Incidental Mutation 'R9468:Zfp942'
ID 715309
Institutional Source Beutler Lab
Gene Symbol Zfp942
Ensembl Gene ENSMUSG00000071267
Gene Name zinc finger protein 942
Synonyms 3110048L19Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R9468 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 22145941-22181445 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 22148422 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 69 (T69I)
Ref Sequence ENSEMBL: ENSMUSP00000089494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074295] [ENSMUST00000091879]
AlphaFold B8JJA7
Predicted Effect probably benign
Transcript: ENSMUST00000074295
AA Change: T69I

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: T69I

DomainStartEndE-ValueType
KRAB 13 69 6.55e-19 SMART
ZnF_C2H2 183 205 1.16e-1 SMART
ZnF_C2H2 211 233 8.22e-2 SMART
ZnF_C2H2 239 261 5.14e-3 SMART
ZnF_C2H2 267 289 8.02e-5 SMART
ZnF_C2H2 295 317 2.32e-1 SMART
ZnF_C2H2 323 345 1.6e-4 SMART
ZnF_C2H2 351 373 8.94e-3 SMART
ZnF_C2H2 379 401 1.95e-3 SMART
ZnF_C2H2 407 429 2.24e-3 SMART
ZnF_C2H2 435 457 7.49e-5 SMART
ZnF_C2H2 463 485 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091879
AA Change: T69I

