Incidental Mutation 'R9499:Slitrk5'
ID 717449
Institutional Source Beutler Lab
Gene Symbol Slitrk5
Ensembl Gene ENSMUSG00000033214
Gene Name SLIT and NTRK-like family, member 5
Synonyms 2610019D03Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.472) question?
Stock # R9499 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 111912547-111920576 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111916496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 40 (T40I)
Ref Sequence ENSEMBL: ENSMUSP00000041499 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042767] [ENSMUST00000227891]
AlphaFold Q810B7
Predicted Effect probably benign
Transcript: ENSMUST00000042767
AA Change: T40I

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000041499
Gene: ENSMUSG00000033214
AA Change: T40I

DomainStartEndE-ValueType
Blast:LRRNT 47 85 3e-18 BLAST
low complexity region 86 96 N/A INTRINSIC
LRR 108 127 2.76e2 SMART
LRR_TYP 128 151 1.67e-2 SMART
LRR 152 175 2.67e-1 SMART
LRR 176 199 1.08e-1 SMART
LRR 202 223 7.38e1 SMART
LRRCT 235 285 2.13e-5 SMART
low complexity region 308 323 N/A INTRINSIC
LRRNT 373 410 9.53e-2 SMART
LRR 433 455 1.45e1 SMART
LRR_TYP 456 479 4.94e-5 SMART
LRR_TYP 480 503 7.78e-3 SMART
LRR_TYP 504 527 2.43e-4 SMART
LRR 528 551 1.86e2 SMART
LRRCT 563 613 3.59e-3 SMART
low complexity region 618 632 N/A INTRINSIC
transmembrane domain 666 688 N/A INTRINSIC
low complexity region 794 816 N/A INTRINSIC
low complexity region 818 823 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000227891
AA Change: T40I

