Incidental Mutation 'R9480:Zpld2'
ID 716168
Institutional Source Beutler Lab
Gene Symbol Zpld2
Ensembl Gene ENSMUSG00000073747
Gene Name zona pellucida like domain containing 2
Synonyms Gm7534
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R9480 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 133918115-133930315 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 133929312 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 331 (P331L)
Ref Sequence ENSEMBL: ENSMUSP00000095461 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097849]
AlphaFold Q3UU21
Predicted Effect probably benign
Transcript: ENSMUST00000097849
AA Change: P331L

PolyPhen 2 Score 0.361 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000095461
Gene: ENSMUSG00000073747
AA Change: P331L

DomainStartEndE-ValueType
low complexity region 1 16 N/A INTRINSIC
internal_repeat_1 21 111 5.47e-40 PROSPERO
low complexity region 112 143 N/A INTRINSIC
low complexity region 158 177 N/A INTRINSIC
internal_repeat_1 181 271 5.47e-40 PROSPERO
low complexity region 322 334 N/A INTRINSIC
ZP 368 618 3.21e-13 SMART
low complexity region 650 668 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T A 16: 14,211,889 (GRCm39) W142R probably damaging Het
Abcc6 A G 7: 45,629,197 (GRCm39) S1350P probably damaging Het
Abraxas2 G T 7: 132,473,323 (GRCm39) V84L probably benign Het
Adam12 T A 7: 133,736,470 (GRCm39) I81F probably damaging Het
Adam22 A G 5: 8,193,077 (GRCm39) V376A probably benign Het
Anapc11 T A 11: 120,496,176 (GRCm39) I60N probably damaging Het
Apcdd1 C T 18: 63,055,731 (GRCm39) probably benign Het
Atrnl1 T A 19: 57,690,420 (GRCm39) V876E possibly damaging Het
Bcar3 C T 3: 122,277,618 (GRCm39) R21* probably null Het
Calb1 T A 4: 15,885,608 (GRCm39) S60T probably benign Het
Ceacam9 A G 7: 16,457,783 (GRCm39) T99A probably damaging Het
Cemip2 C A 19: 21,775,622 (GRCm39) H288Q possibly damaging Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Cnot1 T C 8: 96,497,338 (GRCm39) D213G possibly damaging Het
Col23a1 T A 11: 51,207,774 (GRCm39) C105S unknown Het
Cxcl2 T C 5: 91,052,029 (GRCm39) V45A possibly damaging Het
Ddx21 T C 10: 62,434,652 (GRCm39) T36A probably benign Het
Dlgap4 G T 2: 156,546,514 (GRCm39) R394L possibly damaging Het
Dus2 C T 8: 106,757,052 (GRCm39) Q81* probably null Het
Fat3 T C 9: 15,942,703 (GRCm39) D1223G probably damaging Het
Fgf3 G T 7: 144,396,619 (GRCm39) R211L possibly damaging Het
Galnt17 T A 5: 130,935,576 (GRCm39) E369V probably damaging Het
Gatad2a T C 8: 70,388,459 (GRCm39) D76G probably damaging Het
Gin1 A G 1: 97,705,198 (GRCm39) E96G probably damaging Het
Gpr55 A C 1: 85,868,977 (GRCm39) Y201* probably null Het
Hgsnat T C 8: 26,442,029 (GRCm39) N499D possibly damaging Het
Hipk2 G T 6: 38,680,377 (GRCm39) P988T probably benign Het
Hivep1 A T 13: 42,337,058 (GRCm39) Q2379L probably damaging Het
Kat14 T A 2: 144,215,745 (GRCm39) C77S probably damaging Het
Klhl25 T C 7: 75,516,120 (GRCm39) V342A probably damaging Het
Krt35 T C 11: 99,986,609 (GRCm39) Q135R probably benign Het
Lhfpl2 T A 13: 94,310,733 (GRCm39) M1K probably null Het
Lipk T A 19: 33,999,101 (GRCm39) L132Q probably damaging Het
Lrrc39 T A 3: 116,359,475 (GRCm39) C7S probably benign Het
Ltb4r2 T A 14: 56,000,089 (GRCm39) W237R probably damaging Het
Mesp2 A G 7: 79,461,034 (GRCm39) I120V probably damaging Het
Mfsd6 A G 1: 52,699,835 (GRCm39) V771A unknown Het
Mtfmt A T 9: 65,351,181 (GRCm39) T243S possibly damaging Het
Nlrp12 A T 7: 3,288,993 (GRCm39) C506* probably null Het
Ntng2 T A 2: 29,137,997 (GRCm39) Y19F probably damaging Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Orc4 T C 2: 48,795,563 (GRCm39) T388A probably benign Het
P4hb A T 11: 120,463,551 (GRCm39) V28D probably damaging Het
Phkb T G 8: 86,684,216 (GRCm39) S424R probably benign Het
Poldip2 T C 11: 78,411,988 (GRCm39) L308S probably damaging Het
Prkd1 T A 12: 50,435,283 (GRCm39) E481D probably benign Het
Serping1 C T 2: 84,600,487 (GRCm39) S285N probably benign Het
Sh2d2a A C 3: 87,759,638 (GRCm39) I350L probably benign Het
Siglecf G T 7: 43,001,666 (GRCm39) V159L possibly damaging Het
Sspo A G 6: 48,470,820 (GRCm39) N36S probably damaging Het
Sytl2 C T 7: 90,020,718 (GRCm39) T147M possibly damaging Het
Tmc7 A G 7: 118,141,226 (GRCm39) F635S probably benign Het
Tmco1 C T 1: 167,157,757 (GRCm39) L175F Het
Ttc39d A G 17: 80,524,139 (GRCm39) H266R probably benign Het
Usp33 T G 3: 152,079,086 (GRCm39) I446R possibly damaging Het
Usp48 G A 4: 137,340,996 (GRCm39) G332E probably benign Het
Zbtb49 T A 5: 38,358,409 (GRCm39) T615S possibly damaging Het
Zbtb8a G T 4: 129,253,875 (GRCm39) H206Q probably benign Het
Zfp180 A G 7: 23,804,628 (GRCm39) N349S probably benign Het
Zfp345 A T 2: 150,315,212 (GRCm39) C108* probably null Het
Zfp420 T A 7: 29,575,497 (GRCm39) H572Q probably benign Het
Zfp423 A G 8: 88,631,115 (GRCm39) probably null Het
Zfp820 T A 17: 22,037,994 (GRCm39) T445S possibly damaging Het
Zim1 T C 7: 6,681,050 (GRCm39) I204M probably benign Het
Other mutations in Zpld2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02183:Zpld2 APN 4 133,929,291 (GRCm39) missense probably benign 0.27
IGL03170:Zpld2 APN 4 133,920,345 (GRCm39) missense possibly damaging 0.57
FR4342:Zpld2 UTSW 4 133,929,942 (GRCm39) small insertion probably benign
FR4976:Zpld2 UTSW 4 133,929,941 (GRCm39) small insertion probably benign
R0487:Zpld2 UTSW 4 133,930,089 (GRCm39) missense probably damaging 0.97
R0530:Zpld2 UTSW 4 133,930,221 (GRCm39) missense probably benign
R0553:Zpld2 UTSW 4 133,929,829 (GRCm39) missense possibly damaging 0.85
R1121:Zpld2 UTSW 4 133,930,248 (GRCm39) missense probably benign 0.00
R1458:Zpld2 UTSW 4 133,924,144 (GRCm39) missense probably benign 0.01
R1748:Zpld2 UTSW 4 133,929,430 (GRCm39) missense possibly damaging 0.57
R1748:Zpld2 UTSW 4 133,927,610 (GRCm39) missense probably damaging 1.00
R1913:Zpld2 UTSW 4 133,919,986 (GRCm39) critical splice donor site probably null
R2029:Zpld2 UTSW 4 133,929,669 (GRCm39) missense possibly damaging 0.87
R2069:Zpld2 UTSW 4 133,929,252 (GRCm39) missense possibly damaging 0.63
R2237:Zpld2 UTSW 4 133,929,516 (GRCm39) missense unknown
R2239:Zpld2 UTSW 4 133,929,516 (GRCm39) missense unknown
R3943:Zpld2 UTSW 4 133,927,656 (GRCm39) missense probably benign 0.15
R4646:Zpld2 UTSW 4 133,929,459 (GRCm39) missense probably benign 0.00
R4673:Zpld2 UTSW 4 133,927,658 (GRCm39) missense probably benign 0.01
R4838:Zpld2 UTSW 4 133,920,410 (GRCm39) missense probably benign 0.04
R5002:Zpld2 UTSW 4 133,924,231 (GRCm39) missense probably benign 0.09
R5593:Zpld2 UTSW 4 133,920,350 (GRCm39) missense probably damaging 0.99
R5606:Zpld2 UTSW 4 133,927,523 (GRCm39) missense probably benign 0.13
R6553:Zpld2 UTSW 4 133,929,367 (GRCm39) missense probably damaging 0.99
R6834:Zpld2 UTSW 4 133,920,476 (GRCm39) missense possibly damaging 0.95
R6931:Zpld2 UTSW 4 133,920,464 (GRCm39) missense probably benign 0.28
R7526:Zpld2 UTSW 4 133,927,384 (GRCm39) splice site probably null
R7771:Zpld2 UTSW 4 133,922,754 (GRCm39) missense probably benign 0.01
R8271:Zpld2 UTSW 4 133,930,278 (GRCm39) missense unknown
R8725:Zpld2 UTSW 4 133,930,150 (GRCm39) missense probably benign 0.19
R8727:Zpld2 UTSW 4 133,930,150 (GRCm39) missense probably benign 0.19
R8757:Zpld2 UTSW 4 133,930,282 (GRCm39) missense unknown
R8966:Zpld2 UTSW 4 133,929,712 (GRCm39) missense probably damaging 0.98
R8992:Zpld2 UTSW 4 133,929,978 (GRCm39) missense probably damaging 0.99
R9039:Zpld2 UTSW 4 133,922,858 (GRCm39) missense probably damaging 0.98
R9275:Zpld2 UTSW 4 133,922,770 (GRCm39) missense probably damaging 1.00
R9278:Zpld2 UTSW 4 133,922,770 (GRCm39) missense probably damaging 1.00
R9434:Zpld2 UTSW 4 133,929,553 (GRCm39) missense probably benign 0.01
R9458:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9460:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9461:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9481:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9551:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9552:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
R9553:Zpld2 UTSW 4 133,929,312 (GRCm39) missense probably benign 0.36
RF015:Zpld2 UTSW 4 133,920,338 (GRCm39) missense probably benign
T0975:Zpld2 UTSW 4 133,929,940 (GRCm39) small insertion probably benign
Z1176:Zpld2 UTSW 4 133,929,988 (GRCm39) missense probably benign
Z1176:Zpld2 UTSW 4 133,927,649 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CCGGCCATTTATCTGGTTTG -3'
(R):5'- AGGCCCCACAACAATGAGTATG -3'

Sequencing Primer
(F):5'- GTGTTACTCCATGTTATCCATACAC -3'
(R):5'- CACAACAATGAGTATGTCACCTG -3'
Posted On 2022-07-18