Incidental Mutation 'R9483:Rusc2'
| ID |
716350 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rusc2
|
| Ensembl Gene |
ENSMUSG00000035969 |
| Gene Name |
RUN and SH3 domain containing 2 |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.158)
|
| Stock # |
R9483 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
43381979-43427088 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 43415897 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 401
(N401S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038379
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035645]
[ENSMUST00000098106]
[ENSMUST00000125399]
[ENSMUST00000131668]
[ENSMUST00000135216]
[ENSMUST00000136360]
[ENSMUST00000139198]
[ENSMUST00000144911]
[ENSMUST00000149221]
[ENSMUST00000152322]
[ENSMUST00000173682]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000035645
AA Change: N401S
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000038379
Gene: ENSMUSG00000035969
AA Change: N401S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098106
AA Change: N401S
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000095710
Gene: ENSMUSG00000035969
AA Change: N401S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125399
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131668
AA Change: N401S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000118528
Gene: ENSMUSG00000035969
AA Change: N401S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135216
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136360
|
| SMART Domains |
Protein: ENSMUSP00000123431
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139198
|
| SMART Domains |
Protein: ENSMUSP00000121528
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144911
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149221
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152322
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173682
AA Change: N401S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133715
Gene: ENSMUSG00000035969
AA Change: N401S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010300C02Rik |
T |
G |
1: 37,631,415 (GRCm38) |
E148A |
probably damaging |
Het |
| 2900026A02Rik |
A |
T |
5: 113,191,144 (GRCm38) |
M334K |
probably benign |
Het |
| Abca1 |
A |
T |
4: 53,060,351 (GRCm38) |
I1525N |
probably benign |
Het |
| Abca4 |
A |
T |
3: 122,085,626 (GRCm38) |
I398F |
|
Het |
| Acbd3 |
A |
G |
1: 180,745,156 (GRCm38) |
D327G |
probably benign |
Het |
| Acsm3 |
A |
G |
7: 119,783,943 (GRCm38) |
T544A |
probably damaging |
Het |
| Atp11a |
C |
T |
8: 12,851,087 (GRCm38) |
T972M |
probably damaging |
Het |
| Cbfb |
C |
T |
8: 105,202,491 (GRCm38) |
R147* |
probably null |
Het |
| Ccdc17 |
G |
T |
4: 116,596,947 (GRCm38) |
R54L |
probably benign |
Het |
| Cuedc2 |
G |
T |
19: 46,330,960 (GRCm38) |
A223E |
probably benign |
Het |
| Cul5 |
T |
C |
9: 53,621,174 (GRCm38) |
I787V |
probably benign |
Het |
| D430041D05Rik |
T |
A |
2: 104,257,218 (GRCm38) |
H471L |
probably benign |
Het |
| Ddx39 |
T |
C |
8: 83,722,287 (GRCm38) |
Y264H |
probably benign |
Het |
| Dlgap3 |
C |
A |
4: 127,233,872 (GRCm38) |
R778S |
probably damaging |
Het |
| Esrrg |
T |
C |
1: 188,198,651 (GRCm38) |
V313A |
probably damaging |
Het |
| Fam124a |
T |
C |
14: 62,606,651 (GRCm38) |
I536T |
probably damaging |
Het |
| Fbxo21 |
T |
C |
5: 117,989,207 (GRCm38) |
F275L |
possibly damaging |
Het |
| Gabrg1 |
C |
A |
5: 70,842,215 (GRCm38) |
G2V |
possibly damaging |
Het |
| Gcc1 |
G |
T |
