Incidental Mutation 'R9498:Speer4a3'
ID 717355
Institutional Source Beutler Lab
Gene Symbol Speer4a3
Ensembl Gene ENSMUSG00000095550
Gene Name spermatogenesis associated glutamate (E)-rich protein 4A3
Synonyms Gm21671
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9498 (G1)
Quality Score 102.467
Status Not validated
Chromosome 5
Chromosomal Location 26154795-26159342 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) AACT to A at 26155849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162387]
AlphaFold G3UY31
Predicted Effect probably benign
Transcript: ENSMUST00000162387
SMART Domains Protein: ENSMUSP00000133924
Gene: ENSMUSG00000095550

DomainStartEndE-ValueType
Pfam:Takusan 50 134 2.4e-25 PFAM
low complexity region 154 168 N/A INTRINSIC
low complexity region 235 259 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
Aadacl3 A G 4: 144,182,989 (GRCm39) Y160H probably damaging Het
Abca17 T C 17: 24,484,480 (GRCm39) Y1594C probably damaging Het
Abca8a T C 11: 109,977,374 (GRCm39) I128M probably damaging Het
Abhd12b A G 12: 70,210,237 (GRCm39) I138V probably benign Het
Adcy8 G A 15: 64,792,045 (GRCm39) L304F possibly damaging Het
Alb T C 5: 90,617,362 (GRCm39) F354L probably damaging Het
Ampd3 T A 7: 110,409,053 (GRCm39) S688R probably damaging Het
Aoc1l3 AGGCCCAGCCTGATCCTAAATTTCCTATCCCCATCAGCAAAGGTGGCCCTCAAGTGGCCCAGCC AGGCCCAGCC 6: 48,964,952 (GRCm39) probably benign Het
Areg T G 5: 91,294,553 (GRCm39) L237R probably damaging Het
Arhgef11 A G 3: 87,640,484 (GRCm39) S1243G probably benign Het
B3glct A G 5: 149,673,894 (GRCm39) probably null Het
Casp7 T A 19: 56,424,767 (GRCm39) L162Q probably damaging Het
Cdh20 A G 1: 109,976,635 (GRCm39) N100S probably benign Het
Cdh22 G T 2: 164,954,490 (GRCm39) T677N probably damaging Het
Cmtm5 T A 14: 55,174,205 (GRCm39) S31T probably benign Het
Col6a3 T A 1: 90,713,650 (GRCm39) R2295* probably null Het
Cpa6 T C 1: 10,479,546 (GRCm39) N229S possibly damaging Het
Dagla G T 19: 10,232,218 (GRCm39) Y489* probably null Het
Dnah7b A G 1: 46,253,564 (GRCm39) K1823R probably benign Het
Dnah9 T C 11: 65,739,199 (GRCm39) N4180D probably damaging Het
Dsg3 A C 18: 20,658,278 (GRCm39) E296D probably damaging Het
Ednra A T 8: 78,446,934 (GRCm39) L48Q probably benign Het
Esco2 T C 14: 66,068,752 (GRCm39) D186G probably benign Het
Foxj2 A G 6: 122,819,792 (GRCm39) D560G probably damaging Het
Frmd3 G A 4: 74,038,055 (GRCm39) M105I probably benign Het
Gria4 A T 9: 4,503,560 (GRCm39) probably null Het
Hrob T C 11: 102,150,167 (GRCm39) S410P probably benign Het
Ifi204 T C 1: 173,583,537 (GRCm39) E227G possibly damaging Het
Lgalsl T A 11: 20,779,439 (GRCm39) I69F possibly damaging Het
Myo15b A G 11: 115,770,784 (GRCm39) T1588A Het
Myo9a A G 9: 59,734,466 (GRCm39) S683G probably damaging Het
Ncam2 T C 16: 81,309,887 (GRCm39) I459T probably benign Het
Nedd4l T C 18: 65,294,723 (GRCm39) probably null Het
Nfic T C 10: 81,256,502 (GRCm39) E54G probably damaging Het
Nrxn1 T C 17: 90,897,397 (GRCm39) T920A probably damaging Het
Obsl1 C T 1: 75,467,484 (GRCm39) C1430Y probably damaging Het
Or8k17 A G 2: 86,066,838 (GRCm39) F107L probably damaging Het
Pcbp2 G A 15: 102,406,941 (GRCm39) G357D probably benign Het
Pcdhb1 A G 18: 37,398,516 (GRCm39) S156G probably damaging Het
Pcdhb15 A T 18: 37,606,890 (GRCm39) R41* probably null Het
Pde1b A T 15: 103,435,489 (GRCm39) D448V probably benign Het
Pex7 G A 10: 19,762,859 (GRCm39) R227* probably null Het
