Incidental Mutation 'R9471:Tgm4'
ID 715478
Institutional Source Beutler Lab
Gene Symbol Tgm4
Ensembl Gene ENSMUSG00000025787
Gene Name transglutaminase 4 (prostate)
Synonyms Eapa1, 9530008N10Rik, experimental autoimmune prostatitis antigen 1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R9471 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 122863806-122896623 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 122869444 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 8 (I8V)
Ref Sequence ENSEMBL: ENSMUSP00000026893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026893] [ENSMUST00000215247] [ENSMUST00000217607]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000026893
AA Change: I8V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000026893
Gene: ENSMUSG00000025787
AA Change: I8V

DomainStartEndE-ValueType
Pfam:Transglut_N 8 118 4e-26 PFAM
TGc 247 340 6.25e-42 SMART
Pfam:Transglut_C 573 670 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215247
Predicted Effect probably benign
Transcript: ENSMUST00000217607
AA Change: I8V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6b A G 5: 137,565,319 (GRCm39) K368E probably damaging Het
Adgrl2 T C 3: 148,558,365 (GRCm39) T448A probably benign Het
Aff4 C T 11: 53,271,473 (GRCm39) P337S probably benign Het
Alg12 G A 15: 88,690,621 (GRCm39) Q406* probably null Het
Anapc5 T C 5: 122,944,308 (GRCm39) Y302C probably damaging Het
Apol7a A G 15: 77,273,680 (GRCm39) S261P possibly damaging Het
Atad5 G T 11: 80,023,524 (GRCm39) K1545N possibly damaging Het
Atp6v1f T A 6: 29,467,941 (GRCm39) D42E probably benign Het
Bcl6 T A 16: 23,791,857 (GRCm39) N166Y probably benign Het
Btbd7 C T 12: 102,760,145 (GRCm39) R601Q probably damaging Het
Casp1 A G 9: 5,304,187 (GRCm39) E287G probably benign Het
Cd300c A T 11: 114,847,216 (GRCm39) V193E probably damaging Het
Cd300lg T A 11: 101,944,920 (GRCm39) S377T probably benign Het
Ceacam13 T A 7: 17,753,012 (GRCm39) *264R probably null Het
Clasrp G A 7: 19,319,172 (GRCm39) R498* probably null Het
Clec4n T A 6: 123,221,505 (GRCm39) N146K probably benign Het
Cntln T A 4: 84,968,019 (GRCm39) V746E possibly damaging Het
Defa29 T C 8: 21,816,901 (GRCm39) T31A possibly damaging Het
Egr4 A G 6: 85,489,695 (GRCm39) S122P possibly damaging Het
Fam221a T G 6: 49,349,520 (GRCm39) D28E probably damaging Het
Fanca G A 8: 124,000,897 (GRCm39) T1161I possibly damaging Het
Fcsk T C 8: 111,610,041 (GRCm39) E991G probably benign Het
Frat2 A G 19: 41,836,113 (GRCm39) S80P probably benign Het
Gse1 C A 8: 121,301,845 (GRCm39) S985R unknown Het
H2-M3 T A 17: 37,581,988 (GRCm39) I148N probably damaging Het
Hs6st3 G T 14: 119,376,235 (GRCm39) V137L probably damaging Het
Ighv1-42 T A 12: 114,900,927 (GRCm39) M53L probably benign Het
Klhl24 C T 16: 19,941,735 (GRCm39) T561I Het
Klhl26 C G 8: 70,904,803 (GRCm39) G369A probably damaging Het
Klra5 C A 6: 129,883,686 (GRCm39) W147L possibly damaging Het
Lrrd1 A T 5: 3,913,980 (GRCm39) D750V Het
Mc5r A G 18: 68,472,127 (GRCm39) D162G probably damaging Het
Mrc2 T A 11: 105,234,559 (GRCm39) S1026R probably benign Het
Nf1 A G 11: 79,436,195 (GRCm39) H1945R probably damaging Het
Nr4a2 A G 2: 57,002,114 (GRCm39) M113T probably benign Het
Obox2 G A 7: 15,131,113 (GRCm39) G73D probably damaging Het
Or1af1 G A 2: 37,110,400 (GRCm39) A300T probably damaging Het
Or2t48 A T 11: 58,420,355 (GRCm39) C152* probably null Het
Pappa2 C T 1: 158,642,029 (GRCm39) M1342I probably benign Het
Pla2g6 A T 15: 79,202,039 (GRCm39) L44Q probably damaging Het
Pnpla1 A T 17: 29,099,973 (GRCm39) Q280L probably benign Het
Pramel23 T A 4: 143,423,749 (GRCm39) T347S probably damaging Het
Prdm1 C T 10: 44,326,174 (GRCm39) G117S probably damaging Het
Prss36 A T 7: 127,545,605 (GRCm39) F6I probably benign Het
Sat2 A G 11: 69,513,725 (GRCm39) Y81C probably damaging Het