6: 28,418,090 (GRCm38) |
A748D |
probably damaging |
Het |
| Gjb6 |
T |
C |
14: 57,124,054 (GRCm38) |
D250G |
probably benign |
Het |
| Gm44501 |
A |
T |
17: 40,578,981 (GRCm38) |
K129* |
probably null |
Het |
| Hmcn2 |
T |
G |
2: 31,430,363 (GRCm38) |
L3952R |
|
Het |
| Hpd |
A |
G |
5: 123,174,472 (GRCm38) |
I278T |
probably damaging |
Het |
| Igsf3 |
T |
C |
3: 101,439,501 (GRCm38) |
F584S |
probably damaging |
Het |
| Igsf3 |
T |
A |
3: 101,439,588 (GRCm38) |
F613Y |
probably damaging |
Het |
| Ik |
A |
G |
18: 36,753,582 (GRCm38) |
D369G |
probably benign |
Het |
| Ikbke |
A |
G |
1: 131,270,982 (GRCm38) |
L365P |
probably damaging |
Het |
| Il22ra2 |
A |
T |
10: 19,632,794 (GRCm38) |
Q190L |
possibly damaging |
Het |
| Itga6 |
T |
C |
2: 71,849,490 (GRCm38) |
V1033A |
probably benign |
Het |
| Kif18a |
T |
C |
2: 109,289,687 (GRCm38) |
Y112H |
probably damaging |
Het |
| Krt75 |
T |
C |
15: 101,573,803 (GRCm38) |
H10R |
probably benign |
Het |
| L3mbtl1 |
T |
A |
2: 162,948,814 (GRCm38) |
L93H |
probably benign |
Het |
| Lrfn1 |
G |
A |
7: 28,458,758 (GRCm38) |
C34Y |
probably damaging |
Het |
| Lrrc47 |
A |
T |
4: 154,017,463 (GRCm38) |
I396F |
probably damaging |
Het |
| Mgat3 |
T |
A |
15: 80,211,440 (GRCm38) |
V156E |
probably benign |
Het |
| Mtus2 |
A |
G |
5: 148,295,490 (GRCm38) |
D1120G |
possibly damaging |
Het |
| Muc5ac |
G |
T |
7: 141,811,728 (GRCm38) |
E2700* |
probably null |
Het |
| Nxpe5 |
A |
T |
5: 138,230,329 (GRCm38) |
|
probably benign |
Het |
| Olfr1109 |
A |
T |
2: 87,093,046 (GRCm38) |
M117K |
possibly damaging |
Het |
| Olfr621-ps1 |
T |
C |
7: 103,629,724 (GRCm38) |
T79A |
probably damaging |
Het |
| Pcdhga4 |
T |
A |
18: 37,686,693 (GRCm38) |
S432T |
possibly damaging |
Het |
| Pdk4 |
T |
A |
6: 5,486,716 (GRCm38) |
M353L |
probably benign |
Het |
| Ppp1r13b |
T |
A |
12: 111,833,776 (GRCm38) |
K645N |
probably benign |
Het |
| Ppt1 |
A |
T |
4: 122,857,574 (GRCm38) |
D288V |
possibly damaging |
Het |
| Prkcb |
A |
G |
7: 122,582,440 (GRCm38) |
Y417C |
probably damaging |
Het |
| Prss22 |
A |
G |
17: 23,996,747 (GRCm38) |
I67T |
probably damaging |
Het |
| Rab29 |
T |
C |
1: 131,867,770 (GRCm38) |
V40A |
possibly damaging |
Het |
| Rae1 |
T |
C |
2: 173,008,148 (GRCm38) |
|
probably null |
Het |
| Rasa3 |
C |
T |
8: 13,580,033 (GRCm38) |
|
probably null |
Het |
| Rasgrp3 |
A |
G |
17: 75,500,722 (GRCm38) |
D258G |
probably benign |
Het |
| Rcc1 |
T |
A |
4: 132,335,497 (GRCm38) |
T208S |
probably benign |
Het |
| Rgs3 |
C |
A |
4: 62,657,117 (GRCm38) |
Y580* |
probably null |
Het |
| Rpe65 |
C |
T |
3: 159,622,681 (GRCm38) |
P405S |
probably damaging |
Het |
| Rsf1 |
GGCGGC |
GGCGGCGGCAGCGGC |
7: 97,579,930 (GRCm38) |
|
probably benign |
Het |
| Rsph4a |
A |
G |
10: 33,914,422 (GRCm38) |
E669G |
probably damaging |
Het |
| Rusc1 |
A |
T |
3: 89,086,806 (GRCm38) |
V964E |
probably benign |
Het |
| Slc10a1 |
G |
T |
12: 80,956,090 (GRCm38) |
T258K |
probably damaging |
Het |
| Slc5a9 |
A |
G |
4: 111,890,221 (GRCm38) |
L323P |
probably damaging |
Het |
| Slc6a17 |
T |
A |
3: 107,471,456 (GRCm38) |
I637F |
possibly damaging |
Het |
| Slc8a2 |
A |
G |
7: 16,152,855 (GRCm38) |
E641G |
possibly damaging |
Het |
| Sptbn2 |
G |
T |
19: 4,739,946 (GRCm38) |
A1321S |
probably damaging |
Het |
| Ssh2 |
G |
T |
11: 77,393,150 (GRCm38) |
A77S |
possibly damaging |
Het |
| St13 |
G |
T |
15: 81,366,386 (GRCm38) |
N316K |
probably damaging |
Het |
| Taf10 |
A |
G |
7: 105,743,855 (GRCm38) |
M121T |
probably benign |