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: T69I

DomainStartEndE-ValueType
KRAB 13 69 6.55e-19 SMART
ZnF_C2H2 183 205 1.16e-1 SMART
ZnF_C2H2 211 233 8.22e-2 SMART
ZnF_C2H2 239 261 5.14e-3 SMART
ZnF_C2H2 267 289 8.02e-5 SMART
ZnF_C2H2 295 317 2.32e-1 SMART
ZnF_C2H2 323 345 1.6e-4 SMART
ZnF_C2H2 351 373 8.94e-3 SMART
ZnF_C2H2 379 401 1.95e-3 SMART
ZnF_C2H2 407 429 2.24e-3 SMART
ZnF_C2H2 435 457 7.49e-5 SMART
ZnF_C2H2 463 485 2.99e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930558K02Rik T A 1: 161,784,736 (GRCm39) N68Y probably damaging Het
Acsf3 A T 8: 123,539,769 (GRCm39) I466F probably damaging Het
Akr1b7 T C 6: 34,392,316 (GRCm39) I43T probably benign Het
Alyref T A 11: 120,486,790 (GRCm39) D157V probably damaging Het
Anapc2 T C 2: 25,163,132 (GRCm39) L123P possibly damaging Het
Catsperg2 A T 7: 29,409,432 (GRCm39) probably null Het
Ccz1 G T 5: 143,929,438 (GRCm39) T330K probably benign Het
Chordc1 T A 9: 18,213,425 (GRCm39) F92Y probably benign Het
Cyp2c29 A T 19: 39,296,166 (GRCm39) D199V probably benign Het
Cyp2c70 A G 19: 40,168,889 (GRCm39) S133P probably damaging Het
Dync1li2 G A 8: 105,147,258 (GRCm39) P479S probably benign Het
Fcmr G T 1: 130,801,951 (GRCm39) K68N possibly damaging Het
Frmpd2 T A 14: 33,266,432 (GRCm39) D949E possibly damaging Het
Fscn2 A G 11: 120,253,283 (GRCm39) E250G probably damaging Het
Grk2 A T 19: 4,344,952 (GRCm39) I39N probably damaging Het
Hmmr T A 11: 40,614,314 (GRCm39) R125* probably null Het
Jarid2 T A 13: 45,073,306 (GRCm39) C1195S probably damaging Het
Kcnq4 A T 4: 120,568,494 (GRCm39) D407E probably benign Het
Kif24 A T 4: 41,404,794 (GRCm39) I402N probably damaging Het
Kmt2b A G 7: 30,284,513 (GRCm39) V793A probably damaging Het
Kntc1 T C 5: 123,954,776 (GRCm39) Y2065H probably damaging Het
Krt5 C A 15: 101,615,980 (GRCm39) S545I unknown Het
Larp1b A T 3: 40,930,990 (GRCm39) I290L probably benign Het
Lnx2 C T 5: 146,979,289 (GRCm39) probably benign Het
Lonrf2 A G 1: 38,839,839 (GRCm39) S419P probably damaging Het
Lrrc19 A T 4: 94,526,521 (GRCm39) D345E probably benign Het
Micu3 T A 8: 40,807,422 (GRCm39) L251* probably null Het
Mucl1 G T 15: 103,784,035 (GRCm39) T57N possibly damaging Het
Myh8 C T 11: 67,197,730 (GRCm39) R1866W probably damaging Het
Ndc80 G A 17: 71,806,306 (GRCm39) Q583* probably null Het
Nrap G A 19: 56,330,632 (GRCm39) T1143I possibly damaging Het
Nrde2 A G 12: 100,106,268 (GRCm39) V523A probably benign Het
Or12e9 T A 2: 87,202,116 (GRCm39) V80E probably damaging Het
Or2at4 A T 7: 99,385,180 (GRCm39) I277F possibly damaging Het
Or4c11 C T 2: 88,695,795 (GRCm39) P282L possibly damaging Het
Or5p70 C T 7: 107,994,849 (GRCm39) P174L possibly damaging Het
Pcdhb16 T A 18: 37,611,482 (GRCm39) S147R probably damaging Het
Phf21b T C 15: 84,689,299 (GRCm39) T76A probably damaging Het
Pknox2 A G 9: 36,822,495 (GRCm39) V218A probably benign Het
Plekhg3 C T 12: 76,607,009 (GRCm39) T23I probably damaging Het
Ptprb A G 10: 116,113,274 (GRCm39) T85A probably benign Het
Ptprc A G 1: 138,044,754 (GRCm39) L36P probably benign Het
Rasgrf1 A G 9: 89,880,756 (GRCm39) Q834R probably benign Het
Rnft1 G A 11: 86,381,242 (GRCm39) V211I probably benign Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,127 (GRCm39) probably benign Het
Ryr1 G A 7: 28,772,510 (GRCm39) L2468F probably damaging Het
Scaf4 C T 16: 90,026,287 (GRCm39) A1177T unknown Het
Sec14l3 A G 11: 4,025,200 (GRCm39) Y270C probably damaging Het
Serpind1 A T 16: 17,154,179 (GRCm39) K2I possibly damaging Het
Slc6a20b A G 9: 123,439,416 (GRCm39) S138P probably damaging Het
Son T A 16: 91,454,439 (GRCm39) M1062K possibly damaging Het
Sorl1 T C 9: 42,035,384 (GRCm39) E9G probably benign Het
Spmip9 T C 6: 70,890,627 (GRCm39) Q55R probably benign Het
Stx16 T C 2: 173,933,327 (GRCm39) L102P probably damaging Het
Syt12 A T 19: 4,497,744 (GRCm39) S413T probably damaging Het
Tie1 A G 4: 118,333,376 (GRCm39) L830P probably damaging Het
Tmem156 C T 5: 65,237,531 (GRCm39) R43K probably damaging Het
Tnfrsf19 A G 14: 61,261,623 (GRCm39) S59P possibly damaging Het
Tpk1 T C 6: 43,536,901 (GRCm39) D54G probably benign Het
Trim39 G T 17: 36,571,492 (GRCm39) T422K probably benign Het
Ttn T G 2: 76,536,112 (GRCm39) E35082A Het
Vac14 T A 8: 111,397,738 (GRCm39) D484E probably benign Het
Vmn1r158 G T 7: 22,489,888 (GRCm39) T107N probably damaging Het
Vmn1r51 T A 6: 90,106,930 (GRCm39) I282N probably damaging Het
Vps26a A T 10: 62,300,516 (GRCm39) Y217N probably damaging Het
Zmym4 A G 4: 126,800,993 (GRCm39) S536P probably benign Het
Znrf3 A G 11: 5,288,696 (GRCm39) V24A probably damaging Het
Zranb3 A G 1: 127,891,496 (GRCm39) probably null Het
Zzef1 T C 11: 72,814,009 (GRCm39) probably null Het
Other mutations in Zfp942
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Zfp942 APN 17 22,148,042 (GRCm39) missense probably benign
IGL00586:Zfp942 APN 17 22,147,605 (GRCm39) missense probably damaging 1.00
IGL02973:Zfp942 APN 17 22,151,972 (GRCm39) critical splice donor site probably null
IGL03212:Zfp942 APN 17 22,148,445 (GRCm39) nonsense probably null
IGL03382:Zfp942 APN 17 22,148,083 (GRCm39) missense probably benign 0.04
R0008:Zfp942 UTSW 17 22,147,319 (GRCm39) missense probably damaging 1.00
R0113:Zfp942 UTSW 17 22,148,066 (GRCm39) missense probably benign 0.18
R0244:Zfp942 UTSW 17 22,147,553 (GRCm39) missense probably benign 0.02
R0369:Zfp942 UTSW 17 22,148,017 (GRCm39) missense probably benign 0.41
R1664:Zfp942 UTSW 17 22,147,420 (GRCm39) missense possibly damaging 0.83
R1824:Zfp942 UTSW 17 22,147,522 (GRCm39) missense probably damaging 1.00
R4545:Zfp942 UTSW 17 22,147,285 (GRCm39) missense probably benign 0.00
R4785:Zfp942 UTSW 17 22,148,400 (GRCm39) missense probably damaging 1.00
R5493:Zfp942 UTSW 17 22,151,985 (GRCm39) missense probably null 0.66
R6568:Zfp942 UTSW 17 22,148,043 (GRCm39) missense probably benign 0.14
R6733:Zfp942 UTSW 17 22,147,733 (GRCm39) nonsense probably null
R7650:Zfp942 UTSW 17 22,147,818 (GRCm39) missense probably benign 0.07
R7935:Zfp942 UTSW 17 22,148,208 (GRCm39) nonsense probably null
R8065:Zfp942 UTSW 17 22,149,391 (GRCm39) missense probably damaging 0.96
R8067:Zfp942 UTSW 17 22,149,391 (GRCm39) missense probably damaging 0.96
R8237:Zfp942 UTSW 17 22,147,226 (GRCm39) missense possibly damaging 0.92
R8513:Zfp942 UTSW 17 22,147,282 (GRCm39) missense probably benign
R9539:Zfp942 UTSW 17 22,148,014 (GRCm39) missense probably damaging 1.00
R9782:Zfp942 UTSW 17 22,147,463 (GRCm39) missense probably benign 0.05
X0025:Zfp942 UTSW 17 22,148,288 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCCTTGATTTAGACCAATGGTAGAAC -3'
(R):5'- CCACTTTTGAGAGCTGTATTCTTG -3'

Sequencing Primer
(F):5'- ATTTGCAAGGTTCTCTGGTGTTTCC -3'
(R):5'- CCATTAGTCCCTATGGTCT -3'
Posted On 2022-06-15