Incidental Mutation 'R9506:Vmn2r105'
| ID |
717848 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r105
|
| Ensembl Gene |
ENSMUSG00000091670 |
| Gene Name |
vomeronasal 2, receptor 105 |
| Synonyms |
EG627743 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9506 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20428492-20455134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 20429404 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 557
(M557I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167382]
|
| AlphaFold |
E9Q3A5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167382
AA Change: M557I
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: M557I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
85 |
469 |
6.5e-42 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
3.2e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.5e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi3bp |
A |
G |
16: 56,437,773 (GRCm39) |
T632A |
unknown |
Het |
| Atp2b1 |
T |
C |
10: 98,858,862 (GRCm39) |
S1182P |
probably benign |
Het |
| Best3 |
T |
A |
10: 116,839,826 (GRCm39) |
F225I |
probably damaging |
Het |
| Camk1g |
A |
G |
1: 193,030,363 (GRCm39) |
|
probably null |
Het |
| Cdc42bpb |
G |
A |
12: 111,261,372 (GRCm39) |
P1656S |
probably benign |
Het |
| Cflar |
A |
T |
1: 58,791,975 (GRCm39) |
Q426L |
|
Het |
| Chrna9 |
T |
A |
5: 66,128,213 (GRCm39) |
D140E |
probably damaging |
Het |
| Cmpk2 |
A |
G |
12: 26,519,850 (GRCm39) |
D167G |
probably benign |
Het |
| Csmd1 |
A |
G |
8: 16,250,023 (GRCm39) |
L985P |
probably damaging |
Het |
| Cutal |
A |
G |
2: 34,775,894 (GRCm39) |
D75G |
probably null |
Het |
| Dnah12 |
G |
T |
14: 26,514,168 (GRCm39) |
V1776F |
probably benign |
Het |
| Dnah6 |
A |
G |
6: 73,119,299 (GRCm39) |
V1528A |
probably damaging |
Het |
| Elovl1 |
A |
G |
4: 118,287,912 (GRCm39) |
D16G |
probably damaging |
Het |
| Ermard |
T |
A |
17: 15,281,368 (GRCm39) |
L593M |
probably damaging |
Het |
| Fstl4 |
A |
G |
11: 53,024,950 (GRCm39) |
D274G |
probably benign |
Het |
| Gabrg1 |
C |
T |
5: 70,939,713 (GRCm39) |
V140M |
probably damaging |
Het |
| Glrx2 |
C |
T |
1: 143,622,270 (GRCm39) |
R89* |
probably null |
Het |
| Gsta3 |
A |
C |
1: 21,327,586 (GRCm39) |
D40A |
possibly damaging |
Het |
| H4c3 |
C |
T |
13: 23,882,264 (GRCm39) |
G57S |
probably benign |
Het |
| Hsf2 |
G |
A |
10: 57,381,241 (GRCm39) |
|
probably null |
Het |
| Ifi203 |
A |
G |
1: 173,751,565 (GRCm39) |
S833P |
possibly damaging |
Het |
| Ilk |
T |
C |
7: 105,390,020 (GRCm39) |
Y132H |
probably benign |
Het |
| Jup |
G |
A |
11: 100,267,704 (GRCm39) |
R540C |
probably damaging |
Het |
| Kdm7a |
T |
A |
6: 39,126,305 (GRCm39) |
H560L |
probably benign |
Het |
| Kynu |
T |
A |
2: 43,571,414 (GRCm39) |
N443K |
probably damaging |
Het |
| Mbd5 |
T |
C |
2: 49,162,919 (GRCm39) |
S1134P |
probably damaging |
Het |
| Mknk2 |
T |
C |
10: 80,503,918 (GRCm39) |
D331G |
probably benign |
Het |
| Mtfmt |
C |
T |
9: 65,343,147 (GRCm39) |
R18C |
probably benign |
Het |
| Myo5b |
A |
G |
18: 74,877,831 (GRCm39) |
Q1584R |
possibly damaging |
Het |
| Nup210 |
G |
A |
6: 91,048,856 (GRCm39) |
P467S |
possibly damaging |
Het |
| Nxf1 |
A |
G |
19: 8,749,508 (GRCm39) |
Y135C |
probably damaging |
Het |
| Or4a67 |
T |
C |
2: 88,597,840 (GRCm39) |
Y273C |
probably damaging |
Het |
| Rab11fip3 |
T |
G |
17: 26,213,250 (GRCm39) |
E853A |
probably damaging |
Het |
| Rap1gap2 |
A |
G |
11: 74,305,266 (GRCm39) |
M313T |
probably damaging |
Het |
| Rims2 |
G |
A |
15: 39,335,832 (GRCm39) |
V814I |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,319,384 (GRCm39) |
|
probably null |
Het |
| Slc36a3 |
A |
G |
11: 55,039,457 (GRCm39) |
I57T |
probably benign |
Het |
| Slc5a9 |
G |
A |
4: 111,750,439 (GRCm39) |
R140* |
probably null |
Het |
| Tas2r131 |
T |
A |
6: 132,934,024 (GRCm39) |
T262S |
possibly damaging |
Het |
| Tigd3 |
G |
T |
19: 5,942,860 (GRCm39) |
A90D |
probably damaging |
Het |
| Txnrd3 |
A |
G |
6: 89,638,461 (GRCm39) |
M217V |
possibly damaging |
Het |
| Ube3d |
A |
G |
9: 86,330,825 (GRCm39) |
I119T |
probably damaging |
Het |
| Vcp |
A |
G |
4: 42,983,383 (GRCm39) |
V559A |
probably damaging |
Het |
| Vmn1r173 |
T |
A |
7: 23,401,963 (GRCm39) |
I66N |
probably damaging |
Het |
| Vmn1r234 |
T |
G |
17: 21,449,503 (GRCm39) |
I139S |
probably benign |
Het |
| Wnt7b |
A |
G |
15: 85,465,613 (GRCm39) |
S22P |
unknown |
Het |
| Zfp850 |
C |
A |
7: 27,688,987 (GRCm39) |
R407L |
possibly damaging |
Het |
|
| Other mutations in Vmn2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01433:Vmn2r105
|
APN |
17 |
