Incidental Mutation 'R9476:Dock6'
| ID |
715790 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock6
|
| Ensembl Gene |
ENSMUSG00000032198 |
| Gene Name |
dedicator of cytokinesis 6 |
| Synonyms |
4931431C02Rik, 2410095B20Rik, C330023D02Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.482)
|
| Stock # |
R9476 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
21711476-21764006 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 21724821 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 1515
(L1515F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149156
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034728]
[ENSMUST00000217336]
|
| AlphaFold |
Q8VDR9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000034728
AA Change: L1484F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000034728
Gene: ENSMUSG00000032198
AA Change: L1484F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
42 |
N/A |
INTRINSIC |
|
Pfam:DUF3398
|
63 |
155 |
4.7e-26 |
PFAM |
|
low complexity region
|
419 |
429 |
N/A |
INTRINSIC |
|
low complexity region
|
478 |
489 |
N/A |
INTRINSIC |
|
Pfam:DOCK-C2
|
542 |
721 |
3.4e-46 |
PFAM |
|
low complexity region
|
754 |
770 |
N/A |
INTRINSIC |
|
low complexity region
|
776 |
787 |
N/A |
INTRINSIC |
|
low complexity region
|
945 |
965 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1072 |
N/A |
INTRINSIC |
|
low complexity region
|
1123 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1173 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1340 |
1356 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1554 |
2080 |
6.6e-214 |
PFAM |
|
low complexity region
|
2093 |
2107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000215729
AA Change: L248F
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000217336
AA Change: L1515F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578G10Rik |
T |
G |
4: 42,760,998 (GRCm39) |
W6G |
unknown |
Het |
| Aatk |
A |
T |
11: 119,901,094 (GRCm39) |
C1101S |
probably benign |
Het |
| Abcb4 |
A |
T |
5: 8,977,790 (GRCm39) |
D456V |
probably damaging |
Het |
| Abcc8 |
T |
C |
7: 45,819,270 (GRCm39) |
E186G |
possibly damaging |
Het |
| Adam18 |
T |
C |
8: 25,115,807 (GRCm39) |
N629S |
probably benign |
Het |
| Angpt2 |
T |
G |
8: 18,764,143 (GRCm39) |
N133T |
probably benign |
Het |
| Ankrd13c |
T |
A |
3: 157,697,396 (GRCm39) |
S334T |
probably benign |
Het |
| Ankrd13d |
A |
T |
19: 4,320,289 (GRCm39) |
S151T |
unknown |
Het |
| Ap3d1 |
G |
A |
10: 80,545,655 (GRCm39) |
P1025S |
probably benign |
Het |
| Bhlhe41 |
G |
A |
6: 145,808,948 (GRCm39) |
A288V |
possibly damaging |
Het |
| Cacna1b |
T |
C |
2: 24,540,058 (GRCm39) |
E1467G |
probably damaging |
Het |
| Cacna1h |
T |
A |
17: 25,611,524 (GRCm39) |
T425S |
probably damaging |
Het |
| Cdk13 |
A |
C |
13: 17,902,747 (GRCm39) |
C934W |
probably damaging |
Het |
| Ces1b |
T |
A |
8: 93,799,890 (GRCm39) |
N162I |
probably damaging |
Het |
| Clec9a |
T |
A |
6: 129,398,023 (GRCm39) |
I187K |
possibly damaging |
Het |
| Cpsf3 |
A |
G |
12: 21,350,080 (GRCm39) |
I266M |
probably damaging |
Het |
| Cr2 |
G |
T |
1: 194,840,416 (GRCm39) |
L509M |
probably damaging |
Het |
| Creb3l2 |
C |
A |
6: 37,311,446 (GRCm39) |
G448W |
probably damaging |
Het |
| Csmd1 |
T |
A |
8: 15,981,215 (GRCm39) |
|
probably null |
Het |
| Cul9 |
G |
A |
17: 46,821,833 (GRCm39) |
R1881W |
probably damaging |
Het |
| Cyth1 |
C |
T |
11: 118,076,206 (GRCm39) |
|
probably null |
Het |
| Dnhd1 |
A |
T |
7: 105,352,889 (GRCm39) |
N2681Y |
possibly damaging |
Het |
| Dnm1 |
T |
C |
2: 32,213,739 (GRCm39) |
M476V |
probably benign |
Het |
| Dnmt3a |
A |
G |
12: 3,957,707 (GRCm39) |
H896R |
probably damaging |
Het |
| Dock1 |
T |
G |
7: 134,592,279 (GRCm39) |
I938S |
probably benign |
Het |
| Dusp16 |
T |
C |
6: 134,695,226 (GRCm39) |
H535R |
probably benign |
Het |
| Fancd2os |
T |
A |
6: 113,574,994 (GRCm39) |
Y4F |
probably damaging |
Het |
| Fat4 |
A |
T |
3: 39,037,886 (GRCm39) |
Q3846L |
probably benign |
Het |
| Fbxw10 |
A |
C |
11: 62,743,814 (GRCm39) |
H240P |
probably benign |
Het |
| Frmd4a |
A |
G |
2: 4,608,324 (GRCm39) |
T731A |
