Mutagenetix > Incidental Mutation

Incidental Mutation 'R9071:Sult1e1'

716043

Institutional Source

Beutler Lab

Gene Symbol

Sult1e1

Ensembl Gene

ENSMUSG00000029272

Gene Name

sulfotransferase family 1E, member 1

Synonyms

EST, Ste

MMRRC Submission

068893-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R9071 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87723828-87739453 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to C at 87735681 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000031201 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031201]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000031201

SMART Domains

Protein: ENSMUSP00000031201
Gene: ENSMUSG00000029272

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	38	288	1.1e-91	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

100% (52/52)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice exhibit reduced fertility. Males exhibit abnormal testis morphology with Leydig cell hypertrophy and hyperplasia and reduced caudal sperm motility. Spontaneous fetal loss caused by placental thrombosis occurs in pregnant females. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	G	T	7: 41,274,783 (GRCm39)	R162L	probably benign	Het
Alpi	A	G	1: 87,026,584 (GRCm39)	V469A	probably damaging	Het
Amotl2	G	T	9: 102,595,892 (GRCm39)		probably benign	Het
Ano3	T	A	2: 110,625,418 (GRCm39)		probably null	Het
Atg16l1	G	T	1: 87,683,907 (GRCm39)		probably benign	Het
Atg2b	C	A	12: 105,625,099 (GRCm39)	E626*	probably null	Het
B3galt9	T	C	2: 34,728,435 (GRCm39)	V78A	probably benign	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,128,173 (GRCm39)		probably benign	Het
Ccdc162	G	A	10: 41,457,174 (GRCm39)	Q1588*	probably null	Het
Cd3d	A	T	9: 44,896,340 (GRCm39)	H43L	probably benign	Het
Cenpk	C	T	13: 104,378,870 (GRCm39)	Q164*	probably null	Het
Clybl	C	A	14: 122,608,697 (GRCm39)	D96E	probably benign	Het
Cog1	T	C	11: 113,546,939 (GRCm39)	V511A	probably damaging	Het
Crhr1	T	A	11: 104,064,133 (GRCm39)	I282N	probably damaging	Het
Crybg2	A	G	4: 133,818,542 (GRCm39)	N1433D	probably damaging	Het
Cspp1	A	T	1: 10,159,121 (GRCm39)	I516F	possibly damaging	Het
Cul9	T	C	17: 46,837,379 (GRCm39)	T1030A	probably benign	Het
Cyp2d10	T	C	15: 82,288,361 (GRCm39)	T313A	probably damaging	Het
Ddx11	T	A	17: 66,450,736 (GRCm39)	N549K	probably damaging	Het
Ddx41	A	G	13: 55,680,219 (GRCm39)	V391A	probably damaging	Het
Eif3a	T	C	19: 60,751,634 (GRCm39)	D1227G	unknown	Het
Fam83f	T	C	15: 80,576,206 (GRCm39)	Y286H	probably damaging	Het
Fasn	T	C	11: 120,708,324 (GRCm39)	D647G	probably damaging	Het
Fat4	T	C	3: 39,037,598 (GRCm39)	V3750A	probably benign	Het
Golga2	T	C	2: 32,178,364 (GRCm39)	S14P	probably damaging	Het
Hgsnat	A	G	8: 26,436,302 (GRCm39)	V584A	possibly damaging	Het
Ifi207	A	T	1: 173,557,764 (GRCm39)	F325I	unknown	Het
Igfals	A	T	17: 25,099,670 (GRCm39)	I254F	probably damaging	Het
Matr3	T	C	18: 35,705,803 (GRCm39)	Y243H	possibly damaging	Het
Mki67	G	C	7: 135,301,205 (GRCm39)	D1276E	probably benign	Het
Moap1	T	A	12: 102,709,364 (GRCm39)	K62*	probably null	Het
Msto1	C	A	3: 88,812,414 (GRCm39)		probably benign	Het
Myt1	A	T	2: 181,448,420 (GRCm39)	D697V	possibly damaging	Het
Nampt	T	A	12: 32,892,781 (GRCm39)	V356E	probably damaging	Het
Nell2	T	A	15: 95,244,682 (GRCm39)	K472*	probably null	Het
Nfe2l3	A	C	6: 51,434,243 (GRCm39)	S268R	probably benign	Het
Or8b43	T	C	9: 38,361,032 (GRCm39)	I288T	possibly damaging	Het
Osbpl10	G	T	9: 114,890,908 (GRCm39)	V99L	probably benign	Het
Plod2	A	G	9: 92,485,048 (GRCm39)	I537M	probably benign	Het
Prdm4	A	G	10: 85,729,076 (GRCm39)	L770P	probably benign	Het
Prr27	C	A	5: 87,990,994 (GRCm39)	P202Q	probably benign	Het
Scaper	T	C	9: 55,771,803 (GRCm39)	D371G	probably benign	Het
Sema3e	A	G	5: 14,282,154 (GRCm39)	K430R	probably benign	Het
Sez6l	A	T	5: 112,573,603 (GRCm39)		probably benign	Het
Slco1a5	A	T	6: 142,196,052 (GRCm39)	I317N	possibly damaging	Het
Spata4	T	G	8: 55,055,742 (GRCm39)	F211C	probably damaging	Het
Sspo	A	G	6: 48,433,982 (GRCm39)	E929G	probably benign	Het
Tas2r125	A	T	6: 132,887,400 (GRCm39)	N263Y	probably benign	Het
Ugt3a1	T	A	15: 9,370,224 (GRCm39)	L456*	probably null	Het
Wdr20rt	G	A	12: 65,274,222 (GRCm39)	V562I	probably benign	Het
Zc3h7b	T	C	15: 81,677,964 (GRCm39)	*983Q	probably null	Het
Zfp28	T	A	7: 6,397,544 (GRCm39)	C660S	probably damaging	Het

Other mutations in Sult1e1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01504:Sult1e1	APN	5	87,724,160 (GRCm39)	missense	probably damaging	1.00
IGL01588:Sult1e1	APN	5	87,724,102 (GRCm39)	missense	probably benign	0.01
IGL02685:Sult1e1	APN	5	87,727,765 (GRCm39)	nonsense	probably null
IGL03083:Sult1e1	APN	5	87,737,983 (GRCm39)	missense	probably benign
IGL03137:Sult1e1	APN	5	87,726,475 (GRCm39)	missense	probably benign	0.00
IGL03217:Sult1e1	APN	5	87,737,947 (GRCm39)	missense	possibly damaging	0.46
R0069:Sult1e1	UTSW	5	87,727,756 (GRCm39)	missense	probably damaging	1.00
R0069:Sult1e1	UTSW	5	87,727,756 (GRCm39)	missense	probably damaging	1.00
R0456:Sult1e1	UTSW	5	87,726,493 (GRCm39)	missense	possibly damaging	0.86
R1446:Sult1e1	UTSW	5	87,726,396 (GRCm39)	missense	probably damaging	1.00
R1953:Sult1e1	UTSW	5	87,735,530 (GRCm39)	critical splice acceptor site	probably null
R2697:Sult1e1	UTSW	5	87,726,397 (GRCm39)	missense	probably damaging	1.00
R4791:Sult1e1	UTSW	5	87,734,589 (GRCm39)	missense	possibly damaging	0.61
R4799:Sult1e1	UTSW	5	87,738,027 (GRCm39)	missense	possibly damaging	0.70
R5103:Sult1e1	UTSW	5	87,724,091 (GRCm39)	missense	probably benign
R5158:Sult1e1	UTSW	5	87,735,453 (GRCm39)	missense	probably damaging	1.00
R5219:Sult1e1	UTSW	5	87,726,445 (GRCm39)	missense	probably damaging	0.98
R6148:Sult1e1	UTSW	5	87,727,770 (GRCm39)	missense	probably damaging	1.00
R6530:Sult1e1	UTSW	5	87,724,147 (GRCm39)	missense	probably benign	0.18
R6866:Sult1e1	UTSW	5	87,734,625 (GRCm39)	missense	probably damaging	1.00
R7295:Sult1e1	UTSW	5	87,726,512 (GRCm39)	nonsense	probably null
R8812:Sult1e1	UTSW	5	87,735,501 (GRCm39)	missense	probably benign
R8890:Sult1e1	UTSW	5	87,727,719 (GRCm39)	missense	probably benign	0.01
R9252:Sult1e1	UTSW	5	87,737,973 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AACTTCACTAATCCAGGTGGTACC -3'
(R):5'- CCCAAGTTTCACCACTTAGTCAAG -3'

Sequencing Primer
(F):5'- TGGTACCTGTAACAATTAAATATGCC -3'
(R):5'- CTTTAATCTCAGCACTCGGGAGG -3'

Posted On

2022-07-01