20,448,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01909:Vmn2r105
|
APN |
17 |
20,444,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01925:Vmn2r105
|
APN |
17 |
20,428,973 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02021:Vmn2r105
|
APN |
17 |
20,448,157 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02828:Vmn2r105
|
APN |
17 |
20,429,345 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02838:Vmn2r105
|
APN |
17 |
20,447,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Vmn2r105
|
APN |
17 |
20,446,631 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0212:Vmn2r105
|
UTSW |
17 |
20,428,827 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0268:Vmn2r105
|
UTSW |
17 |
20,428,938 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0271:Vmn2r105
|
UTSW |
17 |
20,454,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0613:Vmn2r105
|
UTSW |
17 |
20,428,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,448,119 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1162:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1263:Vmn2r105
|
UTSW |
17 |
20,428,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1363:Vmn2r105
|
UTSW |
17 |
20,428,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1464:Vmn2r105
|
UTSW |
17 |
20,449,004 (GRCm39) |
splice site |
probably benign |
|
|
R2029:Vmn2r105
|
UTSW |
17 |
20,444,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2421:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2422:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2570:Vmn2r105
|
UTSW |
17 |
20,447,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3848:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4030:Vmn2r105
|
UTSW |
17 |
20,429,016 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4275:Vmn2r105
|
UTSW |
17 |
20,448,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Vmn2r105
|
UTSW |
17 |
20,446,613 (GRCm39) |
missense |
probably benign |
|
|
R4801:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Vmn2r105
|
UTSW |
17 |
20,428,953 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4929:Vmn2r105
|
UTSW |
17 |
20,448,280 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5022:Vmn2r105
|
UTSW |
17 |
20,428,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5475:Vmn2r105
|
UTSW |
17 |
20,455,044 (GRCm39) |
missense |
probably benign |
|
|
R5576:Vmn2r105
|
UTSW |
17 |
20,444,836 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5795:Vmn2r105
|
UTSW |
17 |
20,448,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5895:Vmn2r105
|
UTSW |
17 |
20,448,929 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6017:Vmn2r105
|
UTSW |
17 |
20,428,889 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6210:Vmn2r105
|
UTSW |
17 |
20,448,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6491:Vmn2r105
|
UTSW |
17 |
20,447,992 (GRCm39) |
nonsense |
probably null |
|
|
R6542:Vmn2r105
|
UTSW |
17 |
20,448,803 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6729:Vmn2r105
|
UTSW |
17 |
20,428,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7020:Vmn2r105
|
UTSW |
17 |
20,429,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn2r105
|
UTSW |
17 |
20,428,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7488:Vmn2r105
|
UTSW |
17 |
20,429,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7491:Vmn2r105
|
UTSW |
17 |
20,448,827 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7555:Vmn2r105
|
UTSW |
17 |
20,447,937 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7863:Vmn2r105
|
UTSW |
17 |
20,428,937 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8137:Vmn2r105
|
UTSW |
17 |
20,454,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8166:Vmn2r105
|
UTSW |
17 |
20,428,904 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8186:Vmn2r105
|
UTSW |
17 |
20,444,880 (GRCm39) |
nonsense |
probably null |
|
|
R8214:Vmn2r105
|
UTSW |
17 |
20,448,775 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8497:Vmn2r105
|
UTSW |
17 |
20,455,134 (GRCm39) |
start codon destroyed |
probably null |
0.75 |
|
R8850:Vmn2r105
|
UTSW |
17 |
20,428,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Vmn2r105
|
UTSW |
17 |
20,429,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9272:Vmn2r105
|
UTSW |
17 |
20,447,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9549:Vmn2r105
|
UTSW |
17 |
20,448,023 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCTTGACAATAGGAGTGTG -3'
(R):5'- TGATCCAACTGAAGCCATCC -3'
Sequencing Primer
(F):5'- GTGTCTGTTTTTCACAAAGATGCC -3'
(R):5'- TGCCTCAGTAGTTATAGCAAGAG -3'
|
| Posted On |
2022-07-18 |
Incidental Mutation