Mutagenetix > Incidental Mutation

Incidental Mutation 'R9502:Lrrk2'

717680

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R9502 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 91723162 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 576 (A576V)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

probably damaging
Transcript: ENSMUST00000060642
AA Change: A576V

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: A576V

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019D03Rik	T	A	1: 52,925,503 (GRCm38)	H22L	possibly damaging	Het
4930452B06Rik	A	G	14: 8,659,452 (GRCm38)	F48L	probably damaging	Het
5430419D17Rik	T	C	7: 131,235,086 (GRCm38)	V419A	possibly damaging	Het
9530053A07Rik	A	G	7: 28,137,466 (GRCm38)	D270G	probably benign	Het
Abca2	C	A	2: 25,436,883 (GRCm38)	Y590*	probably null	Het
Acot1	G	T	12: 84,014,579 (GRCm38)	E220*	probably null	Het
Acsl5	T	G	19: 55,283,312 (GRCm38)	I292S	probably benign	Het
Acvr1b	C	T	15: 101,194,829 (GRCm38)	H118Y	probably benign	Het
Aggf1	A	G	13: 95,370,942 (GRCm38)	C112R	probably benign	Het
Ap2a2	T	A	7: 141,598,776 (GRCm38)	N105K	probably benign	Het
Aste1	G	A	9: 105,396,681 (GRCm38)	C40Y	probably benign	Het
Carmil1	T	C	13: 24,139,374 (GRCm38)	T232A	probably benign	Het
Ccser2	A	G	14: 36,909,133 (GRCm38)	F649L	probably benign	Het
Cenpf	G	A	1: 189,656,781 (GRCm38)	T1618I	probably damaging	Het
Ces5a	G	A	8: 93,535,680 (GRCm38)	Q10*	probably null	Het
Cfh	A	T	1: 140,112,582 (GRCm38)	L592Q	possibly damaging	Het
Chchd6	T	C	6: 89,419,781 (GRCm38)	H216R	probably damaging	Het
Chrm5	A	T	2: 112,480,695 (GRCm38)	H25Q	probably damaging	Het
Clasp2	C	T	9: 113,908,798 (GRCm38)	T1080I	probably benign	Het
Clic6	G	T	16: 92,498,700 (GRCm38)	G83C	probably damaging	Het
Coro1c	A	T	5: 113,850,720 (GRCm38)	S187R	probably damaging	Het
Cyp2a4	A	G	7: 26,308,579 (GRCm38)	D137G	probably benign	Het
Ddhd1	G	T	14: 45,657,222 (GRCm38)	Q264K	possibly damaging	Het
Dhdds	A	T	4: 133,980,186 (GRCm38)	Y235N	probably damaging	Het
Ephb1	T	C	9: 102,041,287 (GRCm38)	E341G	probably damaging	Het
Fam53b	T	C	7: 132,760,011 (GRCm38)	D96G	probably benign	Het
Fermt1	G	T	2: 132,939,468 (GRCm38)	R67S	probably benign	Het
Fmnl2	C	A	2: 53,108,300 (GRCm38)	P559H	unknown	Het
Foxo3	C	T	10: 42,197,025 (GRCm38)	V499M	probably damaging	Het
Frmpd2	T	A	14: 33,505,447 (GRCm38)	F261I	probably benign	Het
Garem2	T	A	5: 30,116,752 (GRCm38)	L703Q	possibly damaging	Het
Ggct	T	A	6: 54,985,887 (GRCm38)	I180F	possibly damaging	Het
Gigyf2	T	A	1: 87,403,724 (GRCm38)	I198K	unknown	Het
Gucy2d	T	C	7: 98,458,735 (GRCm38)	F700L	probably benign	Het
Gucy2g	T	A	19: 55,210,384 (GRCm38)	I776F	probably damaging	Het
Has1	T	C	17: 17,843,709 (GRCm38)	Y556C	probably damaging	Het
Hecw1	T	C	13: 14,371,982 (GRCm38)	I145V	probably damaging	Het
Helz2	T	A	2: 181,236,452 (GRCm38)	Y851F	possibly damaging	Het
Hes7	C	A	11: 69,122,885 (GRCm38)	P190Q	probably benign	Het
Hist1h2ae	T	C	13: 23,570,871 (GRCm38)	I80V	probably benign	Het
Hivep1	T	C	13: 42,169,303 (GRCm38)	C79R		Het
Hnrnpr	A	G	4: 136,329,370 (GRCm38)	D227G	probably damaging	Het
Hoxb9	C	A	11: 96,271,718 (GRCm38)	F59L	probably benign	Het
Hspb1	A	T	5: 135,889,076 (GRCm38)	H135L	probably benign	Het
Igkv1-122	T	A	6: 68,017,364 (GRCm38)	F79I	probably benign	Het
Igtp	G	C	11: 58,206,974 (GRCm38)	V324L	possibly damaging	Het
Il18r1	G	A	1: 40,489,692 (GRCm38)	A299T	probably benign	Het
Kat14	C	A	2: 144,393,607 (GRCm38)	P329Q	probably damaging	Het
