Incidental Mutation 'R9502:Spag9'
| ID |
717662 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Spag9
|
| Ensembl Gene |
ENSMUSG00000020859 |
| Gene Name |
sperm associated antigen 9 |
| Synonyms |
JLP, Mapk8ip4, 3110018C07Rik, JIP4, 4733401I23Rik, syd1, 4831406C20Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.785)
|
| Stock # |
R9502 (G1)
|
| Quality Score |
223.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
93886917-94016911 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 93959792 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 327
(V327A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042271
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024979]
[ENSMUST00000041956]
[ENSMUST00000075695]
[ENSMUST00000092777]
[ENSMUST00000103168]
[ENSMUST00000132079]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000024979
AA Change: V184A
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000024979
Gene: ENSMUSG00000020859
AA Change: V184A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
8e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000041956
AA Change: V327A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000042271
Gene: ENSMUSG00000020859
AA Change: V327A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Jnk-SapK_ap_N
|
24 |
179 |
2e-61 |
PFAM |
|
Pfam:JIP_LZII
|
390 |
460 |
5.3e-32 |
PFAM |
|
coiled coil region
|
710 |
744 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
889 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
961 |
1107 |
1e-5 |
SMART |
|
Blast:WD40
|
1062 |
1102 |
1e-17 |
BLAST |
|
low complexity region
|
1270 |
1288 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000075695
AA Change: V184A
PolyPhen 2
Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000075115
Gene: ENSMUSG00000020859
AA Change: V184A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
253 |
305 |
1e-25 |
PDB |
|
low complexity region
|
306 |
339 |
N/A |
INTRINSIC |
|
coiled coil region
|
571 |
605 |
N/A |
INTRINSIC |
|
low complexity region
|
734 |
750 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
822 |
968 |
3e-5 |
SMART |
|
Blast:WD40
|
923 |
963 |
7e-18 |
BLAST |
|
low complexity region
|
1131 |
1149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092777
AA Change: V184A
PolyPhen 2
Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000090452
Gene: ENSMUSG00000020859
AA Change: V184A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
254 |
306 |
1e-25 |
PDB |
|
low complexity region
|
307 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
572 |
606 |
N/A |
INTRINSIC |
|
low complexity region
|
735 |
751 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
823 |
969 |
3e-5 |
SMART |
|
Blast:WD40
|
924 |
964 |
7e-18 |
BLAST |
|
low complexity region
|
1132 |
1150 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103168
AA Change: V184A
PolyPhen 2
Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099457
Gene: ENSMUSG00000020859
AA Change: V184A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
PDB:2W83|D
|
249 |
301 |
1e-25 |
PDB |
|
low complexity region
|
302 |
335 |
N/A |
INTRINSIC |
|
coiled coil region
|
567 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
730 |
746 |
N/A |
INTRINSIC |
|
SCOP:d1kb0a2
|
818 |
964 |
3e-5 |
SMART |
|
Blast:WD40
|
919 |
959 |
8e-18 |
BLAST |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132079
AA Change: V184A
PolyPhen 2
Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000118850
Gene: ENSMUSG00000020859
AA Change: V184A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
394 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
539 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000115864
Gene: ENSMUSG00000020859
AA Change: V176A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:JIP_LZII
|
240 |
310 |
1.1e-32 |
