Mutagenetix > Incidental Mutation

Incidental Mutation 'R9485:Il1rl2'

716492

Institutional Source

Beutler Lab

Gene Symbol

Il1rl2

Ensembl Gene

ENSMUSG00000070942

Gene Name

interleukin 1 receptor-like 2

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9485 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

40363770-40406722 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT to CTTTATTTTATTTTATTTTATTTTATTTTATTTTATT at 40366470 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000142248 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095020] [ENSMUST00000193388] [ENSMUST00000194296]

AlphaFold

Q9ERS7

Predicted Effect

probably benign
Transcript: ENSMUST00000095020

SMART Domains

Protein: ENSMUSP00000092630
Gene: ENSMUSG00000070942

Domain	Start	End	E-Value	Type
low complexity region	6	18	N/A	INTRINSIC
IG	29	115	7.52e-8	SMART
IG	134	219	1.94e-1	SMART
IG_like	237	333	2.39e1	SMART
transmembrane domain	340	362	N/A	INTRINSIC
TIR	385	542	5.05e-33	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192551

Predicted Effect

probably benign
Transcript: ENSMUST00000193388

SMART Domains

Protein: ENSMUSP00000141507
Gene: ENSMUSG00000070942

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IG	29	115	3.1e-10	SMART
Pfam:Ig_2	127	167	2.4e-1	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000194296

SMART Domains

Protein: ENSMUSP00000142248
Gene: ENSMUSG00000070942

Domain	Start	End	E-Value	Type
low complexity region	6	18	N/A	INTRINSIC
IG	29	115	7.52e-8	SMART
IG	134	219	1.94e-1	SMART
IG_like	237	333	2.39e1	SMART
transmembrane domain	340	362	N/A	INTRINSIC
TIR	385	542	5.05e-33	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele are viable and overtly normal and have normal skin in an unchallenged context. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	C	14: 32,383,400 (GRCm39)	D855G	possibly damaging	Het
4930486L24Rik	A	T	13: 61,001,059 (GRCm39)	V159D	possibly damaging	Het
Ahnak	G	A	19: 8,979,438 (GRCm39)	A241T	probably benign	Het
Apoa4	T	C	9: 46,152,453 (GRCm39)	M1T	probably null	Het
Atn1	T	C	6: 124,722,748 (GRCm39)	K776E	unknown	Het
Atp1a2	A	G	1: 172,105,822 (GRCm39)	*948R	probably null	Het
Atp7b	T	C	8: 22,502,778 (GRCm39)	Q801R	probably damaging	Het
Birc6	T	A	17: 74,945,398 (GRCm39)	S2824T	probably damaging	Het
Cacng3	A	T	7: 122,361,435 (GRCm39)	I109F	probably damaging	Het
Cass4	T	C	2: 172,269,805 (GRCm39)	F629S	probably benign	Het
Ccdc168	T	G	1: 44,095,399 (GRCm39)	K1900Q	possibly damaging	Het
Cnot6l	T	C	5: 96,230,858 (GRCm39)	T370A	probably damaging	Het
Cntnap5c	A	C	17: 58,409,103 (GRCm39)	D447A	probably damaging	Het
Col11a2	T	A	17: 34,258,669 (GRCm39)	L14Q	unknown	Het
Dennd4a	T	G	9: 64,814,388 (GRCm39)	Y1505*	probably null	Het
Dhx32	T	C	7: 133,327,110 (GRCm39)	M464V	possibly damaging	Het
Dip2b	T	C	15: 100,052,924 (GRCm39)	V266A	probably benign	Het
Dnajb6	C	T	5: 29,986,517 (GRCm39)	Q220*	probably null	Het
Dnmt3a	G	A	12: 3,916,121 (GRCm39)	S102N	probably benign	Het
Dph5	A	T	3: 115,681,977 (GRCm39)		probably benign	Het
Ear6	T	A	14: 52,091,489 (GRCm39)	L12H		Het
Erp27	T	C	6: 136,886,548 (GRCm39)	T162A	possibly damaging	Het
Fance	T	A	17: 28,536,479 (GRCm39)	L13H	probably damaging	Het
Fanci	T	A	7: 79,089,405 (GRCm39)	V947D	probably benign	Het
Gab1	G	A	8: 81,515,484 (GRCm39)	T278M	probably damaging	Het
Gbp4	A	T	5: 105,269,796 (GRCm39)	M344K	probably damaging	Het
Gpr87	C	T	3: 59,087,005 (GRCm39)	V167M	possibly damaging	Het
Gramd1a	T	G	7: 30,829,963 (GRCm39)	D708A	unknown	Het
Gzmd	T	A	14: 56,368,160 (GRCm39)	I100F	probably benign	Het
Hcrtr1	T	A	4: 130,031,054 (GRCm39)	M77L	possibly damaging	Het
Hipk2	C	A	6: 38,680,445 (GRCm39)	R965L	possibly damaging	Het
Ift88	T	C	14: 57,675,724 (GRCm39)	M79T	probably benign	Het
Ighv1-12	T	C	12: 114,579,525 (GRCm39)	Y99C	possibly damaging	Het
Il22b	A	G	10: 118,130,314 (GRCm39)	V63A	probably benign	Het
Mllt1	C	T	17: 57,207,184 (GRCm39)	R220H	probably damaging	Het
Mroh8	T	C	2: 157,071,913 (GRCm39)	T531A	probably benign	Het
Myh6	T	C	14: 55,181,802 (GRCm39)	K1833R	probably benign	Het
Nfkbie	C	T	17: 45,871,353 (GRCm39)	T270I	probably damaging	Het
Or4c110	G	A	2: 88,831,709 (GRCm39)	P308S	unknown	Het
Or52b3	A	T	7: 102,204,013 (GRCm39)	N174I	probably damaging	Het
Or52e5	C	T	7: 104,718,703 (GRCm39)	H10Y	possibly damaging	Het
Pcdh8	A	T	14: 80,005,689 (GRCm39)	F900I	probably damaging	Het
Pcolce2	T	A	9: 95,520,720 (GRCm39)	C32*	probably null	Het
Pus7	A	T	5: 23,973,859 (GRCm39)	S212T	probably benign	Het
Rgs12	G	T	5: 35,189,614 (GRCm39)	W1322L	probably damaging	Het
Sec1	G	A	7: 45,328,033 (GRCm39)	T338I	probably damaging	Het
Slc25a36	T	C	9: 96,962,522 (GRCm39)	K156E	probably benign	Het
Snrpn	C	T	7: 59,637,212 (GRCm39)	D35N	probably damaging	Het
Sox9	A	G	11: 112,673,705 (GRCm39)	S99G	probably benign	Het
Spmip3	T	C	1: 177,580,545 (GRCm39)	V130A	possibly damaging	Het
Tacc3	T	C	5: 33,821,644 (GRCm39)	S135P	possibly damaging	Het
Taf2	T	C	15: 54,911,667 (GRCm39)	E583G	probably benign	Het
Tmprss7	T	A	16: 45,498,282 (GRCm39)	K366*	probably null	Het
Trpm6	G	T	19: 18,755,978 (GRCm39)	V74L	probably benign	Het
Ttbk2	G	T	2: 120,575,986 (GRCm39)	T997N	probably benign	Het
Utp25	C	A	1: 192,812,541 (GRCm39)		probably benign	Het
Vmn2r3	T	A	3: 64,183,046 (GRCm39)	I218F	probably damaging	Het
Vps50	T	C	6: 3,592,557 (GRCm39)	V730A	probably damaging	Het
Wdr47	A	T	3: 108,544,371 (GRCm39)	I665F	probably damaging	Het
Wnt7a	T	A	6: 91,343,297 (GRCm39)	N195I	probably benign	Het
Zfp131	A	G	13: 120,251,885 (GRCm39)		probably benign	Het
Zfp709	T	A	8: 72,643,669 (GRCm39)	V366E	possibly damaging	Het
Zfp985	T	A	4: 147,668,280 (GRCm39)	C383S	probably damaging	Het

Other mutations in Il1rl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01631:Il1rl2	APN	1	40,395,974 (GRCm39)	splice site	probably null
IGL02490:Il1rl2	APN	1	40,395,972 (GRCm39)	splice site	probably benign
IGL03201:Il1rl2	APN	1	40,382,200 (GRCm39)	missense	possibly damaging	0.95
IGL03269:Il1rl2	APN	1	40,404,472 (GRCm39)	missense	probably damaging	1.00
R0088:Il1rl2	UTSW	1	40,404,213 (GRCm39)	missense	possibly damaging	0.87
R0418:Il1rl2	UTSW	1	40,365,662 (GRCm39)	missense	unknown
R0504:Il1rl2	UTSW	1	40,368,216 (GRCm39)	missense	probably benign	0.00
R1629:Il1rl2	UTSW	1	40,396,020 (GRCm39)	missense	probably benign	0.02
R1679:Il1rl2	UTSW	1	40,382,320 (GRCm39)	missense	probably benign	0.36
R1680:Il1rl2	UTSW	1	40,390,953 (GRCm39)	missense	possibly damaging	0.61
R1892:Il1rl2	UTSW	1	40,366,694 (GRCm39)	missense	probably damaging	1.00
R1938:Il1rl2	UTSW	1	40,402,484 (GRCm39)	missense	probably damaging	1.00
R2020:Il1rl2	UTSW	1	40,404,374 (GRCm39)	missense	probably damaging	0.98
R4193:Il1rl2	UTSW	1	40,404,208 (GRCm39)	missense	probably damaging	1.00
R4364:Il1rl2	UTSW	1	40,390,951 (GRCm39)	missense	probably benign
R4365:Il1rl2	UTSW	1	40,390,951 (GRCm39)	missense	probably benign
R4657:Il1rl2	UTSW	1	40,366,470 (GRCm39)	intron	probably benign
R4840:Il1rl2	UTSW	1	40,366,547 (GRCm39)	missense	possibly damaging	0.84
R4890:Il1rl2	UTSW	1	40,366,470 (GRCm39)	intron	probably benign
R5051:Il1rl2	UTSW	1	40,382,254 (GRCm39)	missense	probably benign	0.03
R5239:Il1rl2	UTSW	1	40,404,255 (GRCm39)	missense	probably benign	0.03
R5447:Il1rl2	UTSW	1	40,368,316 (GRCm39)	missense	probably damaging	1.00
R6013:Il1rl2	UTSW	1	40,391,017 (GRCm39)	missense	possibly damaging	0.82
R6162:Il1rl2	UTSW	1	40,391,038 (GRCm39)	missense	probably damaging	1.00
R6244:Il1rl2	UTSW	1	40,366,726 (GRCm39)	missense	possibly damaging	0.78
R6798:Il1rl2	UTSW	1	40,404,400 (GRCm39)	missense	probably damaging	1.00
R7667:Il1rl2	UTSW	1	40,404,413 (GRCm39)	missense	probably damaging	0.99
R7855:Il1rl2	UTSW	1	40,382,279 (GRCm39)	missense	probably damaging	1.00
R7857:Il1rl2	UTSW	1	40,366,642 (GRCm39)	missense	probably benign	0.44
R8255:Il1rl2	UTSW	1	40,404,471 (GRCm39)	missense	probably damaging	1.00
R8903:Il1rl2	UTSW	1	40,366,530 (GRCm39)	critical splice acceptor site	probably null
R9236:Il1rl2	UTSW	1	40,368,221 (GRCm39)	missense	probably damaging	1.00
R9448:Il1rl2	UTSW	1	40,366,604 (GRCm39)	missense	probably benign	0.36
R9487:Il1rl2	UTSW	1	40,366,470 (GRCm39)	intron	probably benign
R9621:Il1rl2	UTSW	1	40,366,470 (GRCm39)	intron	probably benign
R9746:Il1rl2	UTSW	1	40,404,519 (GRCm39)	missense	possibly damaging	0.94
Z1177:Il1rl2	UTSW	1	40,366,470 (GRCm39)	intron	probably benign

Predicted Primers

Posted On

2022-07-18