Mutagenetix > Incidental Mutation

Incidental Mutation 'R9493:Vmn1r203'

717072

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r203

Ensembl Gene

ENSMUSG00000069289

Gene Name

vomeronasal 1 receptor 203

Synonyms

V1rh11

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R9493 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22708221-22709156 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22708423 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 68 (L68H)

Ref Sequence

ENSEMBL: ENSMUSP00000089322 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091729] [ENSMUST00000227520] [ENSMUST00000228889]

AlphaFold

Q8R273

Predicted Effect

probably damaging
Transcript: ENSMUST00000091729
AA Change: L68H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000089322
Gene: ENSMUSG00000069289
AA Change: L68H

Domain	Start	End	E-Value	Type
transmembrane domain	19	41	N/A	INTRINSIC
Pfam:V1R	43	304	5.8e-35	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227520
AA Change: L68H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228889
AA Change: L68H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930111J21Rik1	A	G	11: 48,838,191 (GRCm39)	Y799H	probably damaging	Het
Akap5	G	A	12: 76,375,041 (GRCm39)	A158T	probably damaging	Het
Aox4	A	G	1: 58,286,434 (GRCm39)	K689E	probably benign	Het
Arid1b	G	A	17: 5,046,423 (GRCm39)	A404T	unknown	Het
Bltp1	A	G	3: 37,065,885 (GRCm39)	N53S		Het
Camk2b	T	A	11: 5,929,711 (GRCm39)	D396V	probably damaging	Het
Cd53	T	A	3: 106,674,683 (GRCm39)	D128V	probably null	Het
Cdk15	G	T	1: 59,326,943 (GRCm39)	R208L	probably damaging	Het
Celsr1	T	G	15: 85,785,346 (GRCm39)	K2963Q	probably damaging	Het
Celsr2	A	G	3: 108,301,074 (GRCm39)	S2740P	probably damaging	Het
Clca4b	A	T	3: 144,632,964 (GRCm39)	L162H	probably damaging	Het
Cntn1	A	T	15: 92,189,644 (GRCm39)	T656S	probably damaging	Het
Creb3l1	C	T	2: 91,822,231 (GRCm39)		probably null	Het
Dpy19l2	A	G	9: 24,530,459 (GRCm39)	Y507H	probably damaging	Het
Dsc3	A	T	18: 20,122,752 (GRCm39)	C57*	probably null	Het
Gramd1b	A	G	9: 40,217,689 (GRCm39)	Y621H	probably damaging	Het
Ifi207	A	T	1: 173,556,522 (GRCm39)	C739S	probably benign	Het
Il1rap	T	C	16: 26,541,702 (GRCm39)	S648P	probably benign	Het
Ints5	C	T	19: 8,872,686 (GRCm39)	T215I	probably damaging	Het
Itm2c	T	C	1: 85,834,255 (GRCm39)		probably null	Het
Lmo7	T	A	14: 102,137,907 (GRCm39)	S870T	probably benign	Het
Lrpprc	A	T	17: 85,015,548 (GRCm39)	F1288I	probably damaging	Het
Megf11	A	T	9: 64,547,376 (GRCm39)	H209L	probably damaging	Het
Mtss1	C	T	15: 58,926,869 (GRCm39)	R69H	probably damaging	Het
Nms	A	T	1: 38,980,982 (GRCm39)	H56L	probably benign	Het
Or4f54	G	A	2: 111,122,736 (GRCm39)	G41D	probably damaging	Het
Or4k36	C	T	2: 111,146,288 (GRCm39)	H155Y	probably damaging	Het
Or56a5	A	T	7: 104,793,497 (GRCm39)	M7K	possibly damaging	Het
Or5t17	T	C	2: 86,833,140 (GRCm39)	S276P	probably benign	Het
Pds5a	G	A	5: 65,792,747 (GRCm39)	R729W	probably damaging	Het
Pskh1	C	T	8: 106,639,598 (GRCm39)	R93*	probably null	Het
Rapgef2	G	A	3: 79,019,495 (GRCm39)	L59F	probably damaging	Het
Rtn4	G	A	11: 29,691,011 (GRCm39)	V1101I	probably damaging	Het
Sec31b	C	A	19: 44,509,021 (GRCm39)	V653F	probably damaging	Het
Slc10a2	A	G	8: 5,139,047 (GRCm39)	V299A		Het
Slc6a15	A	G	10: 103,229,277 (GRCm39)	I105M	probably benign	Het
Smurf1	A	G	5: 144,833,395 (GRCm39)	V209A		Het
Snapc2	A	G	8: 4,304,591 (GRCm39)	E115G	probably damaging	Het
Sorcs2	T	C	5: 36,199,529 (GRCm39)	E592G	possibly damaging	Het
Spmip6	G	A	4: 41,508,614 (GRCm39)	P17L		Het
Styxl2	T	A	1: 165,926,410 (GRCm39)	K1067N	probably damaging	Het
Tcl1b1	A	T	12: 105,130,823 (GRCm39)	Q102L	probably damaging	Het
Tmc1	T	A	19: 20,801,644 (GRCm39)	N461Y	probably benign	Het
Trim59	C	A	3: 68,945,134 (GRCm39)	G69C	probably damaging	Het
Tubg1	A	G	11: 101,017,003 (GRCm39)	Y435C	probably damaging	Het
Ucp3	A	C	7: 100,131,911 (GRCm39)	H254P	probably benign	Het
Vav2	T	C	2: 27,157,276 (GRCm39)	D842G	probably damaging	Het
Wee2	A	G	6: 40,421,057 (GRCm39)	E49G	probably benign	Het
Zfr	A	G	15: 12,180,706 (GRCm39)		probably null	Het

Other mutations in Vmn1r203

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01356:Vmn1r203	APN	13	22,708,947 (GRCm39)	missense	probably damaging	1.00
IGL01527:Vmn1r203	APN	13	22,708,447 (GRCm39)	missense	possibly damaging	0.89
IGL01808:Vmn1r203	APN	13	22,708,717 (GRCm39)	missense	probably benign	0.02
IGL01887:Vmn1r203	APN	13	22,709,046 (GRCm39)	missense	probably benign	0.00
IGL02340:Vmn1r203	APN	13	22,708,997 (GRCm39)	nonsense	probably null
IGL02543:Vmn1r203	APN	13	22,709,074 (GRCm39)	missense	probably damaging	1.00
IGL02684:Vmn1r203	APN	13	22,708,539 (GRCm39)	missense	possibly damaging	0.95
BB005:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
BB015:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
PIT4519001:Vmn1r203	UTSW	13	22,708,765 (GRCm39)	missense	probably benign	0.01
R0544:Vmn1r203	UTSW	13	22,708,443 (GRCm39)	missense	possibly damaging	0.94
R1365:Vmn1r203	UTSW	13	22,708,756 (GRCm39)	missense	probably benign	0.00
R1396:Vmn1r203	UTSW	13	22,708,678 (GRCm39)	missense	probably benign	0.01
R1794:Vmn1r203	UTSW	13	22,708,521 (GRCm39)	missense	probably damaging	1.00
R2010:Vmn1r203	UTSW	13	22,708,617 (GRCm39)	missense	possibly damaging	0.56
R2169:Vmn1r203	UTSW	13	22,708,905 (GRCm39)	nonsense	probably null
R2333:Vmn1r203	UTSW	13	22,709,113 (GRCm39)	missense	probably damaging	1.00
R2418:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
R2419:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
R4322:Vmn1r203	UTSW	13	22,708,408 (GRCm39)	missense	probably damaging	1.00
R4460:Vmn1r203	UTSW	13	22,708,852 (GRCm39)	missense	probably damaging	0.98
R4686:Vmn1r203	UTSW	13	22,708,528 (GRCm39)	missense	probably damaging	1.00
R5526:Vmn1r203	UTSW	13	22,708,273 (GRCm39)	missense	probably benign	0.01
R6240:Vmn1r203	UTSW	13	22,708,899 (GRCm39)	missense	possibly damaging	0.89
R6607:Vmn1r203	UTSW	13	22,708,891 (GRCm39)	missense	probably benign	0.23
R7575:Vmn1r203	UTSW	13	22,708,588 (GRCm39)	missense	probably benign	0.12
R7928:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
R8375:Vmn1r203	UTSW	13	22,709,154 (GRCm39)	makesense	probably null
R8421:Vmn1r203	UTSW	13	22,709,154 (GRCm39)	makesense	probably null
R8424:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	probably damaging	1.00
R8845:Vmn1r203	UTSW	13	22,708,720 (GRCm39)	missense	possibly damaging	0.81
R8933:Vmn1r203	UTSW	13	22,708,691 (GRCm39)	missense	possibly damaging	0.69
R8956:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
Z1177:Vmn1r203	UTSW	13	22,708,579 (GRCm39)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- ACCCACGTCTACAATTGAAGAGG -3'
(R):5'- ATGTGCCATGCAGACTTTGG -3'

Sequencing Primer
(F):5'- CCACGTCTACAATTGAAGAGGTTTCC -3'
(R):5'- CATGCAGACTTTGGCCTGAGTC -3'

Posted On

2022-07-18