Het |
| Tcta |
T |
C |
9: 108,305,743 (GRCm38) |
T68A |
probably damaging |
Het |
| Timd2 |
A |
T |
11: 46,687,062 (GRCm38) |
Y81N |
probably damaging |
Het |
| Tln2 |
T |
C |
9: 67,392,487 (GRCm38) |
E161G |
probably damaging |
Het |
| Tmed10 |
T |
C |
12: 85,350,847 (GRCm38) |
I123V |
probably benign |
Het |
| Ttf1 |
T |
C |
2: 29,079,480 (GRCm38) |
|
probably null |
Het |
| Tubg1 |
A |
G |
11: 101,126,060 (GRCm38) |
D396G |
probably damaging |
Het |
| Uhmk1 |
A |
G |
1: 170,207,344 (GRCm38) |
|
probably null |
Het |
| Unc13a |
C |
T |
8: 71,650,577 (GRCm38) |
A922T |
probably benign |
Het |
| Usp24 |
T |
A |
4: 106,362,182 (GRCm38) |
V525E |
probably damaging |
Het |
| Usp28 |
C |
A |
9: 49,035,737 (GRCm38) |
Q823K |
probably damaging |
Het |
| Vldlr |
A |
T |
19: 27,246,631 (GRCm38) |
I764F |
probably benign |
Het |
| Vmn2r88 |
T |
C |
14: 51,411,184 (GRCm38) |
Y62H |
|
Het |
| Zfp423 |
T |
A |
8: 87,781,097 (GRCm38) |
N873I |
possibly damaging |
Het |
|
| Other mutations in Rusc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01358:Rusc2
|
APN |
4 |
43,426,116 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01474:Rusc2
|
APN |
4 |
43,416,434 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01541:Rusc2
|
APN |
4 |
43,415,840 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01628:Rusc2
|
APN |
4 |
43,425,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01969:Rusc2
|
APN |
4 |
43,415,738 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02030:Rusc2
|
APN |
4 |
43,416,095 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02079:Rusc2
|
APN |
4 |
43,425,668 (GRCm38) |
missense |
probably benign |
|
|
IGL02115:Rusc2
|
APN |
4 |
43,426,136 (GRCm38) |
splice site |
probably benign |
|
|
IGL02122:Rusc2
|
APN |
4 |
43,421,685 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02350:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02357:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02437:Rusc2
|
APN |
4 |
43,415,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02930:Rusc2
|
APN |
4 |
43,416,376 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03154:Rusc2
|
APN |
4 |
43,425,806 (GRCm38) |
missense |
probably benign |
0.00 |
|
P0026:Rusc2
|
UTSW |
4 |
43,415,840 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0036:Rusc2
|
UTSW |
4 |
43,424,009 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0114:Rusc2
|
UTSW |
4 |
43,422,055 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0255:Rusc2
|
UTSW |
4 |
43,423,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0471:Rusc2
|
UTSW |
4 |
43,425,486 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1381:Rusc2
|
UTSW |
4 |
43,416,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Rusc2
|
UTSW |
4 |
43,416,568 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1416:Rusc2
|
UTSW |
4 |
43,421,617 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1731:Rusc2
|
UTSW |
4 |
43,426,046 (GRCm38) |
missense |
probably benign |
|
|
R1864:Rusc2
|
UTSW |
4 |
43,421,719 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R1897:Rusc2
|
UTSW |
4 |
43,421,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2010:Rusc2
|
UTSW |
4 |
43,415,212 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2212:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2275:Rusc2
|
UTSW |
4 |
43,416,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2885:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R2886:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R3412:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3413:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3414:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3852:Rusc2
|
UTSW |
4 |
43,416,424 (GRCm38) |
missense |
probably benign |
0.45 |
|
R4135:Rusc2
|
UTSW |
4 |
43,425,563 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R4272:Rusc2
|
UTSW |
4 |
43,415,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4574:Rusc2
|
UTSW |
4 |
43,416,080 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4888:Rusc2
|
UTSW |
4 |
43,423,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5010:Rusc2
|
UTSW |
4 |
43,415,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5071:Rusc2
|
UTSW |
4 |
43,415,240 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5131:Rusc2
|
UTSW |
4 |
43,414,948 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5177:Rusc2
|
UTSW |
4 |
43,421,805 (GRCm38) |
splice site |
probably null |
|
|
R5540:Rusc2
|
UTSW |
4 |
43,423,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5561:Rusc2
|
UTSW |
4 |
43,415,932 (GRCm38) |
nonsense |
probably null |
|
|
R5628:Rusc2
|
UTSW |
4 |
43,425,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5645:Rusc2
|
UTSW |
4 |
43,425,758 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6129:Rusc2
|
UTSW |
4 |
43,424,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6362:Rusc2
|
UTSW |
4 |
43,416,416 (GRCm38) |
missense |
probably benign |
0.30 |
|
R6633:Rusc2
|
UTSW |
4 |
43,414,852 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6980:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7491:Rusc2
|
UTSW |
4 |
43,426,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7641:Rusc2
|
UTSW |
4 |
43,425,335 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R7698:Rusc2
|
UTSW |
4 |
43,414,900 (GRCm38) |
nonsense |
probably null |
|
|
R7710:Rusc2
|
UTSW |
4 |
43,416,119 (GRCm38) |
missense |
probably benign |
0.07 |
|
R8052:Rusc2
|
UTSW |
4 |
43,421,851 (GRCm38) |
missense |
probably benign |
|
|
R8061:Rusc2
|
UTSW |
4 |
43,422,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8127:Rusc2
|
UTSW |
4 |
43,423,747 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R8319:Rusc2
|
UTSW |
4 |
43,425,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8355:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8397:Rusc2
|
UTSW |
4 |
43,424,206 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8455:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8553:Rusc2
|
UTSW |
4 |
43,416,508 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8725:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8725:Rusc2
|
UTSW |
4 |
43,415,396 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8727:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8834:Rusc2
|
UTSW |
4 |
43,416,431 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9295:Rusc2
|
UTSW |
4 |
43,416,382 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9666:Rusc2
|
UTSW |
4 |
43,416,262 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9705:Rusc2
|
UTSW |
4 |
43,424,936 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0025:Rusc2
|
UTSW |
4 |
43,422,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0066:Rusc2
|
UTSW |
4 |
43,422,204 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCGACTCTTCCTTCTGCAG -3'
(R):5'- TGGCTTCTGGAAGAGGTAATAC -3'
Sequencing Primer
(F):5'- AGAATGTCTTGCGAGTCCCAC -3'
(R):5'- CTTCTGGAAGAGGTAATACTCAGAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation