Incidental Mutation 'R9497:Fam151b'
ID 717319
Institutional Source Beutler Lab
Gene Symbol Fam151b
Ensembl Gene ENSMUSG00000034334
Gene Name family with sequence similarity 151, member B
Synonyms 4930405M20Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9497 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 92586133-92620523 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 92610621 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 56 (I56K)
Ref Sequence ENSEMBL: ENSMUSP00000045024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040106] [ENSMUST00000225299]
AlphaFold D3YUE4
Predicted Effect probably damaging
Transcript: ENSMUST00000040106
AA Change: I56K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000045024
Gene: ENSMUSG00000034334
AA Change: I56K

DomainStartEndE-ValueType
Pfam:DUF2181 29 263 2.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225299
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik A C 1: 85,973,893 (GRCm39) E70A possibly damaging Het
Abcb5 C A 12: 118,899,850 (GRCm39) Q272H probably damaging Het
Acoxl T C 2: 127,719,706 (GRCm39) Y156H probably damaging Het
Alg9 T C 9: 50,711,436 (GRCm39) F305L probably damaging Het
Apobec4 T C 1: 152,632,947 (GRCm39) V325A probably benign Het
Aqp9 T G 9: 71,069,651 (GRCm39) D46A probably benign Het
Atp13a4 T A 16: 29,288,130 (GRCm39) probably null Het
BC051019 A G 7: 109,315,466 (GRCm39) F263S probably damaging Het
Bicc1 A T 10: 70,776,828 (GRCm39) probably null Het
Birc2 G A 9: 7,861,028 (GRCm39) Q97* probably null Het
Capn13 G T 17: 73,633,362 (GRCm39) T533N probably benign Het
Casp6 G A 3: 129,699,559 (GRCm39) V13M probably benign Het
Cdh10 A T 15: 18,964,267 (GRCm39) E143V probably damaging Het
Cobl T A 11: 12,203,501 (GRCm39) Q1067L probably benign Het
Cr2 A G 1: 194,850,743 (GRCm39) V241A probably damaging Het
Cyp2c23 C T 19: 44,010,085 (GRCm39) V87M probably damaging Het
Cyp2j9 G A 4: 96,460,211 (GRCm39) Q431* probably null Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Cyp4a12b A T 4: 115,271,768 (GRCm39) M160L probably benign Het
Ddhd2 T A 8: 26,217,731 (GRCm39) K715N possibly damaging Het
Ecscr T C 18: 35,851,436 (GRCm39) Y32C probably damaging Het
Ednra A T 8: 78,446,934 (GRCm39) L48Q probably benign Het
Eya4 C T 10: 22,987,458 (GRCm39) probably null Het
F13a1 C A 13: 37,082,118 (GRCm39) V529L probably benign Het
Fat3 A G 9: 15,903,504 (GRCm39) I2997T probably damaging Het
Fgfr2 A T 7: 129,765,763 (GRCm39) F817I probably damaging Het
Fras1 G T 5: 96,884,895 (GRCm39) C2591F probably damaging Het
Fryl T C 5: 73,215,134 (GRCm39) D2214G Het
Galntl6 A T 8: 58,290,410 (GRCm39) D394E probably damaging Het
Ggcx C A 6: 72,406,190 (GRCm39) N605K probably damaging Het
Gja5 A G 3: 96,958,801 (GRCm39) N286S Het
Gm4553 A T 7: 141,719,298 (GRCm39) C43* probably null Het
Gpr158 T C 2: 21,831,825 (GRCm39) V975A probably benign Het
Greb1l T A 18: 10,458,600 (GRCm39) D60E probably benign Het
Hao2 A T 3: 98,784,462 (GRCm39) L301H probably damaging Het
Hic1 A G 11: 75,060,131 (GRCm39) L72P possibly damaging Het
Hs3st5 A C 10: 36,709,370 (GRCm39) N302H probably benign Het
Htr1d A G 4: 136,169,663 (GRCm39) probably benign Het
Inka1 A G 9: 107,861,938 (GRCm39) V128A probably benign Het
Kdm7a T C 6: 39,128,253 (GRCm39) D526G probably damaging Het
Kif5a T C 10: 127,079,353 (GRCm39) S282G probably damaging Het
Klhdc7b T C 15: 89,272,463 (GRCm39) V457A possibly damaging Het
Lcorl A G 5: 45,891,339 (GRCm39) V421A probably benign Het
Ltc4s A G 11: 50,127,386 (GRCm39) S150P unknown Het
Mdfic C T 6: 15,720,852 (GRCm39) R18W unknown Het
Mdfic T G 6: 15,770,508 (GRCm39) D171E probably benign Het
Meis2 T C 2: 115,694,724 (GRCm39) D473G possibly damaging Het
Mettl17 A T 14: 52,129,029 (GRCm39) Q433L unknown Het
Mettl25 T C 10: 105,677,090 (GRCm39) R31G probably damaging Het
Mroh2b T A 15: 4,950,845 (GRCm39) I581N probably damaging Het
Myh7 A T 14: 55,217,841 (GRCm39) N1091K probably benign Het
Mysm1 T C 4: 94,848,635 (GRCm39) D466G probably benign Het
Ncoa6 T C 2: 155,248,238 (GRCm39) T1689A probably damaging Het
Ndfip2 A G 14: 105,542,245 (GRCm39) T332A probably benign Het
Nfkbil1 G A 17: 35,439,605 (GRCm39) P303S probably damaging Het
Nfx1 T G 4: 40,994,104 (GRCm39) N604K probably benign Het
Npb T C 11: 120,499,473 (GRCm39) F47L probably benign Het
Nr2c2 C T 6: 92,133,673 (GRCm39) T259I possibly damaging Het
Nt5el G T 13: 105,236,987 (GRCm39) L79F probably damaging Het
Obsl1 C T 1: 75,467,484 (GRCm39) C1430Y probably damaging Het
Or10al5 T A 17: 38,062,942 (GRCm39) Y66N probably damaging Het
Or10b1 A G 10: 78,355,738 (GRCm39) I99V probably benign Het
Or10g6 A T 9: 39,934,616 (GRCm39) H309L probably benign Het
Or4d5 G A 9: 40,011,935 (GRCm39) P284S probably damaging Het
Or4n4b C T 14: 50,536,362 (GRCm39) V135I probably benign Het
Or6c202 C A 10: 128,996,464 (GRCm39) V130L probably benign Het
Or6f1 G A 7: 85,970,989 (GRCm39) T57M probably damaging Het
Pdcd6 A T 13: 74,453,695 (GRCm39) F148I probably damaging Het
Pih1d1 A T 7: 44,803,789 (GRCm39) Q16L unknown Het
Ppp1r10 T C 17: 36,235,786 (GRCm39) S123P probably damaging Het
Ppp1r13b A T 12: 111,807,446 (GRCm39) M305K probably benign Het
Prg2 A G 2: 84,811,685 (GRCm39) K2E possibly damaging Het
Prkd1 A T 12: 50,438,107 (GRCm39) probably null Het
Rfx7 T A 9: 72,526,423 (GRCm39) H1204Q probably benign Het
Serpina3k A C 12: 104,309,430 (GRCm39) Q291H probably benign Het
Tafa4 T A 6: 96,820,831 (GRCm39) I93F possibly damaging Het
Tas2r107 G T 6: 131,636,549 (GRCm39) Q167K probably benign Het
Tle1 A C 4: 72,071,135 (GRCm39) probably benign Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Trpa1 C T 1: 14,989,026 (GRCm39) E12K probably benign Het
Vmn2r7 T C 3: 64,614,474 (GRCm39) T447A probably benign Het
Wdr86 T C 5: 24,920,538 (GRCm39) Y283C probably benign Het
Zfp329 A T 7: 12,544,215 (GRCm39) Y436* probably null Het
Other mutations in Fam151b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00799:Fam151b APN 13 92,614,361 (GRCm39) missense probably damaging 1.00
IGL02253:Fam151b APN 13 92,614,435 (GRCm39) missense probably damaging 1.00
IGL03084:Fam151b APN 13 92,604,534 (GRCm39) missense probably damaging 0.97
IGL03130:Fam151b APN 13 92,586,701 (GRCm39) missense probably benign 0.01
P0015:Fam151b UTSW 13 92,604,452 (GRCm39) critical splice donor site probably null
R0067:Fam151b UTSW 13 92,610,504 (GRCm39) missense probably benign 0.08
R0067:Fam151b UTSW 13 92,610,504 (GRCm39) missense probably benign 0.08
R0348:Fam151b UTSW 13 92,586,689 (GRCm39) missense probably benign 0.00
R1404:Fam151b UTSW 13 92,610,480 (GRCm39) missense probably damaging 1.00
R1404:Fam151b UTSW 13 92,610,480 (GRCm39) missense probably damaging 1.00
R1482:Fam151b UTSW 13 92,586,674 (GRCm39) missense probably benign 0.03
R1837:Fam151b UTSW 13 92,610,639 (GRCm39) intron probably benign
R1891:Fam151b UTSW 13 92,586,678 (GRCm39) missense probably benign 0.00
R1957:Fam151b UTSW 13 92,614,411 (GRCm39) missense probably damaging 1.00
R1957:Fam151b UTSW 13 92,614,410 (GRCm39) missense probably damaging 1.00
R2175:Fam151b UTSW 13 92,614,426 (GRCm39) missense probably damaging 0.99
R4583:Fam151b UTSW 13 92,604,617 (GRCm39) missense probably damaging 1.00
R6762:Fam151b UTSW 13 92,604,558 (GRCm39) missense possibly damaging 0.79
R8153:Fam151b UTSW 13 92,614,410 (GRCm39) missense probably damaging 1.00
R8881:Fam151b UTSW 13 92,604,630 (GRCm39) missense probably benign 0.00
R8950:Fam151b UTSW 13 92,610,567 (GRCm39) missense probably damaging 1.00
X0021:Fam151b UTSW 13 92,586,734 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TTCTGCAGCAACACGAAGC -3'
(R):5'- CTGTGTTCACTTTGCTAGATGCTAG -3'

Sequencing Primer
(F):5'- CGAAGCACGTTTGTAAAAGTACCTC -3'
(R):5'- CTAGATGCTAGAAAAGATTTGTAGGC -3'
Posted On 2022-07-18