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele have abnormal medium spiny neuron morphology and exhibit behavioral abnormalities. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd6 T C 14: 8,028,329 (GRCm38) I20T possibly damaging Het
Apoa5 G C 9: 46,181,944 (GRCm39) R340P probably damaging Het
Arhgap21 A T 2: 20,886,397 (GRCm39) V270E probably damaging Het
Arhgef17 T C 7: 100,526,102 (GRCm39) M851V possibly damaging Het
Arhgef5 A T 6: 43,260,940 (GRCm39) H1455L Het
Birc6 T A 17: 74,916,064 (GRCm39) L1660Q probably benign Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Cep120 C A 18: 53,819,033 (GRCm39) R886L possibly damaging Het
Cep290 T C 10: 100,372,729 (GRCm39) S1176P probably damaging Het
Cyp2j7 C T 4: 96,115,840 (GRCm39) R202H probably damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Depdc7 C T 2: 104,553,220 (GRCm39) probably null Het
Dnaaf11 T C 15: 66,361,483 (GRCm39) E6G probably damaging Het
Erbb4 G A 1: 68,779,642 (GRCm39) Q45* probably null Het
Ercc6 C T 14: 32,284,525 (GRCm39) R763C probably damaging Het
Gm14401 C T 2: 176,778,337 (GRCm39) A141V probably benign Het
Gm14496 A G 2: 181,638,179 (GRCm39) K418E probably benign Het
Gm8159 T A 14: 15,850,264 (GRCm39) I161K probably damaging Het
Hnrnpk A G 13: 58,544,058 (GRCm39) S116P probably benign Het
Hs3st6 T C 17: 24,977,228 (GRCm39) L236P probably damaging Het
Il15 T A 8: 83,061,177 (GRCm39) H100L probably benign Het
Inpp5f A T 7: 128,295,437 (GRCm39) I744F possibly damaging Het
Kif14 C A 1: 136,455,219 (GRCm39) S1630R probably damaging Het
Madd T C 2: 91,000,434 (GRCm39) T544A probably damaging Het
Mbl2 G A 19: 30,216,664 (GRCm39) A159T probably damaging Het
Mfsd9 T C 1: 40,813,152 (GRCm39) T388A probably damaging Het
Mtor C T 4: 148,599,397 (GRCm39) R1482C probably damaging Het
Myh11 T A 16: 14,064,673 (GRCm39) E215V Het
Nmd3 T C 3: 69,647,329 (GRCm39) V277A possibly damaging Het
Nr2e1 A T 10: 42,447,487 (GRCm39) M175K probably benign Het
Nrxn1 T C 17: 90,937,450 (GRCm39) K669R probably damaging Het
Patl1 T A 19: 11,897,728 (GRCm39) M105K possibly damaging Het
Pck2 T A 14: 55,780,081 (GRCm39) I110N probably damaging Het
Pdzrn3 T C 6: 101,127,855 (GRCm39) D937G probably damaging Het
Phb1 G A 11: 95,562,257 (GRCm39) V45I probably benign Het
Pi4ka T C 16: 17,125,574 (GRCm39) E1187G Het
Piezo2 T C 18: 63,166,033 (GRCm39) E2066G possibly damaging Het
Plin1 T C 7: 79,372,544 (GRCm39) N343D probably benign Het
Polr1b C T 2: 128,957,684 (GRCm39) R580* probably null Het
Rexo5 A G 7: 119,404,480 (GRCm39) E192G probably damaging Het
Rpain T C 11: 70,865,816 (GRCm39) S194P probably damaging Het
Slco6c1 T C 1: 97,055,827 (GRCm39) S25G probably benign Het
Slu7 G A 11: 43,329,095 (GRCm39) V106I probably benign Het
Ssb T A 2: 69,696,982 (GRCm39) D107E probably benign Het
Stc2 A G 11: 31,310,332 (GRCm39) S235P probably benign Het
Sult2a8 A C 7: 14,157,487 (GRCm39) V116G probably damaging Het
Tchh CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC 3: 93,354,015 (GRCm39) probably benign Het
Tgm1 T C 14: 55,950,933 (GRCm39) probably benign Het
Tle5 T C 10: 81,399,988 (GRCm39) V62A probably damaging Het
Trf C T 9: 103,099,283 (GRCm39) V339I probably benign Het
Ucp1 T C 8: 84,024,509 (GRCm39) L278P probably damaging Het
Vmn1r24 T A 6: 57,933,150 (GRCm39) I123F possibly damaging Het
Vmn2r9 T A 5: 108,995,584 (GRCm39) N355Y probably damaging Het
Yipf4 T C 17: 74,806,024 (GRCm39) F221S probably damaging Het
Zfp1005 C A 2: 150,109,856 (GRCm39) T182K unknown Het
Zfp595 A T 13: 67,465,067 (GRCm39) S402T probably damaging Het
Zfp710 A G 7: 79,731,621 (GRCm39) E266G probably damaging Het
Zfp827 T G 8: 79,787,403 (GRCm39) W190G probably damaging Het
Zscan4c T C 7: 10,740,853 (GRCm39) V124A probably benign Het
Other mutations in Slitrk5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Slitrk5 APN 14 111,918,097 (GRCm39) missense probably benign 0.05
IGL01624:Slitrk5 APN 14 111,918,526 (GRCm39) missense probably damaging 1.00
IGL01680:Slitrk5 APN 14 111,916,432 (GRCm39) missense probably benign 0.23
IGL03234:Slitrk5 APN 14 111,916,717 (GRCm39) missense probably benign 0.00
P0019:Slitrk5 UTSW 14 111,918,026 (GRCm39) missense possibly damaging 0.88
R0323:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R0334:Slitrk5 UTSW 14 111,918,256 (GRCm39) missense probably benign
R0392:Slitrk5 UTSW 14 111,916,465 (GRCm39) missense probably benign 0.06
R0659:Slitrk5 UTSW 14 111,918,121 (GRCm39) missense probably benign 0.00
R1344:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R1754:Slitrk5 UTSW 14 111,917,951 (GRCm39) missense probably damaging 1.00
R1983:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R2070:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R2071:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R3001:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3002:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3003:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3885:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3886:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3888:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R4962:Slitrk5 UTSW 14 111,918,679 (GRCm39) missense probably benign 0.02
R4999:Slitrk5 UTSW 14 111,917,648 (GRCm39) missense probably damaging 0.99
R5036:Slitrk5 UTSW 14 111,918,316 (GRCm39) missense possibly damaging 0.87
R5190:Slitrk5 UTSW 14 111,916,852 (GRCm39) missense probably damaging 1.00
R5237:Slitrk5 UTSW 14 111,919,118 (GRCm39) missense possibly damaging 0.94
R5669:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R5793:Slitrk5 UTSW 14 111,917,345 (GRCm39) missense probably damaging 1.00
R5839:Slitrk5 UTSW 14 111,917,030 (GRCm39) missense probably benign 0.00
R6083:Slitrk5 UTSW 14 111,919,157 (GRCm39) missense probably benign 0.01
R6224:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6225:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6230:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6337:Slitrk5 UTSW 14 111,917,684 (GRCm39) missense probably damaging 0.96
R6666:Slitrk5 UTSW 14 111,917,534 (GRCm39) missense probably damaging 0.96
R6818:Slitrk5 UTSW 14 111,917,726 (GRCm39) missense probably benign 0.32
R6895:Slitrk5 UTSW 14 111,919,085 (GRCm39) missense probably damaging 1.00
R7094:Slitrk5 UTSW 14 111,918,268 (GRCm39) missense probably benign 0.02
R7385:Slitrk5 UTSW 14 111,918,131 (GRCm39) missense probably benign 0.32
R8532:Slitrk5 UTSW 14 111,916,909 (GRCm39) missense probably benign
R8994:Slitrk5 UTSW 14 111,918,227 (GRCm39) missense probably benign 0.00
R9344:Slitrk5 UTSW 14 111,916,702 (GRCm39) missense probably damaging 0.97
R9374:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
R9500:Slitrk5 UTSW 14 111,916,726 (GRCm39) missense possibly damaging 0.89
R9512:Slitrk5 UTSW 14 111,917,252 (GRCm39) missense probably damaging 1.00
R9552:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
Z1177:Slitrk5 UTSW 14 111,917,285 (GRCm39) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- GAGAGACTTGCTGATTACCCC -3'
(R):5'- GCCCCTGTGTAATTAACAAACTC -3'

Sequencing Primer
(F):5'- CCAGTAACTTTGGAACAGG -3'
(R):5'- CTCATTGGGATAGAGGCGGCTC -3'
Posted On 2022-07-18