Incidental Mutation 'R9494:Vmn2r69'
ID 717105
Institutional Source Beutler Lab
Gene Symbol Vmn2r69
Ensembl Gene ENSMUSG00000091006
Gene Name vomeronasal 2, receptor 69
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R9494 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 85055584-85064884 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85060768 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 272 (S272L)
Ref Sequence ENSEMBL: ENSMUSP00000132726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171213]
AlphaFold G3XA45
Predicted Effect probably damaging
Transcript: ENSMUST00000171213
AA Change: S272L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: S272L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 465 1.3e-28 PFAM
Pfam:NCD3G 507 559 1.8e-20 PFAM
Pfam:7tm_3 592 827 3.2e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Als2 T C 1: 59,206,664 (GRCm39) D1593G probably damaging Het
Atad2b C A 12: 5,081,852 (GRCm39) P1254T probably benign Het
Brsk2 C T 7: 141,555,955 (GRCm39) R716C possibly damaging Het
Bzw2 T A 12: 36,184,947 (GRCm39) M1L probably benign Het
Cd300ld2 T A 11: 114,901,249 (GRCm39) H277L possibly damaging Het
Col6a5 A T 9: 105,822,732 (GRCm39) D208E unknown Het
Cul3 T A 1: 80,255,169 (GRCm39) S544C probably damaging Het
Enpp1 C A 10: 24,527,234 (GRCm39) R651L probably benign Het
Epha10 C T 4: 124,808,649 (GRCm39) A766V Het
Epor A G 9: 21,870,522 (GRCm39) Y453H probably damaging Het
Fam13a T C 6: 58,930,508 (GRCm39) K468R probably benign Het
Ffar4 C T 19: 38,086,083 (GRCm39) A170V probably benign Het
Fhip1a A T 3: 85,583,565 (GRCm39) Y410* probably null Het
Gm10203 A G 6: 149,031,740 (GRCm39) Y15C unknown Het
Kansl1 T C 11: 104,247,566 (GRCm39) T595A probably benign Het
Lmtk2 A T 5: 144,037,338 (GRCm39) probably benign Het
Mybl2 G A 2: 162,917,843 (GRCm39) V69I possibly damaging Het
Myo1d T C 11: 80,375,093 (GRCm39) K994E probably benign Het
Or5p75-ps1 C A 7: 108,107,800 (GRCm39) T179K unknown Het
Pcdhga10 A T 18: 37,882,421 (GRCm39) R727S probably benign Het
Pgp T A 17: 24,689,809 (GRCm39) L109Q probably damaging Het
Piwil2 C T 14: 70,660,421 (GRCm39) G68D probably benign Het
Pms2 T A 5: 143,853,214 (GRCm39) I193N probably damaging Het
Pnpla7 T A 2: 24,942,390 (GRCm39) L1236* probably null Het
Pole2 A G 12: 69,249,731 (GRCm39) V489A possibly damaging Het
Rapgef2 G A 3: 79,019,495 (GRCm39) L59F probably damaging Het
Rnf32 T C 5: 29,429,145 (GRCm39) S241P probably damaging Het
Samd9l T A 6: 3,375,830 (GRCm39) K477I possibly damaging Het
Stn1 C T 19: 47,513,125 (GRCm39) probably null Het
Svep1 A G 4: 58,070,577 (GRCm39) V2403A possibly damaging Het
Synrg T C 11: 83,881,747 (GRCm39) M361T probably benign Het
Tbc1d2b A T 9: 90,152,563 (GRCm39) Y68N probably damaging Het
Tbc1d4 A T 14: 101,845,895 (GRCm39) M1K probably null Het
Thsd1 C T 8: 22,733,268 (GRCm39) P105L probably benign Het
Tnxb T C 17: 34,904,796 (GRCm39) L1187P probably damaging Het
Trio T C 15: 27,846,843 (GRCm39) T1057A probably benign Het
Tubg1 T C 11: 101,011,724 (GRCm39) I77T probably damaging Het
Txndc11 A G 16: 10,952,156 (GRCm39) L73P probably damaging Het
Uck1 G A 2: 32,148,179 (GRCm39) R182* probably null Het
Vangl1 T C 3: 102,070,665 (GRCm39) S424G probably damaging Het
Zbtb18 A T 1: 177,275,648 (GRCm39) D327V probably benign Het
Zfp607b T C 7: 27,403,092 (GRCm39) F516S probably damaging Het
Zzz3 A G 3: 152,133,468 (GRCm39) I175M possibly damaging Het
Other mutations in Vmn2r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Vmn2r69 APN 7 85,055,739 (GRCm39) missense probably benign
IGL01457:Vmn2r69 APN 7 85,055,836 (GRCm39) missense possibly damaging 0.87
IGL01760:Vmn2r69 APN 7 85,056,072 (GRCm39) missense possibly damaging 0.90
IGL01834:Vmn2r69 APN 7 85,061,576 (GRCm39) missense probably damaging 1.00
IGL02001:Vmn2r69 APN 7 85,056,434 (GRCm39) missense probably benign 0.05
IGL02057:Vmn2r69 APN 7 85,060,990 (GRCm39) missense possibly damaging 0.93
IGL02289:Vmn2r69 APN 7 85,056,054 (GRCm39) missense probably damaging 1.00
IGL02472:Vmn2r69 APN 7 85,058,960 (GRCm39) missense probably benign 0.01
IGL02478:Vmn2r69 APN 7 85,055,889 (GRCm39) missense probably damaging 1.00
IGL02554:Vmn2r69 APN 7 85,059,014 (GRCm39) missense probably damaging 1.00
IGL02723:Vmn2r69 APN 7 85,059,416 (GRCm39) missense probably damaging 1.00
R0526:Vmn2r69 UTSW 7 85,060,711 (GRCm39) missense probably damaging 1.00
R0560:Vmn2r69 UTSW 7 85,058,922 (GRCm39) critical splice donor site probably null
R0909:Vmn2r69 UTSW 7 85,055,873 (GRCm39) missense probably benign 0.00
R0976:Vmn2r69 UTSW 7 85,056,108 (GRCm39) missense probably damaging 1.00
R1158:Vmn2r69 UTSW 7 85,059,058 (GRCm39) splice site probably benign
R1459:Vmn2r69 UTSW 7 85,055,908 (GRCm39) nonsense probably null
R1482:Vmn2r69 UTSW 7 85,056,082 (GRCm39) missense probably damaging 1.00
R1917:Vmn2r69 UTSW 7 85,060,891 (GRCm39) missense probably damaging 1.00
R2016:Vmn2r69 UTSW 7 85,056,493 (GRCm39) missense probably damaging 0.98
R2108:Vmn2r69 UTSW 7 85,059,404 (GRCm39) missense probably benign
R2571:Vmn2r69 UTSW 7 85,064,764 (GRCm39) missense probably benign
R2910:Vmn2r69 UTSW 7 85,055,918 (GRCm39) missense probably damaging 1.00
R2920:Vmn2r69 UTSW 7 85,060,973 (GRCm39) missense probably benign 0.08
R3708:Vmn2r69 UTSW 7 85,061,029 (GRCm39) missense probably damaging 0.98
R3710:Vmn2r69 UTSW 7 85,055,601 (GRCm39) missense probably benign
R4757:Vmn2r69 UTSW 7 85,061,575 (GRCm39) missense probably damaging 0.99
R4823:Vmn2r69 UTSW 7 85,060,508 (GRCm39) missense probably benign 0.21
R4870:Vmn2r69 UTSW 7 85,060,793 (GRCm39) missense possibly damaging 0.93
R4918:Vmn2r69 UTSW 7 85,055,967 (GRCm39) missense probably benign 0.06
R5022:Vmn2r69 UTSW 7 85,060,367 (GRCm39) missense possibly damaging 0.72
R5174:Vmn2r69 UTSW 7 85,064,739 (GRCm39) missense possibly damaging 0.92
R5200:Vmn2r69 UTSW 7 85,055,717 (GRCm39) missense probably damaging 1.00
R5278:Vmn2r69 UTSW 7 85,060,991 (GRCm39) missense probably benign 0.02
R5643:Vmn2r69 UTSW 7 85,056,404 (GRCm39) missense probably damaging 0.98
R5996:Vmn2r69 UTSW 7 85,061,117 (GRCm39) splice site probably null
R6083:Vmn2r69 UTSW 7 85,055,711 (GRCm39) missense probably damaging 1.00
R6140:Vmn2r69 UTSW 7 85,060,657 (GRCm39) missense probably damaging 0.99
R6306:Vmn2r69 UTSW 7 85,064,799 (GRCm39) missense probably benign 0.04
R6330:Vmn2r69 UTSW 7 85,060,835 (GRCm39) missense probably benign
R6380:Vmn2r69 UTSW 7 85,061,067 (GRCm39) missense probably benign
R6466:Vmn2r69 UTSW 7 85,056,378 (GRCm39) missense probably benign 0.01
R6542:Vmn2r69 UTSW 7 85,060,413 (GRCm39) nonsense probably null
R6583:Vmn2r69 UTSW 7 85,059,017 (GRCm39) missense probably benign
R6623:Vmn2r69 UTSW 7 85,056,309 (GRCm39) missense possibly damaging 0.84
R6709:Vmn2r69 UTSW 7 85,061,069 (GRCm39) missense probably benign 0.03
R6732:Vmn2r69 UTSW 7 85,060,351 (GRCm39) missense probably benign 0.00
R6741:Vmn2r69 UTSW 7 85,061,724 (GRCm39) missense probably benign 0.01
R7070:Vmn2r69 UTSW 7 85,060,688 (GRCm39) missense probably damaging 0.98
R7234:Vmn2r69 UTSW 7 85,056,315 (GRCm39) missense probably benign 0.22
R7323:Vmn2r69 UTSW 7 85,060,972 (GRCm39) missense possibly damaging 0.95
R7427:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7428:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7453:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7532:Vmn2r69 UTSW 7 85,059,622 (GRCm39) missense probably benign 0.36
R7556:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7562:Vmn2r69 UTSW 7 85,056,420 (GRCm39) missense probably benign
R7592:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7708:Vmn2r69 UTSW 7 85,061,755 (GRCm39) missense possibly damaging 0.87
R7803:Vmn2r69 UTSW 7 85,056,324 (GRCm39) missense probably benign 0.00
R7960:Vmn2r69 UTSW 7 85,055,973 (GRCm39) missense probably benign
R7966:Vmn2r69 UTSW 7 85,060,762 (GRCm39) missense possibly damaging 0.81
R8071:Vmn2r69 UTSW 7 85,055,713 (GRCm39) nonsense probably null
R8237:Vmn2r69 UTSW 7 85,060,340 (GRCm39) missense probably benign 0.02
R8347:Vmn2r69 UTSW 7 85,064,838 (GRCm39) missense probably benign 0.00
R8737:Vmn2r69 UTSW 7 85,055,783 (GRCm39) missense probably damaging 1.00
R8795:Vmn2r69 UTSW 7 85,064,883 (GRCm39) start codon destroyed probably null 0.94
R8831:Vmn2r69 UTSW 7 85,059,018 (GRCm39) nonsense probably null
R8856:Vmn2r69 UTSW 7 85,061,663 (GRCm39) missense probably benign 0.00
R8998:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R8999:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R9161:Vmn2r69 UTSW 7 85,056,177 (GRCm39) missense possibly damaging 0.88
R9228:Vmn2r69 UTSW 7 85,064,697 (GRCm39) missense probably benign 0.01
R9494:Vmn2r69 UTSW 7 85,056,084 (GRCm39) missense probably benign 0.08
R9541:Vmn2r69 UTSW 7 85,056,209 (GRCm39) missense probably benign
R9620:Vmn2r69 UTSW 7 85,061,504 (GRCm39) missense probably benign 0.10
Z1176:Vmn2r69 UTSW 7 85,055,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAAAGGAAAATTCACTACTGTAG -3'
(R):5'- GGAGTGATTGTTACAAGTGATGACC -3'

Sequencing Primer
(F):5'- TCACTACTGTAGTTTGAAGGGTATAC -3'
(R):5'- TGTTACAAGTGATGACCAAGGAATAC -3'
Posted On 2022-07-18