Incidental Mutation 'R9504:Zfp959'
| ID |
717749 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp959
|
| Ensembl Gene |
ENSMUSG00000003198 |
| Gene Name |
zinc finger protein 959 |
| Synonyms |
BC011426 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R9504 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
56199093-56205928 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 56204793 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 277
(Y277N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000053979
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054780]
[ENSMUST00000224379]
|
| AlphaFold |
Q91VM8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054780
AA Change: Y277N
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000053979
Gene: ENSMUSG00000003198
AA Change: Y277N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
5.28e-14 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
2.57e2 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
1.72e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224379
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh1b1 |
T |
C |
4: 45,802,905 (GRCm39) |
Y148H |
probably damaging |
Het |
| Ankib1 |
A |
G |
5: 3,763,235 (GRCm39) |
V498A |
probably benign |
Het |
| Atp6v0c |
A |
G |
17: 24,383,493 (GRCm39) |
V118A |
possibly damaging |
Het |
| Bcan |
G |
A |
3: 87,900,748 (GRCm39) |
P495L |
probably benign |
Het |
| Bnip3l |
G |
A |
14: 67,246,214 (GRCm39) |
P7L |
possibly damaging |
Het |
| Ccdc178 |
T |
C |
18: 22,238,708 (GRCm39) |
E303G |
possibly damaging |
Het |
| Ccdc47 |
T |
C |
11: 106,101,155 (GRCm39) |
N169S |
probably benign |
Het |
| Cldn23 |
A |
T |
8: 36,293,470 (GRCm39) |
V6E |
probably damaging |
Het |
| Dip2a |
T |
C |
10: 76,132,189 (GRCm39) |
T560A |
probably damaging |
Het |
| Ephb3 |
A |
G |
16: 21,036,830 (GRCm39) |
S352G |
possibly damaging |
Het |
| Far2 |
C |
A |
6: 148,059,453 (GRCm39) |
A256E |
probably damaging |
Het |
| Gga1 |
C |
T |
15: 78,767,528 (GRCm39) |
R89C |
probably damaging |
Het |
| Hbb-bh2 |
A |
G |
7: 103,489,339 (GRCm39) |
S71P |
probably damaging |
Het |
| Lama1 |
T |
A |
17: 68,128,661 (GRCm39) |
V3006D |
|
Het |
| Lypd9 |
A |
G |
11: 58,337,215 (GRCm39) |
V86A |
probably benign |
Het |
| Mrm1 |
G |
A |
11: 84,710,132 (GRCm39) |
R23W |
probably damaging |
Het |
| Nod2 |
A |
T |
8: 89,391,906 (GRCm39) |
I738F |
probably damaging |
Het |
| Or1p1b |
C |
T |
11: 74,131,094 (GRCm39) |
R235C |
probably benign |
Het |
| Or4c35 |
G |
T |
2: 89,808,497 (GRCm39) |
C125F |
probably damaging |
Het |
| Or8b4 |
A |
G |
9: 37,830,163 (GRCm39) |
D70G |
probably damaging |
Het |
| Pkd1l1 |
A |
G |
11: 8,815,631 (GRCm39) |
W1877R |
|
Het |
| Psmd2 |
C |
T |
16: 20,478,160 (GRCm39) |
A515V |
probably benign |
Het |
| Samd9l |
A |
G |
6: 3,372,621 (GRCm39) |
Y1547H |
probably benign |
Het |
| Sgsh |
T |
C |
11: 119,237,375 (GRCm39) |
N413S |
probably benign |
Het |
| Slmap |
G |
A |
14: 26,136,133 (GRCm39) |
P819L |
probably damaging |
Het |
| Steap4 |
A |
G |
5: 8,030,538 (GRCm39) |
N465D |
probably benign |
Het |
| Sult3a2 |
T |
C |
10: 33,642,436 (GRCm39) |
N289S |
probably benign |
Het |
| Tbx2 |
T |
A |
11: 85,724,038 (GRCm39) |
S36T |
possibly damaging |
Het |
| Tcstv1a |
G |
A |
13: 120,355,267 (GRCm39) |
Q122* |
probably null |
Het |
| Tnk2 |
T |
C |
16: 32,498,961 (GRCm39) |
V758A |
possibly damaging |
Het |
| Trrap |
C |
T |
5: 144,742,904 (GRCm39) |
T1425M |
probably damaging |
Het |
| Ttc9b |
A |
G |
7: 27,354,394 (GRCm39) |
K160R |
probably damaging |
Het |
| Vinac1 |
C |
T |
2: 128,881,189 (GRCm39) |
A246T |
|
Het |
|
| Other mutations in Zfp959 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00698:Zfp959
|
APN |
17 |
56,204,565 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02731:Zfp959
|
APN |
17 |
56,202,956 (GRCm39) |
splice site |
probably benign |
|
|
IGL03206:Zfp959
|
APN |
17 |
56,204,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0141:Zfp959
|
UTSW |
17 |
56,205,139 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0347:Zfp959
|
UTSW |
17 |
56,204,180 (GRCm39) |
nonsense |
probably null |
|
|
R0522:Zfp959
|
UTSW |
17 |
56,203,201 (GRCm39) |
missense |
probably null |
1.00 |
|
R1692:Zfp959
|
UTSW |
17 |
56,205,299 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1771:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
splice site |
probably null |
|
|
R1891:Zfp959
|
UTSW |
17 |
56,204,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1945:Zfp959
|
UTSW |
17 |
56,204,231 (GRCm39) |
nonsense |
probably null |
|
|
R1959:Zfp959
|
UTSW |
17 |
56,204,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2317:Zfp959
|
UTSW |
17 |
56,204,326 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4726:Zfp959
|
UTSW |
17 |
56,205,260 (GRCm39) |
splice site |
probably null |
|
|
R4869:Zfp959
|
UTSW |
17 |
56,204,228 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5436:Zfp959
|
UTSW |
17 |
56,204,626 (GRCm39) |
missense |
probably benign |
|
|
R6235:Zfp959
|
UTSW |
17 |
56,204,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6365:Zfp959
|
UTSW |
17 |
56,204,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Zfp959
|
UTSW |
17 |
56,202,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6417:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6420:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Zfp959
|
UTSW |
17 |
56,205,501 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7380:Zfp959
|
UTSW |
17 |
56,205,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7437:Zfp959
|
UTSW |
17 |
56,205,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7568:Zfp959
|
UTSW |
17 |
56,204,886 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Zfp959
|
UTSW |
17 |
56,205,496 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8197:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Zfp959
|
UTSW |
17 |
56,204,299 (GRCm39) |
missense |
probably benign |
|
|
R8970:Zfp959
|
UTSW |
17 |
56,204,836 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9063:Zfp959
|
UTSW |
17 |
56,204,221 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9648:Zfp959
|
UTSW |
17 |
56,204,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9733:Zfp959
|
UTSW |
17 |
56,204,866 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1088:Zfp959
|
UTSW |
17 |
56,205,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGTCAGTGTGGTAAAGCTCT -3'
(R):5'- ACCTCTTACATGCAAAGGTTTTACC -3'
Sequencing Primer
(F):5'- ACGTGTCCAAACTCATATGGG -3'
(R):5'- CATGCAAAGGTTTTACCACACTG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation