Incidental Mutation 'R9478:Cntln'
ID 715915
Institutional Source Beutler Lab
Gene Symbol Cntln
Ensembl Gene ENSMUSG00000038070
Gene Name centlein, centrosomal protein
Synonyms D530005L17Rik, B430108F07Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R9478 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 84802546-85050158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 84897630 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 406 (V406I)
Ref Sequence ENSEMBL: ENSMUSP00000044138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047023] [ENSMUST00000169371]
AlphaFold A2AM05
Predicted Effect probably benign
Transcript: ENSMUST00000047023
AA Change: V406I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000044138
Gene: ENSMUSG00000038070
AA Change: V406I

DomainStartEndE-ValueType
low complexity region 4 24 N/A INTRINSIC
low complexity region 58 86 N/A INTRINSIC
coiled coil region 96 126 N/A INTRINSIC
internal_repeat_1 198 219 1.25e-5 PROSPERO
low complexity region 242 251 N/A INTRINSIC
internal_repeat_1 321 342 1.25e-5 PROSPERO
low complexity region 346 358 N/A INTRINSIC
coiled coil region 404 433 N/A INTRINSIC
low complexity region 434 446 N/A INTRINSIC
coiled coil region 458 481 N/A INTRINSIC
coiled coil region 516 584 N/A INTRINSIC
coiled coil region 606 648 N/A INTRINSIC
coiled coil region 674 780 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
coiled coil region 973 1114 N/A INTRINSIC
low complexity region 1206 1217 N/A INTRINSIC
Blast:HisKA 1270 1326 1e-24 BLAST
low complexity region 1327 1348 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169371
AA Change: V406I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000130491
Gene: ENSMUSG00000038070
AA Change: V406I

DomainStartEndE-ValueType
low complexity region 4 24 N/A INTRINSIC
low complexity region 58 86 N/A INTRINSIC
coiled coil region 96 126 N/A INTRINSIC
internal_repeat_1 198 219 1.24e-5 PROSPERO
low complexity region 242 251 N/A INTRINSIC
internal_repeat_1 321 342 1.24e-5 PROSPERO
low complexity region 346 358 N/A INTRINSIC
coiled coil region 404 433 N/A INTRINSIC
low complexity region 434 446 N/A INTRINSIC
coiled coil region 458 481 N/A INTRINSIC
coiled coil region 516 584 N/A INTRINSIC
coiled coil region 606 648 N/A INTRINSIC
coiled coil region 674 780 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
coiled coil region 972 1113 N/A INTRINSIC
low complexity region 1205 1216 N/A INTRINSIC
Blast:HisKA 1269 1325 1e-24 BLAST
low complexity region 1326 1347 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A T 13: 77,451,573 (GRCm39) I886F possibly damaging Het
3100002H09Rik A G 4: 124,504,151 (GRCm39) S134P unknown Het
Abcf2 A G 5: 24,770,940 (GRCm39) L604P possibly damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Atg14 G T 14: 47,783,138 (GRCm39) H373Q probably damaging Het
Atmin C T 8: 117,681,537 (GRCm39) H179Y probably damaging Het
Catsperg1 G T 7: 28,897,777 (GRCm39) P197T possibly damaging Het
Ccdc7b C T 8: 129,837,473 (GRCm39) Q155* probably null Het
Cep85l T G 10: 53,224,875 (GRCm39) E238A possibly damaging Het
Cfap119 T C 7: 127,184,087 (GRCm39) probably null Het
Csf2rb2 C A 15: 78,168,965 (GRCm39) G730V probably benign Het
Cyp3a59 T A 5: 146,034,997 (GRCm39) L225Q probably damaging Het
Dock1 T A 7: 134,367,962 (GRCm39) F511I probably damaging Het
Dsg1b A T 18: 20,531,008 (GRCm39) Y453F Het
Dync1h1 T C 12: 110,625,137 (GRCm39) F3829L probably benign Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Esco2 C A 14: 66,068,657 (GRCm39) G218* probably null Het
Gale C T 4: 135,692,574 (GRCm39) probably benign Het
Grid1 G A 14: 35,043,664 (GRCm39) D340N probably damaging Het
Hgf A G 5: 16,766,029 (GRCm39) D55G possibly damaging Het
Il17ra A G 6: 120,451,336 (GRCm39) D170G possibly damaging Het
Inha A G 1: 75,486,562 (GRCm39) S286G probably benign Het
Kif1b C T 4: 149,345,616 (GRCm39) probably null Het
Klhl24 T G 16: 19,941,763 (GRCm39) S570R possibly damaging Het
Krt87 G A 15: 101,385,449 (GRCm39) R308W probably benign Het
Lama2 T A 10: 26,891,478 (GRCm39) E2545V probably damaging Het
Lztfl1 T C 9: 123,537,167 (GRCm39) K165E possibly damaging Het
Mab21l3 A T 3: 101,725,987 (GRCm39) D336E probably damaging Het
Matn2 T C 15: 34,345,242 (GRCm39) I83T probably damaging Het
Mfsd9 T C 1: 40,812,941 (GRCm39) D458G probably benign Het
Ncbp3 A G 11: 72,968,768 (GRCm39) D513G probably damaging Het
Neb T A 2: 52,078,788 (GRCm39) K5818N probably benign Het
Nol4 G A 18: 23,053,934 (GRCm39) P120S probably damaging Het
Oit3 C A 10: 59,274,464 (GRCm39) C112F probably damaging Het
Or11g27 A T 14: 50,771,051 (GRCm39) T61S probably benign Het
Or4b1 C A 2: 89,979,595 (GRCm39) A252S possibly damaging Het
Or5p52 G A 7: 107,502,238 (GRCm39) V105M probably damaging Het
Or6c6 T A 10: 129,186,960 (GRCm39) M176K possibly damaging Het
Pank4 G A 4: 155,064,565 (GRCm39) R708Q probably benign Het
Plch1 T A 3: 63,606,825 (GRCm39) L1026F probably benign Het
Poglut3 T C 9: 53,303,236 (GRCm39) F232L probably damaging Het
Ptpn3 A T 4: 57,197,573 (GRCm39) I772N probably damaging Het
Purb A G 11: 6,425,424 (GRCm39) F155L probably damaging Het
Rcor2 C T 19: 7,248,794 (GRCm39) R256W probably damaging Het
Rp1 A G 1: 4,417,545 (GRCm39) L1189P probably benign Het
Scn1a T C 2: 66,156,493 (GRCm39) E472G probably benign Het
Sema3e T C 5: 14,286,386 (GRCm39) Y536H probably damaging Het
Serpina3n A T 12: 104,378,672 (GRCm39) I331F possibly damaging Het
Sertad3 T C 7: 27,175,679 (GRCm39) S38P probably damaging Het
Sfrp4 G T 13: 19,807,610 (GRCm39) R3L unknown Het
Slc35a5 T C 16: 44,964,426 (GRCm39) E269G probably damaging Het
Snrnp200 G A 2: 127,076,993 (GRCm39) probably null Het
Sumo1 A G 1: 59,694,615 (GRCm39) probably null Het
Syne2 A G 12: 76,154,387 (GRCm39) K2020E probably damaging Het
Tcp10a A T 17: 7,601,740 (GRCm39) T247S probably benign Het
Tgds T C 14: 118,352,544 (GRCm39) D290G possibly damaging Het
Trav7d-3 A T 14: 52,982,054 (GRCm39) I32F possibly damaging Het
Vps41 A G 13: 19,046,913 (GRCm39) N788D Het
Zfp521 G A 18: 13,950,372 (GRCm39) T1194I probably damaging Het
Zmynd8 C A 2: 165,649,569 (GRCm39) K841N probably damaging Het
Other mutations in Cntln
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Cntln APN 4 84,924,671 (GRCm39) missense probably benign 0.25
IGL00743:Cntln APN 4 84,897,652 (GRCm39) missense probably benign 0.06
IGL01014:Cntln APN 4 84,968,145 (GRCm39) missense probably benign 0.25
IGL02217:Cntln APN 4 85,018,495 (GRCm39) missense probably damaging 1.00
IGL02323:Cntln APN 4 84,968,026 (GRCm39) missense probably benign 0.00
IGL02353:Cntln APN 4 84,968,087 (GRCm39) missense probably damaging 0.98
IGL02360:Cntln APN 4 84,968,087 (GRCm39) missense probably damaging 0.98
IGL02616:Cntln APN 4 85,033,689 (GRCm39) critical splice donor site probably null
PIT4696001:Cntln UTSW 4 84,892,237 (GRCm39) missense probably damaging 0.99
R0110:Cntln UTSW 4 85,014,994 (GRCm39) missense probably damaging 1.00
R0324:Cntln UTSW 4 85,010,932 (GRCm39) missense probably damaging 0.98
R0349:Cntln UTSW 4 84,914,722 (GRCm39) missense probably damaging 1.00
R0519:Cntln UTSW 4 84,923,290 (GRCm39) splice site probably benign
R0529:Cntln UTSW 4 84,986,062 (GRCm39) missense probably damaging 1.00
R0582:Cntln UTSW 4 84,802,978 (GRCm39) missense probably damaging 1.00
R1077:Cntln UTSW 4 84,914,716 (GRCm39) missense probably damaging 1.00
R1345:Cntln UTSW 4 84,892,228 (GRCm39) missense probably damaging 1.00
R1457:Cntln UTSW 4 85,015,076 (GRCm39) missense probably benign 0.33
R1571:Cntln UTSW 4 84,865,823 (GRCm39) nonsense probably null
R1622:Cntln UTSW 4 84,981,418 (GRCm39) missense probably damaging 1.00
R1681:Cntln UTSW 4 84,865,872 (GRCm39) missense probably damaging 1.00
R1777:Cntln UTSW 4 85,048,916 (GRCm39) missense probably benign 0.23
R1808:Cntln UTSW 4 85,015,000 (GRCm39) missense probably damaging 1.00
R1882:Cntln UTSW 4 85,019,072 (GRCm39) missense probably damaging 1.00
R2056:Cntln UTSW 4 84,967,911 (GRCm39) missense probably benign
R2965:Cntln UTSW 4 84,892,264 (GRCm39) critical splice donor site probably null
R2968:Cntln UTSW 4 84,875,504 (GRCm39) missense probably benign 0.27
R3104:Cntln UTSW 4 84,875,406 (GRCm39) missense possibly damaging 0.95
R3106:Cntln UTSW 4 84,875,406 (GRCm39) missense possibly damaging 0.95
R3121:Cntln UTSW 4 84,923,289 (GRCm39) splice site probably benign
R3617:Cntln UTSW 4 84,923,214 (GRCm39) nonsense probably null
R4009:Cntln UTSW 4 84,981,452 (GRCm39) missense probably benign 0.45
R4036:Cntln UTSW 4 84,924,725 (GRCm39) missense probably damaging 1.00
R4548:Cntln UTSW 4 85,015,079 (GRCm39) missense probably benign 0.27
R4592:Cntln UTSW 4 84,889,419 (GRCm39) missense probably benign 0.00
R4666:Cntln UTSW 4 84,889,453 (GRCm39) missense probably benign 0.13
R4826:Cntln UTSW 4 84,923,281 (GRCm39) missense probably benign 0.03
R4836:Cntln UTSW 4 84,967,957 (GRCm39) nonsense probably null
R4856:Cntln UTSW 4 84,889,466 (GRCm39) missense probably benign 0.35
R4886:Cntln UTSW 4 84,889,466 (GRCm39) missense probably benign 0.35
R4995:Cntln UTSW 4 84,968,120 (GRCm39) missense probably benign 0.00
R5090:Cntln UTSW 4 84,865,830 (GRCm39) missense probably damaging 0.98
R5202:Cntln UTSW 4 84,889,466 (GRCm39) missense probably benign 0.35
R5905:Cntln UTSW 4 84,889,410 (GRCm39) missense probably benign 0.03
R5953:Cntln UTSW 4 84,968,156 (GRCm39) missense possibly damaging 0.92
R6028:Cntln UTSW 4 84,889,410 (GRCm39) missense probably benign 0.03
R6298:Cntln UTSW 4 85,014,998 (GRCm39) missense probably damaging 1.00
R6351:Cntln UTSW 4 85,033,591 (GRCm39) missense probably damaging 0.99
R6371:Cntln UTSW 4 84,802,816 (GRCm39) missense probably damaging 0.98
R6481:Cntln UTSW 4 84,985,747 (GRCm39) missense probably benign 0.00
R6864:Cntln UTSW 4 85,015,029 (GRCm39) missense probably damaging 0.99
R6874:Cntln UTSW 4 84,985,996 (GRCm39) missense probably damaging 1.00
R6919:Cntln UTSW 4 85,033,605 (GRCm39) missense probably benign 0.04
R7071:Cntln UTSW 4 85,018,622 (GRCm39) missense probably damaging 1.00
R7113:Cntln UTSW 4 84,968,064 (GRCm39) missense probably damaging 0.98
R7152:Cntln UTSW 4 84,802,937 (GRCm39) missense possibly damaging 0.87
R7253:Cntln UTSW 4 85,036,710 (GRCm39) missense probably damaging 1.00
R7289:Cntln UTSW 4 84,964,540 (GRCm39) missense possibly damaging 0.80
R7440:Cntln UTSW 4 84,981,453 (GRCm39) missense possibly damaging 0.95
R7670:Cntln UTSW 4 84,897,577 (GRCm39) missense possibly damaging 0.66
R7707:Cntln UTSW 4 84,802,853 (GRCm39) missense probably damaging 1.00
R7895:Cntln UTSW 4 84,981,561 (GRCm39) missense possibly damaging 0.91
R8176:Cntln UTSW 4 84,806,926 (GRCm39) missense probably damaging 0.99
R8247:Cntln UTSW 4 85,019,017 (GRCm39) missense probably benign 0.39
R8264:Cntln UTSW 4 85,016,648 (GRCm39) missense probably damaging 1.00
R8293:Cntln UTSW 4 84,952,075 (GRCm39) missense probably damaging 1.00
R8536:Cntln UTSW 4 84,875,286 (GRCm39) missense probably damaging 1.00
R8844:Cntln UTSW 4 84,892,234 (GRCm39) missense probably damaging 1.00
R8924:Cntln UTSW 4 84,806,936 (GRCm39) missense probably damaging 1.00
R8955:Cntln UTSW 4 84,986,110 (GRCm39) missense possibly damaging 0.85
R8960:Cntln UTSW 4 85,018,961 (GRCm39) missense possibly damaging 0.59
R8979:Cntln UTSW 4 85,048,910 (GRCm39) missense probably damaging 1.00
R9255:Cntln UTSW 4 85,019,103 (GRCm39) missense possibly damaging 0.93
R9314:Cntln UTSW 4 84,924,719 (GRCm39) missense probably damaging 1.00
R9353:Cntln UTSW 4 84,802,597 (GRCm39) unclassified probably benign
R9361:Cntln UTSW 4 84,968,151 (GRCm39) missense probably benign 0.23
R9376:Cntln UTSW 4 84,875,258 (GRCm39) missense probably benign 0.24
R9382:Cntln UTSW 4 84,968,318 (GRCm39) missense probably benign 0.13
R9471:Cntln UTSW 4 84,968,019 (GRCm39) missense possibly damaging 0.62
R9527:Cntln UTSW 4 84,892,120 (GRCm39) missense probably damaging 1.00
R9788:Cntln UTSW 4 84,968,093 (GRCm39) missense probably damaging 1.00
R9793:Cntln UTSW 4 84,985,798 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCAATAACACGTTGTACATTTTG -3'
(R):5'- CTAATATCTTCTGTAGTTCTACATGCG -3'

Sequencing Primer
(F):5'- ATCACTTGTACATTGTGTCTAGTTG -3'
(R):5'- CTGTAGTTCTACATGCGTTTCC -3'
Posted On 2022-06-15