|Institutional Source||Beutler Lab|
|Gene Name||tumor necrosis factor (ligand) superfamily, member 13b|
|Synonyms||D8Ertd387e, BAFF, BLyS, TALL-1, zTNF4|
|Essential gene?||Probably non essential (E-score: 0.084)|
|Stock #||R9474 (G1)|
|Chromosomal Location||10006467-10039072 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 10031648 bp (GRCm38)|
|Amino Acid Change||Tyrosine to Cysteine at position 270 (Y270C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000146694 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000033892] [ENSMUST00000207792] [ENSMUST00000208683]|
AA Change: Y251C
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: Y251C
AA Change: Y270C
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
PHENOTYPE: Homozygous null mice have reduced number of B cells and reduced levels of immunoglobulins. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tnfsf13b||
(F):5'- TACAGCCAGGTAGCGTCAAAC -3'
(R):5'- GATATCAGTTTTCTCCGTCAACAC -3'
(F):5'- GGTAGCGTCAAACTCTCCC -3'
(R):5'- GTTTTCTCCGTCAACACAAATTATTG -3'