Incidental Mutation 'R9506:Tigd3'
ID 717852
Institutional Source Beutler Lab
Gene Symbol Tigd3
Ensembl Gene ENSMUSG00000044390
Gene Name tigger transposable element derived 3
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.702) question?
Stock # R9506 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 5941166-5944156 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 5942860 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Aspartic acid at position 90 (A90D)
Ref Sequence ENSEMBL: ENSMUSP00000059302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055911] [ENSMUST00000118623] [ENSMUST00000136983]
AlphaFold Q7TM95
Predicted Effect probably benign
Transcript: ENSMUST00000025746
SMART Domains Protein: ENSMUSP00000025746
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 1 40 1.4e-19 PFAM
low complexity region 115 131 N/A INTRINSIC
low complexity region 134 152 N/A INTRINSIC
ZnF_C2H2 165 188 4.47e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000055911
AA Change: A90D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000059302
Gene: ENSMUSG00000044390
AA Change: A90D

DomainStartEndE-ValueType
Pfam:CENP-B_N 6 59 2.5e-15 PFAM
CENPB 73 137 2.96e-7 SMART
Pfam:DDE_1 192 360 7.4e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118623
SMART Domains Protein: ENSMUSP00000113465
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 13 84 7.9e-40 PFAM
low complexity region 159 175 N/A INTRINSIC
low complexity region 178 196 N/A INTRINSIC
PDB:3IUF|A 203 263 1e-21 PDB
PHD 286 342 8.64e-9 SMART
RING 287 341 3.83e0 SMART
PHD 343 389 8.9e-11 SMART
RING 344 388 9.75e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136983
SMART Domains Protein: ENSMUSP00000120125
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 12 85 6.2e-41 PFAM
low complexity region 159 175 N/A INTRINSIC
low complexity region 178 196 N/A INTRINSIC
ZnF_C2H2 209 232 4.47e-3 SMART
PHD 272 328 8.64e-9 SMART
RING 273 327 3.83e0 SMART
PHD 329 375 8.9e-11 SMART
RING 330 374 9.75e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp A G 16: 56,437,773 (GRCm39) T632A unknown Het
Atp2b1 T C 10: 98,858,862 (GRCm39) S1182P probably benign Het
Best3 T A 10: 116,839,826 (GRCm39) F225I probably damaging Het
Camk1g A G 1: 193,030,363 (GRCm39) probably null Het
Cdc42bpb G A 12: 111,261,372 (GRCm39) P1656S probably benign Het
Cflar A T 1: 58,791,975 (GRCm39) Q426L Het
Chrna9 T A 5: 66,128,213 (GRCm39) D140E probably damaging Het
Cmpk2 A G 12: 26,519,850 (GRCm39) D167G probably benign Het
Csmd1 A G 8: 16,250,023 (GRCm39) L985P probably damaging Het
Cutal A G 2: 34,775,894 (GRCm39) D75G probably null Het
Dnah12 G T 14: 26,514,168 (GRCm39) V1776F probably benign Het
Dnah6 A G 6: 73,119,299 (GRCm39) V1528A probably damaging Het
Elovl1 A G 4: 118,287,912 (GRCm39) D16G probably damaging Het
Ermard T A 17: 15,281,368 (GRCm39) L593M probably damaging Het
Fstl4 A G 11: 53,024,950 (GRCm39) D274G probably benign Het
Gabrg1 C T 5: 70,939,713 (GRCm39) V140M probably damaging Het
Glrx2 C T 1: 143,622,270 (GRCm39) R89* probably null Het
Gsta3 A C 1: 21,327,586 (GRCm39) D40A possibly damaging Het
H4c3 C T 13: 23,882,264 (GRCm39) G57S probably benign Het
Hsf2 G A 10: 57,381,241 (GRCm39) probably null Het
Ifi203 A G 1: 173,751,565 (GRCm39) S833P possibly damaging Het
Ilk T C 7: 105,390,020 (GRCm39) Y132H probably benign Het
Jup G A 11: 100,267,704 (GRCm39) R540C probably damaging Het
Kdm7a T A 6: 39,126,305 (GRCm39) H560L probably benign Het
Kynu T A 2: 43,571,414 (GRCm39) N443K probably damaging Het
Mbd5 T C 2: 49,162,919 (GRCm39) S1134P probably damaging Het
Mknk2 T C 10: 80,503,918 (GRCm39) D331G probably benign Het
Mtfmt C T 9: 65,343,147 (GRCm39) R18C probably benign Het
Myo5b A G 18: 74,877,831 (GRCm39) Q1584R possibly damaging Het
Nup210 G A 6: 91,048,856 (GRCm39) P467S possibly damaging Het
Nxf1 A G 19: 8,749,508 (GRCm39) Y135C probably damaging Het
Or4a67 T C 2: 88,597,840 (GRCm39) Y273C probably damaging Het
Rab11fip3 T G 17: 26,213,250 (GRCm39) E853A probably damaging Het
Rap1gap2 A G 11: 74,305,266 (GRCm39) M313T probably damaging Het
Rims2 G A 15: 39,335,832 (GRCm39) V814I probably damaging Het
Sec16a A T 2: 26,319,384 (GRCm39) probably null Het
Slc36a3 A G 11: 55,039,457 (GRCm39) I57T probably benign Het
Slc5a9 G A 4: 111,750,439 (GRCm39) R140* probably null Het
Tas2r131 T A 6: 132,934,024 (GRCm39) T262S possibly damaging Het
Txnrd3 A G 6: 89,638,461 (GRCm39) M217V possibly damaging Het
Ube3d A G 9: 86,330,825 (GRCm39) I119T probably damaging Het
Vcp A G 4: 42,983,383 (GRCm39) V559A probably damaging Het
Vmn1r173 T A 7: 23,401,963 (GRCm39) I66N probably damaging Het
Vmn1r234 T G 17: 21,449,503 (GRCm39) I139S probably benign Het
Vmn2r105 C T 17: 20,429,404 (GRCm39) M557I probably benign Het
Wnt7b A G 15: 85,465,613 (GRCm39) S22P unknown Het
Zfp850 C A 7: 27,688,987 (GRCm39) R407L possibly damaging Het
Other mutations in Tigd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0456:Tigd3 UTSW 19 5,942,821 (GRCm39) missense probably damaging 1.00
R0699:Tigd3 UTSW 19 5,941,974 (GRCm39) missense probably benign
R1416:Tigd3 UTSW 19 5,941,753 (GRCm39) missense probably benign
R3945:Tigd3 UTSW 19 5,942,461 (GRCm39) missense probably damaging 0.98
R5945:Tigd3 UTSW 19 5,941,894 (GRCm39) missense probably benign
R6253:Tigd3 UTSW 19 5,942,870 (GRCm39) missense probably damaging 1.00
R7189:Tigd3 UTSW 19 5,943,050 (GRCm39) missense probably benign 0.09
R7956:Tigd3 UTSW 19 5,942,594 (GRCm39) missense possibly damaging 0.88
R8976:Tigd3 UTSW 19 5,941,853 (GRCm39) missense probably benign 0.00
R8979:Tigd3 UTSW 19 5,941,853 (GRCm39) missense probably benign 0.00
R9702:Tigd3 UTSW 19 5,942,836 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAACTGCAGGAGGAGCTTC -3'
(R):5'- TGGAACTCTTGGATGAGTCTAAGATG -3'

Sequencing Primer
(F):5'- CTGCAGGAGGAGCTTCAGGAG -3'
(R):5'- TGAGTCTAAGATGTCCCAGTCAG -3'
Posted On 2022-07-18