt2b	UTSW	7	30,274,449 (GRCm39)	missense	probably benign	0.08
Z1186:Kmt2b	UTSW	7	30,284,732 (GRCm39)	missense	probably benign
Z1186:Kmt2b	UTSW	7	30,274,404 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AAAAGGGAAACTGGTCCTGC -3'
(R):5'- CACCAGTCCTGTTAAGGTTGAGG -3'

Sequencing Primer
(F):5'- GCATGTCCGGCTAAACACTTATCTAG -3'
(R):5'- TTAAGGTTGAGGTGCCCCC -3'

Posted On

2022-06-15