Incidental Mutation 'R9502:Hecw1'
| ID |
717668 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hecw1
|
| Ensembl Gene |
ENSMUSG00000021301 |
| Gene Name |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms |
NEDL1, E130207I19Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9502 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
14401023-14697813 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 14546567 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 145
(I145V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106145
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110516]
[ENSMUST00000223189]
|
| AlphaFold |
Q8K4P8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110516
AA Change: I145V
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000106145
Gene: ENSMUSG00000021301
AA Change: I145V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HECW_N
|
65 |
184 |
6.5e-62 |
PFAM |
|
C2
|
206 |
317 |
1.02e-12 |
SMART |
|
low complexity region
|
463 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
497 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
745 |
N/A |
INTRINSIC |
|
WW
|
827 |
859 |
8.66e-13 |
SMART |
|
coiled coil region
|
873 |
898 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
WW
|
1017 |
1049 |
5.59e-7 |
SMART |
|
Blast:HECTc
|
1137 |
1192 |
3e-26 |
BLAST |
|
low complexity region
|
1193 |
1208 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1223 |
N/A |
INTRINSIC |
|
HECTc
|
1267 |
1604 |
1.36e-185 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223189
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700019D03Rik |
T |
A |
1: 52,964,662 (GRCm39) |
H22L |
possibly damaging |
Het |
| Abca2 |
C |
A |
2: 25,326,895 (GRCm39) |
Y590* |
probably null |
Het |
| Acot1 |
G |
T |
12: 84,061,353 (GRCm39) |
E220* |
probably null |
Het |
| Acsl5 |
T |
G |
19: 55,271,744 (GRCm39) |
I292S |
probably benign |
Het |
| Acvr1b |
C |
T |
15: 101,092,710 (GRCm39) |
H118Y |
probably benign |
Het |
| Aggf1 |
A |
G |
13: 95,507,450 (GRCm39) |
C112R |
probably benign |
Het |
| Ap2a2 |
T |
A |
7: 141,178,689 (GRCm39) |
N105K |
probably benign |
Het |
| Aste1 |
G |
A |
9: 105,273,880 (GRCm39) |
C40Y |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,323,357 (GRCm39) |
T232A |
probably benign |
Het |
| Ccser2 |
A |
G |
14: 36,631,090 (GRCm39) |
F649L |
probably benign |
Het |
| Cdcp3 |
T |
C |
7: 130,836,815 (GRCm39) |
V419A |
possibly damaging |
Het |
| Cenpf |
G |
A |
1: 189,388,978 (GRCm39) |
T1618I |
probably damaging |
Het |
| Ces5a |
G |
A |
8: 94,262,308 (GRCm39) |
Q10* |
probably null |
Het |
| Cfap20dc |
A |
G |
14: 8,659,452 (GRCm38) |
F48L |
probably damaging |
Het |
| Cfh |
A |
T |
1: 140,040,320 (GRCm39) |
L592Q |
possibly damaging |
Het |
| Chchd6 |
T |
C |
6: 89,396,763 (GRCm39) |
H216R |
probably damaging |
Het |
| Chrm5 |
A |
T |
2: 112,311,040 (GRCm39) |
H25Q |
probably damaging |
Het |
| Clasp2 |
C |
T |
9: 113,737,866 (GRCm39) |
T1080I |
probably benign |
Het |
| Clic6 |
G |
T |
16: 92,295,588 (GRCm39) |
G83C |
probably damaging |
Het |
| Coro1c |
A |
T |
5: 113,988,781 (GRCm39) |
S187R |
probably damaging |
Het |
| Cyp2a4 |
A |
G |
7: 26,008,004 (GRCm39) |
D137G |
probably benign |
Het |
| Ddhd1 |
G |
T |
14: 45,894,679 (GRCm39) |
Q264K |
possibly damaging |
Het |
| Dhdds |
A |
T |
4: 133,707,497 (GRCm39) |
Y235N |
probably damaging |
Het |
| Ephb1 |
T |
C |
9: 101,918,486 (GRCm39) |
E341G |
probably damaging |
Het |
| Fam53b |
T |
C |
7: 132,361,740 (GRCm39) |
D96G |
probably benign |
Het |
| Fcgbpl1 |
A |
G |
7: 27,836,891 (GRCm39) |
D270G |
probably benign |
Het |
| Fermt1 |
G |
T |
2: 132,781,388 (GRCm39) |
R67S |
probably benign |
Het |
| Fmnl2 |
C |
A |
2: 52,998,312 (GRCm39) |
P559H |
unknown |
Het |
| Foxo3 |
C |
T |
10: 42,073,021 (GRCm39) |
V499M |
probably damaging |
Het |
| Frmpd2 |
T |
A |
14: 33,227,404 (GRCm39) |
F261I |
probably benign |
Het |
| Garem2 |
T |
A |
5: 30,321,750 (GRCm39) |
L703Q |
possibly damaging |
Het |
| Ggct |
T |
A |
6: 54,962,872 (GRCm39) |
I180F |
possibly damaging |
Het |
| Gigyf2 |
T |
A |
1: 87,331,446 (GRCm39) |
I198K |
unknown |
Het |
| Gucy2d |
T |
C |
7: 98,107,942 (GRCm39) |
F700L |
probably benign |
Het |
| Gucy2g |
T |
A |
19: 55,198,816 (GRCm39) |
I776F |
probably damaging |
Het |
| H2ac8 |
T |
C |
13: 23,755,045 (GRCm39) |
I80V |
probably benign |
Het |
| Has1 |
T |
C |
17: 18,063,971 (GRCm39) |
Y556C |
probably damaging |
Het |
| Helz2 |
T |
A |
2: 180,878,245 (GRCm39) |
Y851F |
possibly damaging |
Het |
| Hes7 |
C |
A |
11: 69,013,711 (GRCm39) |
P190Q |
probably benign |
Het |
| Hivep1 |
T |
C |
13: 42,322,779 (GRCm39) |
C79R |
|
Het |
| Hnrnpr |
A |
G |
4: 136,056,681 (GRCm39) |
D227G |
probably damaging |
Het |
| Hoxb9 |
C |
A |
11: 96,162,544 (GRCm39) |
F59L |
probably benign |
Het |
| Hspb1 |
A |
T |
5: 135,917,930 (GRCm39) |
H135L |
probably benign |
Het |
| Igkv1-122 |
T |
A |
6: 67,994,348 (GRCm39) |
F79I |
probably benign |
Het |
| Igtp |
G |
C |
11: 58,097,800 (GRCm39) |
V324L |
possibly damaging |
Het |
| Il18r1 |
G |
A |
1: 40,528,852 (GRCm39) |
A299T |
probably benign |
Het |
| Kat14 |
C |
A |
2: 144,235,527 (GRCm39) |
P329Q |
probably damaging |
Het |
| Krt33b |
T |
A |
11: 99,917,315 (GRCm39) |
Q179L |
probably benign |
Het |
| Lrrk2 |
C |
T |
15: 91,607,365 (GRCm39) |
A576V |
probably damaging |
Het |
| Map3k11 |
A |
G |
19: 5,740,624 (GRCm39) |
E117G |
probably damaging |
Het |
| Mgme1 |
C |
T |
2: 144,114,156 (GRCm39) |
A86V |
probably benign |
Het |
| Mks1 |
C |
A |
11: 87,753,766 (GRCm39) |
A534E |
probably damaging |
Het |
| Mrpl28 |
T |
A |
17: 26,343,594 (GRCm39) |
I118N |
probably damaging |
Het |
| Mrps22 |
T |
A |
9: 98,480,219 (GRCm39) |
Y102F |
probably damaging |
Het |
| Myt1 |
A |
T |
2: 181,461,991 (GRCm39) |
H1000L |
probably damaging |
Het |
| Ncoa5 |
A |
G |
2: 164,854,802 (GRCm39) |
Y107H |
possibly damaging |
Het |
| Nipsnap3a |
A |
T |
4: 52,994,039 (GRCm39) |
Y40F |
probably benign |
Het |
| Nlrc4 |
T |
A |
17: 74,752,580 (GRCm39) |
Y601F |
probably benign |
Het |
| Obsl1 |
A |
G |
1: 75,466,267 (GRCm39) |
L1487P |
probably damaging |
Het |
| Oit3 |
A |
T |
10: 59,264,173 (GRCm39) |
N320K |
probably damaging |
Het |
| Or1e33 |
T |
C |
11: 73,738,825 (GRCm39) |
N42S |
probably damaging |
Het |
| Or7a38 |
A |
G |
10: 78,753,559 (GRCm39) |
N295S |
probably damaging |
Het |
| Otud4 |
T |
C |
8: 80,400,480 (GRCm39) |
S1065P |
probably benign |
Het |
| P3h1 |
A |
C |
4: 119,094,008 (GRCm39) |
E221A |
possibly damaging |
Het |
| Pgpep1 |
C |
A |
8: 71,103,899 (GRCm39) |
A124S |
probably benign |
Het |
| Pigg |
T |
A |
5: 108,495,782 (GRCm39) |
S940T |
|
Het |
| Proser3 |
G |
T |
7: 30,245,587 (GRCm39) |
T139K |
possibly damaging |
Het |
| Prr36 |
C |
T |
8: 4,264,775 (GRCm39) |
R297H |
unknown |
Het |
| Rai14 |
A |
T |
15: 10,587,947 (GRCm39) |
F306I |
possibly damaging |
Het |
| Rnase13 |
T |
A |
14: 52,159,825 (GRCm39) |
N105Y |
probably damaging |
Het |
| Ros1 |
A |
G |
10: 52,000,174 (GRCm39) |
I1138T |
probably benign |
Het |
| Rsbn1 |
C |
A |
3: 103,822,146 (GRCm39) |
T127K |
possibly damaging |
Het |
| Rsf1 |
G |
GCCGGCGGCC |
7: 97,229,116 (GRCm39) |
|
probably benign |
Het |
| Rtca |
T |
C |
3: 116,301,413 (GRCm39) |
T45A |
probably benign |
Het |
| Sema6b |
G |
T |
17: 56,439,500 (GRCm39) |
D82E |
probably benign |
Het |
| Serpinc1 |
A |
T |
1: 160,821,179 (GRCm39) |
K209* |
probably null |
Het |
| Slc4a1 |
C |
A |
11: 102,247,674 (GRCm39) |
R403L |
probably damaging |
Het |
| Smtn |
A |
G |
11: 3,482,780 (GRCm39) |
V92A |
possibly damaging |
Het |
| Spag9 |
T |
C |
11: 93,959,792 (GRCm39) |
V327A |
probably damaging |
Het |
| Spdl1 |
T |
C |
11: 34,713,283 (GRCm39) |
N233S |
possibly damaging |
Het |
| Stimate |
A |
G |
14: 30,593,463 (GRCm39) |
N189S |
probably damaging |
Het |
| Ston2 |
T |
C |
12: 91,707,424 (GRCm39) |
D62G |
possibly damaging |
Het |
| Sult2a5 |
A |
G |
7: 13,359,243 (GRCm39) |
D73G |
probably benign |
Het |
| Ticrr |
A |
G |
7: 79,343,597 (GRCm39) |
E1154G |
probably benign |
Het |
| Tmem163 |
A |
T |
1: 127,480,529 (GRCm39) |
M111K |
probably damaging |
Het |
| Tmem266 |
T |
C |
9: 55,344,973 (GRCm39) |
V535A |
probably damaging |
Het |
| Tmprss7 |
T |
A |
16: 45,484,555 (GRCm39) |
D535V |
probably damaging |
Het |
| Tmt1a |
T |
C |
15: 100,203,215 (GRCm39) |
V163A |
probably damaging |
Het |
| Tpcn1 |
A |
C |
5: 120,698,390 (GRCm39) |
I44S |
probably benign |
Het |
| Trbv12-1 |
T |
A |
6: 41,090,921 (GRCm39) |
F98I |
probably damaging |
Het |
| Trhde |
A |
T |
10: 114,636,697 (GRCm39) |
V170E |
probably damaging |
Het |
| Trpt1 |
A |
T |
19: 6,975,578 (GRCm39) |
T111S |
probably benign |
Het |
| Ttc13 |
T |
C |
8: 125,410,010 (GRCm39) |
T401A |
possibly damaging |
Het |
| Ulbp1 |
T |
C |
10: 7,423,260 (GRCm39) |
I28V |
probably benign |
Het |
| Vldlr |
A |
T |
19: 27,218,742 (GRCm39) |
D531V |
probably damaging |
Het |
| Vmn2r85 |
T |
A |
10: 130,261,387 (GRCm39) |
T317S |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,696,705 (GRCm39) |
K316R |
probably benign |
Het |
| Vwa3b |
A |
G |
1: 37,099,520 (GRCm39) |
N245S |
probably damaging |
Het |
| Zfp266 |
A |
T |
9: 20,413,413 (GRCm39) |
C82* |
probably null |
Het |
| Zfp746 |
T |
C |
6: 48,041,397 (GRCm39) |
K443R |
probably damaging |
Het |
|
| Other mutations in Hecw1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00591:Hecw1
|
APN |
13 |
14,440,565 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL00813:Hecw1
|
APN |
13 |
14,452,961 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00843:Hecw1
|
APN |
13 |
14,422,158 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00942:Hecw1
|
APN |
13 |
14,515,325 (GRCm39) |
splice site |
probably benign |
|
|
IGL00976:Hecw1
|
APN |
13 |
14,493,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01289:Hecw1
|
APN |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Hecw1
|
APN |
13 |
14,409,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01783:Hecw1
|
APN |
13 |
14,452,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01941:Hecw1
|
APN |
13 |
14,490,895 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02170:Hecw1
|
APN |
13 |
14,438,743 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02172:Hecw1
|
APN |
13 |
14,438,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Hecw1
|
APN |
13 |
14,474,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02357:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02372:Hecw1
|
APN |
13 |
14,438,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02591:Hecw1
|
APN |
13 |
14,531,821 (GRCm39) |
splice site |
probably benign |
|
|
IGL02718:Hecw1
|
APN |
13 |
14,481,520 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02795:Hecw1
|
APN |
13 |
14,497,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02941:Hecw1
|
APN |
13 |
