Incidental Mutation 'R9468:Or5p70'
ID 715278
Institutional Source Beutler Lab
Gene Symbol Or5p70
Ensembl Gene ENSMUSG00000110253
Gene Name olfactory receptor family 5 subfamily P member 70
Synonyms MOR204-37, Olfr495, GA_x6K02T2PBJ9-10725148-10726140
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # R9468 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 107994329-107995321 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 107994849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 174 (P174L)
Ref Sequence ENSEMBL: ENSMUSP00000150689 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210990] [ENSMUST00000215215]
AlphaFold Q8VF12
Predicted Effect possibly damaging
Transcript: ENSMUST00000210990
AA Change: P174L

PolyPhen 2 Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215215
AA Change: P174L

PolyPhen 2 Score 0.562 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik T A 1: 161,784,736 (GRCm39) N68Y probably damaging Het
Acsf3 A T 8: 123,539,769 (GRCm39) I466F probably damaging Het
Akr1b7 T C 6: 34,392,316 (GRCm39) I43T probably benign Het
Alyref T A 11: 120,486,790 (GRCm39) D157V probably damaging Het
Anapc2 T C 2: 25,163,132 (GRCm39) L123P possibly damaging Het
Catsperg2 A T 7: 29,409,432 (GRCm39) probably null Het
Ccz1 G T 5: 143,929,438 (GRCm39) T330K probably benign Het
Chordc1 T A 9: 18,213,425 (GRCm39) F92Y probably benign Het
Cyp2c29 A T 19: 39,296,166 (GRCm39) D199V probably benign Het
Cyp2c70 A G 19: 40,168,889 (GRCm39) S133P probably damaging Het
Dync1li2 G A 8: 105,147,258 (GRCm39) P479S probably benign Het
Fcmr G T 1: 130,801,951 (GRCm39) K68N possibly damaging Het
Frmpd2 T A 14: 33,266,432 (GRCm39) D949E possibly damaging Het
Fscn2 A G 11: 120,253,283 (GRCm39) E250G probably damaging Het
Grk2 A T 19: 4,344,952 (GRCm39) I39N probably damaging Het
Hmmr T A 11: 40,614,314 (GRCm39) R125* probably null Het
Jarid2 T A 13: 45,073,306 (GRCm39) C1195S probably damaging Het
Kcnq4 A T 4: 120,568,494 (GRCm39) D407E probably benign Het
Kif24 A T 4: 41,404,794 (GRCm39) I402N probably damaging Het
Kmt2b A G 7: 30,284,513 (GRCm39) V793A probably damaging Het
Kntc1 T C 5: 123,954,776 (GRCm39) Y2065H probably damaging Het
Krt5 C A 15: 101,615,980 (GRCm39) S545I unknown Het
Larp1b A T 3: 40,930,990 (GRCm39) I290L probably benign Het
Lnx2 C T 5: 146,979,289 (GRCm39) probably benign Het
Lonrf2 A G 1: 38,839,839 (GRCm39) S419P probably damaging Het
Lrrc19 A T 4: 94,526,521 (GRCm39) D345E probably benign Het
Micu3 T A 8: 40,807,422 (GRCm39) L251* probably null Het
Mucl1 G T 15: 103,784,035 (GRCm39) T57N possibly damaging Het
Myh8 C T 11: 67,197,730 (GRCm39) R1866W probably damaging Het
Ndc80 G A 17: 71,806,306 (GRCm39) Q583* probably null Het
Nrap G A 19: 56,330,632 (GRCm39) T1143I possibly damaging Het
Nrde2 A G 12: 100,106,268 (GRCm39) V523A probably benign Het
Or12e9 T A 2: 87,202,116 (GRCm39) V80E probably damaging Het
Or2at4 A T 7: 99,385,180 (GRCm39) I277F possibly damaging Het
Or4c11 C T 2: 88,695,795 (GRCm39) P282L possibly damaging Het
Pcdhb16 T A 18: 37,611,482 (GRCm39) S147R probably damaging Het
Phf21b T C 15: 84,689,299 (GRCm39) T76A probably damaging Het
Pknox2 A G 9: 36,822,495 (GRCm39) V218A probably benign Het
Plekhg3 C T 12: 76,607,009 (GRCm39) T23I probably damaging Het
Ptprb A G 10: 116,113,274 (GRCm39) T85A probably benign Het
Ptprc A G 1: 138,044,754 (GRCm39) L36P probably benign Het
Rasgrf1 A G 9: 89,880,756 (GRCm39) Q834R probably benign Het
Rnft1 G A 11: 86,381,242 (GRCm39) V211I probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,127 (GRCm39) probably benign Het
Ryr1 G A 7: 28,772,510 (GRCm39) L2468F probably damaging Het
Scaf4 C T 16: 90,026,287 (GRCm39) A1177T unknown Het
Sec14l3 A G 11: 4,025,200 (GRCm39) Y270C probably damaging Het
Serpind1 A T 16: 17,154,179 (GRCm39) K2I possibly damaging Het
Slc6a20b A G 9: 123,439,416 (GRCm39) S138P probably damaging Het
Son T A 16: 91,454,439 (GRCm39) M1062K possibly damaging Het
Sorl1 T C 9: 42,035,384 (GRCm39) E9G probably benign Het
Spmip9 T C 6: 70,890,627 (GRCm39) Q55R probably benign Het
Stx16 T C 2: 173,933,327 (GRCm39) L102P probably damaging Het
Syt12 A T 19: 4,497,744 (GRCm39) S413T probably damaging Het
Tie1 A G 4: 118,333,376 (GRCm39) L830P probably damaging Het
Tmem156 C T 5: 65,237,531 (GRCm39) R43K probably damaging Het
Tnfrsf19 A G 14: 61,261,623 (GRCm39) S59P possibly damaging Het
Tpk1 T C 6: 43,536,901 (GRCm39) D54G probably benign Het
Trim39 G T 17: 36,571,492 (GRCm39) T422K probably benign Het
Ttn T G 2: 76,536,112 (GRCm39) E35082A Het
Vac14 T A 8: 111,397,738 (GRCm39) D484E probably benign Het
Vmn1r158 G T 7: 22,489,888 (GRCm39) T107N probably damaging Het
Vmn1r51 T A 6: 90,106,930 (GRCm39) I282N probably damaging Het
Vps26a A T 10: 62,300,516 (GRCm39) Y217N probably damaging Het
Zfp942 G A 17: 22,148,422 (GRCm39) T69I probably benign Het
Zmym4 A G 4: 126,800,993 (GRCm39) S536P probably benign Het
Znrf3 A G 11: 5,288,696 (GRCm39) V24A probably damaging Het
Zranb3 A G 1: 127,891,496 (GRCm39) probably null Het
Zzef1 T C 11: 72,814,009 (GRCm39) probably null Het
Other mutations in Or5p70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01382:Or5p70 APN 7 107,994,452 (GRCm39) missense probably benign 0.31
IGL02430:Or5p70 APN 7 107,994,929 (GRCm39) missense probably benign 0.01
IGL02511:Or5p70 APN 7 107,995,265 (GRCm39) missense probably benign 0.06
IGL02932:Or5p70 APN 7 107,994,720 (GRCm39) missense probably benign 0.03
IGL03222:Or5p70 APN 7 107,994,393 (GRCm39) missense possibly damaging 0.77
FR4340:Or5p70 UTSW 7 107,995,105 (GRCm39) missense probably benign
FR4340:Or5p70 UTSW 7 107,995,100 (GRCm39) missense probably benign
FR4342:Or5p70 UTSW 7 107,995,105 (GRCm39) missense probably benign
FR4342:Or5p70 UTSW 7 107,995,100 (GRCm39) missense probably benign
R0141:Or5p70 UTSW 7 107,994,575 (GRCm39) missense probably benign 0.06
R0600:Or5p70 UTSW 7 107,994,438 (GRCm39) missense probably damaging 0.98
R0635:Or5p70 UTSW 7 107,994,971 (GRCm39) missense probably benign 0.01
R0685:Or5p70 UTSW 7 107,994,470 (GRCm39) missense possibly damaging 0.67
R1220:Or5p70 UTSW 7 107,994,539 (GRCm39) missense probably benign 0.03
R1398:Or5p70 UTSW 7 107,994,708 (GRCm39) missense probably damaging 0.98
R1501:Or5p70 UTSW 7 107,995,289 (GRCm39) missense probably benign 0.00
R1990:Or5p70 UTSW 7 107,995,041 (GRCm39) missense probably benign 0.00
R2091:Or5p70 UTSW 7 107,995,068 (GRCm39) missense probably damaging 1.00
R2473:Or5p70 UTSW 7 107,994,711 (GRCm39) missense probably damaging 1.00
R3120:Or5p70 UTSW 7 107,994,930 (GRCm39) missense possibly damaging 0.67
R4771:Or5p70 UTSW 7 107,995,229 (GRCm39) nonsense probably null
R5240:Or5p70 UTSW 7 107,994,909 (GRCm39) missense probably damaging 0.99
R5510:Or5p70 UTSW 7 107,994,332 (GRCm39) missense probably benign 0.01
R5703:Or5p70 UTSW 7 107,994,707 (GRCm39) missense probably benign 0.23
R6102:Or5p70 UTSW 7 107,994,491 (GRCm39) missense probably damaging 0.99
R6110:Or5p70 UTSW 7 107,995,035 (GRCm39) missense possibly damaging 0.93
R6782:Or5p70 UTSW 7 107,994,744 (GRCm39) missense probably damaging 1.00
R7062:Or5p70 UTSW 7 107,995,037 (GRCm39) nonsense probably null
R7783:Or5p70 UTSW 7 107,995,296 (GRCm39) missense probably benign 0.15
R8386:Or5p70 UTSW 7 107,994,555 (GRCm39) small deletion probably benign
R9347:Or5p70 UTSW 7 107,995,259 (GRCm39) missense probably benign 0.02
R9554:Or5p70 UTSW 7 107,994,365 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTGCGACAGTTGAGTGCTTCC -3'
(R):5'- GGTGGAGAAGGCCTTGTATC -3'

Sequencing Primer
(F):5'- CGACAGTTGAGTGCTTCCTTCTG -3'
(R):5'- AGAAGGCCTTGTATCGACTTTC -3'
Posted On 2022-06-15