Incidental Mutation 'R9487:Itga11'
ID 716674
Institutional Source Beutler Lab
Gene Symbol Itga11
Ensembl Gene ENSMUSG00000032243
Gene Name integrin alpha 11
Synonyms 4732459H24Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R9487 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 62585108-62691264 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62670171 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 765 (N765I)
Ref Sequence ENSEMBL: ENSMUSP00000034774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034774]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000034774
AA Change: N765I

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000034774
Gene: ENSMUSG00000032243
AA Change: N765I

DomainStartEndE-ValueType
Int_alpha 37 90 3.9e-7 SMART
VWA 162 350 2.74e-38 SMART
Int_alpha 421 472 2.19e-1 SMART
Int_alpha 476 532 3.75e-9 SMART
Int_alpha 538 593 1.39e-12 SMART
Int_alpha 600 654 1.08e0 SMART
transmembrane domain 1142 1164 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik C T 1: 53,221,665 (GRCm39) D55N possibly damaging Het
Abcc2 G A 19: 43,806,471 (GRCm39) G762S probably damaging Het
Acta2 C A 19: 34,225,865 (GRCm39) A110S probably damaging Het
Adam26a T C 8: 44,022,456 (GRCm39) T345A possibly damaging Het
Anapc11 T C 11: 120,496,250 (GRCm39) *85R probably null Het
Ang2 A C 14: 51,433,071 (GRCm39) C104G probably damaging Het
Ankzf1 G A 1: 75,174,596 (GRCm39) V529I probably benign Het
Aox4 G T 1: 58,288,097 (GRCm39) V737F probably benign Het
Aqr T C 2: 113,934,528 (GRCm39) N1371S probably benign Het
Bach1 T A 16: 87,526,733 (GRCm39) S732T probably benign Het
Bcr T A 10: 74,967,431 (GRCm39) I555N probably damaging Het
Bicra T C 7: 15,705,717 (GRCm39) T1575A probably damaging Het
Bop1 A G 15: 76,338,076 (GRCm39) L598P probably damaging Het
Cacna1d A T 14: 29,845,419 (GRCm39) F605L possibly damaging Het
Capn15 C T 17: 26,184,353 (GRCm39) V109I possibly damaging Het
Cdkn1b T C 6: 134,897,815 (GRCm39) probably benign Het
Dnah2 T C 11: 69,406,617 (GRCm39) T542A possibly damaging Het
Dsc2 A T 18: 20,180,276 (GRCm39) I159N probably damaging Het
Ecel1 A T 1: 87,075,716 (GRCm39) V774E probably damaging Het
Eif5b T G 1: 38,084,560 (GRCm39) C849W probably damaging Het
Eif5b T A 1: 38,058,451 (GRCm39) L251* probably null Het
Ext2 T C 2: 93,592,956 (GRCm39) D416G probably damaging Het
Fancm G A 12: 65,153,388 (GRCm39) W1281* probably null Het
Flvcr1 A T 1: 190,743,829 (GRCm39) I409K possibly damaging Het
Foxk1 T C 5: 142,437,389 (GRCm39) probably null Het
Frem2 T A 3: 53,560,905 (GRCm39) I1201F possibly damaging Het
Gabra5 A G 7: 57,157,873 (GRCm39) probably benign Het
Gmpr2 G A 14: 55,915,778 (GRCm39) V319I probably damaging Het
Gna12 A T 5: 140,746,338 (GRCm39) L369Q probably damaging Het
Gpr160 A G 3: 30,950,914 (GRCm39) R329G probably benign Het
H2-M10.3 T C 17: 36,677,423 (GRCm39) H285R probably benign Het
H2-M2 A T 17: 37,793,424 (GRCm39) V194E probably benign Het
Hephl1 G A 9: 14,995,830 (GRCm39) R431W possibly damaging Het
Hr A G 14: 70,793,877 (GRCm39) T46A probably benign Het
Hr A G 14: 70,794,205 (GRCm39) H126R possibly damaging Het
Hsf1 T G 15: 76,382,398 (GRCm39) D256E probably benign Het
Ifi208 C T 1: 173,510,961 (GRCm39) T372I probably damaging Het
Ifi47 T G 11: 48,986,620 (GRCm39) F129C probably damaging Het
Il1rl2 CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT CTTTATTTTATTTTATTTTATTTTATTTTATTTTATT 1: 40,366,470 (GRCm39) probably benign Het
Irag2 A G 6: 145,120,257 (GRCm39) I491V probably benign Het
Klhl22 T A 16: 17,589,663 (GRCm39) I108K probably benign Het
Lancl1 T G 1: 67,073,381 (GRCm39) H34P probably benign Het
Lcor C A 19: 41,573,685 (GRCm39) N813K probably damaging Het
Mbd3l1 G A 9: 18,396,274 (GRCm39) G133D probably benign Het
Med12l T C 3: 59,155,353 (GRCm39) F1178L probably benign Het
Mrm1 A T 11: 84,705,531 (GRCm39) N289K probably damaging Het
Myf6 A G 10: 107,330,073 (GRCm39) Y165H probably benign Het
Myo1g C A 11: 6,456,913 (GRCm39) C971F probably benign Het
Myo3a T C 2: 22,245,862 (GRCm39) M3T probably benign Het
Nsrp1 G A 11: 76,937,114 (GRCm39) R361* probably null Het
Or10d4 A C 9: 39,580,611 (GRCm39) Q86P possibly damaging Het
Or10h1b C A 17: 33,395,548 (GRCm39) H57Q possibly damaging Het
Or4a69 T C 2: 89,312,756 (GRCm39) H241R probably damaging Het
Or4a77 T C 2: 89,487,731 (GRCm39) D18G probably damaging Het
Or5p6 A T 7: 107,631,163 (GRCm39) I129N possibly damaging Het
Or8b41 G A 9: 38,054,866 (GRCm39) C140Y probably benign Het
Or8k53 T A 2: 86,177,846 (GRCm39) D88V probably benign Het
Oscar T G 7: 3,614,663 (GRCm39) Y103S probably damaging Het
Pdpr A G 8: 111,852,925 (GRCm39) N610S probably benign Het
Ppp4r3b T C 11: 29,124,697 (GRCm39) I56T probably damaging Het
Pxdn T A 12: 30,044,552 (GRCm39) V510D possibly damaging Het
Rab11fip5 T C 6: 85,324,913 (GRCm39) S465G possibly damaging Het
Rasgrf2 T C 13: 92,267,759 (GRCm39) T82A probably benign Het
Scmh1 G A 4: 120,320,284 (GRCm39) W30* probably null Het
Sema4g T C 19: 44,981,071 (GRCm39) Y40H probably benign Het
Serpinf2 A T 11: 75,323,494 (GRCm39) M404K probably damaging Het
Sgk3 T C 1: 9,950,616 (GRCm39) probably null Het
Slc16a5 A T 11: 115,360,738 (GRCm39) Y307F possibly damaging Het
Slc39a5 G A 10: 128,233,628 (GRCm39) L290F probably damaging Het
Snx32 A C 19: 5,547,736 (GRCm39) D191E probably damaging Het
Sp4 T C 12: 118,262,859 (GRCm39) I396V probably benign Het
Srrd A G 5: 112,490,765 (GRCm39) V42A unknown Het
Stim1 A G 7: 102,080,257 (GRCm39) H547R unknown Het
Svep1 G A 4: 58,070,517 (GRCm39) A2423V probably benign Het
Tep1 A G 14: 51,066,687 (GRCm39) S2304P possibly damaging Het
Tkt C G 14: 30,281,795 (GRCm39) S104R probably benign Het
Tkt T C 14: 30,281,796 (GRCm39) S105P probably damaging Het
Tln1 A T 4: 43,542,893 (GRCm39) N1365K probably damaging Het
Topaz1 G T 9: 122,604,707 (GRCm39) A1104S probably benign Het
Trmt2a A G 16: 18,068,814 (GRCm39) H270R probably damaging Het
Ttll10 G T 4: 156,127,616 (GRCm39) T389K probably benign Het
Tubal3 A G 13: 3,980,674 (GRCm39) I129V probably benign Het
Ucp3 A G 7: 100,131,123 (GRCm39) E192G probably damaging Het
Usp47 A G 7: 111,677,063 (GRCm39) D448G probably damaging Het
Vmn2r98 T A 17: 19,301,496 (GRCm39) L833M possibly damaging Het
Vps13d A G 4: 144,807,869 (GRCm39) probably null Het
Wdr7 A G 18: 63,910,939 (GRCm39) D777G possibly damaging Het
Zcchc8 A G 5: 123,847,300 (GRCm39) I213T probably damaging Het
Zfp281 T C 1: 136,555,143 (GRCm39) I707T probably damaging Het
Zfp335 T C 2: 164,735,395 (GRCm39) H1158R probably damaging Het
Zfp692 C T 11: 58,199,765 (GRCm39) T118M probably damaging Het
Zfr2 T A 10: 81,075,969 (GRCm39) L192Q probably benign Het
Other mutations in Itga11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Itga11 APN 9 62,676,587 (GRCm39) missense possibly damaging 0.58
IGL01108:Itga11 APN 9 62,664,903 (GRCm39) missense probably benign
IGL01348:Itga11 APN 9 62,651,861 (GRCm39) missense possibly damaging 0.83
IGL01739:Itga11 APN 9 62,681,399 (GRCm39) missense probably benign 0.03
IGL01918:Itga11 APN 9 62,680,278 (GRCm39) missense probably benign 0.05
IGL02237:Itga11 APN 9 62,663,057 (GRCm39) critical splice donor site probably null
IGL02418:Itga11 APN 9 62,651,914 (GRCm39) missense probably benign 0.30
IGL02451:Itga11 APN 9 62,642,635 (GRCm39) missense probably damaging 1.00
sneezy UTSW 9 62,639,391 (GRCm39) missense probably damaging 1.00
PIT4812001:Itga11 UTSW 9 62,639,475 (GRCm39) missense probably damaging 1.00
R0013:Itga11 UTSW 9 62,683,895 (GRCm39) missense possibly damaging 0.89
R0013:Itga11 UTSW 9 62,683,895 (GRCm39) missense possibly damaging 0.89
R0032:Itga11 UTSW 9 62,681,377 (GRCm39) missense probably benign 0.05
R0032:Itga11 UTSW 9 62,681,377 (GRCm39) missense probably benign 0.05
R0101:Itga11 UTSW 9 62,651,768 (GRCm39) missense probably damaging 1.00
R0114:Itga11 UTSW 9 62,667,584 (GRCm39) missense possibly damaging 0.85
R0114:Itga11 UTSW 9 62,642,575 (GRCm39) missense probably damaging 1.00
R0212:Itga11 UTSW 9 62,653,251 (GRCm39) missense probably benign 0.22
R0310:Itga11 UTSW 9 62,667,628 (GRCm39) missense probably damaging 1.00
R0455:Itga11 UTSW 9 62,604,243 (GRCm39) missense probably damaging 1.00
R0558:Itga11 UTSW 9 62,659,570 (GRCm39) missense probably benign 0.01
R0607:Itga11 UTSW 9 62,681,653 (GRCm39) missense probably benign 0.00
R0924:Itga11 UTSW 9 62,683,956 (GRCm39) missense probably benign 0.14
R1085:Itga11 UTSW 9 62,585,252 (GRCm39) missense probably benign 0.03
R1477:Itga11 UTSW 9 62,662,493 (GRCm39) missense probably benign
R1647:Itga11 UTSW 9 62,667,652 (GRCm39) missense probably benign 0.01
R1831:Itga11 UTSW 9 62,689,300 (GRCm39) missense probably damaging 1.00
R1880:Itga11 UTSW 9 62,585,231 (GRCm39) missense probably benign 0.06
R1934:Itga11 UTSW 9 62,651,796 (GRCm39) missense probably damaging 1.00
R2025:Itga11 UTSW 9 62,670,093 (GRCm39) missense probably damaging 1.00
R2046:Itga11 UTSW 9 62,634,979 (GRCm39) missense probably damaging 1.00
R2145:Itga11 UTSW 9 62,639,486 (GRCm39) splice site probably benign
R2922:Itga11 UTSW 9 62,675,912 (GRCm39) splice site probably benign
R3011:Itga11 UTSW 9 62,604,262 (GRCm39) missense probably damaging 0.99
R3158:Itga11 UTSW 9 62,676,560 (GRCm39) missense probably benign 0.02
R3809:Itga11 UTSW 9 62,678,664 (GRCm39) missense probably benign
R3836:Itga11 UTSW 9 62,676,565 (GRCm39) missense probably benign 0.00
R4051:Itga11 UTSW 9 62,662,933 (GRCm39) nonsense probably null
R4190:Itga11 UTSW 9 62,639,391 (GRCm39) missense probably damaging 1.00
R4510:Itga11 UTSW 9 62,668,870 (GRCm39) missense probably damaging 0.96
R4511:Itga11 UTSW 9 62,668,870 (GRCm39) missense probably damaging 0.96
R4678:Itga11 UTSW 9 62,642,639 (GRCm39) missense probably damaging 0.98
R4706:Itga11 UTSW 9 62,662,578 (GRCm39) missense possibly damaging 0.64
R4713:Itga11 UTSW 9 62,673,070 (GRCm39) missense probably damaging 1.00
R4798:Itga11 UTSW 9 62,684,009 (GRCm39) splice site probably null
R4909:Itga11 UTSW 9 62,662,581 (GRCm39) missense probably damaging 1.00
R4915:Itga11 UTSW 9 62,659,530 (GRCm39) nonsense probably null
R4957:Itga11 UTSW 9 62,674,930 (GRCm39) missense probably benign 0.00
R4962:Itga11 UTSW 9 62,668,850 (GRCm39) nonsense probably null
R5081:Itga11 UTSW 9 62,662,478 (GRCm39) missense probably benign 0.13
R5265:Itga11 UTSW 9 62,644,694 (GRCm39) missense probably benign 0.05
R5308:Itga11 UTSW 9 62,663,051 (GRCm39) missense probably benign
R5398:Itga11 UTSW 9 62,653,205 (GRCm39) missense probably benign 0.21
R5717:Itga11 UTSW 9 62,659,531 (GRCm39) missense probably benign 0.26
R5885:Itga11 UTSW 9 62,670,132 (GRCm39) missense probably damaging 0.99
R5996:Itga11 UTSW 9 62,662,955 (GRCm39) missense probably benign 0.01
R6394:Itga11 UTSW 9 62,642,548 (GRCm39) splice site probably null
R6751:Itga11 UTSW 9 62,675,866 (GRCm39) missense probably benign 0.02
R7041:Itga11 UTSW 9 62,659,538 (GRCm39) missense probably damaging 1.00
R7264:Itga11 UTSW 9 62,653,190 (GRCm39) missense probably benign 0.02
R7509:Itga11 UTSW 9 62,689,222 (GRCm39) missense probably benign
R7601:Itga11 UTSW 9 62,604,208 (GRCm39) missense probably benign 0.18
R7615:Itga11 UTSW 9 62,651,300 (GRCm39) missense probably benign 0.00
R8263:Itga11 UTSW 9 62,604,262 (GRCm39) missense possibly damaging 0.86
R8285:Itga11 UTSW 9 62,659,540 (GRCm39) missense probably damaging 1.00
R8419:Itga11 UTSW 9 62,662,460 (GRCm39) missense possibly damaging 0.59
R8422:Itga11 UTSW 9 62,674,960 (GRCm39) missense probably benign 0.00
R8469:Itga11 UTSW 9 62,678,680 (GRCm39) missense probably benign 0.00
R8475:Itga11 UTSW 9 62,651,327 (GRCm39) missense probably damaging 1.00
R8871:Itga11 UTSW 9 62,668,823 (GRCm39) nonsense probably null
R8904:Itga11 UTSW 9 62,664,893 (GRCm39) missense probably benign
R8954:Itga11 UTSW 9 62,676,545 (GRCm39) missense possibly damaging 0.58
R8977:Itga11 UTSW 9 62,662,922 (GRCm39) missense probably damaging 0.98
R9011:Itga11 UTSW 9 62,662,909 (GRCm39) missense probably benign 0.43
R9038:Itga11 UTSW 9 62,675,039 (GRCm39) missense possibly damaging 0.90
R9089:Itga11 UTSW 9 62,678,662 (GRCm39) missense probably damaging 1.00
R9262:Itga11 UTSW 9 62,659,678 (GRCm39) splice site probably benign
R9327:Itga11 UTSW 9 62,638,034 (GRCm39) missense probably damaging 1.00
R9794:Itga11 UTSW 9 62,662,868 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATTATCCACATGGGGACTTACC -3'
(R):5'- CCACTTAGTGCCTCCATGTG -3'

Sequencing Primer
(F):5'- ACAGGCTGCTGTCCTCCAG -3'
(R):5'- CATGTGAGGAGGACATGGGAATCC -3'
Posted On 2022-07-18