Incidental Mutation 'R9493:Or4k36'
ID 717045
Institutional Source Beutler Lab
Gene Symbol Or4k36
Ensembl Gene ENSMUSG00000109449
Gene Name olfactory receptor family 4 subfamily K member 36
Synonyms GA_x6K02T2Q125-72366920-72367837, Olfr1280, MOR248-1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.193) question?
Stock # R9493 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111144362-111156348 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111146288 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 155 (H155Y)
Ref Sequence ENSEMBL: ENSMUSP00000151980 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082167] [ENSMUST00000213551] [ENSMUST00000219291]
AlphaFold Q8VGG8
Predicted Effect probably damaging
Transcript: ENSMUST00000082167
AA Change: H155Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080805
Gene: ENSMUSG00000109449
AA Change: H155Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 3.8e-50 PFAM
Pfam:7tm_1 41 287 9.9e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213551
AA Change: H155Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000219291
AA Change: H155Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 A G 11: 48,838,191 (GRCm39) Y799H probably damaging Het
Akap5 G A 12: 76,375,041 (GRCm39) A158T probably damaging Het
Aox4 A G 1: 58,286,434 (GRCm39) K689E probably benign Het
Arid1b G A 17: 5,046,423 (GRCm39) A404T unknown Het
Bltp1 A G 3: 37,065,885 (GRCm39) N53S Het
Camk2b T A 11: 5,929,711 (GRCm39) D396V probably damaging Het
Cd53 T A 3: 106,674,683 (GRCm39) D128V probably null Het
Cdk15 G T 1: 59,326,943 (GRCm39) R208L probably damaging Het
Celsr1 T G 15: 85,785,346 (GRCm39) K2963Q probably damaging Het
Celsr2 A G 3: 108,301,074 (GRCm39) S2740P probably damaging Het
Clca4b A T 3: 144,632,964 (GRCm39) L162H probably damaging Het
Cntn1 A T 15: 92,189,644 (GRCm39) T656S probably damaging Het
Creb3l1 C T 2: 91,822,231 (GRCm39) probably null Het
Dpy19l2 A G 9: 24,530,459 (GRCm39) Y507H probably damaging Het
Dsc3 A T 18: 20,122,752 (GRCm39) C57* probably null Het
Gramd1b A G 9: 40,217,689 (GRCm39) Y621H probably damaging Het
Ifi207 A T 1: 173,556,522 (GRCm39) C739S probably benign Het
Il1rap T C 16: 26,541,702 (GRCm39) S648P probably benign Het
Ints5 C T 19: 8,872,686 (GRCm39) T215I probably damaging Het
Itm2c T C 1: 85,834,255 (GRCm39) probably null Het
Lmo7 T A 14: 102,137,907 (GRCm39) S870T probably benign Het
Lrpprc A T 17: 85,015,548 (GRCm39) F1288I probably damaging Het
Megf11 A T 9: 64,547,376 (GRCm39) H209L probably damaging Het
Mtss1 C T 15: 58,926,869 (GRCm39) R69H probably damaging Het
Nms A T 1: 38,980,982 (GRCm39) H56L probably benign Het
Or4f54 G A 2: 111,122,736 (GRCm39) G41D probably damaging Het
Or56a5 A T 7: 104,793,497 (GRCm39) M7K possibly damaging Het
Or5t17 T C 2: 86,833,140 (GRCm39) S276P probably benign Het
Pds5a G A 5: 65,792,747 (GRCm39) R729W probably damaging Het
Pskh1 C T 8: 106,639,598 (GRCm39) R93* probably null Het
Rapgef2 G A 3: 79,019,495 (GRCm39) L59F probably damaging Het
Rtn4 G A 11: 29,691,011 (GRCm39) V1101I probably damaging Het
Sec31b C A 19: 44,509,021 (GRCm39) V653F probably damaging Het
Slc10a2 A G 8: 5,139,047 (GRCm39) V299A Het
Slc6a15 A G 10: 103,229,277 (GRCm39) I105M probably benign Het
Smurf1 A G 5: 144,833,395 (GRCm39) V209A Het
Snapc2 A G 8: 4,304,591 (GRCm39) E115G probably damaging Het
Sorcs2 T C 5: 36,199,529 (GRCm39) E592G possibly damaging Het
Spmip6 G A 4: 41,508,614 (GRCm39) P17L Het
Styxl2 T A 1: 165,926,410 (GRCm39) K1067N probably damaging Het
Tcl1b1 A T 12: 105,130,823 (GRCm39) Q102L probably damaging Het
Tmc1 T A 19: 20,801,644 (GRCm39) N461Y probably benign Het
Trim59 C A 3: 68,945,134 (GRCm39) G69C probably damaging Het
Tubg1 A G 11: 101,017,003 (GRCm39) Y435C probably damaging Het
Ucp3 A C 7: 100,131,911 (GRCm39) H254P probably benign Het
Vav2 T C 2: 27,157,276 (GRCm39) D842G probably damaging Het
Vmn1r203 T A 13: 22,708,423 (GRCm39) L68H probably damaging Het
Wee2 A G 6: 40,421,057 (GRCm39) E49G probably benign Het
Zfr A G 15: 12,180,706 (GRCm39) probably null Het
Other mutations in Or4k36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01364:Or4k36 APN 2 111,146,015 (GRCm39) missense probably damaging 1.00
IGL01906:Or4k36 APN 2 111,146,246 (GRCm39) missense probably damaging 1.00
R0078:Or4k36 UTSW 2 111,146,249 (GRCm39) missense probably benign 0.04
R0091:Or4k36 UTSW 2 111,146,518 (GRCm39) missense probably benign 0.00
R0295:Or4k36 UTSW 2 111,146,499 (GRCm39) missense probably damaging 0.99
R1650:Or4k36 UTSW 2 111,146,640 (GRCm39) missense probably benign 0.04
R1808:Or4k36 UTSW 2 111,146,343 (GRCm39) missense probably benign 0.00
R2120:Or4k36 UTSW 2 111,145,844 (GRCm39) missense probably benign 0.02
R3084:Or4k36 UTSW 2 111,146,461 (GRCm39) missense probably benign 0.36
R3085:Or4k36 UTSW 2 111,146,461 (GRCm39) missense probably benign 0.36
R3086:Or4k36 UTSW 2 111,146,461 (GRCm39) missense probably benign 0.36
R3148:Or4k36 UTSW 2 111,146,633 (GRCm39) missense possibly damaging 0.93
R4229:Or4k36 UTSW 2 111,146,681 (GRCm39) missense probably damaging 1.00
R4258:Or4k36 UTSW 2 111,145,983 (GRCm39) missense probably benign
R4908:Or4k36 UTSW 2 111,146,574 (GRCm39) missense probably benign 0.09
R4972:Or4k36 UTSW 2 111,146,163 (GRCm39) missense probably damaging 1.00
R5051:Or4k36 UTSW 2 111,146,599 (GRCm39) nonsense probably null
R5551:Or4k36 UTSW 2 111,145,916 (GRCm39) missense possibly damaging 0.52
R7573:Or4k36 UTSW 2 111,146,277 (GRCm39) missense probably benign 0.04
R8808:Or4k36 UTSW 2 111,146,239 (GRCm39) missense possibly damaging 0.70
R9156:Or4k36 UTSW 2 111,145,827 (GRCm39) start codon destroyed probably null 1.00
R9405:Or4k36 UTSW 2 111,146,460 (GRCm39) missense possibly damaging 0.53
R9450:Or4k36 UTSW 2 111,146,398 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- CATGAGCCAGATCCTCTGTG -3'
(R):5'- GCCATCTTTAGAGTGAAGCTGAAC -3'

Sequencing Primer
(F):5'- AGCCAGATCCTCTGTGTGCAC -3'
(R):5'- CTTTAGAGTGAAGCTGAACAGTTAG -3'
Posted On 2022-07-18