Mutagenetix > Incidental Mutation

Incidental Mutation 'R9481:Or8g26'

716255

Institutional Source

Beutler Lab

Gene Symbol

Or8g26

Ensembl Gene

ENSMUSG00000094970

Gene Name

olfactory receptor family 8 subfamily G member 26

Synonyms

MOR171-44, GA_x6K02T2PVTD-32881408-32882343, Olfr943

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R9481 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

39077606-39096420 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39096172 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 230 (S230P)

Ref Sequence

ENSEMBL: ENSMUSP00000148896 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071617] [ENSMUST00000213176] [ENSMUST00000213507] [ENSMUST00000213830] [ENSMUST00000215770]

AlphaFold

Q9EQ92

Predicted Effect

probably damaging
Transcript: ENSMUST00000071617
AA Change: S233P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000071545
Gene: ENSMUSG00000094970
AA Change: S233P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	27	183	9.4e-7	PFAM
Pfam:7tm_4	34	311	7.4e-55	PFAM
Pfam:7tm_1	44	293	6.9e-24	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213176
AA Change: S230P

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213507
AA Change: S230P

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213830
AA Change: S230P

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215770
AA Change: S230P

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb9	T	C	5: 124,228,176 (GRCm39)	T22A	possibly damaging	Het
Acsf2	C	T	11: 94,464,044 (GRCm39)	V47M	probably benign	Het
Ahcyl1	A	T	3: 107,579,388 (GRCm39)	C215*	probably null	Het
Ambn	G	T	5: 88,613,050 (GRCm39)		probably null	Het
Apol9b	G	T	15: 77,619,656 (GRCm39)	V151L	probably benign	Het
Arid1b	A	G	17: 5,369,007 (GRCm39)	Y1070C	probably damaging	Het
Arnt	T	C	3: 95,391,092 (GRCm39)	L322P	possibly damaging	Het
Bdnf	A	G	2: 109,553,935 (GRCm39)	D103G	possibly damaging	Het
Ccdc9	A	T	7: 16,016,761 (GRCm39)	D42E	probably damaging	Het
Cdh13	A	G	8: 119,963,676 (GRCm39)	T419A		Het
Chst13	G	A	6: 90,286,506 (GRCm39)	P152L	probably damaging	Het
Clasp2	A	T	9: 113,670,669 (GRCm39)	R329W	probably damaging	Het
Csmd3	A	G	15: 47,470,459 (GRCm39)	C2495R		Het
Cyba	A	T	8: 123,154,394 (GRCm39)	I43N	possibly damaging	Het
Cyp2a5	A	C	7: 26,540,511 (GRCm39)	T375P	possibly damaging	Het
Cyp2r1	A	G	7: 114,152,369 (GRCm39)	F196S	probably damaging	Het
Efcab2	T	C	1: 178,308,887 (GRCm39)	F130S	probably damaging	Het
Eml6	T	G	11: 29,788,641 (GRCm39)		probably null	Het
Fbln5	A	T	12: 101,734,728 (GRCm39)	C181*	probably null	Het
Glyatl3	A	G	17: 41,221,016 (GRCm39)	V117A	probably benign	Het
Gpc6	A	G	14: 117,163,432 (GRCm39)	S29G	probably benign	Het
Hadhb	T	G	5: 30,368,711 (GRCm39)	S13A	probably benign	Het
Hook1	C	T	4: 95,901,505 (GRCm39)	R488C	probably damaging	Het
Icam5	A	G	9: 20,948,877 (GRCm39)	Y743C	probably damaging	Het
Il15ra	T	C	2: 11,724,854 (GRCm39)	V108A	probably benign	Het
Itga1	T	C	13: 115,152,753 (GRCm39)	N223S	probably benign	Het
Kat6b	AGAGGAGGAGGAGGAGGAGGA	AGAGGAGGAGGAGGAGGA	14: 21,712,417 (GRCm39)		probably benign	Het
Kcnk1	T	C	8: 126,756,281 (GRCm39)	C268R	probably damaging	Het
Kctd19	A	T	8: 106,120,249 (GRCm39)	L264M	probably benign	Het
Kmt2c	A	T	5: 25,554,860 (GRCm39)	I1258K	probably benign	Het
Kmt2c	A	T	5: 25,497,907 (GRCm39)	D3949E	probably damaging	Het
Lyst	G	A	13: 13,857,653 (GRCm39)	E2481K	possibly damaging	Het
Megf10	T	A	18: 57,395,090 (GRCm39)	I484N	probably benign	Het
Mettl21e	T	C	1: 44,245,857 (GRCm39)	I130V	probably benign	Het
Nmnat2	C	A	1: 152,962,181 (GRCm39)	N140K	possibly damaging	Het
Nsmaf	T	C	4: 6,414,976 (GRCm39)	K630R	probably benign	Het
Or2t1	C	T	14: 14,328,756 (GRCm38)	S215L	probably benign	Het
Or5w15	A	T	2: 87,568,576 (GRCm39)	F31I	probably benign	Het
Or8b38	G	T	9: 37,972,707 (GRCm39)	L30F	probably benign	Het
Pafah1b2	G	A	9: 45,884,284 (GRCm39)	Q123*	probably null	Het
Ptprb	T	A	10: 116,155,353 (GRCm39)	N415K	probably benign	Het
Rev3l	T	A	10: 39,701,033 (GRCm39)	D1843E	probably benign	Het
Rps6ka4	T	A	19: 6,809,372 (GRCm39)	R427S	possibly damaging	Het
Scgb2b24	A	T	7: 33,436,795 (GRCm39)	L106I	probably benign	Het
Skint9	A	T	4: 112,248,915 (GRCm39)	M171K	probably benign	Het
Spata17	A	G	1: 186,844,756 (GRCm39)	V281A	possibly damaging	Het
Spef1	A	T	2: 131,014,625 (GRCm39)	V99E	probably damaging	Het
Srpra	C	T	9: 35,126,015 (GRCm39)	T431I	probably damaging	Het
Stk32c	G	A	7: 138,768,173 (GRCm39)	P36L	unknown	Het
Taar7d	T	C	10: 23,903,739 (GRCm39)	I207T	probably benign	Het
Tle1	G	A	4: 72,044,504 (GRCm39)	T501I	probably damaging	Het
Tmem88b	A	T	4: 155,868,733 (GRCm39)	W172R	probably damaging	Het
Usp48	G	A	4: 137,340,996 (GRCm39)	G332E	probably benign	Het
Vcl	G	T	14: 21,070,726 (GRCm39)	V771L	probably benign	Het
Vmn1r200	T	A	13: 22,579,911 (GRCm39)	M238K	probably damaging	Het
Vmn2r96	A	G	17: 18,793,621 (GRCm39)		probably benign	Het
Vsig10l	G	T	7: 43,112,795 (GRCm39)	E18*	probably null	Het
Wdfy3	A	G	5: 102,000,478 (GRCm39)	L2964P	probably benign	Het
Zfp334	G	A	2: 165,222,271 (GRCm39)	R591W	probably damaging	Het
Zpld2	G	A	4: 133,929,312 (GRCm39)	P331L	probably benign	Het

Other mutations in Or8g26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Or8g26	APN	9	39,096,388 (GRCm39)	missense	possibly damaging	0.93
IGL02858:Or8g26	APN	9	39,095,822 (GRCm39)	missense	probably damaging	1.00
IGL02890:Or8g26	APN	9	39,095,564 (GRCm39)	missense	probably damaging	1.00
IGL02996:Or8g26	APN	9	39,096,361 (GRCm39)	missense	probably damaging	1.00
R0334:Or8g26	UTSW	9	39,095,980 (GRCm39)	missense	probably benign	0.01
R0881:Or8g26	UTSW	9	39,095,984 (GRCm39)	missense	probably benign	0.00
R2474:Or8g26	UTSW	9	39,095,846 (GRCm39)	missense	probably damaging	1.00
R3718:Or8g26	UTSW	9	39,096,361 (GRCm39)	missense	probably damaging	1.00
R4358:Or8g26	UTSW	9	39,095,864 (GRCm39)	missense	probably damaging	1.00
R4740:Or8g26	UTSW	9	39,095,664 (GRCm39)	nonsense	probably null
R4763:Or8g26	UTSW	9	39,096,256 (GRCm39)	missense	probably benign	0.15
R4788:Or8g26	UTSW	9	39,095,908 (GRCm39)	missense	probably benign	0.15
R4824:Or8g26	UTSW	9	39,095,501 (GRCm39)	missense	probably benign	0.02
R4866:Or8g26	UTSW	9	39,096,367 (GRCm39)	missense	probably damaging	1.00
R5560:Or8g26	UTSW	9	39,095,480 (GRCm39)	missense	probably benign	0.06
R6278:Or8g26	UTSW	9	39,095,594 (GRCm39)	missense	probably damaging	1.00
R7003:Or8g26	UTSW	9	39,096,239 (GRCm39)	missense	probably benign	0.01
R7721:Or8g26	UTSW	9	39,096,056 (GRCm39)	missense	probably benign	0.00
R8089:Or8g26	UTSW	9	39,095,927 (GRCm39)	missense	probably damaging	1.00
R8293:Or8g26	UTSW	9	39,095,689 (GRCm39)	missense	possibly damaging	0.48
R8818:Or8g26	UTSW	9	39,096,062 (GRCm39)	missense	probably damaging	1.00
R9423:Or8g26	UTSW	9	39,095,838 (GRCm39)	missense	probably damaging	0.98
R9761:Or8g26	UTSW	9	39,096,146 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTGTAAACACAGGCTTCATGAG -3'
(R):5'- AGATCAAGGGGTTCAGCATG -3'

Sequencing Primer
(F):5'- TCTGCAAATCAGATGTGATCAGCC -3'
(R):5'- TTCAGCATGGGTACAACAGTAG -3'

Posted On

2022-07-18