Krt33b	T	A	11: 100,026,489 (GRCm38)	Q179L	probably benign	Het
Map3k11	A	G	19: 5,690,596 (GRCm38)	E117G	probably damaging	Het
Mettl7a1	T	C	15: 100,305,334 (GRCm38)	V163A	probably damaging	Het
Mgme1	C	T	2: 144,272,236 (GRCm38)	A86V	probably benign	Het
Mks1	C	A	11: 87,862,940 (GRCm38)	A534E	probably damaging	Het
Mrpl28	T	A	17: 26,124,620 (GRCm38)	I118N	probably damaging	Het
Mrps22	T	A	9: 98,598,166 (GRCm38)	Y102F	probably damaging	Het
Myt1	A	T	2: 181,820,198 (GRCm38)	H1000L	probably damaging	Het
Ncoa5	A	G	2: 165,012,882 (GRCm38)	Y107H	possibly damaging	Het
Nipsnap3a	A	T	4: 52,994,039 (GRCm38)	Y40F	probably benign	Het
Nlrc4	T	A	17: 74,445,585 (GRCm38)	Y601F	probably benign	Het
Obsl1	A	G	1: 75,489,623 (GRCm38)	L1487P	probably damaging	Het
Oit3	A	T	10: 59,428,351 (GRCm38)	N320K	probably damaging	Het
Olfr1354	A	G	10: 78,917,725 (GRCm38)	N295S	probably damaging	Het
Olfr393	T	C	11: 73,847,999 (GRCm38)	N42S	probably damaging	Het
Otud4	T	C	8: 79,673,851 (GRCm38)	S1065P	probably benign	Het
P3h1	A	C	4: 119,236,811 (GRCm38)	E221A	possibly damaging	Het
Pgpep1	C	A	8: 70,651,249 (GRCm38)	A124S	probably benign	Het
Pigg	T	A	5: 108,347,916 (GRCm38)	S940T		Het
Proser3	G	T	7: 30,546,162 (GRCm38)	T139K	possibly damaging	Het
Prr36	C	T	8: 4,214,775 (GRCm38)	R297H	unknown	Het
Rai14	A	T	15: 10,587,861 (GRCm38)	F306I	possibly damaging	Het
Rnase13	T	A	14: 51,922,368 (GRCm38)	N105Y	probably damaging	Het
Ros1	A	G	10: 52,124,078 (GRCm38)	I1138T	probably benign	Het
Rsbn1	C	A	3: 103,914,830 (GRCm38)	T127K	possibly damaging	Het
Rsf1	G	GCCGGCGGCC	7: 97,579,909 (GRCm38)		probably benign	Het
Rtca	T	C	3: 116,507,764 (GRCm38)	T45A	probably benign	Het
Sema6b	G	T	17: 56,132,500 (GRCm38)	D82E	probably benign	Het
Serpinc1	A	T	1: 160,993,609 (GRCm38)	K209*	probably null	Het
Slc4a1	C	A	11: 102,356,848 (GRCm38)	R403L	probably damaging	Het
Smtn	A	G	11: 3,532,780 (GRCm38)	V92A	possibly damaging	Het
Spag9	T	C	11: 94,068,966 (GRCm38)	V327A	probably damaging	Het
Spdl1	T	C	11: 34,822,456 (GRCm38)	N233S	possibly damaging	Het
Ston2	T	C	12: 91,740,650 (GRCm38)	D62G	possibly damaging	Het
Sult2a5	A	G	7: 13,625,318 (GRCm38)	D73G	probably benign	Het
Ticrr	A	G	7: 79,693,849 (GRCm38)	E1154G	probably benign	Het
Tmem110	A	G	14: 30,871,506 (GRCm38)	N189S	probably damaging	Het
Tmem163	A	T	1: 127,552,792 (GRCm38)	M111K	probably damaging	Het
Tmem266	T	C	9: 55,437,689 (GRCm38)	V535A	probably damaging	Het
Tmprss7	T	A	16: 45,664,192 (GRCm38)	D535V	probably damaging	Het
Tpcn1	A	C	5: 120,560,325 (GRCm38)	I44S	probably benign	Het
Trbv12-1	T	A	6: 41,113,987 (GRCm38)	F98I	probably damaging	Het
Trhde	A	T	10: 114,800,792 (GRCm38)	V170E	probably damaging	Het
Trpt1	A	T	19: 6,998,210 (GRCm38)	T111S	probably benign	Het
Ttc13	T	C	8: 124,683,271 (GRCm38)	T401A	possibly damaging	Het
Ulbp1	T	C	10: 7,473,260 (GRCm38)	I28V	probably benign	Het
Vldlr	A	T	19: 27,241,342 (GRCm38)	D531V	probably damaging	Het
Vmn2r85	T	A	10: 130,425,518 (GRCm38)	T317S	probably damaging	Het
Vps33a	T	C	5: 123,558,642 (GRCm38)	K316R	probably benign	Het
Vwa3b	A	G	1: 37,060,439 (GRCm38)	N245S	probably damaging	Het
Zfp266	A	T	9: 20,502,117 (GRCm38)	C82*	probably null	Het
Zfp746	T	C	6: 48,064,463 (GRCm38)	K443R	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- AGCTGCATACCCAGACATTGAATTATG -3'
(R):5'- TCTTTTAACCTTAAAGCAGAAGGAAGG -3'

Sequencing Primer
(F):5'- ACCCAGACATTGAATTATGTTTTACC -3'
(R):5'- AGTAAGTAGCATTCCTCCATGGC -3'

Posted On

2022-07-18