Incidental Mutation 'R9476:Vmn2r61'
ID |
715775 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r61
|
Ensembl Gene |
ENSMUSG00000090967 |
Gene Name |
vomeronasal 2, receptor 61 |
Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.101)
|
Stock # |
R9476 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 41949593 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glutamic Acid
at position 671
(V671E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
AlphaFold |
L7N2B8 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000166131
AA Change: V671E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000129576 Gene: ENSMUSG00000090967 AA Change: V671E
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 83 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930578G10Rik |
T |
G |
4: 42,760,998 (GRCm39) |
W6G |
unknown |
Het |
Aatk |
A |
T |
11: 119,901,094 (GRCm39) |
C1101S |
probably benign |
Het |
Abcb4 |
A |
T |
5: 8,977,790 (GRCm39) |
D456V |
probably damaging |
Het |
Abcc8 |
T |
C |
7: 45,819,270 (GRCm39) |
E186G |
possibly damaging |
Het |
Adam18 |
T |
C |
8: 25,115,807 (GRCm39) |
N629S |
probably benign |
Het |
Angpt2 |
T |
G |
8: 18,764,143 (GRCm39) |
N133T |
probably benign |
Het |
Ankrd13c |
T |
A |
3: 157,697,396 (GRCm39) |
S334T |
probably benign |
Het |
Ankrd13d |
A |
T |
19: 4,320,289 (GRCm39) |
S151T |
unknown |
Het |
Ap3d1 |
G |
A |
10: 80,545,655 (GRCm39) |
P1025S |
probably benign |
Het |
Bhlhe41 |
G |
A |
6: 145,808,948 (GRCm39) |
A288V |
possibly damaging |
Het |
Cacna1b |
T |
C |
2: 24,540,058 (GRCm39) |
E1467G |
probably damaging |
Het |
Cacna1h |
T |
A |
17: 25,611,524 (GRCm39) |
T425S |
probably damaging |
Het |
Cdk13 |
A |
C |
13: 17,902,747 (GRCm39) |
C934W |
probably damaging |
Het |
Ces1b |
T |
A |
8: 93,799,890 (GRCm39) |
N162I |
probably damaging |
Het |
Clec9a |
T |
A |
6: 129,398,023 (GRCm39) |
I187K |
possibly damaging |
Het |
Cpsf3 |
A |
G |
12: 21,350,080 (GRCm39) |
I266M |
probably damaging |
Het |
Cr2 |
G |
T |
1: 194,840,416 (GRCm39) |
L509M |
probably damaging |
Het |
Creb3l2 |
C |
A |
6: 37,311,446 (GRCm39) |
G448W |
probably damaging |
Het |
Csmd1 |
T |
A |
8: 15,981,215 (GRCm39) |
|
probably null |
Het |
Cul9 |
G |
A |
17: 46,821,833 (GRCm39) |
R1881W |
probably damaging |
Het |
Cyth1 |
C |
T |
11: 118,076,206 (GRCm39) |
|
probably null |
Het |
Dnhd1 |
A |
T |
7: 105,352,889 (GRCm39) |
N2681Y |
possibly damaging |
Het |
Dnm1 |
T |
C |
2: 32,213,739 (GRCm39) |
M476V |
probably benign |
Het |
Dnmt3a |
A |
G |
12: 3,957,707 (GRCm39) |
H896R |
probably damaging |
Het |
Dock1 |
T |
G |
7: 134,592,279 (GRCm39) |
I938S |
probably benign |
Het |
Dock6 |
G |
A |
9: 21,724,821 (GRCm39) |
L1515F |
probably damaging |
Het |
Dusp16 |
T |
C |
6: 134,695,226 (GRCm39) |
H535R |
probably benign |
Het |
Fancd2os |
T |
A |
6: 113,574,994 (GRCm39) |
Y4F |
probably damaging |
Het |
Fat4 |
A |
T |
3: 39,037,886 (GRCm39) |
Q3846L |
probably benign |
Het |
Fbxw10 |
A |
C |
11: 62,743,814 (GRCm39) |
H240P |
probably benign |
Het |
Frmd4a |
A |
G |
2: 4,608,324 (GRCm39) |
T731A |
probably benign |
Het |
Gm44501 |
T |
A |
17: 40,889,820 (GRCm39) |
H111Q |
possibly damaging |
Het |
Gsdmc |
T |
C |
15: 63,650,551 (GRCm39) |
M277V |
probably benign |
Het |
Hira |
A |
G |
16: 18,772,789 (GRCm39) |
D867G |
probably damaging |
Het |
Hmcn1 |
A |
G |
1: 150,462,127 (GRCm39) |
S5184P |
probably benign |
Het |
Ighv1-26 |
A |
C |
12: 114,752,407 (GRCm39) |
F7V |
probably benign |
Het |
Igkv4-81 |
C |
T |
6: 68,967,796 (GRCm39) |
E102K |
possibly damaging |
Het |
Inmt |
G |
T |
6: 55,147,990 (GRCm39) |
S213Y |
possibly damaging |
Het |
Ints2 |
T |
A |
11: 86,135,335 (GRCm39) |
M360L |
probably benign |
Het |
Itih3 |
A |
G |
14: 30,631,416 (GRCm39) |
S827P |
probably benign |
Het |
Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
Kcnk12 |
C |
A |
17: 88,054,122 (GRCm39) |
R180L |
probably benign |
Het |
Kndc1 |
G |
A |
7: 139,510,031 (GRCm39) |
S1291N |
probably benign |
Het |
Mettl21a |
T |
C |
1: 64,647,285 (GRCm39) |
T91A |
probably damaging |
Het |
Mmrn2 |
A |
G |
14: 34,120,407 (GRCm39) |
I426V |
possibly damaging |
Het |
Mrpl21 |
T |
G |
19: 3,337,704 (GRCm39) |
V137G |
probably damaging |
Het |
Nrbp2 |
T |
C |
15: 75,961,626 (GRCm39) |
N218S |
probably damaging |
Het |
Nrip1 |
T |
C |
16: 76,089,820 (GRCm39) |
N579S |
probably benign |
Het |
Nsf |
T |
C |
11: 103,763,988 (GRCm39) |
N365S |
probably damaging |
Het |
Or6c5 |
A |
G |
10: 129,074,656 (GRCm39) |
I213V |
probably damaging |
Het |
Or7g28 |
A |
T |
9: 19,272,383 (GRCm39) |
D89E |
probably benign |
Het |
Osbpl3 |
C |
T |
6: 50,313,194 (GRCm39) |
|
probably null |
Het |
Oscar |
T |
A |
7: 3,614,843 (GRCm39) |
H43L |
probably benign |
Het |
Pam |
C |
T |
1: 97,826,065 (GRCm39) |
|
probably null |
Het |
Parn |
A |
T |
16: 13,358,942 (GRCm39) |
M600K |
probably benign |
Het |
Pcdha11 |
C |
A |
18: 37,139,532 (GRCm39) |
T387N |
probably benign |
Het |
Plce1 |
G |
A |
19: 38,766,337 (GRCm39) |
E2121K |
possibly damaging |
Het |
Prune2 |
T |
A |
19: 17,096,706 (GRCm39) |
Y737N |
possibly damaging |
Het |
Ptch1 |
G |
A |
13: 63,681,448 (GRCm39) |
P613L |
probably benign |
Het |
Ptprt |
A |
C |
2: 161,397,381 (GRCm39) |
C1129G |
probably damaging |
Het |
Rara |
C |
T |
11: 98,860,983 (GRCm39) |
S157L |
probably benign |
Het |
Rest |
T |
A |
5: 77,416,098 (GRCm39) |
M104K |
probably damaging |
Het |
Rfc1 |
A |
G |
5: 65,437,142 (GRCm39) |
S513P |
probably damaging |
Het |
Rnf40 |
T |
A |
7: 127,201,808 (GRCm39) |
I1000N |
probably damaging |
Het |
Scube2 |
C |
T |
7: 109,430,969 (GRCm39) |
G410E |
probably damaging |
Het |
Sh3gl2 |
A |
G |
4: 85,304,089 (GRCm39) |
E264G |
probably benign |
Het |
Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
Smc4 |
T |
G |
3: 68,914,662 (GRCm39) |
S92A |
probably damaging |
Het |
Spata31d1b |
A |
G |
13: 59,863,467 (GRCm39) |
D205G |
probably benign |
Het |
Spata31e4 |
A |
G |
13: 50,856,149 (GRCm39) |
T596A |
possibly damaging |
Het |
Spef2 |
T |
C |
15: 9,713,203 (GRCm39) |
R390G |
probably damaging |
Het |
Speg |
T |
C |
1: 75,377,768 (GRCm39) |
F842S |
probably damaging |
Het |
Stk17b |
G |
T |
1: 53,796,898 (GRCm39) |
H290N |
probably damaging |
Het |
Stpg3 |
A |
T |
2: 25,103,516 (GRCm39) |
V191D |
probably benign |
Het |
Supt6 |
C |
T |
11: 78,120,290 (GRCm39) |
R350H |
probably damaging |
Het |
Tet3 |
T |
C |
6: 83,380,935 (GRCm39) |
E411G |
possibly damaging |
Het |
Tet3 |
T |
A |
6: 83,381,808 (GRCm39) |
|
probably null |
Het |
Tns3 |
A |
G |
11: 8,395,702 (GRCm39) |
I1234T |
probably damaging |
Het |
Trim34b |
A |
G |
7: 103,980,503 (GRCm39) |
E197G |
probably damaging |
Het |
Vcan |
G |
T |
13: 89,851,531 (GRCm39) |
T1143K |
possibly damaging |
Het |
Wdtc1 |
A |
G |
4: 133,049,529 (GRCm39) |
V29A |
probably damaging |
Het |
Zfp462 |
G |
A |
4: 55,080,735 (GRCm39) |
M2450I |
probably benign |
Het |
Zfp869 |
A |
T |
8: 70,159,849 (GRCm39) |
C241* |
probably null |
Het |
|
Other mutations in Vmn2r61 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Predicted Primers |
PCR Primer
(F):5'- CACAGCTGTGGTTCTTGTAGTC -3'
(R):5'- GTGACCATGTTCAGCCTGAG -3'
Sequencing Primer
(F):5'- TCTTTGTGAAGCACAGAGACAC -3'
(R):5'- GCCTGAGTATCTTGATCAATGAAGG -3'
|
Posted On |
2022-06-15 |