Incidental Mutation 'R9489:Mrc1'
| ID |
716797 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc1
|
| Ensembl Gene |
ENSMUSG00000026712 |
| Gene Name |
mannose receptor, C type 1 |
| Synonyms |
CD206, MR |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R9489 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
14234225-14336834 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 14324110 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 1149
(N1149S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028045]
|
| AlphaFold |
Q61830 |
| PDB Structure |
CRYSTAL STRUCTURE OF THE CYSTEINE RICH DOMAIN OF MANNOSE RECEPTOR [X-RAY DIFFRACTION]
Crystal structure of the cysteine rich domain of mannose receptor complexed with Acetylgalactosamine-4-sulfate [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH 3-SO4-LEWIS(X) [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MANNOSE RECEPTOR COMPLEXED WITH 3-SO4-LEWIS(A) [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028045
AA Change: N1149S
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000028045
Gene: ENSMUSG00000026712
AA Change: N1149S
| Domain | Start | End | E-Value | Type |
|---|
|
RICIN
|
22 |
142 |
8.09e-18 |
SMART |
|
FN2
|
161 |
209 |
1.83e-27 |
SMART |
|
CLECT
|
216 |
341 |
8.87e-26 |
SMART |
|
CLECT
|
362 |
487 |
3.51e-38 |
SMART |
|
CLECT
|
504 |
626 |
8.2e-30 |
SMART |
|
CLECT
|
646 |
778 |
2.34e-34 |
SMART |
|
CLECT
|
800 |
923 |
2.17e-29 |
SMART |
|
low complexity region
|
935 |
941 |
N/A |
INTRINSIC |
|
CLECT
|
944 |
1079 |
3.35e-35 |
SMART |
|
CLECT
|
1094 |
1212 |
4.11e-21 |
SMART |
|
CLECT
|
1229 |
1355 |
3.63e-31 |
SMART |
|
transmembrane domain
|
1388 |
1410 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
PHENOTYPE: Male homozygotes for one targeted null mutation die in utero. Heterozygous females clear lutropin from the circulation more slowly and have smaller litters due to reduced implantation. Another targeted knockout is viable and homozygotes are less susceptible to parasitic infection. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Targeted(2)
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930486L24Rik |
T |
A |
13: 61,002,683 (GRCm39) |
S24C |
probably damaging |
Het |
| 6430548M08Rik |
G |
A |
8: 120,872,380 (GRCm39) |
V103I |
possibly damaging |
Het |
| Acaca |
C |
T |
11: 84,183,842 (GRCm39) |
T1240I |
probably benign |
Het |
| Adam19 |
T |
C |
11: 46,028,449 (GRCm39) |
V694A |
probably benign |
Het |
| Adipor1 |
A |
G |
1: 134,352,553 (GRCm39) |
D108G |
probably damaging |
Het |
| Arhgef4 |
A |
G |
1: 34,761,745 (GRCm39) |
T334A |
unknown |
Het |
| Bcl11a |
T |
C |
11: 24,114,582 (GRCm39) |
F642L |
probably benign |
Het |
| Camk2d |
T |
C |
3: 126,561,209 (GRCm39) |
Y108H |
probably damaging |
Het |
| Castor2 |
G |
T |
5: 134,164,536 (GRCm39) |
V166L |
probably benign |
Het |
| Catsper1 |
A |
G |
19: 5,387,785 (GRCm39) |
T355A |
probably benign |
Het |
| Ccdc69 |
T |
A |
11: 54,945,856 (GRCm39) |
N50I |
possibly damaging |
Het |
| Chd8 |
A |
T |
14: 52,457,055 (GRCm39) |
L971Q |
probably damaging |
Het |
| Chrna10 |
C |
A |
7: 101,762,801 (GRCm39) |
A130S |
probably benign |
Het |
| Ciao1 |
G |
A |
2: 127,087,684 (GRCm39) |
T217I |
probably damaging |
Het |
| Cldn1 |
A |
T |
16: 26,181,924 (GRCm39) |
I95N |
probably damaging |
Het |
| Cluh |
C |
T |
11: 74,558,772 (GRCm39) |
R1253C |
possibly damaging |
Het |
| Cngb3 |
A |
T |
4: 19,505,187 (GRCm39) |
Q640L |
probably benign |
Het |
| Cyp2c40 |
A |
T |
19: 39,766,443 (GRCm39) |
V384D |
probably damaging |
Het |
| Cyp2d26 |
T |
A |
15: 82,674,672 (GRCm39) |
M437L |
probably benign |
Het |
| Cyp2j7 |
T |
C |
4: 96,103,591 (GRCm39) |
T315A |
probably damaging |
Het |
| D430041D05Rik |
A |
G |
2: 104,087,189 (GRCm39) |
S596P |
probably benign |
Het |
| Dagla |
A |
T |
19: 10,233,053 (GRCm39) |
V448D |
probably damaging |
Het |
| Ddx59 |
A |
T |
1: 136,344,594 (GRCm39) |
E88D |
probably benign |
Het |
| Dnhd1 |
A |
G |
7: 105,300,804 (GRCm39) |
I54V |
probably benign |
Het |
| Dnttip1 |
A |
C |
2: 164,593,162 (GRCm39) |
D95A |
probably benign |
Het |
| Efna3 |
T |
C |
3: 89,222,818 (GRCm39) |
T207A |
probably benign |
Het |
| Eprs1 |
A |
C |
1: 185,139,895 (GRCm39) |
S995R |
probably benign |
Het |
| Eprs1 |
G |
A |
1: 185,139,896 (GRCm39) |
S995N |
probably benign |
Het |
| Erbb2 |
T |
C |
11: 98,311,746 (GRCm39) |
V94A |
possibly damaging |
Het |
| Etl4 |
A |
T |
2: 20,771,345 (GRCm39) |
I607F |
possibly damaging |
Het |
| Ets2 |
G |
T |
16: 95,516,121 (GRCm39) |
E234* |
probably null |
Het |
| Fgf6 |
A |
C |
6: 126,992,814 (GRCm39) |
Y89S |
probably damaging |
Het |
| Fmn2 |
C |
T |
1: 174,436,194 (GRCm39) |
Q722* |
probably null |
Het |
| Gata3un |
CGG |
CG |
2: 9,888,075 (GRCm39) |
|
probably null |
Het |
| Gdpd5 |
A |
G |
7: 99,103,031 (GRCm39) |
D330G |
|
Het |
| Glipr1 |
A |
G |
10: 111,832,801 (GRCm39) |
S46P |
probably damaging |
Het |
| Gnptab |
A |
G |
10: 88,268,992 (GRCm39) |
Y565C |
probably damaging |
Het |
| H2-M10.2 |
C |
T |
17: 36,596,936 (GRCm39) |
V47I |
probably benign |
Het |
| Heatr5b |
T |
A |
17: 79,060,679 (GRCm39) |
K1999* |
probably null |
Het |
| Iqgap3 |
C |
A |
3: 88,016,176 (GRCm39) |
F986L |
probably damaging |
Het |
| Kif9 |
G |
A |
9: 110,346,710 (GRCm39) |
R616H |
probably benign |
Het |
| Krt87 |
G |
T |
15: 101,336,484 (GRCm39) |
C56* |
probably null |
Het |
| Ldlr |
A |
G |
9: 21,646,626 (GRCm39) |
D264G |
probably damaging |
Het |
| Lrrk2 |
A |
T |
15: 91,621,420 (GRCm39) |
D998V |
probably benign |
Het |
| Mcm5 |
C |
T |
8: 75,844,168 (GRCm39) |
S313F |
probably benign |
Het |
| Mmp9 |
A |
G |
2: 164,793,146 (GRCm39) |
N432D |
probably benign |
Het |
| Mta1 |
A |
T |
12: 113,095,085 (GRCm39) |
M448L |
probably benign |
Het |
| Myo1c |
T |
A |
11: 75,559,899 (GRCm39) |
V661E |
probably benign |
Het |
| Ndc1 |
T |
C |
4: 107,247,863 (GRCm39) |
|
probably null |
Het |
| Npy |
A |
C |
6: 49,804,545 (GRCm39) |
T89P |
possibly damaging |
Het |
| Or12e13 |
T |
G |
2: 87,663,478 (GRCm39) |
F32V |
probably benign |
Het |
| Or52e19 |
A |
G |
7: 102,959,452 (GRCm39) |
I175V |
probably benign |
Het |
| Or52e8 |
A |
T |
7: 104,624,856 (GRCm39) |
M116K |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,093 (GRCm39) |
V258A |
probably damaging |
Het |
| Osgin2 |
G |
T |
4: 15,998,427 (GRCm39) |
H398Q |
probably damaging |
Het |
| Pepd |
A |
C |
7: 34,743,218 (GRCm39) |
D419A |
probably benign |
Het |
| Pikfyve |
A |
T |
1: 65,303,561 (GRCm39) |
S1694C |
probably benign |
Het |
| Polq |
A |
G |
16: 36,843,173 (GRCm39) |
I236V |
probably benign |
Het |
| Prkag3 |
T |
G |
1: 74,786,378 (GRCm39) |
Q189P |
probably damaging |
Het |
| Rab6b |
A |
T |
9: 103,017,601 (GRCm39) |
T31S |
probably benign |
Het |
| Ralgapb |
C |
T |
2: 158,268,283 (GRCm39) |
P129S |
possibly damaging |
Het |
| Ryr3 |
A |
T |
2: 112,491,966 (GRCm39) |
L3795Q |
probably damaging |
Het |
| Sash1 |
C |
T |
10: 8,605,169 (GRCm39) |
V1074M |
probably benign |
Het |
| Scfd2 |
T |
C |
5: 74,680,235 (GRCm39) |
D306G |
probably damaging |
Het |
| Scg2 |
A |
G |
1: 79,412,936 (GRCm39) |
Y556H |
probably damaging |
Het |
| Serpina3j |
A |
G |
12: 104,286,093 (GRCm39) |
N416S |
probably damaging |
Het |
| Serpinb6c |
T |
A |
13: 34,081,421 (GRCm39) |
Q76L |
probably null |
Het |
| Setd7 |
G |
A |
3: 51,450,139 (GRCm39) |
Q96* |
probably null |
Het |
| Sf3b4 |
C |
T |
3: 96,080,946 (GRCm39) |
R85W |
probably damaging |
Het |
| Sik3 |
T |
A |
9: 46,120,117 (GRCm39) |
H735Q |
probably benign |
Het |
| Slain1 |
A |
C |
14: 103,902,112 (GRCm39) |
T60P |
|
Het |
| Slc36a3 |
T |
C |
11: 55,040,726 (GRCm39) |
E69G |
unknown |
Het |
| Sorcs3 |
A |
T |
19: 48,711,364 (GRCm39) |
Y643F |
probably damaging |
Het |
| Spta1 |
A |
G |
1: 174,035,880 (GRCm39) |
Y1062C |
probably damaging |
Het |
| Ssc5d |
C |
T |
7: 4,940,599 (GRCm39) |
P904L |
probably benign |
Het |
| Stat5b |
T |
A |
11: 100,699,276 (GRCm39) |
H25L |
possibly damaging |
Het |
| Synj2 |
A |
G |
17: 6,063,794 (GRCm39) |
I513V |
probably benign |
Het |
| Tenm2 |
T |
C |
11: 36,834,791 (GRCm39) |
E68G |
probably damaging |
Het |
| Thsd7a |
C |
T |
6: 12,352,022 (GRCm39) |
G1058R |
|
Het |
| Traf3ip2 |
T |
A |
10: 39,521,772 (GRCm39) |
D443E |
probably benign |
Het |
| Traf6 |
G |
T |
2: 101,524,625 (GRCm39) |
C235F |
probably damaging |
Het |
| Treh |
A |
G |
9: 44,592,416 (GRCm39) |
D47G |
probably damaging |
Het |
| Txndc16 |
A |
T |
14: 45,442,799 (GRCm39) |
F132Y |
probably damaging |
Het |
| Uggt1 |
A |
T |
1: 36,273,886 (GRCm39) |
|
probably null |
Het |
| Usp25 |
A |
T |
16: 76,874,046 (GRCm39) |
I541F |
probably damaging |
Het |
| Zfp51 |
A |
G |
17: 21,684,291 (GRCm39) |
E302G |
probably damaging |
Het |
| Zfp648 |
A |
T |
1: 154,080,110 (GRCm39) |
T90S |
probably benign |
Het |
| Zfp84 |
A |
G |
7: 29,476,264 (GRCm39) |
T319A |
possibly damaging |
Het |
| Zkscan17 |
T |
A |
11: 59,378,037 (GRCm39) |
H538L |
probably damaging |
Het |
| Zyg11a |
G |
T |
4: 108,062,376 (GRCm39) |
P142T |
probably damaging |
Het |
|
| Other mutations in Mrc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01013:Mrc1
|
APN |
2 |
14,333,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01326:Mrc1
|
APN |
2 |
14,271,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Mrc1
|
APN |
2 |
14,314,895 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01758:Mrc1
|
APN |
2 |
14,243,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01799:Mrc1
|
APN |
2 |
14,243,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02280:Mrc1
|
APN |
2 |
14,249,024 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02435:Mrc1
|
APN |
2 |
14,253,671 (GRCm39) |
nonsense |
probably null |
|
|
IGL03073:Mrc1
|
APN |
2 |
14,310,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Mrc1
|
APN |
2 |
14,298,289 (GRCm39) |
nonsense |
probably null |
|
|
IGL03155:Mrc1
|
APN |
2 |
14,335,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03289:Mrc1
|
APN |
2 |
14,313,634 (GRCm39) |
critical splice donor site |
probably null |
|
|
amlodipine
|
UTSW |
2 |
14,275,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
losartan
|
UTSW |
2 |
14,299,597 (GRCm39) |
splice site |
probably null |
|
|
Shug
|
UTSW |
2 |
14,275,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
sussigkeit
|
UTSW |
2 |
14,330,192 (GRCm39) |
splice site |
probably null |
|
|
R0011:Mrc1
|
UTSW |
2 |
14,266,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0011:Mrc1
|
UTSW |
2 |
14,266,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0066:Mrc1
|
UTSW |
2 |
14,266,011 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0066:Mrc1
|
UTSW |
2 |
14,266,011 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0110:Mrc1
|
UTSW |
2 |
14,243,353 (GRCm39) |
splice site |
probably benign |
|
|
R0234:Mrc1
|
UTSW |
2 |
14,284,705 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0234:Mrc1
|
UTSW |
2 |
14,284,705 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0381:Mrc1
|
UTSW |
2 |
14,312,720 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0505:Mrc1
|
UTSW |
2 |
14,314,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Mrc1
|
UTSW |
2 |
14,274,937 (GRCm39) |
splice site |
probably benign |
|
|
R0613:Mrc1
|
UTSW |
2 |
14,299,630 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0626:Mrc1
|
UTSW |
2 |
14,333,382 (GRCm39) |
nonsense |
probably null |
|
|
R1122:Mrc1
|
UTSW |
2 |
14,266,147 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1281:Mrc1
|
UTSW |
2 |
14,298,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1399:Mrc1
|
UTSW |
2 |
14,284,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1428:Mrc1
|
UTSW |
2 |
14,320,074 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1571:Mrc1
|
UTSW |
2 |
14,313,544 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1596:Mrc1
|
UTSW |
2 |
14,253,701 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1730:Mrc1
|
UTSW |
2 |
14,332,655 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1733:Mrc1
|
UTSW |
2 |
14,261,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Mrc1
|
UTSW |
2 |
14,332,655 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1860:Mrc1
|
UTSW |
2 |
14,333,390 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1872:Mrc1
|
UTSW |
2 |
14,330,192 (GRCm39) |
splice site |
probably null |
|
|
R1889:Mrc1
|
UTSW |
2 |
14,313,488 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1938:Mrc1
|
UTSW |
2 |
14,324,052 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1971:Mrc1
|
UTSW |
2 |
14,249,103 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2031:Mrc1
|
UTSW |
2 |
14,326,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Mrc1
|
UTSW |
2 |
14,275,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Mrc1
|
UTSW |
2 |
14,332,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2168:Mrc1
|
UTSW |
2 |
14,249,015 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2273:Mrc1
|
UTSW |
2 |
14,330,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2901:Mrc1
|
UTSW |
2 |
14,333,354 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3767:Mrc1
|
UTSW |
2 |
14,323,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3795:Mrc1
|
UTSW |
2 |
14,293,793 (GRCm39) |
splice site |
probably benign |
|
|
R4028:Mrc1
|
UTSW |
2 |
14,243,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4668:Mrc1
|
UTSW |
2 |
14,298,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4828:Mrc1
|
UTSW |
2 |
14,275,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4897:Mrc1
|
UTSW |
2 |
14,323,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4950:Mrc1
|
UTSW |
2 |
14,276,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Mrc1
|
UTSW |
2 |
14,249,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5068:Mrc1
|
UTSW |
2 |
14,311,327 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Mrc1
|
UTSW |
2 |
14,314,869 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5366:Mrc1
|
UTSW |
2 |
14,326,725 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5436:Mrc1
|
UTSW |
2 |
14,271,326 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5552:Mrc1
|
UTSW |
2 |
14,284,768 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5631:Mrc1
|
UTSW |
2 |
14,333,383 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Mrc1
|
UTSW |
2 |
14,313,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5978:Mrc1
|
UTSW |
2 |
14,320,204 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5993:Mrc1
|
UTSW |
2 |
14,310,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6030:Mrc1
|
UTSW |
2 |
14,321,712 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6030:Mrc1
|
UTSW |
2 |
14,321,712 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Mrc1
|
UTSW |
2 |
14,261,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Mrc1
|
UTSW |
2 |
14,261,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6228:Mrc1
|
UTSW |
2 |
14,276,115 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6344:Mrc1
|
UTSW |
2 |
14,248,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Mrc1
|
UTSW |
2 |
14,275,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6520:Mrc1
|
UTSW |
2 |
14,312,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6619:Mrc1
|
UTSW |
2 |
14,299,597 (GRCm39) |
splice site |
probably null |
|
|
R6631:Mrc1
|
UTSW |
2 |
14,243,296 (GRCm39) |
missense |
probably benign |
|
|
R6737:Mrc1
|
UTSW |
2 |
14,276,088 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6782:Mrc1
|
UTSW |
2 |
14,266,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6887:Mrc1
|
UTSW |
2 |
14,330,048 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7108:Mrc1
|
UTSW |
2 |
14,308,957 (GRCm39) |
nonsense |
probably null |
|
|
R7120:Mrc1
|
UTSW |
2 |
14,313,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7460:Mrc1
|
UTSW |
2 |
14,253,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7567:Mrc1
|
UTSW |
2 |
14,330,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7606:Mrc1
|
UTSW |
2 |
14,242,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Mrc1
|
UTSW |
2 |
14,284,788 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7826:Mrc1
|
UTSW |
2 |
14,299,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Mrc1
|
UTSW |
2 |
14,253,771 (GRCm39) |
missense |
probably benign |
|
|
R8279:Mrc1
|
UTSW |
2 |
14,271,168 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8888:Mrc1
|
UTSW |
2 |
14,312,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8895:Mrc1
|
UTSW |
2 |
14,312,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Mrc1
|
UTSW |
2 |
14,253,735 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9315:Mrc1
|
UTSW |
2 |
14,248,969 (GRCm39) |
nonsense |
probably null |
|
|
R9366:Mrc1
|
UTSW |
2 |
14,321,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9373:Mrc1
|
UTSW |
2 |
14,274,999 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9418:Mrc1
|
UTSW |
2 |
14,234,358 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9420:Mrc1
|
UTSW |
2 |
14,312,790 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9564:Mrc1
|
UTSW |
2 |
14,266,117 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9572:Mrc1
|
UTSW |
2 |
14,234,334 (GRCm39) |
missense |
probably benign |
|
|
R9605:Mrc1
|
UTSW |
2 |
14,324,110 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9606:Mrc1
|
UTSW |
2 |
14,313,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9781:Mrc1
|
UTSW |
2 |
14,310,175 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9781:Mrc1
|
UTSW |
2 |
14,249,100 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Mrc1
|
UTSW |
2 |
14,293,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Mrc1
|
UTSW |
2 |
14,248,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGTACTCAATTATTGGCTCGTTG -3'
(R):5'- TCACAGAGGTCTCAGCTTGG -3'
Sequencing Primer
(F):5'- CTCAATTATTGGCTCGTTGATAATGC -3'
(R):5'- GGTTTCTGGCACATTATCACTAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation