Incidental Mutation 'R9497:Or10al5'
ID 717331
Institutional Source Beutler Lab
Gene Symbol Or10al5
Ensembl Gene ENSMUSG00000060017
Gene Name olfactory receptor family 10 subfamily AL member 5
Synonyms Olfr121, GA_x6K02T2PSCP-2211113-2212078, MOR263-4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R9497 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38059757-38063895 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38062942 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 66 (Y66N)
Ref Sequence ENSEMBL: ENSMUSP00000084377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074555] [ENSMUST00000174675]
AlphaFold Q5CZY0
Predicted Effect probably damaging
Transcript: ENSMUST00000074555
AA Change: Y66N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084377
Gene: ENSMUSG00000060017
AA Change: Y66N

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.9e-56 PFAM
Pfam:7TM_GPCR_Srsx 41 311 2.1e-5 PFAM
Pfam:7tm_1 47 296 8.3e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174675
AA Change: Y66N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017
AA Change: Y66N

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik A C 1: 85,973,893 (GRCm39) E70A possibly damaging Het
Abcb5 C A 12: 118,899,850 (GRCm39) Q272H probably damaging Het
Acoxl T C 2: 127,719,706 (GRCm39) Y156H probably damaging Het
Alg9 T C 9: 50,711,436 (GRCm39) F305L probably damaging Het
Apobec4 T C 1: 152,632,947 (GRCm39) V325A probably benign Het
Aqp9 T G 9: 71,069,651 (GRCm39) D46A probably benign Het
Atp13a4 T A 16: 29,288,130 (GRCm39) probably null Het
BC051019 A G 7: 109,315,466 (GRCm39) F263S probably damaging Het
Bicc1 A T 10: 70,776,828 (GRCm39) probably null Het
Birc2 G A 9: 7,861,028 (GRCm39) Q97* probably null Het
Capn13 G T 17: 73,633,362 (GRCm39) T533N probably benign Het
Casp6 G A 3: 129,699,559 (GRCm39) V13M probably benign Het
Cdh10 A T 15: 18,964,267 (GRCm39) E143V probably damaging Het
Cobl T A 11: 12,203,501 (GRCm39) Q1067L probably benign Het
Cr2 A G 1: 194,850,743 (GRCm39) V241A probably damaging Het
Cyp2c23 C T 19: 44,010,085 (GRCm39) V87M probably damaging Het
Cyp2j9 G A 4: 96,460,211 (GRCm39) Q431* probably null Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Cyp4a12b A T 4: 115,271,768 (GRCm39) M160L probably benign Het
Ddhd2 T A 8: 26,217,731 (GRCm39) K715N possibly damaging Het
Ecscr T C 18: 35,851,436 (GRCm39) Y32C probably damaging Het
Ednra A T 8: 78,446,934 (GRCm39) L48Q probably benign Het
Eya4 C T 10: 22,987,458 (GRCm39) probably null Het
F13a1 C A 13: 37,082,118 (GRCm39) V529L probably benign Het
Fam151b A T 13: 92,610,621 (GRCm39) I56K probably damaging Het
Fat3 A G 9: 15,903,504 (GRCm39) I2997T probably damaging Het
Fgfr2 A T 7: 129,765,763 (GRCm39) F817I probably damaging Het
Fras1 G T 5: 96,884,895 (GRCm39) C2591F probably damaging Het
Fryl T C 5: 73,215,134 (GRCm39) D2214G Het
Galntl6 A T 8: 58,290,410 (GRCm39) D394E probably damaging Het
Ggcx C A 6: 72,406,190 (GRCm39) N605K probably damaging Het
Gja5 A G 3: 96,958,801 (GRCm39) N286S Het
Gm4553 A T 7: 141,719,298 (GRCm39) C43* probably null Het
Gpr158 T C 2: 21,831,825 (GRCm39) V975A probably benign Het
Greb1l T A 18: 10,458,600 (GRCm39) D60E probably benign Het
Hao2 A T 3: 98,784,462 (GRCm39) L301H probably damaging Het
Hic1 A G 11: 75,060,131 (GRCm39) L72P possibly damaging Het
Hs3st5 A C 10: 36,709,370 (GRCm39) N302H probably benign Het
Htr1d A G 4: 136,169,663 (GRCm39) probably benign Het
Inka1 A G 9: 107,861,938 (GRCm39) V128A probably benign Het
Kdm7a T C 6: 39,128,253 (GRCm39) D526G probably damaging Het
Kif5a T C 10: 127,079,353 (GRCm39) S282G probably damaging Het
Klhdc7b T C 15: 89,272,463 (GRCm39) V457A possibly damaging Het
Lcorl A G 5: 45,891,339 (GRCm39) V421A probably benign Het
Ltc4s A G 11: 50,127,386 (GRCm39) S150P unknown Het
Mdfic C T 6: 15,720,852 (GRCm39) R18W unknown Het
Mdfic T G 6: 15,770,508 (GRCm39) D171E probably benign Het
Meis2 T C 2: 115,694,724 (GRCm39) D473G possibly damaging Het
Mettl17 A T 14: 52,129,029 (GRCm39) Q433L unknown Het
Mettl25 T C 10: 105,677,090 (GRCm39) R31G probably damaging Het
Mroh2b T A 15: 4,950,845 (GRCm39) I581N probably damaging Het
Myh7 A T 14: 55,217,841 (GRCm39) N1091K probably benign Het
Mysm1 T C 4: 94,848,635 (GRCm39) D466G probably benign Het
Ncoa6 T C 2: 155,248,238 (GRCm39) T1689A probably damaging Het
Ndfip2 A G 14: 105,542,245 (GRCm39) T332A probably benign Het
Nfkbil1 G A 17: 35,439,605 (GRCm39) P303S probably damaging Het
Nfx1 T G 4: 40,994,104 (GRCm39) N604K probably benign Het
Npb T C 11: 120,499,473 (GRCm39) F47L probably benign Het
Nr2c2 C T 6: 92,133,673 (GRCm39) T259I possibly damaging Het
Nt5el G T 13: 105,236,987 (GRCm39) L79F probably damaging Het
Obsl1 C T 1: 75,467,484 (GRCm39) C1430Y probably damaging Het
Or10b1 A G 10: 78,355,738 (GRCm39) I99V probably benign Het
Or10g6 A T 9: 39,934,616 (GRCm39) H309L probably benign Het
Or4d5 G A 9: 40,011,935 (GRCm39) P284S probably damaging Het
Or4n4b C T 14: 50,536,362 (GRCm39) V135I probably benign Het
Or6c202 C A 10: 128,996,464 (GRCm39) V130L probably benign Het
Or6f1 G A 7: 85,970,989 (GRCm39) T57M probably damaging Het
Pdcd6 A T 13: 74,453,695 (GRCm39) F148I probably damaging Het
Pih1d1 A T 7: 44,803,789 (GRCm39) Q16L unknown Het
Ppp1r10 T C 17: 36,235,786 (GRCm39) S123P probably damaging Het
Ppp1r13b A T 12: 111,807,446 (GRCm39) M305K probably benign Het
Prg2 A G 2: 84,811,685 (GRCm39) K2E possibly damaging Het
Prkd1 A T 12: 50,438,107 (GRCm39) probably null Het
Rfx7 T A 9: 72,526,423 (GRCm39) H1204Q probably benign Het
Serpina3k A C 12: 104,309,430 (GRCm39) Q291H probably benign Het
Tafa4 T A 6: 96,820,831 (GRCm39) I93F possibly damaging Het
Tas2r107 G T 6: 131,636,549 (GRCm39) Q167K probably benign Het
Tle1 A C 4: 72,071,135 (GRCm39) probably benign Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Trpa1 C T 1: 14,989,026 (GRCm39) E12K probably benign Het
Vmn2r7 T C 3: 64,614,474 (GRCm39) T447A probably benign Het
Wdr86 T C 5: 24,920,538 (GRCm39) Y283C probably benign Het
Zfp329 A T 7: 12,544,215 (GRCm39) Y436* probably null Het
Other mutations in Or10al5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01348:Or10al5 APN 17 38,063,177 (GRCm39) missense probably benign 0.03
R0100:Or10al5 UTSW 17 38,063,594 (GRCm39) missense probably benign 0.12
R0328:Or10al5 UTSW 17 38,063,284 (GRCm39) missense possibly damaging 0.57
R1641:Or10al5 UTSW 17 38,062,916 (GRCm39) missense possibly damaging 0.90
R2358:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3711:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3712:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R4658:Or10al5 UTSW 17 38,063,054 (GRCm39) missense probably damaging 1.00
R4913:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R5229:Or10al5 UTSW 17 38,063,192 (GRCm39) missense probably benign 0.00
R5611:Or10al5 UTSW 17 38,062,975 (GRCm39) missense possibly damaging 0.94
R6159:Or10al5 UTSW 17 38,063,038 (GRCm39) missense probably damaging 1.00
R6375:Or10al5 UTSW 17 38,062,990 (GRCm39) missense probably benign
R6500:Or10al5 UTSW 17 38,063,577 (GRCm39) missense probably damaging 1.00
R6818:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R7027:Or10al5 UTSW 17 38,063,300 (GRCm39) missense probably damaging 1.00
R7498:Or10al5 UTSW 17 38,063,242 (GRCm39) missense probably damaging 0.96
R7888:Or10al5 UTSW 17 38,062,888 (GRCm39) missense probably damaging 1.00
R8299:Or10al5 UTSW 17 38,062,891 (GRCm39) nonsense probably null
Z1176:Or10al5 UTSW 17 38,063,658 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCAGGAGAACAGCTTGTC -3'
(R):5'- GACTCATTCGTGTTGCATAGTG -3'

Sequencing Primer
(F):5'- CAGCTTGTCTGTCAAACGC -3'
(R):5'- TATGGCCATGCAGCGGTCATAG -3'
Posted On 2022-07-18