Incidental Mutation 'R9484:Cadps2'
| ID |
716435 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9484 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23626646 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 214
(Y214C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111018
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115356]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018122
AA Change: Y214C
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069074
AA Change: Y214C
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115356
AA Change: Y214C
PolyPhen 2
Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000111013
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115358
AA Change: Y214C
PolyPhen 2
Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115361
AA Change: Y214C
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142913
AA Change: Y185C
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: Y185C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163871
AA Change: Y214C
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: Y214C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: Y185C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.2%
- 20x: 97.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acads |
A |
T |
5: 115,250,845 (GRCm39) |
C151S |
probably damaging |
Het |
| Actr8 |
T |
C |
14: 29,708,301 (GRCm39) |
I193T |
probably benign |
Het |
| Btbd2 |
T |
C |
10: 80,480,103 (GRCm39) |
N419S |
probably benign |
Het |
| Cacna2d1 |
T |
A |
5: 16,561,831 (GRCm39) |
W821R |
probably damaging |
Het |
| Calu |
T |
A |
6: 29,366,162 (GRCm39) |
L180Q |
probably damaging |
Het |
| Corin |
C |
T |
5: 72,497,280 (GRCm39) |
V615I |
probably damaging |
Het |
| Cyp8b1 |
A |
T |
9: 121,744,983 (GRCm39) |
D116E |
probably benign |
Het |
| D630036H23Rik |
C |
A |
12: 36,431,711 (GRCm39) |
A96S |
unknown |
Het |
| Ddx24 |
A |
T |
12: 103,377,555 (GRCm39) |
Y717N |
probably damaging |
Het |
| Dmap1 |
G |
T |
4: 117,533,308 (GRCm39) |
Q249K |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,900,508 (GRCm39) |
W3922R |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,517,773 (GRCm39) |
F2036L |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,625,311 (GRCm39) |
I4064T |
probably benign |
Het |
| Dock9 |
A |
C |
14: 121,818,844 (GRCm39) |
V1546G |
probably damaging |
Het |
| Eif1ad4 |
A |
T |
12: 87,862,249 (GRCm39) |
Q37L |
possibly damaging |
Het |
| Eif3a |
A |
T |
19: 60,755,006 (GRCm39) |
S1059T |
unknown |
Het |
| Ep300 |
A |
G |
15: 81,521,026 (GRCm39) |
E1262G |
unknown |
Het |
| Evl |
T |
A |
12: 108,652,716 (GRCm39) |
I387N |
probably damaging |
Het |
| Fat2 |
A |
C |
11: 55,200,752 (GRCm39) |
V774G |
probably damaging |
Het |
| Fez1 |
T |
A |
9: 36,755,093 (GRCm39) |
Y31N |
probably benign |
Het |
| Fkbp10 |
A |
G |
11: 100,313,960 (GRCm39) |
I435V |
probably damaging |
Het |
| Flnb |
A |
G |
14: 7,929,004 (GRCm38) |
D1911G |
probably benign |
Het |
| Fnbp1 |
T |
C |
2: 30,973,038 (GRCm39) |
Y154C |
probably benign |
Het |
| Fndc10 |
T |
C |
4: 155,779,496 (GRCm39) |
I180T |
possibly damaging |
Het |
| Frmd4a |
G |
A |
2: 4,609,026 (GRCm39) |
V965I |
possibly damaging |
Het |
| Gabrr2 |
A |
G |
4: 33,071,352 (GRCm39) |
H64R |
possibly damaging |
Het |
| Glis3 |
T |
C |
19: 28,508,403 (GRCm39) |
D527G |
probably damaging |
Het |
| H2-Ob |
T |
A |
17: 34,459,989 (GRCm39) |
F33L |
probably damaging |
Het |
| Hbb-bh1 |
C |
T |
7: 103,492,239 (GRCm39) |
E27K |
probably benign |
Het |
| Ifnb1 |
T |
A |
4: 88,440,915 (GRCm39) |
T33S |
probably benign |
Het |
| Igkv4-80 |
T |
A |
6: 68,993,766 (GRCm39) |
T42S |
probably damaging |
Het |
| Irs2 |
C |
T |
8: 11,057,334 (GRCm39) |
G366D |
probably damaging |
Het |
| Kcnk2 |
CAAA |
CAA |
1: 188,988,891 (GRCm39) |
|
probably null |
Het |
| Krtap5-3 |
T |
A |
7: 141,756,068 (GRCm39) |
C302S |
unknown |
Het |
| Lgi1 |
A |
G |
19: 38,294,757 (GRCm39) |
K510E |
probably benign |
Het |
| Lgi2 |