probably benign |
Het |
| Gm44501 |
T |
A |
17: 40,889,820 (GRCm39) |
H111Q |
possibly damaging |
Het |
| Gsdmc |
T |
C |
15: 63,650,551 (GRCm39) |
M277V |
probably benign |
Het |
| Hira |
A |
G |
16: 18,772,789 (GRCm39) |
D867G |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,462,127 (GRCm39) |
S5184P |
probably benign |
Het |
| Ighv1-26 |
A |
C |
12: 114,752,407 (GRCm39) |
F7V |
probably benign |
Het |
| Igkv4-81 |
C |
T |
6: 68,967,796 (GRCm39) |
E102K |
possibly damaging |
Het |
| Inmt |
G |
T |
6: 55,147,990 (GRCm39) |
S213Y |
possibly damaging |
Het |
| Ints2 |
T |
A |
11: 86,135,335 (GRCm39) |
M360L |
probably benign |
Het |
| Itih3 |
A |
G |
14: 30,631,416 (GRCm39) |
S827P |
probably benign |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Kcnk12 |
C |
A |
17: 88,054,122 (GRCm39) |
R180L |
probably benign |
Het |
| Kndc1 |
G |
A |
7: 139,510,031 (GRCm39) |
S1291N |
probably benign |
Het |
| Mettl21a |
T |
C |
1: 64,647,285 (GRCm39) |
T91A |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,120,407 (GRCm39) |
I426V |
possibly damaging |
Het |
| Mrpl21 |
T |
G |
19: 3,337,704 (GRCm39) |
V137G |
probably damaging |
Het |
| Nrbp2 |
T |
C |
15: 75,961,626 (GRCm39) |
N218S |
probably damaging |
Het |
| Nrip1 |
T |
C |
16: 76,089,820 (GRCm39) |
N579S |
probably benign |
Het |
| Nsf |
T |
C |
11: 103,763,988 (GRCm39) |
N365S |
probably damaging |
Het |
| Or6c5 |
A |
G |
10: 129,074,656 (GRCm39) |
I213V |
probably damaging |
Het |
| Or7g28 |
A |
T |
9: 19,272,383 (GRCm39) |
D89E |
probably benign |
Het |
| Osbpl3 |
C |
T |
6: 50,313,194 (GRCm39) |
|
probably null |
Het |
| Oscar |
T |
A |
7: 3,614,843 (GRCm39) |
H43L |
probably benign |
Het |
| Pam |
C |
T |
1: 97,826,065 (GRCm39) |
|
probably null |
Het |
| Parn |
A |
T |
16: 13,358,942 (GRCm39) |
M600K |
probably benign |
Het |
| Pcdha11 |
C |
A |
18: 37,139,532 (GRCm39) |
T387N |
probably benign |
Het |
| Plce1 |
G |
A |
19: 38,766,337 (GRCm39) |
E2121K |
possibly damaging |
Het |
| Prune2 |
T |
A |
19: 17,096,706 (GRCm39) |
Y737N |
possibly damaging |
Het |
| Ptch1 |
G |
A |
13: 63,681,448 (GRCm39) |
P613L |
probably benign |
Het |
| Ptprt |
A |
C |
2: 161,397,381 (GRCm39) |
C1129G |
probably damaging |
Het |
| Rara |
C |
T |
11: 98,860,983 (GRCm39) |
S157L |
probably benign |
Het |
| Rest |
T |
A |
5: 77,416,098 (GRCm39) |
M104K |
probably damaging |
Het |
| Rfc1 |
A |
G |
5: 65,437,142 (GRCm39) |
S513P |
probably damaging |
Het |
| Rnf40 |
T |
A |
7: 127,201,808 (GRCm39) |
I1000N |
probably damaging |
Het |
| Scube2 |
C |
T |
7: 109,430,969 (GRCm39) |
G410E |
probably damaging |
Het |
| Sh3gl2 |
A |
G |
4: 85,304,089 (GRCm39) |
E264G |
probably benign |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Smc4 |
T |
G |
3: 68,914,662 (GRCm39) |
S92A |
probably damaging |
Het |
| Spata31d1b |
A |
G |
13: 59,863,467 (GRCm39) |
D205G |
probably benign |
Het |
| Spata31e4 |
A |
G |
13: 50,856,149 (GRCm39) |
T596A |
possibly damaging |
Het |
| Spef2 |
T |
C |
15: 9,713,203 (GRCm39) |
R390G |
probably damaging |
Het |
| Speg |
T |
C |
1: 75,377,768 (GRCm39) |
F842S |
probably damaging |
Het |
| Stk17b |
G |
T |
1: 53,796,898 (GRCm39) |
H290N |
probably damaging |
Het |
| Stpg3 |
A |
T |
2: 25,103,516 (GRCm39) |
V191D |
probably benign |
Het |
| Supt6 |
C |
T |
11: 78,120,290 (GRCm39) |
R350H |
probably damaging |
Het |
| Tet3 |
T |
C |
6: 83,380,935 (GRCm39) |
E411G |
possibly damaging |
Het |
| Tet3 |
T |
A |
6: 83,381,808 (GRCm39) |
|
probably null |
Het |
| Tns3 |
A |
G |
11: 8,395,702 (GRCm39) |
I1234T |
probably damaging |
Het |
| Trim34b |
A |
G |
7: 103,980,503 (GRCm39) |
E197G |
probably damaging |
Het |
| Vcan |
G |
T |
13: 89,851,531 (GRCm39) |
T1143K |
possibly damaging |
Het |
| Vmn2r61 |
T |
A |
7: 41,949,593 (GRCm39) |
V671E |
probably damaging |
Het |
| Wdtc1 |
A |
G |
4: 133,049,529 (GRCm39) |
V29A |
probably damaging |
Het |
| Zfp462 |
G |
A |
4: 55,080,735 (GRCm39) |
M2450I |
probably benign |
Het |
| Zfp869 |
A |
T |
8: 70,159,849 (GRCm39) |
C241* |
probably null |
Het |
|
| Other mutations in Dock6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Dock6
|
APN |
9 |
21,757,930 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01025:Dock6
|
APN |
9 |
21,723,103 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01390:Dock6
|
APN |
9 |
21,714,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02025:Dock6
|
APN |
9 |
21,720,885 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02028:Dock6
|
APN |
9 |
21,750,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02311:Dock6
|
APN |
9 |
21,755,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02441:Dock6
|
APN |
9 |
21,753,222 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02504:Dock6
|
APN |
9 |
21,757,951 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02516:Dock6
|
APN |
9 |
21,713,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02836:Dock6
|
APN |
9 |
21,713,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock6
|
APN |
9 |
21,723,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
backwater
|
UTSW |
9 |
21,735,712 (GRCm39) |
missense |
probably benign |
0.29 |
|
bayfront
|
UTSW |
9 |
21,733,041 (GRCm39) |
missense |
probably benign |
0.29 |
|
marshland
|
UTSW |
9 |
21,752,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
Shallows
|
UTSW |
9 |
21,731,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03048:Dock6
|
UTSW |
9 |
21,720,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0370:Dock6
|
UTSW |
9 |
21,725,861 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0504:Dock6
|
UTSW |
9 |
21,713,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0633:Dock6
|
UTSW |
9 |
21,755,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Dock6
|
UTSW |
9 |
21,752,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0671:Dock6
|
UTSW |
9 |
21,715,923 (GRCm39) |
splice site |
probably benign |
|
|
R0839:Dock6
|
UTSW |
9 |
21,729,188 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0948:Dock6
|
UTSW |
9 |
21,712,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1022:Dock6
|
UTSW |
9 |
21,744,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1024:Dock6
|
UTSW |
9 |
21,744,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Dock6
|
UTSW |
9 |
21,757,814 (GRCm39) |
missense |
probably benign |
|
|
R1463:Dock6
|
UTSW |
9 |
21,743,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1481:Dock6
|
UTSW |
9 |
21,731,918 (GRCm39) |
missense |
probably benign |
|
|
R1494:Dock6
|
UTSW |
9 |
21,726,038 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1547:Dock6
|
UTSW |
9 |
21,725,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Dock6
|
UTSW |
9 |
21,716,139 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1782:Dock6
|
UTSW |
9 |
21,723,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Dock6
|
UTSW |
9 |
21,740,870 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1908:Dock6
|
UTSW |
9 |
21,752,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1916:Dock6
|
UTSW |
9 |
21,724,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Dock6
|
UTSW |
9 |
21,757,814 (GRCm39) |
missense |
probably benign |
|
|
R2197:Dock6
|
UTSW |
9 |
21,744,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2316:Dock6
|
UTSW |
9 |
21,750,973 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2341:Dock6
|
UTSW |
9 |
21,750,782 (GRCm39) |
splice site |
probably benign |
|
|
R2519:Dock6
|
UTSW |
9 |
21,727,629 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R2924:Dock6
|
UTSW |
9 |
21,720,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2939:Dock6
|
UTSW |
9 |
21,750,496 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2940:Dock6
|
UTSW |
9 |
21,750,496 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3078:Dock6
|
UTSW |
9 |
21,757,050 (GRCm39) |
splice site |
probably benign |
|
|
R3081:Dock6
|
UTSW |
9 |
21,750,496 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3810:Dock6
|
UTSW |
9 |
21,712,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4246:Dock6
|
UTSW |
9 |
21,750,786 (GRCm39) |
splice site |
probably null |
|
|
R4604:Dock6
|
UTSW |
9 |
21,713,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4833:Dock6
|
UTSW |
9 |
21,755,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Dock6
|
UTSW |
9 |
21,723,068 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4896:Dock6
|
UTSW |
9 |
21,735,733 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4926:Dock6
|
UTSW |
9 |
21,757,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5183:Dock6
|
UTSW |
9 |
21,752,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5211:Dock6
|
UTSW |
9 |
21,731,648 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5337:Dock6
|
UTSW |
9 |
21,740,844 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5353:Dock6
|
UTSW |
9 |
21,726,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5429:Dock6
|
UTSW |
9 |
21,744,177 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5463:Dock6
|
UTSW |
9 |
21,721,254 (GRCm39) |
splice site |
probably null |
|
|
R5476:Dock6
|
UTSW |
9 |
21,720,885 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5511:Dock6
|
UTSW |
9 |
21,728,703 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5534:Dock6
|
UTSW |
9 |
21,714,372 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Dock6
|
UTSW |
9 |
21,735,789 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5823:Dock6
|
UTSW |
9 |
21,716,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5831:Dock6
|
UTSW |
9 |
21,714,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Dock6
|
UTSW |
9 |
21,731,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5930:Dock6
|
UTSW |
9 |
21,735,712 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6159:Dock6
|
UTSW |
9 |
21,733,041 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6633:Dock6
|
UTSW |
9 |
21,732,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6633:Dock6
|
UTSW |
9 |
21,731,627 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6665:Dock6
|
UTSW |
9 |
21,751,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6744:Dock6
|
UTSW |
9 |
21,742,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6903:Dock6
|
UTSW |
9 |
21,720,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Dock6
|
UTSW |
9 |
21,756,846 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7024:Dock6
|
UTSW |
9 |
21,731,666 (GRCm39) |
missense |
probably benign |
|
|
R7030:Dock6
|
UTSW |
9 |
21,724,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7045:Dock6
|
UTSW |
9 |
21,733,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Dock6
|
UTSW |
9 |
21,712,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7356:Dock6
|
UTSW |
9 |
21,721,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7400:Dock6
|
UTSW |
9 |
21,713,103 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7847:Dock6
|
UTSW |
9 |
21,712,503 (GRCm39) |
missense |
unknown |
|
|
R7863:Dock6
|
UTSW |
9 |
21,757,954 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7991:Dock6
|
UTSW |
9 |
21,757,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7992:Dock6
|
UTSW |
9 |
21,744,135 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8012:Dock6
|
UTSW |
9 |
21,757,807 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8184:Dock6
|
UTSW |
9 |
21,741,596 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8213:Dock6
|
UTSW |
9 |
21,742,740 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8560:Dock6
|
UTSW |
9 |
21,714,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8828:Dock6
|
UTSW |
9 |
21,757,797 (GRCm39) |
missense |
probably benign |
|
|
R9090:Dock6
|
UTSW |
9 |
21,752,796 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9221:Dock6
|
UTSW |
9 |
21,721,153 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9271:Dock6
|
UTSW |
9 |
21,752,796 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9301:Dock6
|
UTSW |
9 |
21,729,111 (GRCm39) |
missense |
probably benign |
|
|
R9308:Dock6
|
UTSW |
9 |
21,728,744 (GRCm39) |
nonsense |
probably null |
|
|
R9526:Dock6
|
UTSW |
9 |
21,713,802 (GRCm39) |
nonsense |
probably null |
|
|
R9544:Dock6
|
UTSW |
9 |
21,732,830 (GRCm39) |
nonsense |
probably null |
|
|
R9716:Dock6
|
UTSW |
9 |
21,742,418 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGAAACTTGCTGATCGCC -3'
(R):5'- GGTCAATATTGCCAAGTCACTTG -3'
Sequencing Primer
(F):5'- GGTCCTGTAGCAATGCTCTGC -3'
(R):5'- TCACTTGACAAGGTCAGAACAAAG -3'
|
| Posted On |
2022-06-15 |
Incidental Mutation