PFAM |
|
coiled coil region
|
559 |
593 |
N/A |
INTRINSIC |
|
low complexity region
|
723 |
739 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted, knock-out(1) Gene trapped(4) |
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700019D03Rik |
T |
A |
1: 52,964,662 (GRCm39) |
H22L |
possibly damaging |
Het |
| Abca2 |
C |
A |
2: 25,326,895 (GRCm39) |
Y590* |
probably null |
Het |
| Acot1 |
G |
T |
12: 84,061,353 (GRCm39) |
E220* |
probably null |
Het |
| Acsl5 |
T |
G |
19: 55,271,744 (GRCm39) |
I292S |
probably benign |
Het |
| Acvr1b |
C |
T |
15: 101,092,710 (GRCm39) |
H118Y |
probably benign |
Het |
| Aggf1 |
A |
G |
13: 95,507,450 (GRCm39) |
C112R |
probably benign |
Het |
| Ap2a2 |
T |
A |
7: 141,178,689 (GRCm39) |
N105K |
probably benign |
Het |
| Aste1 |
G |
A |
9: 105,273,880 (GRCm39) |
C40Y |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,323,357 (GRCm39) |
T232A |
probably benign |
Het |
| Ccser2 |
A |
G |
14: 36,631,090 (GRCm39) |
F649L |
probably benign |
Het |
| Cdcp3 |
T |
C |
7: 130,836,815 (GRCm39) |
V419A |
possibly damaging |
Het |
| Cenpf |
G |
A |
1: 189,388,978 (GRCm39) |
T1618I |
probably damaging |
Het |
| Ces5a |
G |
A |
8: 94,262,308 (GRCm39) |
Q10* |
probably null |
Het |
| Cfap20dc |
A |
G |
14: 8,659,452 (GRCm38) |
F48L |
probably damaging |
Het |
| Cfh |
A |
T |
1: 140,040,320 (GRCm39) |
L592Q |
possibly damaging |
Het |
| Chchd6 |
T |
C |
6: 89,396,763 (GRCm39) |
H216R |
probably damaging |
Het |
| Chrm5 |
A |
T |
2: 112,311,040 (GRCm39) |
H25Q |
probably damaging |
Het |
| Clasp2 |
C |
T |
9: 113,737,866 (GRCm39) |
T1080I |
probably benign |
Het |
| Clic6 |
G |
T |
16: 92,295,588 (GRCm39) |
G83C |
probably damaging |
Het |
| Coro1c |
A |
T |
5: 113,988,781 (GRCm39) |
S187R |
probably damaging |
Het |
| Cyp2a4 |
A |
G |
7: 26,008,004 (GRCm39) |
D137G |
probably benign |
Het |
| Ddhd1 |
G |
T |
14: 45,894,679 (GRCm39) |
Q264K |
possibly damaging |
Het |
| Dhdds |
A |
T |
4: 133,707,497 (GRCm39) |
Y235N |
probably damaging |
Het |
| Ephb1 |
T |
C |
9: 101,918,486 (GRCm39) |
E341G |
probably damaging |
Het |
| Fam53b |
T |
C |
7: 132,361,740 (GRCm39) |
D96G |
probably benign |
Het |
| Fcgbpl1 |
A |
G |
7: 27,836,891 (GRCm39) |
D270G |
probably benign |
Het |
| Fermt1 |
G |
T |
2: 132,781,388 (GRCm39) |
R67S |
probably benign |
Het |
| Fmnl2 |
C |
A |
2: 52,998,312 (GRCm39) |
P559H |
unknown |
Het |
| Foxo3 |
C |
T |
10: 42,073,021 (GRCm39) |
V499M |
probably damaging |
Het |
| Frmpd2 |
T |
A |
14: 33,227,404 (GRCm39) |
F261I |
probably benign |
Het |
| Garem2 |
T |
A |
5: 30,321,750 (GRCm39) |
L703Q |
possibly damaging |
Het |
| Ggct |
T |
A |
6: 54,962,872 (GRCm39) |
I180F |
possibly damaging |
Het |
| Gigyf2 |
T |
A |
1: 87,331,446 (GRCm39) |
I198K |
unknown |
Het |
| Gucy2d |
T |
C |
7: 98,107,942 (GRCm39) |
F700L |
probably benign |
Het |
| Gucy2g |
T |
A |
19: 55,198,816 (GRCm39) |
I776F |
probably damaging |
Het |
| H2ac8 |
T |
C |
13: 23,755,045 (GRCm39) |
I80V |
probably benign |
Het |
| Has1 |
T |
C |
17: 18,063,971 (GRCm39) |
Y556C |
probably damaging |
Het |
| Hecw1 |
T |
C |
13: 14,546,567 (GRCm39) |
I145V |
probably damaging |
Het |
| Helz2 |
T |
A |
2: 180,878,245 (GRCm39) |
Y851F |
possibly damaging |
Het |
| Hes7 |
C |
A |
11: 69,013,711 (GRCm39) |
P190Q |
probably benign |
Het |
| Hivep1 |
T |
C |
13: 42,322,779 (GRCm39) |
C79R |
|
Het |
| Hnrnpr |
A |
G |
4: 136,056,681 (GRCm39) |
D227G |
probably damaging |
Het |
| Hoxb9 |
C |
A |
11: 96,162,544 (GRCm39) |
F59L |
probably benign |
Het |
| Hspb1 |
A |
T |
5: 135,917,930 (GRCm39) |
H135L |
probably benign |
Het |
| Igkv1-122 |
T |
A |
6: 67,994,348 (GRCm39) |
F79I |
probably benign |
Het |
| Igtp |
G |
C |
11: 58,097,800 (GRCm39) |
V324L |
possibly damaging |
Het |
| Il18r1 |
G |
A |
1: 40,528,852 (GRCm39) |
A299T |
probably benign |