14,552,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,070 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03366:Hecw1
|
APN |
13 |
14,552,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
deflated
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Demoralized
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
Letdown
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
BB001:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Hecw1
|
UTSW |
13 |
14,420,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Hecw1
|
UTSW |
13 |
14,552,368 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0555:Hecw1
|
UTSW |
13 |
14,411,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Hecw1
|
UTSW |
13 |
14,455,027 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1476:Hecw1
|
UTSW |
13 |
14,480,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1479:Hecw1
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1551:Hecw1
|
UTSW |
13 |
14,491,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Hecw1
|
UTSW |
13 |
14,552,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Hecw1
|
UTSW |
13 |
14,515,328 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1735:Hecw1
|
UTSW |
13 |
14,552,350 (GRCm39) |
missense |
probably null |
0.09 |
|
R1872:Hecw1
|
UTSW |
13 |
14,455,034 (GRCm39) |
nonsense |
probably null |
|
|
R1897:Hecw1
|
UTSW |
13 |
14,552,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Hecw1
|
UTSW |
13 |
14,471,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2085:Hecw1
|
UTSW |
13 |
14,438,672 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2134:Hecw1
|
UTSW |
13 |
14,552,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Hecw1
|
UTSW |
13 |
14,552,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Hecw1
|
UTSW |
13 |
14,490,723 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2274:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2275:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2937:Hecw1
|
UTSW |
13 |
14,420,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3830:Hecw1
|
UTSW |
13 |
14,520,643 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3971:Hecw1
|
UTSW |
13 |
14,411,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4066:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Hecw1
|
UTSW |
13 |
14,491,724 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4366:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4511:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4558:Hecw1
|
UTSW |
13 |
14,422,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4804:Hecw1
|
UTSW |
13 |
14,480,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4854:Hecw1
|
UTSW |
13 |
14,491,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5104:Hecw1
|
UTSW |
13 |
14,515,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Hecw1
|
UTSW |
13 |
14,520,614 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5167:Hecw1
|
UTSW |
13 |
14,460,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5392:Hecw1
|
UTSW |
13 |
14,420,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Hecw1
|
UTSW |
13 |
14,497,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5504:Hecw1
|
UTSW |
13 |
14,515,487 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5764:Hecw1
|
UTSW |
13 |
14,497,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6228:Hecw1
|
UTSW |
13 |
14,520,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Hecw1
|
UTSW |
13 |
14,409,010 (GRCm39) |
nonsense |
probably null |
|
|
R6252:Hecw1
|
UTSW |
13 |
14,446,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6291:Hecw1
|
UTSW |