Sbspon T C 1: 15,962,677 (GRCm39) D67G probably benign Het
Shank2 G A 7: 143,964,752 (GRCm39) V787M possibly damaging Het
Stoml1 A T 9: 58,163,968 (GRCm39) I96F probably damaging Het
Tet2 C T 3: 133,191,680 (GRCm39) G918D probably damaging Het
Tmem156 C T 5: 65,237,531 (GRCm39) R43K probably damaging Het
Trim44 T C 2: 102,230,651 (GRCm39) S127G unknown Het
Ttn C T 2: 76,598,846 (GRCm39) V19356M probably damaging Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Vmn2r67 A C 7: 84,799,723 (GRCm39) probably null Het
Wdr90 C A 17: 26,080,015 (GRCm39) V107L possibly damaging Het
Zfp316 T C 5: 143,241,161 (GRCm39) D286G unknown Het
Zfp981 C A 4: 146,622,080 (GRCm39) P335Q probably benign Het
Zscan18 T C 7: 12,508,343 (GRCm39) T386A possibly damaging Het
Other mutations in Tgm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Tgm4 APN 9 122,891,447 (GRCm39) unclassified probably benign
IGL01402:Tgm4 APN 9 122,880,519 (GRCm39) missense possibly damaging 0.82
IGL02000:Tgm4 APN 9 122,885,531 (GRCm39) missense probably damaging 1.00
IGL02120:Tgm4 APN 9 122,875,594 (GRCm39) missense probably damaging 0.98
IGL03130:Tgm4 APN 9 122,885,580 (GRCm39) missense probably damaging 1.00
IGL03188:Tgm4 APN 9 122,874,101 (GRCm39) missense probably null 0.06
R0329:Tgm4 UTSW 9 122,877,622 (GRCm39) critical splice donor site probably null
R0480:Tgm4 UTSW 9 122,891,484 (GRCm39) missense probably benign
R0644:Tgm4 UTSW 9 122,880,523 (GRCm39) missense probably damaging 1.00
R0990:Tgm4 UTSW 9 122,875,576 (GRCm39) missense probably benign 0.02
R1604:Tgm4 UTSW 9 122,874,129 (GRCm39) missense probably benign 0.39
R1644:Tgm4 UTSW 9 122,880,481 (GRCm39) missense probably damaging 1.00
R2056:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2058:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2059:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2076:Tgm4 UTSW 9 122,880,160 (GRCm39) missense probably benign 0.24
R2437:Tgm4 UTSW 9 122,877,614 (GRCm39) nonsense probably null
R4392:Tgm4 UTSW 9 122,895,817 (GRCm39) missense probably benign 0.10
R4407:Tgm4 UTSW 9 122,885,595 (GRCm39) missense probably damaging 1.00
R4752:Tgm4 UTSW 9 122,880,451 (GRCm39) missense probably damaging 1.00
R5288:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5365:Tgm4 UTSW 9 122,895,866 (GRCm39) missense probably damaging 1.00
R5386:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5790:Tgm4 UTSW 9 122,890,808 (GRCm39) missense probably damaging 0.98
R5890:Tgm4 UTSW 9 122,890,703 (GRCm39) missense probably damaging 1.00
R6102:Tgm4 UTSW 9 122,885,600 (GRCm39) missense probably benign
R6358:Tgm4 UTSW 9 122,885,583 (GRCm39) missense probably damaging 1.00
R6956:Tgm4 UTSW 9 122,893,768 (GRCm39) missense possibly damaging 0.93
R6966:Tgm4 UTSW 9 122,880,207 (GRCm39) missense possibly damaging 0.68
R7091:Tgm4 UTSW 9 122,869,525 (GRCm39) missense probably damaging 1.00
R7258:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7313:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7369:Tgm4 UTSW 9 122,885,749 (GRCm39) critical splice donor site probably null
R7802:Tgm4 UTSW 9 122,880,401 (GRCm39) intron probably benign
R8219:Tgm4 UTSW 9 122,874,117 (GRCm39) missense probably benign
R8787:Tgm4 UTSW 9 122,890,910 (GRCm39) missense probably damaging 1.00
R8936:Tgm4 UTSW 9 122,869,541 (GRCm39) missense possibly damaging 0.92
R9045:Tgm4 UTSW 9 122,877,616 (GRCm39) missense possibly damaging 0.94
R9328:Tgm4 UTSW 9 122,885,697 (GRCm39) missense possibly damaging 0.93
R9359:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9403:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9746:Tgm4 UTSW 9 122,875,634 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TCTTCCCGCTGTGTGCTAAG -3'
(R):5'- TCTTGGCCATCGCACATTTATAAAC -3'

Sequencing Primer
(F):5'- TGTGTGCTAAGGATCCCCC -3'
(R):5'- GGCCATCGCACATTTATAAACCTTTG -3'
Posted On 2022-06-15