Het |
| Kat14 |
C |
A |
2: 144,235,527 (GRCm39) |
P329Q |
probably damaging |
Het |
| Krt33b |
T |
A |
11: 99,917,315 (GRCm39) |
Q179L |
probably benign |
Het |
| Lrrk2 |
C |
T |
15: 91,607,365 (GRCm39) |
A576V |
probably damaging |
Het |
| Map3k11 |
A |
G |
19: 5,740,624 (GRCm39) |
E117G |
probably damaging |
Het |
| Mgme1 |
C |
T |
2: 144,114,156 (GRCm39) |
A86V |
probably benign |
Het |
| Mks1 |
C |
A |
11: 87,753,766 (GRCm39) |
A534E |
probably damaging |
Het |
| Mrpl28 |
T |
A |
17: 26,343,594 (GRCm39) |
I118N |
probably damaging |
Het |
| Mrps22 |
T |
A |
9: 98,480,219 (GRCm39) |
Y102F |
probably damaging |
Het |
| Myt1 |
A |
T |
2: 181,461,991 (GRCm39) |
H1000L |
probably damaging |
Het |
| Ncoa5 |
A |
G |
2: 164,854,802 (GRCm39) |
Y107H |
possibly damaging |
Het |
| Nipsnap3a |
A |
T |
4: 52,994,039 (GRCm39) |
Y40F |
probably benign |
Het |
| Nlrc4 |
T |
A |
17: 74,752,580 (GRCm39) |
Y601F |
probably benign |
Het |
| Obsl1 |
A |
G |
1: 75,466,267 (GRCm39) |
L1487P |
probably damaging |
Het |
| Oit3 |
A |
T |
10: 59,264,173 (GRCm39) |
N320K |
probably damaging |
Het |
| Or1e33 |
T |
C |
11: 73,738,825 (GRCm39) |
N42S |
probably damaging |
Het |
| Or7a38 |
A |
G |
10: 78,753,559 (GRCm39) |
N295S |
probably damaging |
Het |
| Otud4 |
T |
C |
8: 80,400,480 (GRCm39) |
S1065P |
probably benign |
Het |
| P3h1 |
A |
C |
4: 119,094,008 (GRCm39) |
E221A |
possibly damaging |
Het |
| Pgpep1 |
C |
A |
8: 71,103,899 (GRCm39) |
A124S |
probably benign |
Het |
| Pigg |
T |
A |
5: 108,495,782 (GRCm39) |
S940T |
|
Het |
| Proser3 |
G |
T |
7: 30,245,587 (GRCm39) |
T139K |
possibly damaging |
Het |
| Prr36 |
C |
T |
8: 4,264,775 (GRCm39) |
R297H |
unknown |
Het |
| Rai14 |
A |
T |
15: 10,587,947 (GRCm39) |
F306I |
possibly damaging |
Het |
| Rnase13 |
T |
A |
14: 52,159,825 (GRCm39) |
N105Y |
probably damaging |
Het |
| Ros1 |
A |
G |
10: 52,000,174 (GRCm39) |
I1138T |
probably benign |
Het |
| Rsbn1 |
C |
A |
3: 103,822,146 (GRCm39) |
T127K |
possibly damaging |
Het |
| Rsf1 |
G |
GCCGGCGGCC |
7: 97,229,116 (GRCm39) |
|
probably benign |
Het |
| Rtca |
T |
C |
3: 116,301,413 (GRCm39) |
T45A |
probably benign |
Het |
| Sema6b |
G |
T |
17: 56,439,500 (GRCm39) |
D82E |
probably benign |
Het |
| Serpinc1 |
A |
T |
1: 160,821,179 (GRCm39) |
K209* |
probably null |
Het |
| Slc4a1 |
C |
A |
11: 102,247,674 (GRCm39) |
R403L |
probably damaging |
Het |
| Smtn |
A |
G |
11: 3,482,780 (GRCm39) |
V92A |
possibly damaging |
Het |
| Spdl1 |
T |
C |
11: 34,713,283 (GRCm39) |
N233S |
possibly damaging |
Het |
| Stimate |
A |
G |
14: 30,593,463 (GRCm39) |
N189S |
probably damaging |
Het |
| Ston2 |
T |
C |
12: 91,707,424 (GRCm39) |
D62G |
possibly damaging |
Het |
| Sult2a5 |
A |
G |
7: 13,359,243 (GRCm39) |
D73G |
probably benign |
Het |
| Ticrr |
A |
G |
7: 79,343,597 (GRCm39) |
E1154G |
probably benign |
Het |
| Tmem163 |
A |
T |
1: 127,480,529 (GRCm39) |
M111K |
probably damaging |
Het |
| Tmem266 |
T |
C |
9: 55,344,973 (GRCm39) |
V535A |
probably damaging |
Het |
| Tmprss7 |
T |
A |
16: 45,484,555 (GRCm39) |
D535V |
probably damaging |
Het |
| Tmt1a |
T |
C |
15: 100,203,215 (GRCm39) |
V163A |
probably damaging |
Het |
| Tpcn1 |
A |
C |
5: 120,698,390 (GRCm39) |
I44S |
probably benign |
Het |
| Trbv12-1 |
T |
A |
6: 41,090,921 (GRCm39) |
F98I |
probably damaging |
Het |
| Trhde |
A |
T |
10: 114,636,697 (GRCm39) |
V170E |
probably damaging |
Het |
| Trpt1 |
A |
T |
19: 6,975,578 (GRCm39) |
T111S |
probably benign |
Het |
| Ttc13 |
T |
C |
8: 125,410,010 (GRCm39) |
T401A |
possibly damaging |
Het |
| Ulbp1 |
T |
C |
10: 7,423,260 (GRCm39) |
I28V |
probably benign |
Het |
| Vldlr |
A |
T |
19: 27,218,742 (GRCm39) |
D531V |
probably damaging |
Het |
| Vmn2r85 |
T |
A |
10: 130,261,387 (GRCm39) |
T317S |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,696,705 (GRCm39) |
K316R |
probably benign |
Het |
| Vwa3b |
A |
G |
1: 37,099,520 (GRCm39) |
N245S |
probably damaging |
Het |
| Zfp266 |
A |
T |
9: 20,413,413 (GRCm39) |
C82* |
probably null |
Het |
| Zfp746 |
T |
C |
6: 48,041,397 (GRCm39) |
K443R |
probably damaging |
Het |
|
| Other mutations in Spag9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00422:Spag9
|
APN |
11 |
93,988,692 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01776:Spag9
|
APN |
11 |
94,007,553 (GRCm39) |
splice site |
probably benign |
|
|
IGL02095:Spag9
|
APN |
11 |
93,999,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02307:Spag9
|
APN |
11 |
93,992,986 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02417:Spag9
|
APN |
11 |
94,007,567 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02480:Spag9
|
APN |
11 |
93,999,413 (GRCm39) |
nonsense |
probably null |
|
|
IGL02864:Spag9
|
APN |
11 |
93,997,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02976:Spag9
|
APN |
11 |
93,974,779 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02979:Spag9
|
APN |
11 |
93,988,190 (GRCm39) |
missense |
probably benign |
|
|
IGL03349:Spag9
|
APN |
11 |
93,984,335 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
dazzle
|
UTSW |
11 |
93,984,450 (GRCm39) |
nonsense |
probably null |
|
|
R0128:Spag9
|
UTSW |
11 |
93,984,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Spag9
|
UTSW |
11 |
93,982,579 (GRCm39) |
splice site |
probably benign |
|
|
R1463:Spag9
|
UTSW |
11 |
94,007,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Spag9
|
UTSW |
11 |
93,988,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1605:Spag9
|
UTSW |
11 |
93,939,365 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1649:Spag9
|
UTSW |
11 |
93,999,278 (GRCm39) |
splice site |
probably null |
|
|
R1697:Spag9
|
UTSW |
11 |
93,887,391 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1952:Spag9
|
UTSW |
11 |
93,988,184 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2011:Spag9
|
UTSW |
11 |
93,983,201 (GRCm39) |
nonsense |
probably null |
|
|
R2012:Spag9
|
UTSW |
11 |
93,983,201 (GRCm39) |
nonsense |
probably null |
|
|
R2351:Spag9
|
UTSW |
11 |
93,983,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Spag9
|
UTSW |
11 |
94,007,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3027:Spag9
|
UTSW |
11 |
93,977,203 (GRCm39) |
missense |
probably null |
1.00 |
|
R3766:Spag9
|
UTSW |
11 |
93,951,109 (GRCm39) |
intron |
probably benign |
|
|
R3777:Spag9
|
UTSW |
11 |
93,989,852 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3937:Spag9
|
UTSW |
11 |
93,935,305 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3937:Spag9
|
UTSW |
11 |
93,935,243 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4417:Spag9
|
UTSW |
11 |
93,951,172 (GRCm39) |
intron |
probably benign |
|
|
R4445:Spag9
|
UTSW |
11 |
93,988,079 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4711:Spag9
|
UTSW |
11 |
94,005,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4799:Spag9
|
UTSW |
11 |
93,939,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4799:Spag9
|
UTSW |
11 |
93,939,342 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4816:Spag9
|
UTSW |
11 |
93,939,425 (GRCm39) |
intron |
probably benign |
|
|
R4843:Spag9
|
UTSW |
11 |
93,988,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5020:Spag9
|
UTSW |
11 |
93,988,612 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5119:Spag9
|
UTSW |
11 |
94,013,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5298:Spag9
|
UTSW |
11 |
93,990,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5305:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Spag9
|
UTSW |
11 |
93,982,577 (GRCm39) |
splice site |
probably null |
|
|
R5636:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5638:Spag9
|
UTSW |
11 |
