Incidental Mutation 'R9494:Ffar4'
ID 717128
Institutional Source Beutler Lab
Gene Symbol Ffar4
Ensembl Gene ENSMUSG00000054200
Gene Name free fatty acid receptor 4
Synonyms Gpr120, Pgr4, Gpr129, Ffa4, O3far1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R9494 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 38085527-38102711 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 38086083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 170 (A170V)
Ref Sequence ENSEMBL: ENSMUSP00000063660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067098]
AlphaFold Q7TMA4
Predicted Effect probably benign
Transcript: ENSMUST00000067098
AA Change: A170V

PolyPhen 2 Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000063660
Gene: ENSMUSG00000054200
AA Change: A170V

DomainStartEndE-ValueType
Pfam:7tm_1 57 321 1.7e-39 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Als2 T C 1: 59,206,664 (GRCm39) D1593G probably damaging Het
Atad2b C A 12: 5,081,852 (GRCm39) P1254T probably benign Het
Brsk2 C T 7: 141,555,955 (GRCm39) R716C possibly damaging Het
Bzw2 T A 12: 36,184,947 (GRCm39) M1L probably benign Het
Cd300ld2 T A 11: 114,901,249 (GRCm39) H277L possibly damaging Het
Col6a5 A T 9: 105,822,732 (GRCm39) D208E unknown Het
Cul3 T A 1: 80,255,169 (GRCm39) S544C probably damaging Het
Enpp1 C A 10: 24,527,234 (GRCm39) R651L probably benign Het
Epha10 C T 4: 124,808,649 (GRCm39) A766V Het
Epor A G 9: 21,870,522 (GRCm39) Y453H probably damaging Het
Fam13a T C 6: 58,930,508 (GRCm39) K468R probably benign Het
Fhip1a A T 3: 85,583,565 (GRCm39) Y410* probably null Het
Gm10203 A G 6: 149,031,740 (GRCm39) Y15C unknown Het
Kansl1 T C 11: 104,247,566 (GRCm39) T595A probably benign Het
Lmtk2 A T 5: 144,037,338 (GRCm39) probably benign Het
Mybl2 G A 2: 162,917,843 (GRCm39) V69I possibly damaging Het
Myo1d T C 11: 80,375,093 (GRCm39) K994E probably benign Het
Or5p75-ps1 C A 7: 108,107,800 (GRCm39) T179K unknown Het
Pcdhga10 A T 18: 37,882,421 (GRCm39) R727S probably benign Het
Pgp T A 17: 24,689,809 (GRCm39) L109Q probably damaging Het
Piwil2 C T 14: 70,660,421 (GRCm39) G68D probably benign Het
Pms2 T A 5: 143,853,214 (GRCm39) I193N probably damaging Het
Pnpla7 T A 2: 24,942,390 (GRCm39) L1236* probably null Het
Pole2 A G 12: 69,249,731 (GRCm39) V489A possibly damaging Het
Rapgef2 G A 3: 79,019,495 (GRCm39) L59F probably damaging Het
Rnf32 T C 5: 29,429,145 (GRCm39) S241P probably damaging Het
Samd9l T A 6: 3,375,830 (GRCm39) K477I possibly damaging Het
Stn1 C T 19: 47,513,125 (GRCm39) probably null Het
Svep1 A G 4: 58,070,577 (GRCm39) V2403A possibly damaging Het
Synrg T C 11: 83,881,747 (GRCm39) M361T probably benign Het
Tbc1d2b A T 9: 90,152,563 (GRCm39) Y68N probably damaging Het
Tbc1d4 A T 14: 101,845,895 (GRCm39) M1K probably null Het
Thsd1 C T 8: 22,733,268 (GRCm39) P105L probably benign Het
Tnxb T C 17: 34,904,796 (GRCm39) L1187P probably damaging Het
Trio T C 15: 27,846,843 (GRCm39) T1057A probably benign Het
Tubg1 T C 11: 101,011,724 (GRCm39) I77T probably damaging Het
Txndc11 A G 16: 10,952,156 (GRCm39) L73P probably damaging Het
Uck1 G A 2: 32,148,179 (GRCm39) R182* probably null Het
Vangl1 T C 3: 102,070,665 (GRCm39) S424G probably damaging Het
Vmn2r69 A G 7: 85,056,084 (GRCm39) W685R probably benign Het
Vmn2r69 G A 7: 85,060,768 (GRCm39) S272L probably damaging Het
Zbtb18 A T 1: 177,275,648 (GRCm39) D327V probably benign Het
Zfp607b T C 7: 27,403,092 (GRCm39) F516S probably damaging Het
Zzz3 A G 3: 152,133,468 (GRCm39) I175M possibly damaging Het
Other mutations in Ffar4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Ffar4 APN 19 38,095,837 (GRCm39) missense probably benign
IGL01734:Ffar4 APN 19 38,102,295 (GRCm39) missense probably damaging 1.00
IGL01932:Ffar4 APN 19 38,085,978 (GRCm39) missense probably damaging 1.00
IGL02160:Ffar4 APN 19 38,085,903 (GRCm39) missense possibly damaging 0.91
IGL02486:Ffar4 APN 19 38,102,208 (GRCm39) missense possibly damaging 0.68
R0047:Ffar4 UTSW 19 38,102,452 (GRCm39) unclassified probably benign
R0492:Ffar4 UTSW 19 38,085,630 (GRCm39) missense probably benign
R4956:Ffar4 UTSW 19 38,086,028 (GRCm39) missense probably benign 0.01
R5091:Ffar4 UTSW 19 38,085,627 (GRCm39) missense probably benign
R5634:Ffar4 UTSW 19 38,102,373 (GRCm39) unclassified probably benign
R5756:Ffar4 UTSW 19 38,102,406 (GRCm39) missense probably damaging 0.99
R6778:Ffar4 UTSW 19 38,102,112 (GRCm39) missense possibly damaging 0.56
R8030:Ffar4 UTSW 19 38,095,839 (GRCm39) missense possibly damaging 0.80
R9047:Ffar4 UTSW 19 38,102,232 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- TGCTCTTCTACGTGATGACAATG -3'
(R):5'- TCCAGAGTATTGGGCACTGG -3'

Sequencing Primer
(F):5'- CTTCTACGTGATGACAATGAGCGG -3'
(R):5'- TGGGTCTGCCAAAAAGGATACAATTC -3'
Posted On 2022-07-18