Incidental Mutation 'R9506:Wnt7b'
ID 717845
Institutional Source Beutler Lab
Gene Symbol Wnt7b
Ensembl Gene ENSMUSG00000022382
Gene Name wingless-type MMTV integration site family, member 7B
Synonyms Wnt-7b
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9506 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 85535437-85582473 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85581412 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 22 (S22P)
Ref Sequence ENSEMBL: ENSMUSP00000023015 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023015] [ENSMUST00000109424] [ENSMUST00000167968] [ENSMUST00000229191] [ENSMUST00000229495]
AlphaFold P28047
Predicted Effect unknown
Transcript: ENSMUST00000023015
AA Change: S22P
SMART Domains Protein: ENSMUSP00000023015
Gene: ENSMUSG00000022382
AA Change: S22P

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
WNT1 40 349 1.29e-214 SMART
Predicted Effect silent
Transcript: ENSMUST00000109424
SMART Domains Protein: ENSMUSP00000105051
Gene: ENSMUSG00000022382

DomainStartEndE-ValueType
low complexity region 20 38 N/A INTRINSIC
WNT1 44 353 1.29e-214 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167968
SMART Domains Protein: ENSMUSP00000130627
Gene: ENSMUSG00000022382

DomainStartEndE-ValueType
WNT1 1 282 1.21e-182 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000229191
Predicted Effect probably benign
Transcript: ENSMUST00000229495
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
PHENOTYPE: Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,617,410 T632A unknown Het
Atp2b1 T C 10: 99,023,000 S1182P probably benign Het
Best3 T A 10: 117,003,921 F225I probably damaging Het
Camk1g A G 1: 193,348,055 probably null Het
Cdc42bpb G A 12: 111,294,938 P1656S probably benign Het
Cflar A T 1: 58,752,816 Q426L Het
Chrna9 T A 5: 65,970,870 D140E probably damaging Het
Cmpk2 A G 12: 26,469,851 D167G probably benign Het
Csmd1 A G 8: 16,200,009 L985P probably damaging Het
Cutal A G 2: 34,885,882 D75G probably null Het
Dnah12 G T 14: 26,792,211 V1776F probably benign Het
Dnah6 A G 6: 73,142,316 V1528A probably damaging Het
Elovl1 A G 4: 118,430,715 D16G probably damaging Het
Ermard T A 17: 15,061,106 L593M probably damaging Het
Fstl4 A G 11: 53,134,123 D274G probably benign Het
Gabrg1 C T 5: 70,782,370 V140M probably damaging Het
Glrx2 C T 1: 143,746,532 R89* probably null Het
Gsta3 A C 1: 21,257,362 D40A possibly damaging Het
Hist1h4c C T 13: 23,698,281 G57S probably benign Het
Hsf2 G A 10: 57,505,145 probably null Het
Ifi203 A G 1: 173,923,999 S833P possibly damaging Het
Ilk T C 7: 105,740,813 Y132H probably benign Het
Jup G A 11: 100,376,878 R540C probably damaging Het
Kdm7a T A 6: 39,149,371 H560L probably benign Het
Kynu T A 2: 43,681,402 N443K probably damaging Het
Mbd5 T C 2: 49,272,907 S1134P probably damaging Het
Mknk2 T C 10: 80,668,084 D331G probably benign Het
Mtfmt C T 9: 65,435,865 R18C probably benign Het
Myo5b A G 18: 74,744,760 Q1584R possibly damaging Het
Nup210 G A 6: 91,071,874 P467S possibly damaging Het
Nxf1 A G 19: 8,772,144 Y135C probably damaging Het
Olfr1200 T C 2: 88,767,496 Y273C probably damaging Het
Rab11fip3 T G 17: 25,994,276 E853A probably damaging Het
Rap1gap2 A G 11: 74,414,440 M313T probably damaging Het
Rims2 G A 15: 39,472,436 V814I probably damaging Het
Sec16a A T 2: 26,429,372 probably null Het
Slc36a3 A G 11: 55,148,631 I57T probably benign Het
Slc5a9 G A 4: 111,893,242 R140* probably null Het
Tas2r131 T A 6: 132,957,061 T262S possibly damaging Het
Tigd3 G T 19: 5,892,832 A90D probably damaging Het
Txnrd3 A G 6: 89,661,479 M217V possibly damaging Het
Ube2cbp A G 9: 86,448,772 I119T probably damaging Het
Vcp A G 4: 42,983,383 V559A probably damaging Het
Vmn1r173 T A 7: 23,702,538 I66N probably damaging Het
Vmn1r234 T G 17: 21,229,241 I139S probably benign Het
Vmn2r105 C T 17: 20,209,142 M557I probably benign Het
Zfp850 C A 7: 27,989,562 R407L possibly damaging Het
Other mutations in Wnt7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02543:Wnt7b APN 15 85558896 splice site probably benign
R0243:Wnt7b UTSW 15 85558902 critical splice donor site probably null
R0735:Wnt7b UTSW 15 85537495 missense probably damaging 1.00
R0835:Wnt7b UTSW 15 85537777 missense probably damaging 1.00
R1917:Wnt7b UTSW 15 85559080 missense probably damaging 1.00
R1919:Wnt7b UTSW 15 85559080 missense probably damaging 1.00
R3914:Wnt7b UTSW 15 85537858 missense possibly damaging 0.90
R5893:Wnt7b UTSW 15 85581374 intron probably benign
R7483:Wnt7b UTSW 15 85537414 missense possibly damaging 0.95
R7498:Wnt7b UTSW 15 85543679 missense probably damaging 1.00
R7787:Wnt7b UTSW 15 85543911 missense probably damaging 0.99
R8079:Wnt7b UTSW 15 85537445 missense probably damaging 1.00
R8278:Wnt7b UTSW 15 85543686 missense
R9382:Wnt7b UTSW 15 85558974 missense probably damaging 1.00
Z1177:Wnt7b UTSW 15 85559069 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGAGTCTCAACGAGGCTG -3'
(R):5'- AGATGCGTTCGTGTGTCAC -3'

Sequencing Primer
(F):5'- CTCAACGAGGCTGGGTTG -3'
(R):5'- TCACCATGGTGGCAACG -3'
Posted On 2022-07-18