Pkp1 T A 1: 135,817,820 (GRCm39) Y105F probably benign Het
Plbd1 T C 6: 136,589,244 (GRCm39) T529A possibly damaging Het
Plxnc1 C G 10: 94,649,004 (GRCm39) Q1258H possibly damaging Het
Prr36 T A 8: 4,263,291 (GRCm39) T792S unknown Het
Rasgrf1 A T 9: 89,826,921 (GRCm39) T177S probably benign Het
Rbm14 A G 19: 4,853,495 (GRCm39) S296P probably benign Het
Rfx8 T C 1: 39,724,674 (GRCm39) Y229C probably damaging Het
Rgs3 A T 4: 62,575,412 (GRCm39) S600C probably damaging Het
Slc29a4 T A 5: 142,704,233 (GRCm39) S296T probably benign Het
Srsf6 A G 2: 162,774,009 (GRCm39) E68G probably benign Het
Syt13 A T 2: 92,781,749 (GRCm39) N317Y possibly damaging Het
Tars2 A T 3: 95,647,553 (GRCm39) L701Q probably damaging Het
Tbc1d16 A T 11: 119,048,681 (GRCm39) V324E probably damaging Het
Tbc1d21 A G 9: 58,273,924 (GRCm39) L84P probably damaging Het
Trappc6b A G 12: 59,097,127 (GRCm39) M65T possibly damaging Het
Tubb1 A G 2: 174,299,403 (GRCm39) N362D probably benign Het
Tubgcp5 C T 7: 55,463,233 (GRCm39) T475M possibly damaging Het
Ugt2b37 T C 5: 87,402,244 (GRCm39) K129R probably benign Het
Vmn2r55 A G 7: 12,404,812 (GRCm39) V197A probably damaging Het
Wfdc3 G A 2: 164,584,997 (GRCm39) L4F possibly damaging Het
Zfp141 T A 7: 42,125,770 (GRCm39) Q234L probably benign Het
Zfp850 T C 7: 27,689,275 (GRCm39) K311R possibly damaging Het
Other mutations in Speer4a3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Speer4a3 APN 5 26,159,222 (GRCm39) missense probably benign
IGL01018:Speer4a3 APN 5 26,155,721 (GRCm39) missense probably benign
IGL02487:Speer4a3 APN 5 26,156,605 (GRCm39) missense probably benign 0.00
IGL02612:Speer4a3 APN 5 26,156,614 (GRCm39) missense probably benign 0.32
IGL02654:Speer4a3 APN 5 26,158,205 (GRCm39) missense probably benign 0.00
R1344:Speer4a3 UTSW 5 26,158,107 (GRCm39) missense probably benign 0.07
R1462:Speer4a3 UTSW 5 26,156,623 (GRCm39) missense possibly damaging 0.94
R1462:Speer4a3 UTSW 5 26,156,623 (GRCm39) missense possibly damaging 0.94
R2213:Speer4a3 UTSW 5 26,158,175 (GRCm39) missense probably benign
R6856:Speer4a3 UTSW 5 26,155,843 (GRCm39) missense probably benign
R7069:Speer4a3 UTSW 5 26,154,842 (GRCm39) missense possibly damaging 0.94
R7165:Speer4a3 UTSW 5 26,155,849 (GRCm39) small deletion probably benign
R7737:Speer4a3 UTSW 5 26,155,849 (GRCm39) small deletion probably benign
R8393:Speer4a3 UTSW 5 26,158,076 (GRCm39) missense probably damaging 1.00
R8729:Speer4a3 UTSW 5 26,158,178 (GRCm39) missense probably damaging 0.99
R8815:Speer4a3 UTSW 5 26,158,191 (GRCm39) missense probably damaging 1.00
R8901:Speer4a3 UTSW 5 26,155,857 (GRCm39) small deletion probably benign
R8922:Speer4a3 UTSW 5 26,156,594 (GRCm39) missense possibly damaging 0.89
R9125:Speer4a3 UTSW 5 26,156,596 (GRCm39) missense possibly damaging 0.78
R9156:Speer4a3 UTSW 5 26,155,857 (GRCm39) small deletion probably benign
R9451:Speer4a3 UTSW 5 26,156,569 (GRCm39) nonsense probably null
R9474:Speer4a3 UTSW 5 26,158,136 (GRCm39) missense probably damaging 1.00
R9685:Speer4a3 UTSW 5 26,155,849 (GRCm39) small deletion probably benign
R9717:Speer4a3 UTSW 5 26,154,829 (GRCm39) missense probably damaging 0.99
R9766:Speer4a3 UTSW 5 26,155,849 (GRCm39) small deletion probably benign
RF039:Speer4a3 UTSW 5 26,155,857 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- AATGTGCCAATGGTATCAGATAGTC -3'
(R):5'- TCCTTGAAATGGCTGGTTGC -3'

Sequencing Primer
(F):5'- GCCAATGGTATCAGATAGTCATAGCC -3'
(R):5'- ACAGCTGTCATGGATGTATTGAG -3'
Posted On 2022-07-18