13 |
14,697,592 (GRCm39) |
unclassified |
probably benign |
|
|
R6321:Hecw1
|
UTSW |
13 |
14,697,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6325:Hecw1
|
UTSW |
13 |
14,491,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6328:Hecw1
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6557:Hecw1
|
UTSW |
13 |
14,491,231 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6566:Hecw1
|
UTSW |
13 |
14,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Hecw1
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
R6821:Hecw1
|
UTSW |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Hecw1
|
UTSW |
13 |
14,491,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7078:Hecw1
|
UTSW |
13 |
14,609,044 (GRCm39) |
start codon destroyed |
probably null |
0.21 |
|
R7114:Hecw1
|
UTSW |
13 |
14,486,356 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7140:Hecw1
|
UTSW |
13 |
14,491,118 (GRCm39) |
missense |
probably benign |
|
|
R7150:Hecw1
|
UTSW |
13 |
14,609,045 (GRCm39) |
start codon destroyed |
probably benign |
|
|
R7288:Hecw1
|
UTSW |
13 |
14,490,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7447:Hecw1
|
UTSW |
13 |
14,531,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7479:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7552:Hecw1
|
UTSW |
13 |
14,490,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Hecw1
|
UTSW |
13 |
14,438,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Hecw1
|
UTSW |
13 |
14,493,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7803:Hecw1
|
UTSW |
13 |
14,408,927 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7924:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Hecw1
|
UTSW |
13 |
14,552,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Hecw1
|
UTSW |
13 |
14,422,286 (GRCm39) |
splice site |
probably null |
|
|
R8195:Hecw1
|
UTSW |
13 |
14,480,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8252:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8696:Hecw1
|
UTSW |
13 |
14,531,743 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8827:Hecw1
|
UTSW |
13 |
14,438,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Hecw1
|
UTSW |
13 |
14,422,275 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8914:Hecw1
|
UTSW |
13 |
14,422,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Hecw1
|
UTSW |
13 |
14,481,395 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9126:Hecw1
|
UTSW |
13 |
14,546,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9185:Hecw1
|
UTSW |
13 |
14,491,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9203:Hecw1
|
UTSW |
13 |
14,491,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9236:Hecw1
|
UTSW |
13 |
14,490,643 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9291:Hecw1
|
UTSW |
13 |
14,491,522 (GRCm39) |
missense |
probably benign |
|
|
R9312:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9438:Hecw1
|
UTSW |
13 |
14,481,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9642:Hecw1
|
UTSW |
13 |
14,515,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Hecw1
|
UTSW |
13 |
14,472,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Hecw1
|
UTSW |
13 |
14,405,308 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
X0066:Hecw1
|
UTSW |
13 |
14,455,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
Z1176:Hecw1
|
UTSW |
13 |
14,474,918 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGACTCTCATTAAGCCTGTCTCTG -3'
(R):5'- TTCCTCTGCCACGTGTTGAG -3'
Sequencing Primer
(F):5'- GCTTTTACATGGTTCCTAAGCAC -3'
(R):5'- GGTGGTATCTTTGAATAGTTCCAAC -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation