Incidental Mutation 'R9479:Klf11'
ID 716137
Institutional Source Beutler Lab
Gene Symbol Klf11
Ensembl Gene ENSMUSG00000020653
Gene Name Kruppel-like transcription factor 11
Synonyms D12Ertd427e, Tieg3, Tieg2, Tieg2b
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9479 (G1)
Quality Score 225.009
Status Not validated
Chromosome 12
Chromosomal Location 24701370-24712781 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 24705029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 161 (M161T)
Ref Sequence ENSEMBL: ENSMUSP00000020982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020982] [ENSMUST00000139940] [ENSMUST00000144046] [ENSMUST00000146894]
AlphaFold Q8K1S5
Predicted Effect probably benign
Transcript: ENSMUST00000020982
AA Change: M161T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000020982
Gene: ENSMUSG00000020653
AA Change: M161T

DomainStartEndE-ValueType
low complexity region 267 275 N/A INTRINSIC
low complexity region 356 367 N/A INTRINSIC
ZnF_C2H2 384 408 5.9e-3 SMART
ZnF_C2H2 414 438 9.22e-5 SMART
ZnF_C2H2 444 466 1.38e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139940
Predicted Effect probably benign
Transcript: ENSMUST00000144046
AA Change: M144T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000146894
AA Change: M144T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox3 A G 1: 58,177,568 (GRCm39) Y261C probably benign Het
Arhgef10 T C 8: 15,047,632 (GRCm39) V1165A probably damaging Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Bhmt2 G A 13: 93,799,833 (GRCm39) A201V probably damaging Het
Ccdc115 A T 1: 34,476,895 (GRCm39) S115T possibly damaging Het
Clca4b A G 3: 144,617,100 (GRCm39) V850A probably benign Het
Commd8 A T 5: 72,318,350 (GRCm39) H144Q probably benign Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Csnka2ip T C 16: 64,298,262 (GRCm39) K701E unknown Het
Cyb5d2 A G 11: 72,669,702 (GRCm39) C219R Het
Ep400 T C 5: 110,877,730 (GRCm39) T835A unknown Het
Fam169a A G 13: 97,246,543 (GRCm39) Y228C possibly damaging Het
Fam169a A G 13: 97,250,695 (GRCm39) D342G possibly damaging Het
Fbxw21 A T 9: 108,968,612 (GRCm39) C455S probably benign Het
Fbxw26 A G 9: 109,561,625 (GRCm39) S190P probably damaging Het
Gabra5 A G 7: 57,058,440 (GRCm39) I436T Het
Gm9767 G A 10: 25,954,916 (GRCm39) G156D Het
Grid1 G A 14: 35,043,664 (GRCm39) D340N probably damaging Het
Gsn T C 2: 35,186,227 (GRCm39) probably null Het
Hao1 A G 2: 134,396,204 (GRCm39) S17P probably benign Het
Hspa1l A G 17: 35,196,735 (GRCm39) N258S probably benign Het
Isyna1 C T 8: 71,048,193 (GRCm39) R200C probably damaging Het
Itgb2 A T 10: 77,396,942 (GRCm39) K659M probably benign Het
Ktn1 A T 14: 47,962,174 (GRCm39) K1114N probably damaging Het
Lonrf1 G A 8: 36,697,668 (GRCm39) R439* probably null Het
Lrrc26 C T 2: 25,180,571 (GRCm39) P191S probably benign Het
Ogdh T C 11: 6,297,854 (GRCm39) I576T possibly damaging Het
Or10al4 T C 17: 38,036,986 (GRCm39) S24P probably damaging Het
Or14c45 T C 7: 86,176,285 (GRCm39) C107R possibly damaging Het
Or14j4 A G 17: 37,920,718 (GRCm39) F308S probably damaging Het
Or4k40 A T 2: 111,251,013 (GRCm39) F94L probably damaging Het
Or4p20 T C 2: 88,253,677 (GRCm39) R231G probably damaging Het
Or7g20 G A 9: 18,946,730 (GRCm39) V104I probably benign Het
Pcnt A G 10: 76,217,963 (GRCm39) V2104A probably benign Het
Pds5a G A 5: 65,792,747 (GRCm39) R729W probably damaging Het
Pgap1 G A 1: 54,582,275 (GRCm39) Q191* probably null Het
Pglyrp3 A G 3: 91,935,310 (GRCm39) I187V probably benign Het
Pkdrej T A 15: 85,699,571 (GRCm39) I2122F possibly damaging Het
Pold1 G A 7: 44,191,079 (GRCm39) R251W probably damaging Het
Prr22 A G 17: 57,078,335 (GRCm39) M163V probably benign Het
Ptprc A T 1: 138,001,388 (GRCm39) N814K probably benign Het
Rapgef2 G A 3: 79,019,495 (GRCm39) L59F probably damaging Het
Rbm22 T C 18: 60,699,492 (GRCm39) L147P probably damaging Het
Rgsl1 G A 1: 153,657,445 (GRCm39) S391F unknown Het
Rnf13 A T 3: 57,727,983 (GRCm39) D221V possibly damaging Het
Senp2 T A 16: 21,842,398 (GRCm39) L154Q probably damaging Het
Srfbp1 A G 18: 52,621,332 (GRCm39) Q131R possibly damaging Het
Tmprss11a A T 5: 86,562,402 (GRCm39) Y314* probably null Het
Ttn G T 2: 76,666,286 (GRCm39) P11590Q unknown Het
Txnrd3 C T 6: 89,640,084 (GRCm39) T266M possibly damaging Het
Zfp810 T C 9: 22,194,497 (GRCm39) S64G possibly damaging Het
Other mutations in Klf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01630:Klf11 APN 12 24,710,368 (GRCm39) missense probably benign 0.01
IGL02202:Klf11 APN 12 24,703,631 (GRCm39) missense probably benign 0.37
IGL02527:Klf11 APN 12 24,705,322 (GRCm39) missense probably benign 0.31
IGL02964:Klf11 APN 12 24,705,626 (GRCm39) missense probably damaging 1.00
R0254:Klf11 UTSW 12 24,703,582 (GRCm39) missense probably damaging 1.00
R0553:Klf11 UTSW 12 24,705,089 (GRCm39) missense probably benign 0.12
R0739:Klf11 UTSW 12 24,710,247 (GRCm39) missense probably damaging 1.00
R1584:Klf11 UTSW 12 24,705,304 (GRCm39) missense probably damaging 1.00
R1592:Klf11 UTSW 12 24,703,737 (GRCm39) missense probably damaging 1.00
R2356:Klf11 UTSW 12 24,703,582 (GRCm39) missense probably damaging 1.00
R3085:Klf11 UTSW 12 24,705,490 (GRCm39) missense probably benign
R4690:Klf11 UTSW 12 24,705,071 (GRCm39) missense probably damaging 0.97
R5023:Klf11 UTSW 12 24,705,358 (GRCm39) missense probably benign 0.00
R5483:Klf11 UTSW 12 24,705,410 (GRCm39) nonsense probably null
R5528:Klf11 UTSW 12 24,704,929 (GRCm39) missense probably benign 0.00
R6148:Klf11 UTSW 12 24,701,567 (GRCm39) critical splice donor site probably null
R6698:Klf11 UTSW 12 24,703,618 (GRCm39) missense probably damaging 1.00
R6799:Klf11 UTSW 12 24,705,638 (GRCm39) missense possibly damaging 0.59
R7317:Klf11 UTSW 12 24,705,518 (GRCm39) missense possibly damaging 0.59
R7384:Klf11 UTSW 12 24,703,742 (GRCm39) missense probably damaging 0.97
R7440:Klf11 UTSW 12 24,705,490 (GRCm39) missense probably benign
R7473:Klf11 UTSW 12 24,705,141 (GRCm39) splice site probably null
R7477:Klf11 UTSW 12 24,703,562 (GRCm39) missense probably benign 0.01
R7658:Klf11 UTSW 12 24,703,670 (GRCm39) missense probably damaging 1.00
R9378:Klf11 UTSW 12 24,705,043 (GRCm39) missense probably benign 0.01
R9663:Klf11 UTSW 12 24,705,731 (GRCm39) missense probably damaging 1.00
R9721:Klf11 UTSW 12 24,710,240 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAACCTTTGATGTGGTGCTG -3'
(R):5'- ACCAAGTTAGTGACGAGTAAGCC -3'

Sequencing Primer
(F):5'- AGTGTATAACTCCTCCTCAGAGC -3'
(R):5'- TAAGCCATTTGCCAAGCGTG -3'
Posted On 2022-07-18