T |
A |
5: 52,695,936 (GRCm39) |
D341V |
probably benign |
Het |
| Lin7c |
T |
C |
2: 109,724,813 (GRCm39) |
I14T |
probably benign |
Het |
| Lrrc19 |
A |
T |
4: 94,531,573 (GRCm39) |
M13K |
probably benign |
Het |
| Lrrc69 |
T |
C |
4: 14,666,012 (GRCm39) |
I315M |
probably benign |
Het |
| Mtcl3 |
G |
A |
10: 29,072,969 (GRCm39) |
D754N |
probably damaging |
Het |
| Myo5c |
A |
T |
9: 75,204,770 (GRCm39) |
D1541V |
probably damaging |
Het |
| Mypn |
T |
G |
10: 63,003,019 (GRCm39) |
M373L |
probably benign |
Het |
| Nckipsd |
C |
A |
9: 108,689,837 (GRCm39) |
H333N |
probably damaging |
Het |
| Nrg2 |
A |
T |
18: 36,157,401 (GRCm39) |
L428Q |
probably null |
Het |
| Or13a20 |
T |
C |
7: 140,231,904 (GRCm39) |
L4S |
probably benign |
Het |
| Or2b28 |
C |
A |
13: 21,531,587 (GRCm39) |
T163K |
probably damaging |
Het |
| Or5an11 |
T |
C |
19: 12,245,735 (GRCm39) |
I47T |
possibly damaging |
Het |
| Otogl |
T |
A |
10: 107,657,894 (GRCm39) |
|
probably null |
Het |
| Otogl |
C |
T |
10: 107,737,156 (GRCm39) |
G86D |
probably damaging |
Het |
| Papln |
A |
T |
12: 83,838,618 (GRCm39) |
Q1249L |
probably benign |
Het |
| Plxna2 |
G |
T |
1: 194,327,202 (GRCm39) |
G379C |
probably damaging |
Het |
| Pofut2 |
T |
C |
10: 77,095,260 (GRCm39) |
I35T |
probably benign |
Het |
| Pros1 |
A |
G |
16: 62,744,887 (GRCm39) |
T501A |
possibly damaging |
Het |
| Rapgef1 |
T |
C |
2: 29,625,821 (GRCm39) |
S1042P |
possibly damaging |
Het |
| Rps6kb1 |
C |
T |
11: 86,408,443 (GRCm39) |
E185K |
probably damaging |
Het |
| Slc13a2 |
A |
T |
11: 78,294,233 (GRCm39) |
L216Q |
probably damaging |
Het |
| Slc22a14 |
T |
C |
9: 119,009,615 (GRCm39) |
Y160C |
probably damaging |
Het |
| Slc22a4 |
T |
A |
11: 53,879,773 (GRCm39) |
I429F |
possibly damaging |
Het |
| Slc26a3 |
A |
G |
12: 31,511,785 (GRCm39) |
K457E |
probably damaging |
Het |
| Slc47a2 |
T |
C |
11: 61,227,060 (GRCm39) |
I169M |
possibly damaging |
Het |
| Slco1a1 |
C |
T |
6: 141,854,672 (GRCm39) |
V660I |
probably benign |
Het |
| Smyd1 |
A |
G |
6: 71,202,450 (GRCm39) |
Y252H |
probably damaging |
Het |
| Spp2 |
A |
T |
1: 88,334,695 (GRCm39) |
|
probably benign |
Het |
| Stra8 |
T |
A |
6: 34,911,121 (GRCm39) |
W250R |
probably damaging |
Het |
| Syne1 |
A |
C |
10: 5,170,359 (GRCm39) |
L5183R |
probably damaging |
Het |
| Tdrd9 |
T |
C |
12: 112,012,684 (GRCm39) |
S1203P |
probably damaging |
Het |
| Th |
C |
A |
7: 142,453,620 (GRCm39) |
E27* |
probably null |
Het |
| Thada |
C |
A |
17: 84,736,619 (GRCm39) |
L887F |
probably damaging |
Het |
| Timm23 |
T |
C |
14: 31,902,586 (GRCm39) |
T186A |
probably benign |
Het |
| Tmem132b |
A |
T |
5: 125,860,420 (GRCm39) |
E555V |
probably damaging |
Het |
| Tnik |
A |
T |
3: 28,649,093 (GRCm39) |
Q457L |
unknown |
Het |
| Uba7 |
C |
A |
9: 107,861,037 (GRCm39) |
H942Q |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,966,078 (GRCm39) |
S233P |
unknown |
Het |
| Urm1 |
T |
A |
2: 29,732,760 (GRCm39) |
N72K |
probably damaging |
Het |
| Usp10 |
T |
C |
8: 120,675,504 (GRCm39) |
S508P |
possibly damaging |
Het |
| Usp37 |
G |
A |
1: 74,499,081 (GRCm39) |
P632S |
probably damaging |
Het |
| Wdr77 |
T |
A |
3: 105,872,404 (GRCm39) |
N209K |
probably benign |
Het |
| Zbtb24 |
C |
T |
10: 41,327,429 (GRCm39) |
T105M |
probably benign |
Het |
| Zfp341 |
T |
A |
2: 154,485,763 (GRCm39) |
I671N |
probably damaging |
Het |
| Zfp414 |
A |
G |
17: 33,848,984 (GRCm39) |
T73A |
probably benign |
Het |
| Zfp574 |
A |
T |
7: 24,781,404 (GRCm39) |
I809F |
possibly damaging |
Het |
| Zfp62 |
T |
C |
11: 49,108,108 (GRCm39) |
I733T |
probably damaging |
Het |
| Zfp719 |
A |
G |
7: 43,239,581 (GRCm39) |
I390V |
possibly damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,297 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCCAGGGTCATACACACTCC -3'
(R):5'- CTAAAGAGTGACCGTGTGGC -3'
Sequencing Primer
(F):5'- CTTGCATGCATCAGACGTG -3'
(R):5'- TGACCGTGTGGCCAGAATG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation