Incidental Mutation 'R9484:Corin'
| ID |
716431 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.237)
|
| Stock # |
R9484 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 72497280 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 615
(V615I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005352
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005352
AA Change: V615I
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: V615I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167460
AA Change: V549I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: V549I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175766
AA Change: V474I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: V474I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176974
AA Change: V512I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: V512I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177290
AA Change: V482I
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: V482I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.2%
- 20x: 97.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acads |
A |
T |
5: 115,250,845 (GRCm39) |
C151S |
probably damaging |
Het |
| Actr8 |
T |
C |
14: 29,708,301 (GRCm39) |
I193T |
probably benign |
Het |
| Btbd2 |
T |
C |
10: 80,480,103 (GRCm39) |
N419S |
probably benign |
Het |
| Cacna2d1 |
T |
A |
5: 16,561,831 (GRCm39) |
W821R |
probably damaging |
Het |
| Cadps2 |
T |
C |
6: 23,626,646 (GRCm39) |
Y214C |
probably benign |
Het |
| Calu |
T |
A |
6: 29,366,162 (GRCm39) |
L180Q |
probably damaging |
Het |
| Cyp8b1 |
A |
T |
9: 121,744,983 (GRCm39) |
D116E |
probably benign |
Het |
| D630036H23Rik |
C |
A |
12: 36,431,711 (GRCm39) |
A96S |
unknown |
Het |
| Ddx24 |
A |
T |
12: 103,377,555 (GRCm39) |
Y717N |
probably damaging |
Het |
| Dmap1 |
G |
T |
4: 117,533,308 (GRCm39) |
Q249K |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,900,508 (GRCm39) |
W3922R |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,517,773 (GRCm39) |
F2036L |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,625,311 (GRCm39) |
I4064T |
probably benign |
Het |
| Dock9 |
A |
C |
14: 121,818,844 (GRCm39) |
V1546G |
probably damaging |
Het |
| Eif1ad4 |
A |
T |
12: 87,862,249 (GRCm39) |
Q37L |
possibly damaging |
Het |
| Eif3a |
A |
T |
19: 60,755,006 (GRCm39) |
S1059T |
unknown |
Het |
| Ep300 |
A |
G |
15: 81,521,026 (GRCm39) |
E1262G |
unknown |
Het |
| Evl |
T |
A |
12: 108,652,716 (GRCm39) |
I387N |
probably damaging |
Het |
| Fat2 |
A |
C |
11: 55,200,752 (GRCm39) |
V774G |
probably damaging |
Het |
| Fez1 |
T |
A |
9: 36,755,093 (GRCm39) |
Y31N |
probably benign |
Het |
| Fkbp10 |
A |
G |
11: 100,313,960 (GRCm39) |
I435V |
probably damaging |
Het |
| Flnb |
A |
G |
14: 7,929,004 (GRCm38) |
D1911G |
probably benign |
Het |
| Fnbp1 |
T |
C |
2: 30,973,038 (GRCm39) |
Y154C |
probably benign |
Het |
| Fndc10 |
T |
C |
4: 155,779,496 (GRCm39) |
I180T |
possibly damaging |
Het |
| Frmd4a |
G |
A |
2: 4,609,026 (GRCm39) |
V965I |
possibly damaging |
Het |
| Gabrr2 |
A |
G |
4: 33,071,352 (GRCm39) |
H64R |
possibly damaging |
Het |
| Glis3 |
T |
C |
19: 28,508,403 (GRCm39) |
D527G |
probably damaging |
Het |
| H2-Ob |
T |
A |
17: 34,459,989 (GRCm39) |
F33L |
probably damaging |
Het |
| Hbb-bh1 |
C |
T |
7: 103,492,239 (GRCm39) |
E27K |
probably benign |
Het |
| Ifnb1 |
T |
A |
4: 88,440,915 (GRCm39) |
T33S |
probably benign |
Het |
| Igkv4-80 |
T |
A |
6: 68,993,766 (GRCm39) |
T42S |
probably damaging |
Het |
| Irs2 |
C |
T |
8: 11,057,334 (GRCm39) |
G366D |
probably damaging |
Het |
| Kcnk2 |
CAAA |
CAA |
1: 188,988,891 (GRCm39) |
|
probably null |
Het |
| Krtap5-3 |
T |
A |
7: 141,756,068 (GRCm39) |
C302S |
unknown |
Het |
| Lgi1 |
A |
G |
19: 38,294,757 (GRCm39) |
K510E |
probably benign |
Het |
| Lgi2 |
T |
A |
5: 52,695,936 (GRCm39) |
D341V |
probably benign |
Het |
| Lin7c |
T |
C |
2: 109,724,813 (GRCm39) |
I14T |
probably benign |
Het |
| Lrrc19 |
A |
T |
4: 94,531,573 (GRCm39) |
M13K |
probably benign |
Het |
| Lrrc69 |
T |
C |
4: 14,666,012 (GRCm39) |
I315M |
probably benign |
Het |
| Mtcl3 |
G |
A |
10: 29,072,969 (GRCm39) |
D754N |
probably damaging |
Het |
| Myo5c |
A |
T |
9: 75,204,770 (GRCm39) |
D1541V |
probably damaging |
Het |
| Mypn |
T |
G |
10: 63,003,019 (GRCm39) |
M373L |
probably benign |
Het |
| Nckipsd |
C |
A |
9: 108,689,837 (GRCm39) |
H333N |
probably damaging |
Het |
| Nrg2 |
A |
T |
18: 36,157,401 (GRCm39) |
L428Q |
probably null |
Het |
| Or13a20 |
T |
C |
7: 140,231,904 (GRCm39) |
L4S |
probably benign |
Het |
| Or2b28 |
C |
A |
13: 21,531,587 (GRCm39) |
T163K |
probably damaging |
Het |
| Or5an11 |
T |
C |
19: 12,245,735 (GRCm39) |
I47T |
possibly damaging |
Het |
| Otogl |
T |
A |
10: 107,657,894 (GRCm39) |
|
probably null |
Het |
| Otogl |
C |
T |
10: 107,737,156 (GRCm39) |
G86D |
probably damaging |
Het |
| Papln |
A |
T |
12: 83,838,618 (GRCm39) |
Q1249L |
probably benign |
Het |
| Plxna2 |
G |
T |
1: 194,327,202 (GRCm39) |
G379C |
probably damaging |
Het |
| Pofut2 |
T |
C |
10: 77,095,260 (GRCm39) |
I35T |
probably benign |
Het |
| Pros1 |
A |
G |
16: 62,744,887 (GRCm39) |
T501A |
possibly damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,625,821 (GRCm39) |
S1042P |
possibly damaging |
Het |
| Rps6kb1 |
C |
T |
11: 86,408,443 (GRCm39) |
E185K |
probably damaging |
Het |
| Slc13a2 |
A |
T |
11: 78,294,233 (GRCm39) |
L216Q |
probably damaging |
Het |
| Slc22a14 |
T |
C |
9: 119,009,615 (GRCm39) |
Y160C |
probably damaging |
Het |
| Slc22a4 |
T |
A |
11: 53,879,773 (GRCm39) |
I429F |
possibly damaging |
Het |
| Slc26a3 |
A |
G |
12: 31,511,785 (GRCm39) |
K457E |
probably damaging |
Het |
| Slc47a2 |
T |
C |
11: 61,227,060 (GRCm39) |
I169M |
possibly damaging |
Het |
| Slco1a1 |
C |
T |
6: 141,854,672 (GRCm39) |
V660I |
probably benign |
Het |
| Smyd1 |
A |
G |
6: 71,202,450 (GRCm39) |
Y252H |
probably damaging |
Het |
| Spp2 |
A |
T |
1: 88,334,695 (GRCm39) |
|
probably benign |
Het |
| Stra8 |
T |
A |
6: 34,911,121 (GRCm39) |
W250R |
probably damaging |
Het |
| Syne1 |
A |
C |
10: 5,170,359 (GRCm39) |
L5183R |
probably damaging |
Het |
| Tdrd9 |
T |
C |
12: 112,012,684 (GRCm39) |
S1203P |
probably damaging |
Het |
| Th |
C |
A |
7: 142,453,620 (GRCm39) |
E27* |
probably null |
Het |
| Thada |
C |
A |
17: 84,736,619 (GRCm39) |
L887F |
probably damaging |
Het |
| Timm23 |
T |
C |
14: 31,902,586 (GRCm39) |
T186A |
probably benign |
Het |
| Tmem132b |
A |
T |
5: 125,860,420 (GRCm39) |
E555V |
probably damaging |
Het |
| Tnik |
A |
T |
3: 28,649,093 (GRCm39) |
Q457L |
unknown |
Het |
| Uba7 |
C |
A |
9: 107,861,037 (GRCm39) |
H942Q |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,966,078 (GRCm39) |
S233P |
unknown |
Het |
| Urm1 |
T |
A |
2: 29,732,760 (GRCm39) |
N72K |
probably damaging |
Het |
| Usp10 |
T |
C |
8: 120,675,504 (GRCm39) |
S508P |
possibly damaging |
Het |
| Usp37 |
G |
A |
1: 74,499,081 (GRCm39) |
P632S |
probably damaging |
Het |
| Wdr77 |
T |
A |
3: 105,872,404 (GRCm39) |
N209K |
probably benign |
Het |
| Zbtb24 |
C |
T |
10: 41,327,429 (GRCm39) |
T105M |
probably benign |
Het |
| Zfp341 |
T |
A |
2: 154,485,763 (GRCm39) |
I671N |
probably damaging |
Het |
| Zfp414 |
A |
G |
17: 33,848,984 (GRCm39) |
T73A |
probably benign |
Het |
| Zfp574 |
A |
T |
7: 24,781,404 (GRCm39) |
I809F |
possibly damaging |
Het |
| Zfp62 |
T |
C |
11: 49,108,108 (GRCm39) |
I733T |
probably damaging |
Het |
| Zfp719 |
A |
G |
7: 43,239,581 (GRCm39) |
I390V |
possibly damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTGGACTCACCTACACAG -3'
(R):5'- GTGCCTATATGCTTCTACACAGTTC -3'
Sequencing Primer
(F):5'- TGGACTCACCTACACAGCCTAATTG -3'
(R):5'- GCTTCTACACAGTTCCTTACACATAC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation