Incidental Mutation 'R9506:Mknk2'
ID 717833
Institutional Source Beutler Lab
Gene Symbol Mknk2
Ensembl Gene ENSMUSG00000020190
Gene Name MAP kinase-interacting serine/threonine kinase 2
Synonyms Mnk2
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9506 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 80665327-80678112 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 80668084 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 331 (D331G)
Ref Sequence ENSEMBL: ENSMUSP00000143508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003433] [ENSMUST00000197276] [ENSMUST00000198819] [ENSMUST00000199949] [ENSMUST00000200082]
AlphaFold Q8CDB0
Predicted Effect probably benign
Transcript: ENSMUST00000003433
AA Change: D284G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000003433
Gene: ENSMUSG00000020190
AA Change: D284G

DomainStartEndE-ValueType
low complexity region 13 23 N/A INTRINSIC
S_TKc 36 321 7.09e-88 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197276
SMART Domains Protein: ENSMUSP00000143679
Gene: ENSMUSG00000020190

DomainStartEndE-ValueType
SCOP:d1koba_ 52 118 3e-11 SMART
PDB:2AC3|A 59 118 3e-32 PDB
Blast:S_TKc 71 118 1e-24 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000198819
Predicted Effect probably benign
Transcript: ENSMUST00000199949
Predicted Effect probably benign
Transcript: ENSMUST00000200082
AA Change: D331G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000143508
Gene: ENSMUSG00000020190
AA Change: D331G

DomainStartEndE-ValueType
low complexity region 60 70 N/A INTRINSIC
S_TKc 83 368 7.09e-88 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
PHENOTYPE: Homozygous null mice are viable and fertile with no gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,617,410 T632A unknown Het
Atp2b1 T C 10: 99,023,000 S1182P probably benign Het
Best3 T A 10: 117,003,921 F225I probably damaging Het
Camk1g A G 1: 193,348,055 probably null Het
Cdc42bpb G A 12: 111,294,938 P1656S probably benign Het
Cflar A T 1: 58,752,816 Q426L Het
Chrna9 T A 5: 65,970,870 D140E probably damaging Het
Cmpk2 A G 12: 26,469,851 D167G probably benign Het
Csmd1 A G 8: 16,200,009 L985P probably damaging Het
Cutal A G 2: 34,885,882 D75G probably null Het
Dnah12 G T 14: 26,792,211 V1776F probably benign Het
Dnah6 A G 6: 73,142,316 V1528A probably damaging Het
Elovl1 A G 4: 118,430,715 D16G probably damaging Het
Ermard T A 17: 15,061,106 L593M probably damaging Het
Fstl4 A G 11: 53,134,123 D274G probably benign Het
Gabrg1 C T 5: 70,782,370 V140M probably damaging Het
Glrx2 C T 1: 143,746,532 R89* probably null Het
Gsta3 A C 1: 21,257,362 D40A possibly damaging Het
Hist1h4c C T 13: 23,698,281 G57S probably benign Het
Hsf2 G A 10: 57,505,145 probably null Het
Ifi203 A G 1: 173,923,999 S833P possibly damaging Het
Ilk T C 7: 105,740,813 Y132H probably benign Het
Jup G A 11: 100,376,878 R540C probably damaging Het
Kdm7a T A 6: 39,149,371 H560L probably benign Het
Kynu T A 2: 43,681,402 N443K probably damaging Het
Mbd5 T C 2: 49,272,907 S1134P probably damaging Het
Mtfmt C T 9: 65,435,865 R18C probably benign Het
Myo5b A G 18: 74,744,760 Q1584R possibly damaging Het
Nup210 G A 6: 91,071,874 P467S possibly damaging Het
Nxf1 A G 19: 8,772,144 Y135C probably damaging Het
Olfr1200 T C 2: 88,767,496 Y273C probably damaging Het
Rab11fip3 T G 17: 25,994,276 E853A probably damaging Het
Rap1gap2 A G 11: 74,414,440 M313T probably damaging Het
Rims2 G A 15: 39,472,436 V814I probably damaging Het
Sec16a A T 2: 26,429,372 probably null Het
Slc36a3 A G 11: 55,148,631 I57T probably benign Het
Slc5a9 G A 4: 111,893,242 R140* probably null Het
Tas2r131 T A 6: 132,957,061 T262S possibly damaging Het
Tigd3 G T 19: 5,892,832 A90D probably damaging Het
Txnrd3 A G 6: 89,661,479 M217V possibly damaging Het
Ube2cbp A G 9: 86,448,772 I119T probably damaging Het
Vcp A G 4: 42,983,383 V559A probably damaging Het
Vmn1r173 T A 7: 23,702,538 I66N probably damaging Het
Vmn1r234 T G 17: 21,229,241 I139S probably benign Het
Vmn2r105 C T 17: 20,209,142 M557I probably benign Het
Wnt7b A G 15: 85,581,412 S22P unknown Het
Zfp850 C A 7: 27,989,562 R407L possibly damaging Het
Other mutations in Mknk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01468:Mknk2 APN 10 80667664 splice site probably benign
IGL02471:Mknk2 APN 10 80668121 missense probably damaging 0.99
IGL02643:Mknk2 APN 10 80668601 missense probably damaging 1.00
H8562:Mknk2 UTSW 10 80668934 splice site probably benign
IGL03052:Mknk2 UTSW 10 80669662 missense probably benign 0.12
R0645:Mknk2 UTSW 10 80671908 splice site probably null
R2061:Mknk2 UTSW 10 80671557 critical splice donor site probably null
R2105:Mknk2 UTSW 10 80668601 missense possibly damaging 0.90
R2167:Mknk2 UTSW 10 80668701 missense probably damaging 1.00
R3847:Mknk2 UTSW 10 80667975 nonsense probably null
R4649:Mknk2 UTSW 10 80669339 missense probably damaging 1.00
R5062:Mknk2 UTSW 10 80671769 missense probably damaging 1.00
R5358:Mknk2 UTSW 10 80671763 missense probably benign 0.19
R5433:Mknk2 UTSW 10 80667225 missense probably benign 0.00
R5518:Mknk2 UTSW 10 80668641 missense possibly damaging 0.92
R5813:Mknk2 UTSW 10 80675862 missense probably benign 0.34
R6060:Mknk2 UTSW 10 80671634 missense probably benign 0.00
R6151:Mknk2 UTSW 10 80669025 splice site probably null
R6366:Mknk2 UTSW 10 80671933 missense probably damaging 0.99
R7640:Mknk2 UTSW 10 80668566 missense probably benign 0.00
R7827:Mknk2 UTSW 10 80667187 missense probably benign 0.03
R7943:Mknk2 UTSW 10 80675867 missense probably benign 0.00
R8075:Mknk2 UTSW 10 80672148 intron probably benign
R9114:Mknk2 UTSW 10 80668989 missense probably damaging 1.00
R9140:Mknk2 UTSW 10 80671593 missense probably benign 0.22
R9451:Mknk2 UTSW 10 80669662 missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- ACAATGCTAGACCCTTCTTGTATG -3'
(R):5'- GCCTGTGTGACTGTCTCCATTG -3'

Sequencing Primer
(F):5'- CGTGCCCAGCAAGAGTTG -3'
(R):5'- GTGTGACTGTCTCCATTGTCCCC -3'
Posted On 2022-07-18