Mutagenetix > Incidental Mutation

Incidental Mutation 'R9481:Scgb2b24'

716244

Institutional Source

Beutler Lab

Gene Symbol

Scgb2b24

Ensembl Gene

ENSMUSG00000046438

Gene Name

secretoglobin, family 2B, member 24

Synonyms

Abpz, Abpbg24, C2b, Scgb2b3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R9481 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

33436618-33438720 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33436795 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Isoleucine at position 106 (L106I)

Ref Sequence

ENSEMBL: ENSMUSP00000052456 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055444]

AlphaFold

Q7M747

Predicted Effect

probably benign
Transcript: ENSMUST00000055444
AA Change: L106I

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000052456
Gene: ENSMUSG00000046438
AA Change: L106I

Domain	Start	End	E-Value	Type
low complexity region	5	11	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	5.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb9	T	C	5: 124,228,176 (GRCm39)	T22A	possibly damaging	Het
Acsf2	C	T	11: 94,464,044 (GRCm39)	V47M	probably benign	Het
Ahcyl1	A	T	3: 107,579,388 (GRCm39)	C215*	probably null	Het
Ambn	G	T	5: 88,613,050 (GRCm39)		probably null	Het
Apol9b	G	T	15: 77,619,656 (GRCm39)	V151L	probably benign	Het
Arid1b	A	G	17: 5,369,007 (GRCm39)	Y1070C	probably damaging	Het
Arnt	T	C	3: 95,391,092 (GRCm39)	L322P	possibly damaging	Het
Bdnf	A	G	2: 109,553,935 (GRCm39)	D103G	possibly damaging	Het
Ccdc9	A	T	7: 16,016,761 (GRCm39)	D42E	probably damaging	Het
Cdh13	A	G	8: 119,963,676 (GRCm39)	T419A		Het
Chst13	G	A	6: 90,286,506 (GRCm39)	P152L	probably damaging	Het
Clasp2	A	T	9: 113,670,669 (GRCm39)	R329W	probably damaging	Het
Csmd3	A	G	15: 47,470,459 (GRCm39)	C2495R		Het
Cyba	A	T	8: 123,154,394 (GRCm39)	I43N	possibly damaging	Het
Cyp2a5	A	C	7: 26,540,511 (GRCm39)	T375P	possibly damaging	Het
Cyp2r1	A	G	7: 114,152,369 (GRCm39)	F196S	probably damaging	Het
Efcab2	T	C	1: 178,308,887 (GRCm39)	F130S	probably damaging	Het
Eml6	T	G	11: 29,788,641 (GRCm39)		probably null	Het
Fbln5	A	T	12: 101,734,728 (GRCm39)	C181*	probably null	Het
Glyatl3	A	G	17: 41,221,016 (GRCm39)	V117A	probably benign	Het
Gpc6	A	G	14: 117,163,432 (GRCm39)	S29G	probably benign	Het
Hadhb	T	G	5: 30,368,711 (GRCm39)	S13A	probably benign	Het
Hook1	C	T	4: 95,901,505 (GRCm39)	R488C	probably damaging	Het
Icam5	A	G	9: 20,948,877 (GRCm39)	Y743C	probably damaging	Het
Il15ra	T	C	2: 11,724,854 (GRCm39)	V108A	probably benign	Het
Itga1	T	C	13: 115,152,753 (GRCm39)	N223S	probably benign	Het
Kat6b	AGAGGAGGAGGAGGAGGAGGA	AGAGGAGGAGGAGGAGGA	14: 21,712,417 (GRCm39)		probably benign	Het
Kcnk1	T	C	8: 126,756,281 (GRCm39)	C268R	probably damaging	Het
Kctd19	A	T	8: 106,120,249 (GRCm39)	L264M	probably benign	Het
Kmt2c	A	T	5: 25,554,860 (GRCm39)	I1258K	probably benign	Het
Kmt2c	A	T	5: 25,497,907 (GRCm39)	D3949E	probably damaging	Het
Lyst	G	A	13: 13,857,653 (GRCm39)	E2481K	possibly damaging	Het
Megf10	T	A	18: 57,395,090 (GRCm39)	I484N	probably benign	Het
Mettl21e	T	C	1: 44,245,857 (GRCm39)	I130V	probably benign	Het
Nmnat2	C	A	1: 152,962,181 (GRCm39)	N140K	possibly damaging	Het
Nsmaf	T	C	4: 6,414,976 (GRCm39)	K630R	probably benign	Het
Or2t1	C	T	14: 14,328,756 (GRCm38)	S215L	probably benign	Het
Or5w15	A	T	2: 87,568,576 (GRCm39)	F31I	probably benign	Het
Or8b38	G	T	9: 37,972,707 (GRCm39)	L30F	probably benign	Het
Or8g26	T	C	9: 39,096,172 (GRCm39)	S230P	possibly damaging	Het
Pafah1b2	G	A	9: 45,884,284 (GRCm39)	Q123*	probably null	Het
Ptprb	T	A	10: 116,155,353 (GRCm39)	N415K	probably benign	Het
Rev3l	T	A	10: 39,701,033 (GRCm39)	D1843E	probably benign	Het
Rps6ka4	T	A	19: 6,809,372 (GRCm39)	R427S	possibly damaging	Het
Skint9	A	T	4: 112,248,915 (GRCm39)	M171K	probably benign	Het
Spata17	A	G	1: 186,844,756 (GRCm39)	V281A	possibly damaging	Het
Spef1	A	T	2: 131,014,625 (GRCm39)	V99E	probably damaging	Het
Srpra	C	T	9: 35,126,015 (GRCm39)	T431I	probably damaging	Het
Stk32c	G	A	7: 138,768,173 (GRCm39)	P36L	unknown	Het
Taar7d	T	C	10: 23,903,739 (GRCm39)	I207T	probably benign	Het
Tle1	G	A	4: 72,044,504 (GRCm39)	T501I	probably damaging	Het
Tmem88b	A	T	4: 155,868,733 (GRCm39)	W172R	probably damaging	Het
Usp48	G	A	4: 137,340,996 (GRCm39)	G332E	probably benign	Het
Vcl	G	T	14: 21,070,726 (GRCm39)	V771L	probably benign	Het
Vmn1r200	T	A	13: 22,579,911 (GRCm39)	M238K	probably damaging	Het
Vmn2r96	A	G	17: 18,793,621 (GRCm39)		probably benign	Het
Vsig10l	G	T	7: 43,112,795 (GRCm39)	E18*	probably null	Het
Wdfy3	A	G	5: 102,000,478 (GRCm39)	L2964P	probably benign	Het
Zfp334	G	A	2: 165,222,271 (GRCm39)	R591W	probably damaging	Het
Zpld2	G	A	4: 133,929,312 (GRCm39)	P331L	probably benign	Het

Other mutations in Scgb2b24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01825:Scgb2b24	APN	7	33,438,652 (GRCm39)	missense	probably damaging	0.97
IGL02328:Scgb2b24	APN	7	33,438,050 (GRCm39)	splice site	probably benign
PIT4618001:Scgb2b24	UTSW	7	33,438,036 (GRCm39)	missense	probably damaging	0.96
R3441:Scgb2b24	UTSW	7	33,438,025 (GRCm39)	missense	probably damaging	1.00
R5874:Scgb2b24	UTSW	7	33,436,830 (GRCm39)	missense	probably damaging	0.99
R6572:Scgb2b24	UTSW	7	33,437,902 (GRCm39)	missense	probably damaging	1.00
R6800:Scgb2b24	UTSW	7	33,437,894 (GRCm39)	missense	probably benign	0.01
R7431:Scgb2b24	UTSW	7	33,438,674 (GRCm39)	missense	probably benign	0.13
R8096:Scgb2b24	UTSW	7	33,438,646 (GRCm39)	splice site	probably null
R8458:Scgb2b24	UTSW	7	33,436,779 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCCTCTGAAGACCTTGTTCATAGAG -3'
(R):5'- TCTTTCCTGTGGACAAGGAGC -3'

Sequencing Primer
(F):5'- ACCTTGTTCATAGAGACGGGGC -3'
(R):5'- GGACAAGGAGCAGTCTTTTTC -3'

Posted On

2022-07-18