93,959,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5654:Spag9
|
UTSW |
11 |
93,981,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Spag9
|
UTSW |
11 |
94,005,079 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5814:Spag9
|
UTSW |
11 |
93,973,654 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5912:Spag9
|
UTSW |
11 |
93,935,251 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6038:Spag9
|
UTSW |
11 |
94,002,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Spag9
|
UTSW |
11 |
94,002,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6269:Spag9
|
UTSW |
11 |
93,935,333 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6294:Spag9
|
UTSW |
11 |
93,984,311 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6389:Spag9
|
UTSW |
11 |
93,977,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6420:Spag9
|
UTSW |
11 |
93,977,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6460:Spag9
|
UTSW |
11 |
93,959,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6482:Spag9
|
UTSW |
11 |
93,984,328 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6860:Spag9
|
UTSW |
11 |
93,972,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7086:Spag9
|
UTSW |
11 |
93,988,690 (GRCm39) |
missense |
probably benign |
|
|
R7179:Spag9
|
UTSW |
11 |
93,980,258 (GRCm39) |
splice site |
probably null |
|
|
R7225:Spag9
|
UTSW |
11 |
93,988,184 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7351:Spag9
|
UTSW |
11 |
93,983,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7366:Spag9
|
UTSW |
11 |
93,999,347 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7378:Spag9
|
UTSW |
11 |
94,005,177 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7401:Spag9
|
UTSW |
11 |
93,988,515 (GRCm39) |
missense |
probably benign |
|
|
R7506:Spag9
|
UTSW |
11 |
93,999,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7507:Spag9
|
UTSW |
11 |
93,958,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7513:Spag9
|
UTSW |
11 |
94,002,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7655:Spag9
|
UTSW |
11 |
93,887,389 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7656:Spag9
|
UTSW |
11 |
93,887,389 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7664:Spag9
|
UTSW |
11 |
93,992,986 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7665:Spag9
|
UTSW |
11 |
93,904,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7862:Spag9
|
UTSW |
11 |
94,002,892 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8074:Spag9
|
UTSW |
11 |
94,002,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8085:Spag9
|
UTSW |
11 |
93,989,870 (GRCm39) |
missense |
probably benign |
|
|
R8469:Spag9
|
UTSW |
11 |
93,982,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8547:Spag9
|
UTSW |
11 |
94,013,647 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8709:Spag9
|
UTSW |
11 |
93,958,916 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8732:Spag9
|
UTSW |
11 |
93,962,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8899:Spag9
|
UTSW |
11 |
93,983,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8983:Spag9
|
UTSW |
11 |
93,958,815 (GRCm39) |
missense |
probably benign |
|
|
R9043:Spag9
|
UTSW |
11 |
93,951,085 (GRCm39) |
missense |
|
|
|
R9050:Spag9
|
UTSW |
11 |
93,935,294 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9575:Spag9
|
UTSW |
11 |
93,962,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9667:Spag9
|
UTSW |
11 |
93,887,119 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9683:Spag9
|
UTSW |
11 |
93,988,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Spag9
|
UTSW |
11 |
94,005,062 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGTGTGACATTGTCTAACCTC -3'
(R):5'- TCCTGCCAGAAGAATGTCCTC -3'
Sequencing Primer
(F):5'- GTCTAACCTCATATTTCCTAGAACAC -3'
(R):5'- CTGTAGCACAACATGAACTG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation